Longitudinal assessment of systemic steroid therapy on hyperinflammatory endothelial biomarker profiles and serology responses of COVID-19 patientsArticle Published on 2022-09-082022-11-15 Journal: Journal of Translational Medicine [Category] SARS, 바이오마커, [키워드] Abstract Biomarker COVID-19 COVID-19 patient CXCL9 cytokine Dexamethasone endothelial Hyperinflammatory Inflammation longitudinal profile response serology therapy [DOI] 10.1186/s12967-022-03583-5 PMC 바로가기
Circulating Endothelial Cells: A New Possible Marker of Endothelial Damage in Kawasaki Disease, Multisystem Inflammatory Syndrome in Children and Acute SARS-CoV-2 InfectionArticle Published on 2022-09-032022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 바이오마커, 치료기술, [키워드] acute COVID-19 Biomarker Cell CellSearch characterized children circulating circulating endothelial cells conducted coronary artery lesions correlation COVID-19 damage decrease disease Diseases endothelial Endothelial cell Endothelial dysfunction endothelial injury enrolled incidence Inflammatory Kawasaki disease lesion mechanism Mild MIS-C multicenter multisystem inflammatory syndrome in children New Patient patients pediatric Prospective Study SARS-CoV-2 syndrome systemic inflammation Vascular injury Whole blood [DOI] 10.3390/ijms231710106 PMC 바로가기
Consecutive central and branch retinal vein occlusions in the same eye of a young healthy COVID-19 patient: A unique case reportCase report Published on 2022-09-012022-10-05 Journal: American Journal of Ophthalmology Case Reports [Category] 바이오마커, [키워드] Anti-vascular endothelial growth factor Anticoagulant Aspirin branch retinal vein occlusion Case report Central retinal vein occlusion Complete coronavirus disease correlated COVID-19 decrease demonstrated Diagnosis diagnosis of COVID-19 edema endothelial etiology Fluorescein Follow-up growth factor had no healthy hemorrhages identify Infection intravitreal knowledge low-dose macular edema observation occurred Patient Prophylaxis retinal vein risk factor tomography Treatment undergo unique visual acuity was done was increased while with COVID-19 [DOI] 10.1016/j.ajoc.2022.101669 [Article Type] Case report
Cleavage-Responsive Biofactory T Cells Suppress Infectious Diseases-Associated HypercytokinemiaArticle Published on 2022-09-012022-11-15 Journal: Advanced Science [Category] 바이오마커, [키워드] activate administration Alpha Blood chimeric cleavage cleavage site coronavirus disease COVID-19 digestion Diseases domain drug endothelial engineered blood vessel engineered T cell enzyme EPCR Express expressing hypercytokinemia immune cells in vivo induce Infectious disease lentiviral system lung tissue multiple organ failure Necrosis overcome peptide Prevent Protein receptor Release Sepsis suppress T cell therapeutic thrombin receptor TRAP Treatment Vascular damage vessel [DOI] 10.1002/advs.202201883 PMC 바로가기
Antibodies against the SARS-CoV-2 S1-RBD cross-react with dengue virus and hinder dengue pathogenesisArticle Published on 2022-08-152022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] acute respiratory syndrome addition anti-SARS-CoV-2 antibody Antibody-dependent enhancement antigenic bleeding controls coronavirus COVID-19 COVID-19 patient cross-protection cross-react cross-reactive antibody cross-reactivity dengue patient dengue virus Diagnosis disease disease severity domain endothelial envelope protein epitope False-positive hyperimmune IgG in vitro induce Infection inhibited mice Neutralizing nonstructural protein 1 passive transfer Pathogenesis peptide promote purified random reaction reduced reported SARS-CoV-2 SARS-COV-2 infection sera serology test significantly increased Spike protein Spread the SARS-CoV-2 [DOI] 10.3389/fimmu.2022.941923 PMC 바로가기
Blood biomarkers representing maternal-fetal interface tissues used to predict early-and late-onset preeclampsia but not COVID-19 infectionResearch article Published on 2022-08-082022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 바이오마커, [키워드] Applying AUROC Biomarker Biomarkers Blood blood transcriptome change characteristic chose Cluster Co-infection collected combinations confidence interval COVID-19 COVID-19 infection COVID-19 pandemic dataset defined DEGs differentially expressed disorder dysfunction early-onset eligible endothelial event experiments explained expressed identify independent Infection information interferon Intervention IRF6 ITGA5 machine learning males mechanism MOST overlapped P2RX7 pandemic placental positive predict predicted Predictive predictor preeclampsia Pregnancy proportion Regulatory representing Result selected severe COVID-19 significantly tissue tissues transcript Transcriptome was determined with COVID-19 Z-score [DOI] 10.1016/j.csbj.2022.08.011 [Article Type] Research article
