healthy individuals – Page 3 – Communicable Diseases Research

A prolonged innate systemic immune response in COVID-19

Research

Published on 2022-06-152022-10-05
Journal: Scientific Reports [Category] 치료기술, 치료법, 치료제,

Favorable vaccine-induced SARS-CoV-2-specific T cell response profile in patients undergoing immune-modifying therapies

면역 조절 요법을 받는 환자에서 유리한 백신 유도 SARS-CoV-2 특이적 T 세포 반응 프로파일

Article

Published on 2022-06-152022-09-12
Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 진단,

A multiplex protein panel assay for severity prediction and outcome prognosis in patients with COVID-19: An observational multi-cohort study

Research article

Published on 2022-06-092022-10-05
Journal: EClinicalMedicine [Category] 바이오마커, 임상,

[키워드] accelerate Accuracy agency APACHE II assessment Berlin Biomarker Biomarkers Charité clinical clinical disease progression Clinical outcome clinical risk clinical trials Cohort conducted Council COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 severity death Dexamethasone disease prognosis disease severity education ERC European finding foundation funding Germany hallmark Healthcare system healthy individuals help hospitalised introduced LC-MS/MS LLOQ machine learning median Medicine Mild Mobility moderate multiplex node observational study outcome Patient patient cohort patients with COVID-19 peptide peptides predicted Prognosis Prognostic value Protein proteomics quantification Registered registry Research resource SARS-CoV2 Science sensitivity severe COVID-19 severity Severity stratification SOFA Spectrometry Standard of care stratified Support supported survival System targeted proteomics the median the WHO Therapies Treatment Wellcome Trust
[DOI] 10.1016/j.eclinm.2022.101495 [Article Type] Research article

Acute cardiac side effects after COVID-19 mRNA vaccination: a case series

COVID-19 mRNA 백신 접종 후 급성 심장 부작용: 사례 시리즈

Case Reports

Published on 2022-06-022022-09-11
Journal: European Journal of Medical Research [Category] COVID19(2023년), SARS, 변종,

[키워드] affecting age analyzed approval Asymptomatic BNT162b2 cardiac adverse event cardiac adverse events Cardiac arrhythmia Case series case sery CDC criteria chest pain clinical Clinical data clinical information Containment COVID-19 defined determined by Diagnosis Dyspnea eight Electrocardiography elevated female females Germany healthy individuals Hospitalization Host Infection Inflammation Information System inoculation magnetic resonance imaging male males Mild Moderna MRI mRNA mRNA vaccination mRNA vaccine mrna-1237 mRNA-1273 myocarditis occur onset of symptoms organ damage pandemic pathophysiology Patient patients Pericarditis Registered reported required retrieved risk factor Risk factors SARS-CoV-2 second dose severe cases severity Side effect Support Symptom symptom onset the disease the vaccine troponin troponin levels vaccination Vaccine variants viral mutation was performed
[DOI] 10.1186/s40001-022-00695-y PMC 바로가기 [Article Type] Case Reports

Role of triggering receptor expressed on myeloid cells-1 (TREM-1) in COVID-19 and other viral pneumonias: a systematic review and meta-analysis of clinical studies

COVID-19 및 기타 바이러스성 폐렴에서 골수 세포-1(TREM-1)에 발현된 트리거 수용체의 역할: 임상 연구의 체계적인 검토 및 메타 분석

Meta-Analysis

Published on 2022-06-012022-09-11
Journal: Inflammopharmacology [Category] MERS, 바이오마커,

[키워드] 95% CI analyzed Biomarker clinical study conducted contributing to controls coronavirus coronavirus disease coronavirus disease-2019 COVID-19 Disease progression disease severity Diseases effect size elevated eligible evaluate Evidence expressed expression Google Scholar healthy healthy control healthy controls healthy individuals Human immune response infected patient infected patients Infection infections Inflammatory item marker material Meta-analysis Mild-to-moderate Mortality myeloid cells myeloid cells-1 no differences observational studies observational study outcome Patient patients with COVID-19 performed Pneumonia pneumonias PRISMA pro-inflammatory provided receptor Reporting review role SARS-CoV-2 severe COVID-19 severity shown significantly SMD standardized mean difference subgroup analysis systematic review systematic reviews the disease TREM-1 triggering Viral viral infections Viral pneumonia viral pneumonias viruses was performed were expressed
[DOI] 10.1007/s10787-022-00972-6 PMC 바로가기 [Article Type] Meta-Analysis

Early Th2 inflammation in the upper respiratory mucosa as a predictor of severe COVID-19 and modulation by early treatment with inhaled corticosteroids: a mechanistic analysis

