People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burdenCOVID-19에 걸린 위독한 사람들은 사망을 예측하고 SARS-CoV-2 폐 바이러스 부담을 반영하는 말초 면역 프로필을 나타냅니다Article Published on 2021-12-212022-09-12 Journal: Cell Reports Medicine [Category] SARS, 유전자 메커니즘, 진단, [키워드] analyses Analysis association Blood contribute COVID-19 COVID-19 outcome Critically ill CXCL10 death gene modules higher risk immune cell state Immune profile immune state Inflammatory Inflammatory cytokines inflammatory monocytes interferon signaling Lower respiratory tract lung machine learning molecular feature monocyte Mortality myeloid cell outcomes peripheral Predictive respiratory sample SARS-CoV-2 severe COVID-19 single-cell Single-cell RNA sequencing single-cell RNA-seq subsequent transcriptional profile type I interferon upregulation viral burden with COVID-19 [DOI] 10.1016/j.xcrm.2021.100476 PMC 바로가기 [Article Type] Article
Deep dissection of the antiviral immune profile of patients with COVID-19COVID-19 환자의 항바이러스 면역 프로파일에 대한 심층 분석Article Published on 2021-12-162022-09-10 Journal: Communications Biology [Category] SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] Anti-RBD antibodies Anti-S1 anti-SARS-CoV-2 humoral antibody Antiviral antiviral antibodies assist B.1.351 Beta binding CD4 Cell coronavirus coronavirus 2 COVID-19 patient COVID-19 patients Critically ill deep Epitopes evidenced expressing finding growth factor help Humoral immunity identify IgG antibody IgG1 IgG3 Immune profile immune response immune responses immunodominant LAG-3 linear epitope Mutation N proteins Neutralizing activity nucleocapsid occur Patient patients patients with COVID-19 proportion Protein Proteins RBD Receptor-binding domain reduced respiratory responses against S protein S protein-specific antibody SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins screened severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly significantly higher specific antibodies specificity Subtypes suppressor cells T cell T cells TGF-β the receptor-binding domain transforming growth factor Vaccines variant viral infection [DOI] 10.1038/s42003-021-02852-1 PMC 바로가기 [Article Type] Article
Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses브라질 남부의 소아 COVID-19 환자는 풍부한 바이러스 mRNA와 강력한 특정 항바이러스 반응을 나타냅니다.Article Published on 2021-11-252022-09-10 Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, [키워드] adult COVID-19 patient Adults anti-viral response antibodies antibody Antimicrobial responses Brazil CD8 cellular cellular immunity characterized children Cohort contribute COVID-19 COVID-19 patient COVID-19 patients COVID-19 symptom COVID-19 symptoms CX3CR1 dendritic dendritic cells disease Factor HLA-DR humoral immune response Immune profile immune responses infected children Infectious diseases less lymphocyte Lymphocytes mechanism mRNA N and M N and M peptide pools non-specific pediatric Pediatric patients peptide peptide pool peptide pools response SARS-CoV-2 scenario severity South structural proteins Support susceptible T cell T cell response T cells T cells response TNF Transmission Viral Viral load virus [DOI] 10.1038/s41467-021-27120-y PMC 바로가기 [Article Type] Article
SARS-CoV-2 recombinant proteins stimulate distinct cellular and humoral immune response profiles in samples from COVID-19 convalescent patientsSARS-CoV-2 재조합 단백질은 COVID-19 회복기 환자의 샘플에서 뚜렷한 세포 및 체액 면역 반응 프로필을 자극합니다Original Article Published on 2021-11-232022-09-10 Journal: Clinics [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen antigens blood sample Blood samples CD3+ cellular Cellular immune response cellular immune responses cellular immunity chemiluminescence Contact contact with convalescent convalescent individual convalescent individuals coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent patient Determination domain Donor ELISA ELISAs examined groups humoral humoral immune response Humoral response IFN-γ IgG antibodies IgG antibody Immune profile immune response immune responses Immunity individual individuals investigated Lymphocytes membrane nucleocapsid overlapping Patient peptide peptide pool peptide pools peptides pool profile Proteins RBD Receptor-binding domain Recombinant protein recombinant proteins regions respiratory S1/S2 SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 spike sequence serum serum IgG antibodies serum IgG antibody severe acute respiratory syndrome Coronavirus shown stimulate Stimulation T cell T cells T lymphocyte T lymphocytes volunteers [DOI] 10.6061/clinics/2021/e3548 PMC 바로가기 [Article Type] Original Article
SARS-CoV-2 Variants, RBD Mutations, Binding Affinity, and Antibody EscapeArticle Published on 2021-11-092022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE2 acute respiratory syndrome affinity amino-acid Analysis antibodies antibody binding binding affinity binding energy Breakthrough infection changes in complex complexes Contagion coronavirus coronavirus disease country COVID-19 delta variant detrimental docking driving ENhance enzyme escape geometric Gibbs free energy highest hydrophilic hydrophobic Immune profile L452R mechanism Missense mutation Mutation mutations notable pandemic physical prevalent preventive measures producing RBD receptor reduction residue responsible risk SARS-CoV-2 SARS-CoV-2 variant Structure the binding affinity the epidemic the RBD the receptor-binding domain the spike protein therapeutic Transmissibility understanding vaccination rates Vaccine-induced immunity Vaccines variant variants virus were used [DOI] 10.3390/ijms222212114 PMC 바로가기 [Article Type] Article
