An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse ModelADAM17 중화 항체는 COVID-19 마우스 모델에서 바이러스 부담을 증가시키면서 염증과 사망률을 감소시킵니다Article Published on 2022-06-102022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 ADAM17 ADAM19 adverse outcome Alter angiotensin anti-viral role antibody appear blockade blocked burden Cell cell entry receptor cellular activation cleave COVID-19 COVID-19 pathogenesis COVID-19 patients Critical ectodomain Increasing Inflammation Inflammatory inflammatory cascade K18-hACE2 less lung Lung pathology lung; metalloproteinase mice Model monoclonal antibody mouse mouse model pathway Proinflammatory cytokine promote protease Proteins SARS-CoV SARS-CoV-2 SARS-CoV-2 viruses significantly increased significantly lower therapeutic TNF-α Transgenic mouse transmembrane viral burden virus while [DOI] 10.3389/fimmu.2022.918881 PMC 바로가기 [Article Type] Article
Bacillus Calmette-Guérin-induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 miceBacillus Calmette-Guérin에 의해 유도된 훈련된 면역은 K18-hACE2 마우스에서 SARS-CoV-2 공격으로부터 보호합니다Article Published on 2022-06-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 변종, [키워드] Activation antibodies B.1.617.1 B.1.617.2 Bacillus Bacillus Calmette-Guérin BCG causal relationship confirmed case COVID-19 experimental evidence Glycolysis Heterologous immune responses Immunity induce Infectious disease Innate innate immune response Innate immunity investigated K18-hACE2 K18-hACE2 mice myeloid cell neutralization pathway PROTECT provide reported resulting robust SARS-CoV-2 SARS-CoV-2 variant the WHO vaccination Vaccine vaccine breakthrough infections variants WT SARS-CoV-2 [DOI] 10.1172/jci.insight.157393 PMC 바로가기 [Article Type] Article
Differential Pathogenesis of SARS-CoV-2 Variants of Concern in Human ACE2-Expressing Mice인간 ACE2-발현 마우스에서 우려되는 SARS-CoV-2 변이체의 차별적 병인 발생Article Published on 2022-05-252022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2-expressing mice acute respiratory syndrome acute respiratory syndrome coronavirus Alpha B.1 B.1 lineage B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Brain caused chemokine chemokines circulating circulating variant Clinical sign concern contagious coronavirus COVID-19 cytokine Cytokines death evaluated exhibited hACE2 Human Infection Inflammation inoculated intranasally K18-hACE2 K18-hACE2 mice less lineages lung Lungs mice mouse-adapted SARS-CoV-2 omicron pandemic Pathogenesis pathogenesis of SARS-CoV-2 question Replication resulting SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity significantly significantly higher significantly lower significantly more survival rate the disease Transcription variant variants of concern virus virus titer [DOI] 10.3390/v14061139 PMC 바로가기 [Article Type] Article
Effective protection of ZF2001 against the SARS-CoV-2 Delta variant in lethal K18-hACE2 mice치명적인 K18-hACE2 마우스에서 SARS-CoV-2 Delta 변이체에 대한 ZF2001의 효과적인 보호Article Published on 2022-05-202022-09-11 Journal: Virology Journal [Category] COVID19(2023년), SARS, 변종, [키워드] aluminum approval China Delta delta variant Efficacy Epidemics hACE2 improvement K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice Lung histopathology mechanism neutralizing antibody omicron Prevent protection Protective protective effect protein subunit vaccine reduced required Research research and development SARS-CoV-2 SARS-CoV-2 Delta variant severe cases severe pneumonia Subunit vaccine survival rates the SARS-CoV-2 Vaccine Vaccine design variant virus was used ZF2001 ZF2001. [DOI] 10.1186/s12985-022-01818-x PMC 바로가기 [Article Type] Article
An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron Research Published on 2022-04-272022-10-05 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] ACE2 ameliorated Antiviral antiviral potency B.1.1.529 B.1.1.7 B.1.617.1 Developing drug target EC50 effective IC50 in viral in vitro in vivo Infection inhibitor K18-hACE2 lethal infection lung mice MPro nasal omicron oral oral bioavailability protease provide Replication SARS-CoV-2 SARS-CoV-2 Mpro SARS-CoV-2 variant survival tissue damage transgenic mice Treatment variant variants wild-type SARS-CoV-2 [DOI] 10.1038/s41564-022-01119-7 [Article Type] Research
Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination백신 접종으로 유도된 오미크론 포함 SARS-CoV-2 변이체에 대한 광범위 중화 항체Article Published on 2022-04-272022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 Adenovirus Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies Antibody Response Beta binding broad spectrum Complete complex COVID-19 vaccine Cryo-electron microscopy defined Delta demonstrated develop drug elicited epitope exhibited Gamma hACE2 highlighting Infection investigated K18-hACE2 mAb monoclonal antibody nCoV neutralization neutralizing antibody omicron other variant other variants Prophylactic Protein Protein binding provided Research SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein the RBD the spike protein therapeutic Transgenic mouse vaccination Vaccines variant VOCs [DOI] 10.1038/s41392-022-00987-z PMC 바로가기 [Article Type] Article
Evaluating Antibody Mediated Protection against Alpha, Beta, and Delta SARS-CoV-2 Variants of Concern in K18-hACE2 Transgenic MiceK18-hACE2 형질전환 마우스에서 우려되는 알파, 베타 및 델타 SARS-CoV-2 변이체에 대한 항체 매개 보호 평가Article Published on 2022-03-232022-09-11 Journal: Journal of Virology [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] Alpha Alpha VOC angiotensin angiotensin converting enzyme Beta Brain can be used concern convalescent convalescent plasma COVID-19 COVID-19 pandemic COVID-19 patient Critically ill decrease Delta Delta VOC disease dose Efficacy elevated enzyme evaluate Evaluating hACE2 hcp Human IgG titer immune evasion immunization in vivo model K18 K18-hACE2 K18-hACE2 transgenic mice lethality lung Mediated mice modeling modeling COVID-19 monoclonal antibody Mortality not decreased nucleocapsid nucleocapsid IgG pandemic passive immunity passive immunization polyclonal antibodies polyclonal antibody problem protection RBD Receptor binding domain response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants serum single dose Strains survival These data transgenic Transgenic mouse Treatment treatment group Vaccine variants variants of concern Viral Viral RNA while [DOI] 10.1128/jvi.02184-21 PMC 바로가기 [Article Type] Article
Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 ExpressionK18-hACE2 마우스의 치명적인 신경 보급 및 SARS-CoV-2 향성은 hACE2 발현에 부분적으로만 의존합니다Article Published on 2022-03-052022-09-11 Journal: Viruses [Category] SARS, 치료기술, [키워드] ACE2 ACE2 protein ACE2-expressing cell ACE2-expressing cells Analysis angiotensin animal animal models AT1 axonal transport blood-brain barrier Brain bronchiolar Cell Cohort comparative pathology COVID-19 Critical cytokeratin cytokeratin 18 promoter days post-infection death Dependent detectable dose ENhance epidemiological data euthanasia evaluated Evidence expressing expression hACE2 Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hypothermia immunohistochemistry In situ hybridization in vivo in vivo imaging independent independent of inoculated intranasal K18-hACE2 Lineage Mild-to-moderate neuroepithelium Neuron neurons occur olfactory olfactory bulb olfactory neuroepithelium overexpression pathologic PFUs Pneumocytes Pneumonia portal question resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis spatiotemporal subsequent transgenic mice translational translational animal model Transmission transmission electron microscopy Transport tropism vasculature viral pathogenesis Viremia Virological [DOI] 10.3390/v14030535 PMC 바로가기 [Article Type] Article
Hamsters Expressing Human Angiotensin-Converting Enzyme 2 Develop Severe Disease following Exposure to SARS-CoV-2Article Published on 2022-02-222023-07-07 Journal: mBio [Category] COVID19(2023년), [키워드] angiotensin-converting enzyme 2 cardiac lesions K18-hACE2 Nasal cavity Neuropathology olfactory bulb SARS-CoV-2 transgenic hamsters. [DOI] 10.1128/mbio.02906-21 PMC 바로가기
Nasal delivery of broadly neutralizing antibodies protects mice from lethal challenge with SARS-CoV-2 delta and omicron variantsResearch Article Published on 2022-02-182023-06-15 Journal: Virologica Sinica [Category] COVID19(2023년), MERS, SARS, [키워드] Coronavirus disease 2019 (COVID-2019) K18-hACE2 Omicron variant Prophylactic protection severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [DOI] 10.1016/j.virs.2022.02.005 PMC 바로가기 [Article Type] Research Article