Genomic surveillance of SARS-CoV-2 tracks early interstate transmission of P.1 lineage and diversification within P.2 clade in BrazilSARS-COV-2 트랙의 게놈 감시 브라질의 p.2 Clade 내에서 p.1 계보 및 다각화의 초기 고속도로 전송Research Article Published on 2021-10-132022-09-10 Journal: PLoS Neglected Tropical Diseases [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] absence Antibody neutralization B.1.1.28 B.1.1.33 Brazil clade clades collected concern continuous monitoring country COVID-19 case COVID-19 cases Critical critical state descending described detect dispersal E484K mutation effective Effectiveness except for FIVE Gamma Genetic variant genomic data Genomic surveillance identify immune system isolate landscape Lineage lineages measure MONITOR N.9 North Occurrence P.1 P.2 pandemic performed predominant provided reached Region regions replaced Research resulting Rio de Janeiro Rio Grande SARS-CoV-2 SARS-CoV-2 isolates SARS-CoV-2 lineage SARS-CoV-2 pandemic SARS-CoV2 Sequencing Spread the SARS-CoV-2 Transmissibility Transmission transmission rate transmission rates Vaccine variant variants of concern variants of interest Viral viral lineage whole-genome sequencing widespread [DOI] 10.1371/journal.pntd.0009835 PMC 바로가기 [Article Type] Research Article
Temporal spread and evolution of SARS‐CoV‐2 in the second pandemic wave in BrazilResearch Article Published on 2021-10-082022-10-04 Journal: Journal of medical virology [Category] MERS, SARS, 변종, 치료기술, [키워드] acute respiratory syndrome amino acid substitution Analysis Bayesian approach Brazil concerning coronavirus disease country deaths demonstrated dissemination evaluated Evolution faster Frequency Gamma growth highlighting information Lineage Mutation North novel lineage nucleotide occurred P.1 P.2 pandemic phylodynamic Prevalence public health raised Region regions SARS Coronavirus SARS‐CoV‐2 SARS‑CoV2 sequence Skyline slight rise South America Spread statistically Temporal the spike protein These data variant WGS [DOI] 10.1002/jmv.27371 PMC 바로가기 [Article Type] Research Article
Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 lineages circulating in Brazil브라질에서 순환하는 SARS-COV-2 계통에 대한 Chadox1 NCOV-19 (AZD1222) 백신의 효능Clinical Trial Published on 2021-10-062022-08-13 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 임상, [키워드] 95% CI Analysis AZD1222 B.1.1.28 Brazil caused ChAdOx1 ChAdOx1 nCoV-19 circulating clinical trials COVID-19 COVID-19 vaccine determine E484K Efficacy Efficiency Exploratory analysis Gamma genotyping hospitalisation Infectious diseases ISRCTN89951424 Lineage lineages Mutation nose nose and throat Nose and throat swabs occurred other variants P.1 P.2 PCR performed phase post-hoc analysis post-hoc exploratory analysis PROTECT protection provided raise Randomised trial SARS-CoV-2 SARS-CoV-2 lineage Sequencing shown Spike protein Swab swabs symptomatic symptomatic COVID-19 symptomatic participants tested the spike protein throat swab Trial Trial registration Vaccine vaccine efficacy vaccine trial Vaccines variant variants variants of SARS-CoV-2 viral infection Zeta [DOI] 10.1038/s41467-021-25982-w PMC 바로가기 [Article Type] Clinical Trial
Emergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay우루과이에서 Q675H 및 Q677H 스파이크 돌연변이를 갖는 B.1.1.28 유래 P.6 계통의 출현 및 확산Article Published on 2021-09-102022-09-10 Journal: Viruses [Category] SARS, 변종, 유전자 메커니즘, [키워드] analyzed B.1.1.28 cleavage site dissemination emergence epidemic wave Evidence evidence of followed by genetic diversity Lineage lineages Local Mutation nine P.1 P.2 pandemic phylogenetics phylogeography predominant prevalent Q675H Q677H replaced REPLACED BY S1/S2 boundary SARS-CoV-2 SARS-CoV-2 pandemic Spain spike Spread spread to the SARS-CoV-2 Transmission Uruguay USA variant Viral viral variant VoC VOCs [DOI] 10.3390/v13091801 PMC 바로가기 [Article Type] Article
An in-depth in silico and immunoinformatics approach for designing a potential multi-epitope construct for the effective development of vaccine to combat against SARS-CoV-2 encompassing variants of concern and interest우려 및 관심의 변이를 포함하는 SARS-CoV-2에 대항하는 백신의 효과적인 개발을 위한 잠재적인 다중 에피토프 구성을 설계하기 위한 심층 실리코 및 면역정보학 접근 방식Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 변종, [키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Antibody titer antigenicity approach B cell B cell epitope B-cell epitope B.1.1.7 B.1.351 B.1.427 B.1.429 B.1.526 B.1.617.1 B.1.617.2 binding Cell cells coronavirus COVID-19 effective elevated epitope Health immune response Immunity immunoinformatics in silico in vitro linker linkers MEV Multi-epitope vaccine NK cells nucleotide nucleotide sequence ORF1 ORF10 ORF1ab ORF3a ORF6 ORF7a ORF7b ORF8 outbreak P.1 P.2 Pathogens Physicochemical properties polyprotein present Prevent preventive measure receptor S protein SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 T cell T cell epitope T-cell the vaccine TLR2 TLR4 Toll-like receptor Toll-like receptors turn utility Vaccine vaccine construct variants variants of concern variants of interest variants of SARS-CoV-2 viral pathogen were used [DOI] 10.1016/j.compbiomed.2021.104703 PMC 바로가기 [Article Type] Article
