ISG – Page 3 – Communicable Diseases Research

Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome

무증상 코비드 -19 감염에서 상향 조절 된 유형 I 인터페론 반응은 개선 된 임상 결과와 관련이 있습니다.

Article

Published on 2021-11-252022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 치료법, 치료제,

TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction

TMPRSS2는 NCOA7 매개 제한으로부터 SARS-CoV-2 회피를 촉진합니다

Research Article

Published on 2021-11-222022-09-10
Journal: PLoS Pathogens [Category] MERS, SARS, 유전자 메커니즘,

[키워드] acquisition Activation Antiviral Antiviral effect antiviral effects ATPase biological significance Cell cell surface characterized cleavage coactivator concomitant use consequence coronavirus Critical cytoplasmic dysregulation ectopic expression Effect effector endocytic Endosomal acidification epithelial cells evade furin furin cleavage furin cleavage site gene knockout HCoV HCoV-229E HCoV-NL63 highly pathogenic Host immune response host immune responses IFN IFN treatment IFNs immune responses Inborn errors Infection infections inhibit inhibit SARS-CoV-2 inhibited inhibitor innate immune response innate immune responses interact interferon interferons ISG ISGs isoform lentivirus less Lung epithelial cells lysosomal protease mechanism MERS MERS-CoV NCOA7 NL63 nuclear nuclear receptor option overexpression Particle pathway patients with COVID-19 plasma membrane polybasic promote protease Protein pseudotyped Pseudotyped viruses receptor removal repertoire Research RNA robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike seasonal severe COVID-19 spike Spike protein Support the interferon TMPRSS TMPRSS2 TMPRSS2 protease Trigger vacuolar Vesicle Viral viral spike protein virus virus entry virus infection virus infections viruses
[DOI] 10.1371/journal.ppat.1009820 PMC 바로가기 [Article Type] Research Article

Large Screening Identifies ACE2 Positively Correlates With NF-κB Signaling Activity and Targeting NF-κB Signaling Drugs Suppress ACE2 Levels

Pharmacology

Published on 2021-11-192022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

The Effect of Allicin on the Proteome of SARS-CoV-2 Infected Calu-3 Cells

Microbiology

Published on 2021-10-282022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] Allicin Allium Antiviral ARHGAP17 Bacteria Calu-3 Calu-3 cell calu-3 cells caused cell cultures changes in CLTCL1 compounds decrease derivative dose Effect effector effectors exposure expression fungi Future greater GSH Host human cell IFI16 Ifi44 IFN signaling pathway immunomodulatory activity interferon-stimulated gene investigated ISG ISG15 low molecular weight metabolism Modification OAS ORF3 OSBPL2 pathway plant produced Protein proteome proteomics Quantitative reduced Research SARS-CoV-2 SARS-COV-2 infection stability tight junction tissue damage Tolerance Toxicity Transcription translation Treatment uninfected cells Vero E6 VERO E6 cells Vesicular Transport Viral particles Viral protein Viral RNA was used
[DOI] 10.3389/fmicb.2021.746795 PMC 바로가기 [Article Type] Microbiology

Similarities and Differences in the Acute-Phase Response to SARS-CoV-2 in Rhesus Macaques and African Green Monkeys

Immunology

Published on 2021-10-062022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] absolute monocyte count acute response African African green monkey AGM AGMs alteration Analysis Blood breadth Cohort Correlation analysis COVID-19 COVID-19 disease Critical defined difference effective vaccine Evidence exhibiting gene network greater green hallmark help immune Infection interferon ISG ISGs macaque Monkey nasopharyngeal neutrophil (PMN) neutrophil degranulation NHP normalized occurred outcome pathology pathway Post-infection presenting Pulmonary pathology Regulation response rhesus macaque SARS-CoV-2 SARS-COV-2 infection similarity stimulated Systems biology timepoint transcriptional transcriptional change Transcriptome type I understanding upregulation WGCNA
[DOI] 10.3389/fimmu.2021.754642 PMC 바로가기 [Article Type] Immunology

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

I형 인터페론 자가항체는 COVID-19 환자의 전신 면역 변화와 관련이 있습니다

Research Article

Published on 2021-09-222022-09-10
Journal: Science Translational Medicine [Category] MERS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration antibodies autoantibodies autoantibody caused change circulating leukocyte circulating leukocytes Control coronavirus coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 Critical Critical disease dendritic cell description diagnosed disease course disease pathogenesis Effect elevated epitope evaluated Evidence evidence of expressed expression functional healthy controls help IFNs immune immune system Immunoglobulin in some increased expression individual individuals with COVID-19 inhibitory receptor interferon interferon response interferons ISG lack LAIR1 leukocyte leukocytes longitudinal mechanisms moderate disease monocyte Monocytes mononuclear cell mononuclear cells myeloid cell myeloid cells Patient patients with COVID-19 Peripheral blood Peripheral blood mononuclear cells peripheral blood samples Population Prevalence producing receptor reduced respiratory response SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe case severe cases severe disease severity single-cell Single-cell transcriptomics subset Support systemic impact systemic impacts the disease Transcriptome transcriptome sequencing transcriptomics turn Type type I Type I IFN type I interferon type I interferons
[DOI] 10.1126/scitranslmed.abh2624 PMC 바로가기 [Article Type] Research Article

