N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune Recognition
Research Article
[키워드] ACE2
acute respiratory syndrome
Brain
CAP
caused
comparable
Complete
contribute
coronavirus
coronavirus disease
CoV
COVID-19
disease
effective vaccine
exhibited
expression
guanine
IFN-I
immune response
immunological
in vitro
Infection
Innate
interferons
ISG15
liver
MDA5
MHV
mice
morbidity and mortality
mouse hepatitis virus
mutant
mutant virus
Mutation
myeloid cell
N7-methylation
nonstructural protein 14
nonstructural protein 14 (nsp14)
nsp14
pandemic
Pathogenesis
phenotype
Prevent
Preventing
previous study
Recognition
reduced
replicated
required
restored
RNA
RNA cap structure
RNA methylation
SARS-CoV-2
SARS-COV-2 infection
Signaling
significantly
subsequent
the vaccine
therapy
transgenic mice
type I interferon
understanding
upregulated
viral replication
Viral RNA
virulence
wild-type
[DOI] 10.1128/mbio.03662-21 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1128/mbio.03662-21 PMC 바로가기 [Article Type] Research Article