중증 COVID-19의 예측인자로서 상부 호흡기 점막의 초기 Th2 염증 및 흡입 코르티코스테로이드 조기 치료에 의한 조절: 기계론적 분석

Clinical Trial

Published on 2022-06-012022-09-11
Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료법, 치료제,

[키워드] 1:1 adaptive airway Analysis Anti-viral antipyretics assigned AstraZeneca Biomarker Blood blood sample Blood samples Budesonide CCL17 chemokine clinical benefit clinical symptom clinical trial clinically Cohort collected Concentration Corticosteroid Course COVID-19 COVID-19 disease COVID-19 disease course Data collection decrease deteriorate dose early treatment Efficacy elevated enzyme eosinophil epithelial epithelial lining Evolution experimental analysis healthy controls healthy individuals IL-33 immunoassay individual Inflammation Inflammatory Inflammatory mediators Inflammatory response Inhaled inhaled budesonide inhaled corticosteroid initial interferon interferon response interleukin Intervention investigated Ligand marker mechanism Meso Scale Discovery modulated modulation mucosa mucosal nasal Nasal sample nasal samples Necrosis negative control nose Observational data open label outcomes over Oxford parallel group participant Patient patients with SARS-CoV-2 Phase 2 Primary outcome Proteins randomisation randomised Randomly receive recruited reducing Registered respiratory tract SARS-COV-2 infection severe COVID-19 severe COVID-19 disease shown systemic inflammation T-cell Response Th2 the SARS-CoV-2 Treatment Trial tumour necrosis factor tumour necrosis factor-α twice a day University of Oxford upper respiratory usual care usual care group was collected were assessed were used Whole blood with COVID-19
[DOI] 10.1016/S2213-2600(22)00002-9 PMC 바로가기 [Article Type] Clinical Trial

The pandemic brain: Neuroinflammation in non-infected individuals during the COVID-19 pandemic

대유행 뇌: COVID-19 대유행 동안 감염되지 않은 개인의 신경염

Article

Published on 2022-05-012022-09-11
Journal: Brain, behavior, and immunity [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘,

[키워드] Activation aligned Brain Brain imaging change Combination control subject control subjects COVID-19 pandemic COVID-19 research dataset demonstrated Depression dysregulation Effect elevated enrolled examined explosion expression fatigue functions Future Health healthy individuals hippocampus increase in independent individual Inflammatory marker inflammatory markers interleukin interleukin-16 intraparietal sulcus involved kDa Magnetic resonance spectroscopy marker measure mechanism Mental mental fatigue mental health molecular monocyte monocyte chemoattractant protein-1 MRS multiple comparisons myoinositol negative test Neuroimaging Neuroinflammation non-infected pandemic pet physical positron emission Positron emission tomography precuneus preliminary findings Prevalence Protein Research SARS-CoV-2 antibodies serum Serum level serum levels several gene several genes statistical significance Stress Stressor subjects Symptom symptom burden Symptoms tomography transcriptomics TSPO uninfected virus while
[DOI] 10.1016/j.bbi.2022.02.018 PMC 바로가기 [Article Type] Article

Evaluation of zinc, copper, and Cu:Zn ratio in serum, and their implications in the course of COVID-19

Research article

Published on 2022-05-012022-10-05
Journal: Journal of trace elements in medicine and biology [Category] 바이오마커,

Stratification of COVID-19 patients based on quantitative immune-related gene expression in whole blood

전혈의 면역 관련 유전자 발현량을 기반으로 한 코로나19 환자 계층화

Article

Published on 2022-05-012022-09-11
Journal: Molecular immunology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 added amplification Analysis analyzed Biomarker Blood carried cause clinically coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cases COVID-19 disease COVID-19 patient Critical Critically ill Critically ill patient critically ill patients dcRT-MLPA. Determination differentially expressed gene Differentially expressed genes disease severity expression gene encoding Gene Expression healthy controls healthy individuals identify immune immune response immune-related gene immune-related genes Immunity immunopathology in some individual infected individuals infected with SARS-CoV-2 Intervention life-threatening lower expression lymphocyte lymphocyte counts majority marker mechanism Mild Mild symptom mild symptoms multiplex notable Patient Peripheral blood Predictive probe provide Quantitative reduced reflect reverse transcriptase risk stratification SARS-CoV-2 separated several genes severe acute respiratory syndrome Coronavirus severity of COVID-19 subgroup symptom onset Symptoms transcript transcriptase transcriptional Treatment Whole blood whole blood sample
[DOI] 10.1016/j.molimm.2022.03.004 PMC 바로가기 [Article Type] Article

Speech as a Biomarker for COVID-19 Detection Using Machine Learning

기계 학습을 사용한 COVID-19 탐지를 위한 바이오마커로서의 음성

Article

Published on 2022-04-182022-09-11
Journal: Computational Intelligence and Neuroscience [Category] 바이오마커,