Single-cell immune profiling reveals distinct immune response in asymptomatic COVID-19 patients

단일 세포 면역 프로파일링은 무증상 COVID-19 환자에서 뚜렷한 면역 반응을 나타냅니다

Clinical Trial

Published on 2021-09-162022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 임상,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Asymptomatic Asymptomatic COVID-19 asymptomatic infections asymptomatic patient asymptomatic patients BCR CD16 CD4 CD56 CD8 Cell cell population clonal expansion collected coronavirus disease Evidence evidence of expression healthy controls identify immune profiling immune response immune signature individual infected individuals Infection Infectious diseases interferon Interferon-gamma interferon-stimulated gene interferon-stimulated genes ISG ISGs lack magnitude moderate mononuclear cell natural killer NK cells Patient patients performed Peripheral blood receptor respiratory reveal robust SARS-CoV-2 SARS-CoV-2-infected individual Sequencing severe acute respiratory syndrome Coronavirus severe disease Severe patient single-cell T cell T cells TCR temporal dynamics Transcriptome upregulation Variability while
[DOI] 10.1038/s41392-021-00753-7 PMC 바로가기 [Article Type] Clinical Trial

The interferon landscape along the respiratory tract impacts the severity of COVID-19

호흡기를 따라 나타나는 인터페론 풍경은 COVID-19의 심각성에 영향을 미칩니다

Article

Published on 2021-09-162022-09-12
Journal: Cell [Category] Fulltext, MERS, 진단,

[키워드] Abstract acute respiratory syndrome age airways anatomical Apoptosis cell death characterized coronavirus coronavirus disease COVID-19 COVID-19 patient critical patient dendritic cell disease disease risk disease severity elevated epithelial cell Express expression IFN IFN-I IFN-III IFN-stimulated genes IFN-λ1 ill patient immune Impact in-depth analysis interferon interferons (IFNs ISG lower airway lung Mild p53 Pathologies pathology pathway Patient pattern recognition receptor Production proliferation PROTECT Protective reduced reduction in respiratory tract reveal SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2-infected patient severe COVID-19 severity severity of COVID-19 subject Transcription type I Type I IFN type III Type III IFN upper airway upper respiratory tract viral burden Viral load
[DOI] 10.1016/j.cell.2021.08.016 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Spike protein enhances ACE2 expression via facilitating Interferon effects in bronchial epithelium

SARS-CoV-2 스파이크 단백질은 기관지 상피에서 인터페론 효과를 촉진하여 ACE2 발현을 향상시킵니다.

Article

Published on 2021-09-012022-09-11
Journal: Immunology letters [Category] SARS, 치료기술,

[키워드] ACE2 ACE2 expression activate Activation Analysis Antiviral association BEAS-2B BEAS-2B cell Beas-2B cells Bronchial epithelium co-immunoprecipitation co-IP downstream Effect Effects ENhance epithelial cell epithelial cell line expression help Host identify IFN Infection Interaction interferon ISG ISG15 ISGs JAK-STAT signaling JAK1 non-structural protein non-structural proteins overexpressed overexpression Phosphorylation promote Protein qRT-PCR receptor ACE2 RNA-Seq S protein SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 S spike STAT Stat1 STAT2 the SARS-CoV-2 Transcriptome transcriptome analysis Type upstream was performed were measured western blot
[DOI] 10.1016/j.imlet.2021.06.008 PMC 바로가기 [Article Type] Article

Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS

Article

Published on 2021-08-262022-10-04
Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 임상, 치료기술, 치료법,

[키워드] Acute inflammation acute respiratory distress Analysis ARDS candidate drug cause causes characterized colony stimulating factor Control COVID-19 Critically ill patient Dexamethasone dysregulated elevated etiologies expression expression of gene feature Gene Expression granulocyte host gene expression host response identify Immunity immunological Inflammation interferon-stimulated gene ISG lower airway Lower respiratory tract mechanical ventilation Mild modulate modulated Molecular medicine observé Patient patients with COVID-19 predicted proinflammatory gene PTEN reduced reveal RNA sequencing SARS-CoV-2 SARS-CoV-2 viral load Signaling syndrome tracheal tracheal aspirate transcriptional Translational research viral infection Viral pneumonia
[DOI] 10.1038/s41467-021-25040-5 PMC 바로가기 [Article Type] Article