Receptor-binding domain recombinant protein on alum-CpG induces broad protection against SARS-CoV-2 variants of concernAlum-CpG의 수용체 결합 도메인 재조합 단백질은 우려되는 SARS-CoV-2 변이체에 대한 광범위한 보호를 유도합니다Article Published on 2022-06-092022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Alpha) (Beta) addition adjuvant Alpha alum aluminum aluminum hydroxide Antibody titer Antibody titers B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 benefit Beta Cellular immune response conducted Controller convalescent plasma Corbevax COVID-19 CpG Delta dose drug Emergency use authorization evaluated exceeded hydroxide immune response immunized induce Infection intramuscularly mice neutralization Neutralizing antibodies neutralizing antibody neutralizing antibody titers omicron other variants preclinical studies preclinical study Protein Receptor-binding domain reported SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant second dose subunit Subunit vaccine TLR9 TLR9 adjuvant Vaccine vaccine candidate variant variants variants of concern Virus neutralization Wuhan Wuhan isolate yeast [DOI] 10.1016/j.vaccine.2022.05.007 PMC 바로가기 [Article Type] Article
Immune response of booster doses of BBIBP-CORV vaccines against the variants of concern of SARS-CoV-2SARS-CoV-2의 우려 변종에 대한 BBIBP-CORV 백신의 추가 용량의 면역 반응Observational Study Published on 2022-06-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] (alpha Alpha Antibody titer Antibody titers approved BBIBP-CorV Beta booster booster dose booster doses Cohort COVID-19 COVID-19 vaccination COVID-19 vaccinations dose doses Evidence fold immune response inactivated Inactivated vaccine Inactivated Vaccines inactive individual Lineage lineages neutralization test Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers neutralizing effect observational study offered plaque pooled serum primary dose primary doses PRNT recipient recipients reduction reduction in sample pool SARS-CoV-2 SARS-CoV-2 variants serum serum sample serum samples statistically significant Test the SARS-CoV-2 Vaccinations Vaccine vaccine cohort variant variants variants of concern was done Wuhan [DOI] 10.1016/j.jcv.2022.105161 PMC 바로가기 [Article Type] Observational Study
Heterologous ChAdOx1/BNT162b2 vaccination induces stronger immune response than homologous ChAdOx1 vaccination: The pragmatic, multi-center, three-arm, partially randomized HEVACC trial이종 ChAdOx1/BNT162b2 예방 접종은 동종 ChAdOx1 예방 접종보다 더 강한 면역 반응을 유도합니다. 실용적인, 다기관, 3군, 부분 무작위 HEVACC 시험Randomized Controlled Trial Published on 2022-06-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 임상, 진단, [키워드] 1:1 adaptive antibody Antibody titer Antibody titers approved Arm AstraZeneca B.1.617.2 BNT BNT162b2 breath ChAdOx1 comparable conducted COVID-19 COVID-19 vaccine Delta effective first dose Frequency group groups Heterologous Heterologous COVID-19 vaccination homologous immune response immunized immunogenicity induce interim analysis less median mRNA vaccine mRNA vaccines Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers NIAID participant Pfizer Pfizer/BioNTech Pragmatic primary endpoint Randomized reactogenicity regimen response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants severe adverse events spike-specific T cell statistically significant stratified by sex supported T cell T cell responses T cells Trial university vaccination vaccination schedule Vaccine vaccinees Vaccines [DOI] 10.1016/j.ebiom.2022.104073 PMC 바로가기 [Article Type] Randomized Controlled Trial
Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-CSARS-CoV-2 오미크론 변이체에 대한 교차 반응성 면역은 이전에 COVID-19 또는 MIS-C가 있는 소아 환자에서 낮습니다.Article Published on 2022-05-272022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute COVID-19 age Alpha Analysis antibody Antibody titers Beta children clinical disease Cohort convalescent COVID-19 cross-neutralization Delta demonstrated evaluated expected Gamma Hospitalized Immunity less Mild MIS-C neutralization neutralization capacity neutralization titer Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers neutralizing capacity omicron Omicron variants outcome Outpatient outpatients Patient patients pediatric Pediatric patient Re-infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants Support the SARS-CoV-2 Transmission vaccination variant variants virus-neutralizing [DOI] 10.1038/s41467-022-30649-1 PMC 바로가기 [Article Type] Article
Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccineSARS-CoV-2 mRNA 백신 3차 접종 후 오미크론 반응성 B 세포 기억의 효율적인 회수Article Published on 2022-05-262022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] added Alpha antibody Antibody titer Antibody titers Antigen B cell memory Beta booster Cell circulating antibodies circulating antibody correlated COVID-19 Delta dose efficient examined fold immune immune memory Immunity IMPROVE increase in limit memory B memory B cell memory B cells mRNA mRNA vaccination mRNA vaccine neutralizing antibody titers omicron Omicron variants quantity RBD-specific memory B cells recall remained response SARS-CoV-2 spike These data vaccination Vaccine variants variants of concern wild-type [DOI] 10.1016/j.cell.2022.04.009 PMC 바로가기 [Article Type] Article