Molecular surveillance of the on-going SARS-COV-2 epidemic in Ribeirao Preto City, Brazil브라질 Ribeirao Preto City에서 진행 중인 SARS-COV-2 전염병의 분자 감시Article Published on 2021-09-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, [키워드] accelerated acute respiratory syndrome coronavirus Analysis analyzed B.1.1 B.1.1.28 Brazil causative agent circulating circulation city composed contribute coronavirus country COVID-19 demonstrated epicenter Epidemic Genome genomic Genotype highest initial Lineage lineages majority nanopore technology nasopharyngeal P.1 P.2 pandemic Pandemics performed Phylogenetic phylogenetically Phylogeny positive sample predict respiratory SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 RNA SARS-CoV-2 strain SARS-CoV-2 vaccination second wave sequenced severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 state strain Strains Surveillance surveillance data the SARS-CoV-2 variant variants of concern VoC whole genome worldwide pandemic [DOI] 10.1016/j.meegid.2021.104976 PMC 바로가기 [Article Type] Article
Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants새롭게 등장하는 SARS-CoV-2 변이체의 진화, 전파 방식 및 돌연변이 양상Research Article Published on 2021-08-312022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed B.1.1.7 B.1.1.7 lineage B.1.351 B.1.525 B.1.526 B.1.617.2 CDC circulating coronavirus D614G E484K effect on vaccines Effectiveness emerging variants evaluated Frequency Genome genomes geographical distribution geographical distributions highest include landscape Lineage lineages mode Mutation mutational landscape N501Y New P.1 P.2 provided public health respiratory SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Spike protein the WHO today Transmission transmission pattern transmission patterns USA Vaccine variant variants variants of concern variants of interest VoC VOCs VOI VOIs WHO [DOI] 10.1128/mBio.01140-21 PMC 바로가기 [Article Type] Research Article
Optimization and validation of RT-LAMP assay for diagnosis of SARS-CoV2 including the globally dominant Delta variant전 세계적으로 지배적 인 델타 변이체를 포함하여 SARS-COV2의 진단을위한 RT-LAMP 분석의 최적화 및 검증Research Published on 2021-08-302022-09-01 Journal: Virology Journal [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome coronavirus amplification Analysis B.1.1.7 B.1.1.7 (Alpha) B.1.351 B.1.351 (Beta) B.1.427 B.1.429 (Epsilon) B.1.525 B.1.525 (Eta) B.1.526 B.1.526 (Iota) B.1.617.1 B.1.617.1 (Kappa) B.1.617.2 B.1.617.2 (Delta) causative agent condition conserved conserved regions coronavirus coronavirus 2 COVID-19 COVID-19 pandemic delta variant development Diagnosis diagnosis of COVID-19 discrimination DNA polymerase dominant double blind double blind study evaluated gold gold standard Health Organization include infected individual infected individuals Isolation isothermal LAMP Lineage Loop-mediated isothermal amplification molecular Molecular diagnosis objective optimization P.1 P.1 (Gamma) P.2 P.2 (Zeta) P.3 (Theta) pathogenic coronaviruses Patient PCR primer binding site primer binding sites primer set Primers real time PCR Region respiratory Result RT-LAMP SARS-CoV-2 SARS-CoV2 severe acute respiratory syndrome coronavirus 2 Spread supplementary material Testing the disease time variants variants of concern variants of interest Visualization VoC WHO World Health Organization [DOI] 10.1186/s12985-021-01642-9 PMC 바로가기 [Article Type] Research
Mutation hotspots and spatiotemporal distribution of SARS-CoV-2 lineages in Brazil, February 2020-2021Article Published on 2021-08-052022-10-04 Journal: Virus research [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome analyses association Brazil clade coronavirus country COVID-19 COVID-19 pandemic death deaths described disease distribution E484K effective strategy effort Epidemiology Evolution Frequency genome sequence genomic heterogeneous High-throughput nucleotide sequencing hotspot identify immune evasion improvement Infectious diseases information Lineage management Molecular epidemiology Mutation N501Y P.1 P.2 phylogenetics phylogeography Prevalence prevalent lineage progression public health reached Receptor binding regions SARS-CoV-2 SARS-CoV-2 lineage Sequencing Seven severe acute respiratory syndrome coronavirus 2 spatiotemporal Support Surveillance the spike protein [DOI] 10.1016/j.virusres.2021.198532 PMC 바로가기 [Article Type] Article
Predominance of the SARS-CoV-2 Lineage P.1 and Its Sublineage P.1.2 in Patients from the Metropolitan Region of Porto Alegre, Southern Brazil in March 2021Article Published on 2021-08-052022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] approaches assigned B.1.1.28 B.1.1.33 B.1.1.7 B.1.351 B.1.617.2 Brazil clade Consequences COVID-19 COVID-19 pandemic described diffusion dispersal E484K mutation epidemiological genomic High-throughput nucleotide sequencing identify Immunity Infectious diseases introduced Lineage molecular Molecular epidemiology molecular evolution Mortality Mutation P.1 P.2 Phylogenetic Phylogeny Porto Prevalence prevalent lineage Region replaced Rio Grande SARS-CoV-2 lineage sequence sequenced severe acute respiratory syndrome coronavirus 2 South Africa Substitution Surveillance the SARS-CoV-2 Transmissibility United Kingdom viral sample [DOI] 10.3390/pathogens10080988 PMC 바로가기 [Article Type] Article