Comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’'SARS-CoV-2는 폐에서 항응고제 및 섬유소 용해 유전자 발현을 억제한다'에 대한 논평Comment Published on 2022-01-112022-09-10 Journal: eLife [Category] SARS, 유전자 메커니즘, [키워드] Analysis analyzed Anticoagulant asthmatic BALF Bronchoalveolar lavage fluid Coagulation coagulation cascade Coagulopathies Comment comparable Complete COVID-19 COVID-19 patient COVID-19 patients data set data sets dataset datasets expression extrinsic Factor FIBRIN fibrinogen fibrinolysis fibrinolytic Gene Expression Human increases in Inflammatory inhibitor Interaction Local Lungs master regulator mechanism Microbiome mRNA expression obese performed protein C reduced remained reported Retrospective analysis RNA-Seq RNA-sequencing SARS-CoV-2 significantly supported suppresse TFPI These data Tissue Factor Transcriptome transcriptomic analysis upregulation [DOI] 10.7554/eLife.74268 PMC 바로가기 [Article Type] Comment
Stillbirth and fetal capillary infection by SARS-CoV-2SARS-CoV-2에 의한 사산 및 태아 모세관 감염Article Published on 2022-01-012022-09-11 Journal: American journal of obstetrics & gynecology MFM [Category] SARS, 치료기술, 치료제, [키워드] affected can not Capillaries capillary Cell cell type Chain Reaction consequence COVID-19 cytoplasm electron microscopy electron microscopy image Endothelial cell endothelial cells fetal FIBRIN gross examination Hemorrhagic Infarction Infection intravillous involved Ischemia Ischemic necrosis lesion luminal Microscopy mother Multiple Necrosis Occurrence Particle Placenta placental tissue Platelet polymerase chain reaction predicted real-time reverse transcription-polymerase chain reaction reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA Stillbirth subsequent Surveillance synchronous syncytiotrophoblast target cell thrombosis Transmission triggered Vascular vertical transmission vessel virus particles with infection [DOI] 10.1016/j.ajogmf.2021.100523 PMC 바로가기 [Article Type] Article
Investigation of the Molecular Mechanism of Coagulopathy in Severe and Critical Patients With COVID-19COVID-19 중증 및 중환자에서 응고병증의 분자 기전 조사Immunology Published on 2021-12-162022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, [키워드] Anticoagulant antithrombin III (ATIII) association change Coagulation factors coagulation test coagulation tests Coagulopathy collected Control coronavirus disease Coronavirus disease 2019 COVID-19 Critical D-dimer D-dimer (DD) Degradation Disruption FDPs FIBRIN fibrin degradation products fibrinogen following test group healthy controls homeostasis individual investigated investigation involved Lupus lupus anticoagulant molecular mechanism nine p -values partial thromboplastin time pathology Patient patients performed plasma PROC Prognosis prognosis of patients pros Protein protein C protein C (PC) protein S Prothrombin time Regulatory reported severe patients significant difference THROMBOPLASTIN [DOI] 10.3389/fimmu.2021.762782 PMC 바로가기 [Article Type] Immunology
Vascular Damage, Thromboinflammation, Plasmablast Activation, T-Cell Dysregulation and Pathological Histiocytic Response in Pulmonary Draining Lymph Nodes of COVID-19COVID-19의 폐 배수 림프절에서 혈관 손상, 혈전 염증, 원형질모세포 활성화, T-세포 조절 장애 및 병리학적 조직구 반응Immunology Published on 2021-12-132022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] accumulation Activation alveolar damage Analysis Autopsy bronchoalveolar lavage sample bronchoalveolar lavage samples CD105 CD36 collected Control COVID-19 COVID-19 case DAD damage demonstrated Depletion Diffuse alveolar damage downregulation Draining draining lymph node dysfunction dysregulated immune response dysregulation EBV enrolled Epstein Barr virus evidence of evidenced expression profiling FIBRIN FLT1 follicular follicular hyperplasia FOXP3 Gene expression profiling germinal centers herpes Herpes virus herpes viruses histology HLH immunohistochemical staining immunological immunopathology incidence infectious mononucleosis initial LEF1 lymph Lymph node lymph nodes Macrophage macrophage activation marker maturation Microarray microthrombi Migration mounted node Panel pathological pathway peribronchial Peripheral blood phenotype plasmablast plasmablasts positive PROCR provided pulmonary Reactivation response responsible Sample SARS-CoV-2 selected severe COVID-19 staining T-cell T-cell dysregulation T-cells TEK Thromboinflammation thrombosis tissue tracheal upregulation viruses vWF was performed widespread [DOI] 10.3389/fimmu.2021.763098 PMC 바로가기 [Article Type] Immunology
[Clinical, radiological, and histopathological features of pulmonary post-COVID syndrome : A form of autoimmune-mediated interstitial lung disease?][폐 포스트 코로나 증후군의 임상적, 방사선학적, 조직병리학적 특징 : 자가면역 매개 간질성 폐질환의 한 형태?]Review Published on 2021-12-012022-09-11 Journal: Der Pathologe [Category] SARS, 치료기술, [키워드] alveolar fibrin Analysis Antigen autoantibodies autoantibody Autoimmune BAL biopsy Bronchoalveolar lavage clinical evaluation collagen Combination Computed tomography connective tissue connective tissue disease COVID-19 CTD develop Diagnosis disease English enrolled evaluate feature FIBRIN fibrosis healthy histopathological histopathological feature Histopathology Hospitalization ILD interstitial interstitial pneumonia lavage long-COVID lung lung involvement lymphocytosis median age MOST Most patients nuclear observé Organizing pneumonia oxygen Patient patients performed persistence pilot study Pulmonary function tests pulse radiological radiological feature reported SARS-CoV‑2 serology severe COVID-19 similarity Symptom syndrome transbronchial Volume while [DOI] 10.1007/s00292-021-01024-6 PMC 바로가기 [Article Type] Review
