Human Immunodeficiency Viruses Pseudotyped with SARS-CoV-2 Spike Proteins Infect a Broad Spectrum of Human Cell Lines through Multiple Entry MechanismsArticle Published on 2021-05-212022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] A549 cell absence Anti-spike antibody antibody screening bovine CD147 Cell cell line cell lines cell type cells cellular receptors condition coronavirus coronavirus disease COVID-19 enzyme expressing FBS fetal hACE2 HIV Human in viral infect involved LINE mRNA abundance Multiple neutralization overexpression Plasmid produced Protein pseudotyped pseudotyped SARS-CoV-2 pseudotyped SARS-CoV-2 virus Pseudotyped virus RBD receptor replication-competent SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S protein SARS-CoV-2 virus sensitivity serum Spectrum spike the receptor-binding domain the SARS-CoV-2 TMPRSS2 TMPRSS4 viral entry virus was used [DOI] 10.3390/v13060953 PMC 바로가기 [Article Type] Article
Seroprevalence Surveys for Anti-SARS-CoV-2 Antibody in Different Populations in Taiwan With Low Incidence of COVID-19 in 2020 and Severe Outbreaks of SARS in 20032020년 COVID-19 발병률이 낮고 2003년 SARS 발병이 심한 대만의 다양한 인구에서 Anti-SARS-CoV-2 항체에 대한 혈청 유병률 조사Immunology Published on 2021-05-182022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료제, [키워드] Abbott Abbott SARS-CoV-2 IgG acute respiratory syndrome anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody chemiluminescent immunoassay community transmission conducted country COVID-19 COVID-19 vaccine cross-reactivity cross-sectional determined by effective Elecsy Epidemic epidemiological exclusion False-positive frontline healthcare worker group healthy IgG antibodies IgG antibody immunoassay imperative Infection lateral flow immunoassay LINE outbreak pandemic participant Participants Population positive result Prevalence provide qRT-PCR respiratory risk Roche SARS SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 seroprevalence sera Seroprevalence Severe acute respiratory syndrome Spread survey symptomatic patient Taiwan tested [DOI] 10.3389/fimmu.2021.626609 PMC 바로가기 [Article Type] Immunology
Susceptibility to SARS-CoV-2 of Cell Lines and Substrates Commonly Used to Diagnose and Isolate Influenza and Other VirusesResearch Published on 2021-05-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome Affect analyzed angiotensin-converting enzyme 2 canine cell line cell lines cell type cellular coronavirus coronavirus disease COVID-19 D614G mutation diagnose diagnostic disease enzyme evaluated help humans Infection Influenza influenza viruses isolate kidney LINE low expression MDCK MDCK cells mice Other overcome overexpression receptor reported respiratory infections SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus spike protein substitution substrate Surveillance susceptibility susceptible the spike protein virus viruses zoonoses [DOI] 10.3201/eid2705.210023 PMC 바로가기 [Article Type] Research
Predictors of Mortality in Critically Ill COVID-19 Patients Demanding High Oxygen Flow: A Thin Line between Inflammation, Cytokine Storm, and CoagulopathyResearch Article Published on 2021-04-202022-10-29 Journal: Oxidative Medicine and Cellular Longevity [Category] COVID-19, MERS, SARS, [키워드] accompanied Admission age albumin Analysis analyzed ARDS Belgrade Berlin center Chest CT Confirmed COVID-19 infection consecutive patient COVID-19 COVID-19 patient COVID-19 patients Critically ill Critically ill patient CRP D-dimer demographic Final hospital Hospital stay ICU identify IL-6 Ill independent predictor intensive care unit introduced invasive Invasive mechanical ventilation Laboratory LINE Logistic regression analysis lymphocyte median men moderate Mortality mortality rate multivariate logistic regression noninvasive Noninvasive ventilation Oxygen therapy past medical history Patient performed predictor respiratory Result selected serum albumin severe ARDS severity storm the median therapeutic Thin Treatment university were used [DOI] 10.1155/2021/6648199 PMC 바로가기 [Article Type] Research Article
Quinine Inhibits Infection of Human Cell Lines with SARS-CoV-2Article Published on 2021-04-092022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] A549 ACE2 Anti-SARS-CoV-2 Activity Antiviral antiviral activity approved blocked Caco-2 Calu-3 cell line Chloroquine Colon Concentration COVID-19 dependent on drug drug candidates Efficacy epithelial cell expressing Human Hydroxychloroquine indications Infection inhibited inhibitor less LINE lung cell lung cells medical need middle MOI multiplicity of infection pharmacological progeny Quinine Regulatory SARS-CoV-2 SARS-COV-2 infection Side effect tested therapeutic effect TMPRSS2 Treatment vaccination Vero cells while [DOI] 10.3390/v13040647 PMC 바로가기 [Article Type] Article
