Inflammation and immune dysfunction in Parkinson disease Reviews Published on 2022-03-042022-10-05 Journal: Nature reviews. Immunology [Category] 변종, [키워드] immune dysfunction Parkinson disease [DOI] 10.1038/s41577-022-00684-6 [Article Type] Reviews
Lower Cranial Nerve Palsies in the COVID-19 Pandemic: A 10-Case Series of Intensive Care Unit PatientsObservational Study Published on 2022-01-012022-10-05 Journal: European neurology [Category] SARS, 임상, [키워드] Admission appear association Care conducted COVID-19 cranial etiology France Hospitalization Hypothesis immune dysfunction intensity intensive care intensive care unit intubation involved less limb Lower Lower cranial nerve palsy. multifactorial nerve Neurological complication neurological sign no correlation Occurrence palsy Patient patients retrospective SARS-CoV-2 Sery Severe COVID-19 Infection the patient therapy Toxicity treated university Ventilation virus weakness [DOI] 10.1159/000519226 PMC 바로가기 [Article Type] Observational Study
High CD169 Monocyte/Lymphocyte Ratio Reflects Immunophenotype Disruption and Oxygen Need in COVID-19 PatientsArticle Published on 2021-12-182022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] analyzed B-cell Biomarker Blood blood cell blood sample CD169 CD8 T-cell clinical outcomes correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 therapy cytokine Cytokine storm disease Disease progression Disruption dose-dependent manner Evidence flow cytometry fluorescence intensity healthy donor Hospitalization IL-10 IL-6 immune dysfunction immunophenotype in vitro Inflammation inflammatory markers lymphocyte marker maturation monocyte mRNA expression mRNA levels outcome overexpressed Patient PBMC Pneumonia Predictive pulmonary involvement Ratio Respiratory outcome SARS-CoV-2 severity sialoadhesin stimulated T-cell exhaustion the median the spike protein Transcription [DOI] 10.3390/pathogens10121639 PMC 바로가기 [Article Type] Article
Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort studyArticle Published on 2021-12-012022-10-04 Journal: Blood Cancer Journal [Category] SARS, 유전자 메커니즘, 임상, 치료기술, 치료법, [키워드] 95% confidence interval acute respiratory syndrome conducted coronavirus COVID-19 COVID-19 severity Epidemiology group Iceland Icelander immune dysfunction increased risk individual Infectious diseases Monoclonal Gammopathy Multiple Myeloma not affect participant Participants Patient population-based cohort positive precursor risk Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 testing Screen screened severe coronavirus disease severe COVID-19 severity of COVID-19 Study design susceptibility tested Undetermined [DOI] 10.1038/s41408-021-00580-7 PMC 바로가기 [Article Type] Article
Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patientsPBMC에 의한 포스파티딜세린 양성 미세입자의 결합은 COVID-19 환자의 질병 중증도를 분류합니다Article Published on 2021-12-012022-09-11 Journal: Journal of Extracellular Vesicles [Category] 유전자 메커니즘, [키워드] activated addition Affect Apoptosis blood cell Blood cells Blood coagulation carried cascade CD8 CD8+ CD8+ T cells cells Clinical course Coagulation complement complement system correlated strongly COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients disease severity distribution dying cells Frequency gene expression signature immune cells immune dysfunction Inflammation Inflammatory responses initial investigated Laboratory leucocyte lymphocyte Lymphocytes lymphopenia marker memory T cells Microparticle occur Patient PBMC PBMCs PD-L1 Phosphatidylserine Platelet platelet-derived microparticle Platelets SARS-CoV-2 severe lymphopenia T cell T cells Thromboinflammation thrombotic [DOI] 10.1002/jev2.12173 PMC 바로가기 [Article Type] Article
Immune-Mediated Glycocalyx Remodeling in Hospitalized COVID-19 PatientsShort Communication Published on 2021-11-182022-10-31 Journal: Cardiovascular Drugs and Therapy [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress acute respiratory syndrome addition ARDS association circulating Clinical deterioration component contribute coronavirus disease Coronavirus-2 COVID-19 COVID-19 patient Degradation disease elevated glycocalyx hallmark healthy control hospitalized COVID-19 patient IL-6 immune dysfunction immune mechanism immune responses Infection Inflammation Inflammatory cytokine IQR mammalian cells marker Mortality observational study occur offer organ dysfunction pathobiology of COVID-19 pathogenesis of COVID-19 phasic progression prospective cohort study remodeling Result risk stratification SARS-CoV-2 SARS-CoV-2 infections SDC1 Sepsis syndrome therapeutic approaches thrombosis TNFα Vascular vascular dysfunction Vascular injury vessel with COVID-19 [DOI] 10.1007/s10557-021-07288-7 PMC 바로가기 [Article Type] Short Communication
