Circulating Levels of PD-L1, TIM-3 and MMP-7 Are Promising Biomarkers to Differentiate COVID-19 Patients That Require Invasive Mechanical VentilationPD-L1, TIM-3 및 MMP-7의 순환 수준은 침습적 기계 환기가 필요한 COVID-19 환자를 구별하는 유망한 바이오마커입니다Article Published on 2022-03-142022-09-11 Journal: Biomolecules [Category] Coronavirus, MERS, SARS, 바이오마커, [키워드] 105 patient 105 patients acute disease Acute respiratory failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Biomarker Biomarkers caused Clinical data Coronavirus-2 correlated COVID-19 COVID-19 patient diagnosed with COVID-19 disease disease severity eight ELISA evaluate exhibited followed by highest Hospital stay IMV Infectious disease Invasive mechanical ventilation Level lung lesion lung lesions marker Mechanical molecules NIMV PaO Patient patients PD-L1 persistence Potential biomarker potential biomarkers quantified respiratory Respiratory failure ROC analysis RT-PCR SARS-CoV-2 sensitivity Serum level serum levels Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significant decrease specificity T-cell T-cells two group two groups was increased [DOI] 10.3390/biom12030445 PMC 바로가기 [Article Type] Article
Gramicidin S and melittin: potential anti-viral therapeutic peptides to treat SARS-CoV-2 infectionGramicidin S 및 Melittin : SARS-COV-2 감염을 치료하는 잠재적 항 바이러스 치료 펩티드Article Published on 2022-03-022022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] Analysis Anti-SARS-CoV-2 Activity Anti-viral Antibacterial Antiviral approach Bacillus brevis candidate Cell Biology COVID19 cytotoxicity de novo decrease drug Drug discovery GRAMICIDIN in vitro indicated Infection less melittin molecules mRNA pandemic peptide peptides post infection Protein regulated SARS-CoV-2 SARS-COV-2 infection Significant significant decrease the disease the SARS-CoV-2 therapeutic treat treated Treatment Vero Cell Vero cells Viral viral clearance viral infections Viral load [DOI] 10.1038/s41598-022-07341-x PMC 바로가기 [Article Type] Article
Structure- and Interaction-Based Design of Anti-SARS-CoV-2 AptamersAnti-SARS-CoV-2 앱타머의 구조 및 상호 작용 기반 설계Article Published on 2022-02-242022-09-11 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] COVID19(2023년), SARS, 변종, [키워드] approach aptamer Aptamers binding binding affinity blueprint complexes computational method Computational methods Cytometry develop Directed mutagenesis DNA docking drug design ENhance fragment molecular orbitals method functional IMPROVE in silico Infection Interaction iterative methodology molecular molecular docking molecular dynamics molecules Mutagenesis nucleic acids offer pathogen probes Protein protein structure Receptor-binding domain SARS-CoV-2 SARS-CoV-2 spike protein SAXS scratch speed Spike protein Structure synergy target target protein tertiary structure the receptor-binding domain the SARS-CoV-2 time-consuming variants X-ray scattering [DOI] 10.1002/chem.202104481 PMC 바로가기 [Article Type] Article
Theta-Defensins to Counter COVID-19 as Furin Inhibitors: In Silico Efficiency Prediction and Novel Compound Design퓨린 억제제로서 COVID-19에 대응하는 ta-Defensins: 인실리코 효율성 예측 및 새로운 화합물 설계Research Article Published on 2022-02-092022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] MERS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Anti-inflammatory antigenicity antimicrobial peptide antimicrobial peptides arginine bind binding binding site caused Cell cell membrane characterized Compound coronavirus coronavirus disease Coronavirus disease 2019 counter COVID-19 COVID-19 infection Defense defense mechanisms defensin docking docking analysis drug candidate drug candidates Efficiency electrostatic enzyme event furin furin inhibitors Health Organization in silico approaches in vitro in vivo infect Inflammatory inhibit investigated mechanism mechanisms molecules novel pandemic peptide peptides Potential treatment prediction respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spike protein Spike proteins stability Stage subclass the cell the spike protein therapeutic unique WHO World Health Organization [DOI] 10.1155/2022/9735626 PMC 바로가기 [Article Type] Research Article
Repurposing drugs for treatment of SARS-CoV-2 infection: computational design insights into mechanisms of actionSARS-COV-2 감염의 치료를위한 약물 용도 : 작용 메커니즘에 대한 전산 설계 통찰력Article Published on 2022-02-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), MERS, SARS, 신약개발, 치료법, 치료제, [키워드] accelerate binding site Broad Institute caused ChEMBL Compound Computational drug Coronavirus infection COVID-19 COVID-19 pandemic database deaths determine develop drug Drug development Drug repurposing feature Features health emergency help human population identify in vitro in vitro data in vivo inhibit inhibitors inhibitors of SARS-CoV-2 Interaction life Ligand mechanism molecules negatively affected non-structural proteins Novel coronavirus Novel coronavirus infection nucleocapsid nucleocapsid protein pharmacophore predicted progressed Protein Protein binding Protein target protein targets repurposing Research SARS-CoV-2 SARS-CoV-2 genome screened the SARS-CoV-2 genome therapeutic intervention therapeutic interventions Treatment Viral Viral protein Viral proteins Virtual screening virus Visualisation was used [DOI] 10.1080/07391102.2020.1825232 PMC 바로가기 [Article Type] Article