Competent immune responses to SARS-CoV-2 variants in older adults following two doses of mRNA vaccinationmRNA 백신 2회 투여 후 노인의 SARS-CoV-2 변이체에 대한 유능한 면역 반응Article Published on 2022-05-242022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] age aging Antibody titers B.1.617.1 B.1.617.2 boost cellular immunity Cohort comparable Delta dose Efficacy Gamma humoral humoral and cellular immunity Humoral immunity immune response immune responses magnitude mRNA mRNA vaccination mRNA vaccine mRNA-based SARS-CoV-2 vaccine mRNA-based SARS-CoV-2 vaccines Neutralizing antibody titer neutralizing antibody titers neutralizing capacity Older Older adults P.1 recipients reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants second dose second vaccination shown spike mutation vaccination vaccination response vaccinee variant variants Viral virus while [DOI] 10.1038/s41467-022-30617-9 PMC 바로가기 [Article Type] Article
Longitudinal analysis of T cell receptor repertoires reveals shared patterns of antigen-specific response to SARS-CoV-2 infectionT 세포 수용체 레퍼토리의 종단 분석은 SARS-CoV-2 감염에 대한 항원 특이적 반응의 공유 패턴을 보여줍니다Article Published on 2022-05-232022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis breadth CD4+ T cell CD4+ T cells conducted COVID-19 detectable Diversity elevated Frequency immune defense immune response Immunity immunology individual initial Italy longitudinal municipality neutralizing antibody titers outbreak PCR persist positive remained reveal SARS-CoV-2 SARS-COV-2 infection severe disease significant increase Spike protein subsequent T cell T cell receptor T cells TCR TCRs Viral diseases was increased [DOI] 10.1172/jci.insight.151849 PMC 바로가기 [Article Type] Article
Antibody responses against SARS-CoV-2 variants induced by four different SARS-CoV-2 vaccines in health care workers in the Netherlands: A prospective cohort study네덜란드 의료 종사자의 4가지 다른 SARS-CoV-2 백신에 의해 유도된 SARS-CoV-2 변이체에 대한 항체 반응: 전향적 코호트 연구Article Published on 2022-05-172022-09-11 Journal: PLoS Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S Adenovirus adenovirus vector-based vaccines adjusted age and sex Alpha Analysis Antibody Response Antibody titers AZD1222 Beta BNT162b2 booster booster vaccination cellular immunity COV2.S Delta Effectiveness Fold change followed by Gamma geometric geometric mean geometric mean titers GMT group groups head Head-to-head comparison Health care Health care worker highest include initial lack limitation linear mixed model Linear regression mRNA mRNA vaccine mRNA vaccines mRNA-1273 Netherlands neutralization neutralize Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers of BNT162b2 omicron Omicron variant performed prospective cohort prospective cohort study recipient recipients recognize reduction in SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants sera serum vaccination Vaccine variant VoC VOCs was performed was reduced wild-type [DOI] 10.1371/journal.pmed.1003991 PMC 바로가기 [Article Type] Article
A multitope SARS-CoV-2 vaccine provides long-lasting B cell and T cell immunity against Delta and Omicron variants멀티토프 SARS-CoV-2 백신은 Delta 및 Omicron 변이체에 대해 오래 지속되는 B 세포 및 T 세포 면역을 제공합니다Clinical Trial Published on 2022-05-162022-09-11 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] adverse event Antibody titers Asia B cell booster Breakthrough infection breakthrough infections center conducted conserved Control COVID-19 cross-reactive cytotoxic T lymphocyte Delta disease control dose elicited epitope Epitopes evaluated fatigue healthy helper T cell Heterologous human convalescent sera Immunity immunization immunogenicity Inc. injection site pain long-lasting lymphocyte membrane memory immunity Mild Ministry of Health Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers Neutralizing titer nucleocapsid omicron Omicron variants peptide peptides Phase I placebo-controlled Protein provide Randomized representing responsible safety profile sarbecovirus SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants second dose Serious Adverse Event Serious Adverse Events subunit Subunit vaccine T cell Taiwan Trial trials Vaccine variant variants of SARS-CoV-2 virus-neutralizing antibody VOCs waning immunity Welfare were recorded [DOI] 10.1172/JCI157707 PMC 바로가기 [Article Type] Clinical Trial
Detection of SARS-CoV-2 Nucleocapsid, Spike, and Neutralizing Antibodies in Vaccinated Japanese백신을 접종한 일본인에서 SARS-CoV-2 뉴클레오캡시드, 스파이크 및 중화 항체 검출Article Published on 2022-05-052022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody titers coronavirus correlated detection detection system Efficacy Efficiency Elecsy Elecsys evaluate evaluated Fujirebio healthy subject healthy subjects IgG investigated Japanese Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers nucleocapsid patients with COVID-19 respiratory Roche SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 N sensitivity sera serological test severe acute respiratory syndrome Coronavirus specificity spike vaccination were assessed [DOI] 10.3390/v14050965 PMC 바로가기 [Article Type] Article