Antibody responses after documented COVID-19 disease in patients with autoimmune rheumatic disease자가면역 류마티스 질환 환자에서 기록된 COVID-19 질병 후 항체 반응Article Published on 2021-11-012022-09-11 Journal: Clinical Rheumatology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] age anti-N IgG anti-S IgG anti-spike protein IgG antibody Antibody Response Antibody titers Arthritis Autoimmune Autoimmune disease Clinical characteristics Cohort Comorbidities consecutive patient Control controls COVID-19 COVID-19 disease COVID-19 susceptibility days post infection days post-infection detectable Diagnosis disease drug drugs fasciitis females FIVE Health humoral immune response IgG immune dysfunction immune response immune responses Immunosuppressant immunosuppressants less median moderate not differ Patient Point positive proportion protective antibodies Protective antibody protective antibody response Protein rheumatic disease Rheumatic diseases rheumatoid arthritis robust Seven severe COVID-19 severity of COVID-19 Sex spondyloarthritis the antibody [DOI] 10.1007/s10067-021-05801-9 PMC 바로가기 [Article Type] Article
COVID-19 elicits an impaired antibody response against SARS-CoV-2 in patients with haematological malignanciesCOVID-19는 혈액암 환자에서 SARS-CoV-2에 대한 손상된 항체 반응을 유발합니다Clinical Trial Published on 2021-11-012022-09-11 Journal: British Journal of Haematology [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] 95% confidence interval Analysis antibody response against Care Cell Chemoimmunotherapy COVID-19 detectable Efficacy elicit haematological malignancies high mortality HM patient HM patients IgG IgG test immune dysfunction indicate investigated leukemia lymphoid lymphoma malignancy multivariable logistic regression myeloid Myeloma negative patients Neoplasms Patient patients patients with haematological PCR-positive performed plasma Plasma cell plasma cell neoplasms rate of seroconversion SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 PCR Seroconversion Serologically serum antibodies Treatment vaccination Withdrawal [DOI] 10.1111/bjh.17704 PMC 바로가기 [Article Type] Clinical Trial
An Update on Innate Immune Responses during SARS-CoV-2 InfectionSARS-COV-2 감염 동안 타고난 면역 반응에 대한 업데이트Review Published on 2021-10-142022-09-10 Journal: Viruses [Category] MERS, SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral cellular receptor cellular receptors characterized components Coronaviridae family coronavirus COVID-19 pandemic Cytokines Defense disrupt Effect followed by Host hypersecretion IFN-α/β IFNs immune dysfunction immune responses Innate innate immune innate immune response innate immune responses innate immune system interferons invading pathogen invading pathogens member Mortality organ injury Pathogens patients with COVID-19 potential therapeutic targets pro-inflammatory cytokines protease respiratory response responses responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signaling the Coronaviridae Type I IFN type I interferon type I interferons variety Viral [DOI] 10.3390/v13102060 PMC 바로가기 [Article Type] Review
Adipose-Tissue-Derived Mesenchymal Stem Cells Mediate PD-L1 Overexpression in the White Adipose Tissue of Obese Individuals, Resulting in T Cell DysfunctionArticle Published on 2021-10-032022-10-31 Journal: Cells [Category] Coronavirus, MERS, SARS, [키워드] adipocytes adipose adipose-tissue-derived mesenchymal stem cells analyzed ASC blockade conditioned media cytokine secretion cytolytic demonstrated disease expression Human IFNγ IFNγ immune immune dysfunction in vitro increased expression individual individuals inducer Inflammation mechanism mice mononuclear cell obese obesity occur overexpressed PD-1/PD-L1 immune checkpoints PD-L1 reduced SARS-CoV-2 secretion STEM stem cell T cell T cell dysfunction Th1 cell tissue viruses visceral white white adipose tissue [DOI] 10.3390/cells10102645 PMC 바로가기 [Article Type] Article