Development of the DNA-based biosensors for high performance in detection of molecular biomarkers: More rapid, sensitive, and universal분자 바이오마커의 고성능 검출을 위한 DNA 기반 바이오센서 개발: 보다 신속하고 민감하며 보편적Review Published on 2022-02-012022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, 치료제, [키워드] Analytical chemistry antibodies applied biochemical Biology Biomarker Biomarkers caused Corona COVID-19 development Diagnosis Disease diagnosis DNA nanotechnology DNA-Based biosensors early diagnosis Enzymes example help High performance in vitro in vivo Infection introduced molecular Molecular biomarkers. molecules nucleic acid nucleic acids Numerous physiological platform probe producing Research SARS-CoV-2 specificity stability target targets the disease virus Virus Disease [DOI] 10.1016/j.bios.2021.113739 PMC 바로가기 [Article Type] Review
An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection실리코 분석은 SARS-CoV-2 감염에 의해 유발된 사이토카인 폭풍을 잠재적으로 조절하는 약물을 식별합니다Article Published on 2022-01-312022-09-10 Journal: Scientific Reports [Category] 신약개발, 유전자 메커니즘, 치료제, [키워드] “cytokine storm” addition Analysis anti-inflammatory properties anti-inflammatory property approach BALF Bronchoalveolar lavage fluid cause causes Computational biology and bioinformatics connectivity COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 patient Cytokines Data mining dataset drug Effect expected female hormone glucocorticoid Glucocorticoids Health help human cell lines identify immune response immune responses in silico analysis in vitro data Inflammatory Map MEK inhibitor modulating molecules Mortality negative regulation pathology pathway Pathways PKC predicted reveal SARS-CoV-2 SARS-COV-2 infection small molecule Small molecules supported the cytokine storm these compounds Transcription Transcriptome transcriptomic data Treatment triggered [DOI] 10.1038/s41598-022-05597-x PMC 바로가기 [Article Type] Article
Potential COVID-19 Drug Candidates Based on Diazinyl-Thiazol-Imine Moieties: Synthesis and Greener Pastures Biological StudyDiazinyl-Thiazol-Imine 모이어티에 기반한 잠재적인 COVID-19 약물 후보: 합성 및 더 친환경적인 목초지 생물학 연구Article Published on 2022-01-132022-09-10 Journal: Molecules [Category] 치료제, [키워드] Amino acid amino acid residues approved drugs aryl binding affinity binding score binding scores Biological biological activity calculated candidate characterized Compound condensation conditions COVID-19 cytotoxicity determine docking study drug Elemental free energy greener pastures hydrophobic hydrophobic interaction hydrophobic interactions imines-tethered thiazoles in silico molecular docking indicated Ligand ligands M pro molecular molecular docking molecules molnupiravir Pass Pasture PDB phenyl Potential potential therapeutic agent potential therapeutic agents receptor Remdesivir Research statistical analysis suggested synthesis therapeutic agents were used [DOI] 10.3390/molecules27020488 PMC 바로가기 [Article Type] Article
Implications of the Immune Polymorphisms of the Host and the Genetic Variability of SARS-CoV-2 in the Development of COVID-19COVID-19의 발달에서 숙주의 면역 다형성 및 SARS-COV-2의 유전 적 가변성의 의미Review Published on 2022-01-062022-09-10 Journal: Viruses [Category] SARS, 변종, [키워드] ACE2 ACE2 overexpression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 affecting agent angiotensin Angiotensin-converting enzyme binding Characteristics claimed Clinical signs coagulation disorders coronavirus coronavirus disease Coronavirus-2 country COVID-19 develop development dry cough Epigenetic explain Factor Fever Genetic genetic factors genetic susceptibility headache immune polymorphism immune system Immunopathogenesis include increment infection rate involved Loss of Smell loss of smell or taste molecules Most patients pandemic patients polymorphism respiratory responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 severe pneumonia Symptoms Taste Variability Viral viral entry viral infection [DOI] 10.3390/v14010094 PMC 바로가기 [Article Type] Review
Exploring COVID-19 pathogenesis on command-line: A bioinformatics pipeline for handling and integrating omics data명령줄에서 COVID-19 발병 기전 탐색: omics 데이터를 처리하고 통합하기 위한 생물정보학 파이프라인Article Published on 2022-01-012022-09-11 Journal: Advances in protein chemistry and structural biolo [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Bioconductor bioinformatics cholesterol cholesterol metabolism cohort of patients comprehensive view coronavirus COVID-19 COVID-19 pathogenesis Data integration Differentially expressed genes ECM experiment global public health handling healthy highly pathogenic immune system activity infected individuals infected patients information knowledge leukocyte lung mapped marker mechanism metabolism molecules offer Open Access pathway Pathways plasma proteasomal degradation Protein Proteins proteome proteomics Quantitative raw data regulated robust robustness SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 transcript Transcriptome transcriptomics transcriptomics data transcripts virus Wuhan Wuhan, China [DOI] 10.1016/bs.apcsb.2022.04.002 PMC 바로가기 [Article Type] Article