Viruses and Endogenous Retroviruses as Roots for Neuroinflammation and Neurodegenerative DiseasesNeuroscience Published on 2021-03-122022-10-31 Journal: Frontiers in Neuroscience [Category] COVID-19, [키워드] Activation addition being Brain Central nervous system chronic inflammation Clinical severity correlated disease Disease progression Diseases element elements endogenous Evolution HERV Human genome Hypothesis immune immune response inflammation markers Inflammatory LINE modulate neurodegeneration neurodegenerative Neuroinflammation nuclear phylogenetically retrovirus root the disease transcript transcription factor viral infection viral-like particles virus [DOI] 10.3389/fnins.2021.648629 PMC 바로가기 [Article Type] Neuroscience
Psychosocial impact of COVID-19 on cancer patients, survivors, and carers in Australia: a real-time assessment of cancer support servicesOriginal Article Published on 2021-03-112022-10-28 Journal: Supportive Care in Cancer [Category] COVID-19, [키워드] added affected analysed Analysis average Cancer cancer diagnosis Cancer patients cancer survivorship Care Consequences coronavirus coronavirus disease Council COVID-19 distress domain Healthcare provider information LINE long-lasting pandemic Patient patients peaked Psychological distress Psychosocial Psychosocial impact recommendation Result service supplementary material Support supportive care Survivors survivorship susceptibility virus [DOI] 10.1007/s00520-021-06101-3 PMC 바로가기 [Article Type] Original Article
Challenging management of severe chronic disorders in acute pandemic situation: Chronic liver disease under COVID-19 pandemic as the proof-of-principle model to orchestrate the measures in 3PM contextResearch Published on 2021-03-032022-10-31 Journal: The EPMA Journal [Category] COVID-19, [키워드] acute liver failure Acute situation Advanced stages adverse outcome Algorithm approach assigned baseline Cancer Care chronic Chronic disorder chronic liver disease cirrhosis Cirrhosis registry clinical utility condition COVID-19 COVID-19 infection COVID-19 pandemic current death death rates Deterioration disease management Electronic patient records event Expert recommendations female fibrosis green Health policy healthcare Healthcare system Hepatitis highest Impact implementation inherent interval LINE Live transplantation Liver disease lockdown male management measure median age Mortality mortality rates neurological Optimal healthcare modeling orange organized outbreak pandemic Pandemics parameters pathway Patient patient cohorts Patient needs Personalized medicine Personalized treatment algorithms Predictive Predictive preventive personalized medicine (PPPM/3PM) primary care Priority pathways prognostic Red resources responsible risk SARS CoV-2 secondary care sick significantly increased Slovakia Statistics telemedicine consultation Tertiary care the patient treated Treatment [DOI] 10.1007/s13167-021-00231-8 PMC 바로가기 [Article Type] Research
Transcriptomic Analysis of Respiratory Tissue and Cell Line Models to Examine Glycosylation Machinery during SARS-CoV-2 InfectionSARS-CoV-2 감염 중 당화 기계를 검사하기 위한 호흡기 조직 및 세포주 모델의 전사체 분석Article Published on 2021-01-082022-09-10 Journal: Viruses [Category] MERS, 바이오마커, [키워드] addition affecting Analysis approach biological significance Biomarker correlation COVID-19 immunity cytokine Cytokine storm database differentially expressed downstream epitope Epitopes expression functional functional enrichment Functional genomics glycan glycans glycosylation glycosylation pathway glycosylation pathways Host immune response host inflammatory response hypothetical immune function immune response immunomodulatory implicated in silico Infection infectious agents inflammatory signaling LINE Localization macromolecule macromolecules marker Model modulated modulating negative and positive pathogen Pathways performed post-translational modification Protein Proteoglycan proteoglycans receptor Repository respiratory SARS-CoV-2 SARS-COV-2 infection Stratification susceptibility therapeutic Transcription transcriptomic analysis Treatment Viral [DOI] 10.3390/v13010082 PMC 바로가기 [Article Type] Article
Spatiotemporal spread pattern of the COVID-19 cases in ChinaResearch Article Published on 2020-12-312022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] accounted Analysis Area Bay changes in China Clustering COVID-19 case COVID-19 pandemic COVID-19 transmission had no Hong Kong implication LINE Macau occurred pandemic reveal Shenzhen significantly spatiotemporal Spread threat Wuhan [DOI] 10.1371/journal.pone.0244351 PMC 바로가기 [Article Type] Research Article