Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses코로나19 입원 환자를 위한 렘데시비르 및 기타 3가지 약물: WHO 연대 무작위 시험의 최종 결과 및 업데이트된 메타 분석Meta-Analysis Published on 2022-05-212022-09-11 Journal: Lancet (London, England) [Category] 신약개발, 임상, 치료제, [키워드] 1:1 allocation Analysis antiviral drugs assigned average both groups Characteristics Compliance controls country COVID-19 COVID-19 diagnosis database death died discharge discharged disease severity drug drugs eligible patient Endpoint enrolled exclusion Final futility hospital Hospital mortality hospitalised hospitalised patient Hospitalised patients Hydroxychloroquine in both groups in-hospital mortality Inpatient Inpatients interferon ISRCTN Kaplan-Meier Local Lopinavir meta-analyses Meta-analysis Mortality mortality analysis mortality rate ratio no significant effect occurred Open-label outcome oxygen participant Patient patients patients with COVID-19 Placebo placebos primary endpoint progressed progression proportion randomisation Randomised trial Randomly rate ratio receive recruited regions Registered Remdesivir reported secondary Secondary endpoints solidarity Solidarity trial Standard of care study drug the WHO treatment period Trial Ventilated Ventilation were given WHO [DOI] 10.1016/S0140-6736(22)00519-0 PMC 바로가기 [Article Type] Meta-Analysis
Evaluating the role of transthoracic echocardiography in hospitalised patients with COVID-19 infectionObservational Study Published on 2022-05-012022-10-04 Journal: Open Heart [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory syndrome Admission adverse outcome analysed association cardiovascular risk case fatality ratio Cohort cohort study coronavirus COVID-19 COVID-19 pandemic demonstrated diagnostic Diagnostic imaging dysfunction Echocardiogram echocardiographic echocardiography Ejection fraction elevated eligibility criteria Evaluating exploratory feature Features hospital hospitalised hospitalised patient hypertension identify Infection inpatient admission intensive care investigated Mortality myocardial injury myocarditis n=36 non-survivor outcomes parameter Patient PCR polymerase chain positive patient preserved raised retrospective RV dysfunction SARS-CoV-2 significantly troponin levels TTE ventricular virus was performed with COVID-19 [DOI] 10.1136/openhrt-2021-001854 PMC 바로가기 [Article Type] Observational Study
Presepsin as a Novel Biomarker in predicting In-hospital Mortality in Patients With COVID-19 PneumoniaCOVID-19 폐렴 환자의 병원 내 사망률을 예측하는 새로운 바이오마커로서의 PresepsinObservational Study Published on 2022-05-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, 치료기술, [키워드] Admission Biomarker C-reactive protein CD14 Clinical features collected conducted COVID-19 COVID-19 pneumonia CRP D-dimer detect diagnosed with COVID-19 discharged elevated enrolled evaluate evidence of ferritin forms Hospital stay hospitalised patient Hospitalised patients ICU in-hospital mortality indicated Inflammatory inflammatory biomarkers inflammatory markers intensive care intensive care unit Laboratory parameters Level median moderate multicenter non-ICU patient non-ICU patients novel observational study outcome Patient patients with COVID-19 Pneumonia Pneumonia Severity Index positive Presepsin prognostic PSI PSP radiological evidence required retrospective SARS-CoV-2 SARS-CoV-2 RNA Saudi Arabia sensitivity Sepsis Serum ferritin severity significantly soluble CD-14. specificity survived survivor tested throat swab Viral Viral pneumonia was used with COVID-19 [DOI] 10.1016/j.ijid.2022.02.054 PMC 바로가기 [Article Type] Observational Study
Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study Research Published on 2022-04-272022-10-05 Journal: Scientific Reports [Category] 유전자 메커니즘, 진단, 치료법, [키워드] 30-Day mortality affecting Analysis applied approach association clinical Clinical data clinical symptom clinically Clustering Community Confusion cough COVID-19 determine diagnostic diarrhoea disease duration of symptom Dyspnoea fatigue female Fever Gastrointestinal symptom granular hospitalised hospitalised patient identify in-hospital mortality Interpretation ISARIC Mild Mortality no symptoms observation Older organ system Patient pauci-symptomatic presentation presenting prospective cohort recruited recruitment Replication replication analysis reported robust self-reported symptom Symptom Symptoms therapeutic Unsupervised clustering utility vomiting with COVID-19 [DOI] 10.1038/s41598-022-08032-3 [Article Type] Research