Thrombogenicity markers for early diagnosis and prognosis in COVID-19: a change from the current paradigm?COVID-19의 조기 진단 및 예후를 위한 thromogenicity markers: 현재 패러다임의 변화?Observational Study Published on 2021-12-012022-09-11 Journal: Blood coagulation & fibrinolysis : an internationa [Category] SARS, 바이오마커, 임상, 치료기술, [키워드] Admission African Americans Analysis Biomarker Comparisons composite endpoint COVID-19 COVID-19 diagnosis COVID-19 negative COVID-19 patient COVID-19 patients COVID-19 positive patient COVID-19 positive patients death diabete diabetes diagnostic early diagnosis FCS FDA FIBRIN fibrin clot fibrinogen functional Guidance Hospitalization hospitalized COVID-19 Hypothesis identify In-hospital less marker Metrics MOST Multivariate analysis Myocardial infarction negative patients observation observational study Occurrence on admission Organ failure outcome Patient patients positive positive patient positive patients Prognosis prognostic Prospective Study Sequential Organ Failure Assessment SOFA SOFA score Standard stroke suggested Support thromboelastography Thromboembolism thrombogenicity thrombotic thrombotic event Thrombotic events utility were recorded Whole blood with COVID-19 [DOI] 10.1097/MBC.0000000000001069 PMC 바로가기 [Article Type] Observational Study
Clinicopathological findings in patients with COVID-19-associated ischaemic enterocolitis코로나19 관련 허혈성 장염 환자의 임상병리학적 소견Article Published on 2021-12-012022-09-11 Journal: Histopathology [Category] SARS, 유전자 메커니즘, [키워드] Abnormalities affecting aims bowel characteristic Cohort coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection D-dimer level D-dimer levels decompensation elevated evaluate Evidence evidence of examined feature FIBRIN fibrin thrombi Gastrointestinal gastrointestinal tract histological histopathological finding histopathological findings hypercoagulable Hypercoagulable state intubation ischaemic enterocolitis mechanism microthrombi Most patient Most patients muscularis propria Necrosis neutrophil Patient patients perivascular pneumatosis proliferation required respiratory tract infection severe COVID-19 Severe COVID-19 Infection significantly more small intestine small vessel surgery thrombi vessel with COVID-19 [DOI] 10.1111/his.14457 PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19SARS-COV-2 스파이크 단백질 S1은 섬유소 분해에 내성이있는 피브린 (OGEN)을 유도합니다.Diagnostics & Biomarkers Published on 2021-08-272022-09-01 Journal: Bioscience Reports [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus added Blood blood flow change characterized circulation complement contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19 positive patient electron and fluorescence microscopy electron microscopy FIBRIN Fibrin(ogen) fibrinolysis fluorescence microscopy healthy hypercoagulability Hypercoagulation impairment implication induce Infection interfere lung Lungs mass spectrometry Microclot observation ogen Pathologies patients plasma plasma sample plasma samples Platelet platelet-poor plasma Platelets positive patients Protein prothrombin respiratory S1 subunit SARS-CoV-2 spike protein severe acute respiratory syndrome coronavirus 2 Spike protein spike protein S1 Spike protein Sa Treatment trypsinization [DOI] 10.1042/BSR20210611 PMC 바로가기 [Article Type] Diagnostics & Biomarkers
Systemic inflammatory markers and psychophysical olfactory scores in coronavirus disease 2019 patients: is there any correlation?2019년 코로나바이러스 질환 환자의 전신 염증 마커와 정신물리학적 후각 점수: 상관관계가 있습니까?Article Published on 2021-08-012022-09-11 Journal: The Journal of laryngology and otology [Category] 바이오마커, [키워드] Anosmia baseline Blood C-reactive protein center Clinical research Connecticut coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation correlations COVID-19 D-dimer Factors ferritin ferritins FIBRIN fibrin fragment D fragment inflammatory factors Inflammatory marker inflammatory markers lack Lactate lactate dehydrogenase Lactate Dehydrogenases Local Loss of Smell lymphocyte mechanism neutrophil Neutrophil-to-lymphocyte ratio olfactory Patient patients procalcitonin Prognostic value SARS-CoV Serum level serum levels severe coronavirus disease severity significantly Smell systemic systemic inflammatory [DOI] 10.1017/S0022215121001651 PMC 바로가기 [Article Type] Article
Characterization of fibrin/fibrinogen degradation products reagents and their utility in critical care patients with enhanced fibrinolysisArticle Published on 2021-08-012023-07-13 Journal: International journal of laboratory hematology [Category] SARS, [키워드] COVID-19 D-dimer Disseminated intravascular coagulation FIBRIN fibrinogen degradation products Sepsis [DOI] 10.1111/ijlh.13428