Associations between Allelic Variants of the Human IgH 3′ Regulatory Region 1 and the Immune Response to BNT162b2 mRNA VaccineArticle Published on 2021-10-192022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome analyses antibody production Antigen-specific B cells approach B cell response BNT162b2 BNT162b2 mRNA cells coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient effective response effective vaccine Escalation flow cytometry Genetic genetic background HS1.2 Human human immunoglobulin IgH locus Immune profile individuals injection levels of antibodies locus NK cell Pfizer–BioNTech progression Protein Region regulatory region required response Safe SARS-CoV-2 SARS-CoV-2 spike serological significant increase single-nucleotide SNP subject subjects subset Support the disease vaccination Vaccine variant [DOI] 10.3390/vaccines9101207 PMC 바로가기 [Article Type] Article
Distinct cellular immune profiles in the airways and blood of critically ill patients with COVID-19COVID-19에 감염된 중환자의 기도 및 혈액에서 뚜렷한 세포 면역 프로필Observational Study Published on 2021-10-012022-09-12 Journal: Thorax [Category] MERS, 임상, 진단, [키워드] activated T cell airway analysed BALF Blood bronchoalveolar Bronchoalveolar lavage fluid CD4 CD8 T cell Cell cellular COVID-19 Critically ill patient died effector memory examined expressed expressing fatal COVID-19 ICU Immune profile immune response Increased inflammatory mediator intensive care Local Lungs marker pathophysiology patients patients with COVID-19 Peripheral blood plasma Pneumonia Prolonged proportion pulmonary immune response purified reduced respiratory infection responses severe COVID-19 T cell T cell activation T cell receptor these cell unique viral infection were measured with COVID-19 [DOI] 10.1136/thoraxjnl-2020-216256 PMC 바로가기 [Article Type] Observational Study
Asymptomatic and Mild SARS-CoV-2 Infections Elicit Lower Immune Activation and Higher Specific Neutralizing Antibodies in Children Than in Adults무증상 및 경증의 SARS-CoV-2 감염은 성인보다 어린이의 면역 활성화를 낮추고 특정 중화 항체를 더 많이 유발합니다Immunology Published on 2021-09-302022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults age analyzed anti-SARS-CoV-2 antibody baseline blood sample Blood samples Breg children Clinical outcome contribute coronavirus coronavirus disease Coronavirus disease 2019 correlated CoV COVID-19 COVID-19 children COVID-19 group COVID-19 patient COVID-19 patients enrolled Exhaustion expression first positive flow cytometry greater immune activation Immune profile immune response Infection interquartile investigated Lower median NAb NAbs Nasopharyngeal swab nasopharyngeal swabs neutralization test Neutralizing antibodies neutralizing antibodies (NAbs) Non-COVID-19 not differ Patient PCR pediatric plaque reduction neutralization Plaque reduction neutralization test positively correlated quantified reduce regulatory cell regulatory cells respiratory Result SARS-CoV-2 senescence senescent cell serology severe acute respiratory syndrome Coronavirus Specific subjects symptom onset Treg Tregs Tregs and Bregs Viral Viral load virus virus detection [DOI] 10.3389/fimmu.2021.741796 PMC 바로가기 [Article Type] Immunology
Comprehensive Immune Profiling of a Kidney Transplant Recipient With Peri-Operative SARS-CoV-2 Infection: A Case Report수술 전후 SARS-CoV-2 감염이 있는 신장 이식 수혜자의 종합 면역 프로파일링: 증례 보고서Case Reports Published on 2021-09-222022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, [키워드] basiliximab cellular change Comprehensive COVID-19 COVID-19 infection Critical diagnosed Immune profile immune response immunological immunosuppressants Immunosuppression impair induction therapy kidney maintenance outcome performed positive Post-infection Profiling proteomic recipient report robust SARS-CoV-2 SARS-CoV-2 test serological significantly solid organ solid organ transplant symptomatic symptomatic COVID-19 the patient Transplant unique [DOI] 10.3389/fimmu.2021.753558 PMC 바로가기 [Article Type] Case Reports
A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine재조합 SARS-CoV-2 단백질 백신에 대한 강력한 항바이러스 면역 반응 유도를 위한 조합 보조제Immunology Published on 2021-09-162022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] activate Adaptive immune response adaptive immune responses adjuvant adjuvants antibody Antibody titers Antigen B.1.351 breadth candidate cellular response Combination cross-protection effective elicited ENhance Heterologous homologous Immune profile immune responses Immunity IMPROVE induction intranasal intranasal vaccine mice mucosal mucosal adjuvant N501Y mutation nanoemulsion (NE) neutralizing antibody titers NLRP3 P.1 variants passive transfer potent recombinant response RIG-I RIG-I agonist RNA robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants Spike protein TLR TLRs transfer vaccination variant variants variety Viral viral challenge virus-neutralizing antibody [DOI] 10.3389/fimmu.2021.729189 PMC 바로가기 [Article Type] Immunology