experimental model – Page 3 – Communicable Diseases Research

Effects of cigarette smoking on SARS-CoV-2 receptor ACE2 expression in the respiratory epithelium †

호흡기 상피에서 SARS-CoV-2 수용체 ACE2 발현에 대한 흡연의 영향 †

Comment

Published on 2021-04-012022-09-11
Journal: The Journal of pathology [Category] SARS, 유전자 메커니즘,

[키워드] ACE2 ACE2 expression ACE2 receptor acute respiratory syndrome coronavirus airway airway epithelium apical surface cellular entry cigarette smoke cigarette smoking coronavirus 2 COVID-19 COVID-19 symptom COVID-19 symptoms Effect experimental model experimental models future therapeutic gene expression datasets Great Britain highlight human lung tissue implication increase Ireland journal limitation Lung injury morbidity and mortality mortality rates murine model pandemic pathological pathology respiratory respiratory epithelium risk of transmission SARS-CoV-2 SARS-CoV-2 receptor Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 smoke smoking smoking cessation Society Sons structures virus
[DOI] 10.1002/path.5607 PMC 바로가기 [Article Type] Comment

Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Angiotensin-Converting Enzyme 2 Levels: A Comprehensive Analysis Based on Animal Studies

Pharmacology

Published on 2021-03-082022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] ACE2 ACE2 expression ACEi ACEIs acute respiratory syndrome administration airways angiotensin angiotensin converrting enzyme angiotensin receptor blocker angiotensin-converting enzyme inhibitor animal animal study ARB ARBs blocker caused Cell cellular Chronic kidney disease Comprehensive coronavirus coronavirus disease COVID‐19 drug Effect enzyme experimental model experimental models heart failure hypertension inhibitor Lung injury Lungs majority outbreak outcome oxidative damage pandemic pathogen promoter Protective protective factor receptor report reported SARS-CoV-2 SARS‐CoV‐2 suggested Treatment viral entry virus
[DOI] 10.3389/fphar.2021.619524 PMC 바로가기 [Article Type] Pharmacology

Hamster and ferret experimental infection with intranasal low dose of a single strain of SARS-CoV-2

SARS-CoV-2의 단일 균주의 비강 내 저용량으로 햄스터 및 흰 족제비 실험 감염

Article

Published on 2021-03-012022-09-11
Journal: The Journal of General Virology [Category] MERS, SARS, 진단, 치료기술,

[키워드] Antiviral strategies Brain can be used clinical disease COVID-19 drugs excretion experimental animal model experimental model experimental models ferret ferrets French hamster hamsters immune response immune responses in vivo individual Infection infection levels inoculation intranasal Kinetics low dose lung Lungs Medulla oblongata Mild oblongata olfactory olfactory bulb Pathogenesis pathogenicity pathology protective effect remained resolved RNA SARS-CoV-2 SARS-COV-2 infection serological response severe disease severity the disease the SARS-CoV-2 therapeutic strategy understanding undetectable Viral Viral RNA virus
[DOI] 10.1099/jgv.0.001567 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Causes Severe Epithelial Inflammation and Barrier Dysfunction

Virus-Cell Interactions

Published on 2021-02-262022-10-30
Journal: Journal of Virology [Category] COVID-19,

[키워드] accompanied acute respiratory syndrome affected alveolar Asymptomatic barrier cause cell type chip model complex component composed conducted coronavirus Coronavirus disease-19 Course courses COVID-19 Culture cytokine damaged dependent on dissemination Effect endothelial Endothelial cell Endothelium epithelial epithelial cell epithelial/endothelial barrier experimental model experiments expression Factor Health care system homeostatic Host immune reactions in vitro experiments infected with SARS-CoV-2 Infection Inflammatory response Interaction interferon interferons Mild molecular mononuclear cells overcome Prolonged infection promote Replication Research Respiratory system SARS-CoV-2 severe COVID-19 severe COVID-19 disease Symptom systemic symptoms the disease Thromboembolic event variety viral infection Viral load viral particle viral pathogen viral spread Viremia virus virus replication
[DOI] 10.1128/JVI.00110-21 PMC 바로가기 [Article Type] Virus-Cell Interactions

Pathogen-Reservoir Interactions: What We Do Not Know Likely Will Hurt Us

Perspective

Published on 2021-01-282022-10-28
Journal: Viruses [Category] COVID-19, Fulltext, MERS, 조류인플루엔자,

[키워드] activities anthroponosis bats colony coronavirus disease experimental infections experimental model Host information interactions Pathogenesis reservoir reverse transmission SARS-CoV-2 selective virus zoonosis
[DOI] 10.3390/v13020195 PMC 바로가기 [Article Type] Perspective

Coronaviruses Associated with the Superfamily Musteloidea

Minireview

Published on 2021-01-192022-10-29
Journal: mBio [Category] COVID-19, MERS,

Experimental Models to Study COVID-19 Effect in Stem Cells

Review

Published on 2021-01-072022-10-31
Journal: Cells [Category] COVID-19, MERS,

Molecular Mechanisms of Vascular Damage During Lung Injury

폐 손상 중 혈관 손상의 분자 메커니즘

Review

Published on 2021-01-012022-09-11
Journal: Advances in experimental medicine and biology [Category] 유전자 메커니즘,

[키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome ADRS alveolar epithelium ARDS association behavioral risk factors change contribute COVID-19 Cytokines damage disease disease risk Disruption DNA DNA methylation endothelial activation Enzyme inhibitor Enzyme inhibitors Epigenetic epigenetics epithelial Epithelial barrier evaluate experimental model experimental models explained Factor focus Genetic genetic factors Genetic polymorphism genetic polymorphisms Genetic predisposition high mortality rate histone Histone acetylation, DNA methylation Hospitalization humans increased vascular permeability Inflammation Inflammatory response Injury intensive care lung endothelial Lung injury mechanism Modification molecular mechanism molecular mechanisms Mortality occur offer Pathogenesis phenotypic potential therapeutic target Prevent pro-inflammatory cytokines promote Research respiratory distress Respiratory distress syndrome Risk factors susceptibility syndrome systemic and local treat variety Vascular damage Vascular endothelium vascular permeability
[DOI] 10.1007/978-3-030-68748-9_6 PMC 바로가기 [Article Type] Review

Anti-Inflammatory Effects of Amantadine and Memantine: Possible Therapeutics for the Treatment of Covid-19?

Communication

Published on 2020-11-092022-10-30
Journal: Journal of Personalized Medicine [Category] COVID-19,

In Vitro Antiviral Activity of Doxycycline against SARS-CoV-2

Article

Published on 2020-10-312022-10-30
Journal: Molecules [Category] COVID-19, SARS,

[키워드] activities activity acute respiratory syndrome America Anti-inflammatory anti-inflammatory effect antimalarial Antiviral antiviral activity antiviral drug Antiviral effect approach approved drug Asia Clinical treatment clinically Co-infection Concentration containment measures coronavirus coronavirus disease COVID-19 doxycycline Drug discovery effective Europe evaluate experimental model expression high-risk patient identifying in vitro in vitro activity in vitro study initiated intravenous median moderate patients Prevent pro-inflammatory cytokine Prophylaxis Replication required SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 strain Severe COVID-19 Infection Spread Therapies translate Treatment Trial Vero E6 cell virus entry Wuhan, China
[DOI] 10.3390/molecules25215064 PMC 바로가기 [Article Type] Article