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics Reviews Published on 2022-08-022022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 치료제, [키워드] atherosclerotic atherosclerotic lesion benefit Cancer cancers cardiovascular disease cardiovascular diseases cardiovascular event cardiovascular system Cell cholesterol cholesterol homeostasis cholesteryl esters clinics Critical CVD diabetes disease Diseases Disturbed endothelial events Health inhibiting Intervention Lipid Low-Density Lipoprotein cholesterol maintaining mechanism molecular neurodegenerative nonalcoholic fatty liver obesity Osteoporosis pathway preclinical study Prevent PROTECT Regulation regulatory pathways Research shown target Transport Treatment virus infection [DOI] 10.1038/s41392-022-01125-5 [Article Type] Reviews
Serum of Post-COVID-19 Syndrome Patients with or without ME/CFS Differentially Affects Endothelial Cell Function In VitroME/CFS가 있거나 없는 포스트 코로나19 증후군 환자의 혈청은 체외 내피 세포 기능에 차등적으로 영향을 미칩니다Article Published on 2022-08-022022-09-11 Journal: Cells [Category] 바이오마커, [키워드] Activation analysed Angiogenesis autoantibodies autoantibody binding Cell chronic fatigue syndrome compensatory mechanism COVID-19 Cytokines demonstrated develop Diagnostic Criteria dysregulated Effect Encephalomyelitis endothelial endothelial cells Endothelial dysfunction fatigue fatigue syndrome flow cytometry function functional groups healthy control healthy controls hypothesise in vitro investigated involved marker mechanism molecules Myalgic encephalomyelitis/chronic fatigue syndrome nitric oxide Patient patient cohort patient group patient groups patients post-COVID syndrome profile promoted proportion reduced screened secretion sera serum serum cytokines significantly significantly increased small molecule Small molecules syndrome vascular remodelling was measured while [DOI] 10.3390/cells11152376 PMC 바로가기 [Article Type] Article
Increased plasma level of soluble P-selectin in non-hospitalized COVID-19 convalescent donors입원하지 않은 COVID-19 회복기 기증자에서 가용성 P-셀렉틴의 혈장 수준 증가Article Published on 2022-08-012022-09-11 Journal: Thrombosis research [Category] MERS, 바이오마커, 임상, [키워드] Activation acute disease baseline characteristics Biomarker Blood blood donor Blood donors blood sampling CD62P Characteristics Coagulation Coagulation system comparable Control controls convalescent coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 convalescent donor COVID-19 convalescent donors COVID-19 diagnosis COVID-19 symptom COVID-19 symptoms decrease demonstrated disease disease severity Donor donors ELISA endothelial evaluated Factor flow cytometry hospitalized COVID-19 patient hospitalized COVID-19 patients implication in vitro Increased lead longitudinal study marker Moderate COVID-19 MOST non-infected P-selectin Participation phenotype plasma plasma concentration Plasma marker plasma samples Platelet platelet activation Platelet function procoagulant questionnaire recruited reported Research SARS-CoV-2 SARS-COV-2 infection significantly higher Soluble P-selectin. study groups suffered systemic disease Transmission Trial Vascular was determined was measured was obtained was performed were recorded [DOI] 10.1016/j.thromres.2022.06.014 PMC 바로가기 [Article Type] Article
On the origin of nitrosylated hemoglobin in COVID-19: Endothelial NO capture or redox conversion of nitrite?: Experimental results and a cautionary note on challenges in translational researchShort communication Published on 2022-08-012022-10-05 Journal: Redox Biology [Category] 치료기술, [키워드] added affecting antioxidants Ascorbate Bacterial baseline Blood blood collection cardiovascular risk Cell circulating complex Concentration COVID-19 COVID-19 patient cysteine Degradation dietary habit downstream endothelial Endothelial dysfunction Experimental result fraction generate hemoglobin impair in healthy individual include Interaction maintain majority marker metabolism Nitrate nitric oxide nitrite oxidative stress oxygen Patient Premature Prevent released reported Research risk subject Thiols tissue translational uninfected vascular dysfunction [DOI] 10.1016/j.redox.2022.102362 [Article Type] Short communication