Efficacy and safety of baricitinib plus standard of care for the treatment of critically ill hospitalised adults with COVID-19 on invasive mechanical ventilation or extracorporeal membrane oxygenation: an exploratory, randomised, placebo-controlled trialClinical Trial Published on 2022-04-012022-10-04 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 임상, 치료법, [키워드] 1:1 A significant reduction all-cause mortality assigned Baricitinib baseline Blood clots Brazil cardiovascular event Care Cohort Combination company conducted Corticosteroids Critically ill death died double-blind duration of hospitalisation Efficacy efficacy analysis Efficacy and safety Endpoint enrolled evaluate event exploratory extracorporeal membrane oxygenation hazard ratio hospital hospitalised hospitalised patient infections inhibitor intention-to-treat population Invasive mechanical ventilation investigator Janus kinase laboratory-confirmed SARS-CoV-2 infection less Lilly membrane Mortality not differ participant Participants Patient Phase 3 phase 3 trial Placebo placebo-controlled trial placebo-treated participant prevented randomised Randomly receiving reduced reduction Registered risk reduction safety analysis safety population SARS-COV-2 infection selective severely ill patient shown significantly significantly shorter Standard Standard of care Study design study group study population systemic corticosteroid the placebo group Time to recovery Treatment treatment group treatment groups Trial USA ventilator-free day Ventilator-free days was done with COVID-19 [DOI] 10.1016/S2213-2600(22)00006-6 PMC 바로가기 [Article Type] Clinical Trial
Deciphering the quality of SARS-CoV-2 specific T-cell response associated with disease severity, immune memory and heterologous response질병 중증도, 면역 기억 및 이종 반응과 관련된 SARS-CoV-2 특이적 T 세포 반응의 품질 해독Article Published on 2022-04-012022-09-11 Journal: Clinical and Translational Medicine [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] absence acute infection addition anti-S IgG anti-S IgG level anti-S IgG levels antibody antibody levels approach Combination combinations comprehensive analysis coronavirus Coronaviruses correlated COVID-19 disease disease severity Endemic Endemic coronaviruses healthy donor help Heterologous hospitalised patient IFN-γ IL-2 immune memory implication Infection Mild Mild disease non-hospitalised nucleocapsid perforin polyfunctionality protective immunity robust S protein SARS-CoV-2 severe disease Specific T-cell response spike T-cell T-cell exhaustion T-cell Response Vaccine [DOI] 10.1002/ctm2.802 PMC 바로가기 [Article Type] Article
The impact of pre-existing hypertension and its treatment on outcomes in patients admitted to hospital with COVID-19 Research Published on 2022-03-292022-10-05 Journal: Hypertension research : official journal of the Ja [Category] COVID19(2023년), SARS, 치료법, [키워드] 95% CI adjusted age analysed Analysis angiotensin receptor blocker anti-hypertensive drug ARB association cardiac disease covariate death enzyme examined hospital hospitalised patient hypertension in-hospital mortality increased risk inhibitor Logistic regression male median age Mortality multivariable novel corona virus occurred Occurrence Older outcome Patient patients hospitalized protective effect SARS-CoV-2 Treatment with COVID-19 [DOI] 10.1038/s41440-022-00893-5 [Article Type] Research
BMI, sex and outcomes in hospitalised patients in western Sweden during the COVID-19 pandemic Research Published on 2022-03-222022-10-05 Journal: Scientific Reports [Category] 치료법, [키워드] 30-Day mortality 95% CI 95% confidence interval age association average BMI body mass index Comorbidity COVID-19 pandemic Electronic health records evaluate higher risk hospital hospitalised hospitalised patient intensive care logistic regression model Male sex men Mortality multivariable not significant obese Odds ratio Older age outcome outcomes Patient patients risk severe COVID-19 Sex were used while with COVID-19 women [DOI] 10.1038/s41598-022-09027-w [Article Type] Research
Add-on inhaled budesonide in the treatment of hospitalised patients with COVID-19: a randomised clinical trialRandomized Controlled Trial Published on 2022-03-102022-10-05 Journal: The European Respiratory Journal [Category] SARS, 임상, [키워드] addition clinical trial COVID-19 Disease progression hospitalised hospitalised patient inhaled budesonide Patient Pneumonia randomised reduce risk Safe Treatment usual care [DOI] 10.1183/13993003.03036-2021 PMC 바로가기 [Article Type] Randomized Controlled Trial
Ethnic disparities in hospitalisation and hospital-outcomes during the second wave of COVID-19 infection in east LondonArticle Published on 2022-03-082022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 치료법, [키워드] Admission age Analysis Asian association black changes in COVID-19 COVID-19 infection COVID-19 treatments death distribution Epidemiology ethnic group Ethnic groups greater hospital Hospital admission hospitalisation hospitalised patient increased risk Infectious diseases Local London Mortality multivariable analysis NHS outcome pandemic Patient Patient care patients Population public health relative risk factor Risk factors risk of COVID-19 risk of death SARS-COV-2 infection second wave Sex significantly higher Socioeconomic deprivation survival was used white [DOI] 10.1038/s41598-022-07532-6 PMC 바로가기 [Article Type] Article