Evaluation of SARS-CoV-2 Spike S1 Protein Response on PI3K-Mediated IL-8 ReleaseCommunication Published on 2021-05-182022-10-30 Journal: Medical Sciences [Category] COVID-19, SARS, [키워드] Activation acute respiratory syndrome caused cellular cellular response Comorbidity COVID-19 Critical cytokine determine downstream effort Extensive global pandemic IL-8 interleukin-8 mechanism mitigate modulate mortalities Novel coronavirus overcome Pathogenesis pathway PI3K PI3K signaling potential therapeutic target Protein Release response S1 protein SARS-CoV-2 SARS-COV-2 infection Signaling signaling pathway spike the SARS-CoV-2 the Spike Therapeutic approach while [DOI] 10.3390/medsci9020030 PMC 바로가기 [Article Type] Communication
Mass spectrometry-based proteomic platforms for better understanding of SARS-CoV-2 induced pathogenesis and potential diagnostic approachesSARS-CoV-2 유도 병인 및 잠재적 진단 접근법에 대한 더 나은 이해를 위한 질량 분석 기반 단백질체 플랫폼Review Published on 2021-05-012022-09-11 Journal: Proteomics [Category] SARS, 유전자 메커니즘, 진단, [키워드] AMPK applied approach Biomarkers cellular Comparative analysis comparative proteomics COVID-19 dataset diagnostic EGFR EPHA2 Ephrin functional humans in vitro experiments indicate Infection kinase kinase-substrate signaling kinases knowledge MAPK mass mass spectrometry mechanism molecular mechanism molecular mechanisms Pathogenesis pathway Pathways phosphoproteome PI3K platform post-translational modifications prognostic Protein protein targets protein-protein interaction proteome proteomic proteomics receptor SARS-CoV-2 SARS-COV-2 infection signaling pathways targeted proteomics the SARS-CoV-2 Therapeutic strategies tissue tissue sample tissue samples top-down proteomics. Viral viral infection while [DOI] 10.1002/pmic.202000279 PMC 바로가기 [Article Type] Review
Physical exercise effects on the brain during COVID-19 pandemic: links between mental and cardiovascular healthCOVID-19 전염병 동안 뇌에 미치는 신체 운동 효과: 정신 건강과 심혈관 건강 간의 연관성Review Published on 2021-04-012022-09-11 Journal: Neurological Sciences [Category] 유전자 메커니즘, [키워드] ACE2 ACE2 expression Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect affected Ang 1-7 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 antiinflammatory Anxiety BDNF binding Brain cardiovascular complications Cardiovascular health caused Chronic diseases Corona Corona virus coronavirus COVID-19 COVID-19 pandemic death Depression disorders Effect Elevation ENhance enzyme ERK exercise FNDC5 Health heart host cell host cells IGF-1 IMPROVE individual induce Infection Inflammation life lung Lungs maintenance Mental mental health Mobility molecular mechanism molecular mechanisms neurological neuronal other tissues outbreak oxygen oxygen supply pandemic pathological mechanism pathway physical physical activity Physical exercise physiological response PI3K Quality of life quarantine Quarantine period receptor reducing SARS-CoV-2 SARS-COV-2 infection Sedentary behavior severe acute respiratory syndrome Coronavirus survival Treatment Virus Disease [DOI] 10.1007/s10072-021-05082-9 PMC 바로가기 [Article Type] Review
Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication항바이러스 약물 검사를 통해 DNA 손상 반응 억제제가 SARS-CoV-2 복제의 강력한 차단제임을 확인Report Published on 2021-03-182022-09-11 Journal: Cell Reports [Category] MERS, SARS, 신약개발, 진단, 치료기술, 치료제, [키워드] Abstract Anti-SARS-CoV-2 Activity antiviral activity Antiviral agents ATR ATR kinase berzosertib block blocked cell type cell types cellular cellular signaling pathway cellular signaling pathways clinical trials Compound compounds coronavirus Coronavirus replication CoV infection COVID-19 Critical Cytopathic effect DDR DNA-damage response pathway drug drug candidate effective epithelial cell epithelial cells exhibited Health Health crisis high-throughput screen highlight host-pathogen interactions human epithelial cells identify inhibited inhibiting inhibitor inhibitors involved Kinase inhibitor kinase inhibitors library MAPK mechanism MERS MERS-CoV MERS-CoV infection Middle East Middle East respiratory syndrome Coronavirus modulate mTOR mTOR-PI3K-AKT pathway multiple coronaviruses nucleoside analogs Pathways PI3K precipitated Protein protein kinase protein kinase inhibitor protein kinase inhibitors provide Replication respiratory respiratory syndrome coronavirus SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication shown signaling cascades signaling pathway signaling pathways Stage the SARS-CoV-2 therapeutic therapy Treatment treatment of COVID-19 [DOI] 10.1016/j.celrep.2021.108940 PMC 바로가기 [Article Type] Report
D -Limonene Is a Potential Monoterpene to Inhibit PI3K/Akt/IKK-α/NF-κB p65 Signaling Pathway in Coronavirus Disease 2019 Pulmonary FibrosisMedicine Published on 2021-03-092022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] analyzed Angiogenesis binding collagen coronavirus disease Coronavirus disease 2019 coronavirus disease related pulmonary fibrosis COVID COVID-19 D-limonene database differentially expressed gene docked downloaded expression GeneCard Inflammatory response Lung fibrosis mechanism metabolism monoterpene NF-κB p65 pathway pharmacological Phosphorylation PI3K PI3K/Akt signaling pathway Potential Prevalence PROTECT Protein pulmonary pulmonary fibrosis reported Severe acute respiratory syndrome signaling pathway target targets therapeutic Treatment [DOI] 10.3389/fmed.2021.591830 PMC 바로가기 [Article Type] Medicine
Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2 Research Published on 2021-03-082022-10-05 Journal: Nature Genetics [Category] SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome airway caused Cell coronavirus Coronavirus infection COVID-19 pandemic CRISPR demonstrated develop drug expression Factor Factors functional Genetic Health Host human cell line human coronavirus 229E identify in viral infect lung cells lysosomal Outbreaks overexpression patients with COVID-19 performed PI3K Protein pseudovirus infection SARS-CoV-2 SARS-COV-2 infection Single-cell RNA-sequencing TMEM106B Tmem41b Zoonotic coronavirus [DOI] 10.1038/s41588-021-00805-2 [Article Type] Research
Chemical composition and pharmacological mechanism of ephedra-glycyrrhiza drug pair against coronavirus disease 2019 (COVID-19)코로나바이러스 질병 2019(COVID-19)에 대한 마황-글리시리자 약물 쌍의 화학 성분 및 약리학적 메커니즘Research Paper Published on 2021-02-282022-08-31 Journal: Aging (Albany NY) [Category] MERS, 진단, 치료제, [키워드] 3CLpro ACE2 ALB Analysis analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral effects approach blood circulation CAMP Chemical chemokine chemokine signaling pathways complex Compound coronavirus disease COVID-19 demonstrated digestive digestive system Diseases docking result Effectiveness enrichment analysis ephedra flexibility FOS glycyrrhiza high correlation IL2 immune regulation Jak-STAT molecular docking molecular dynamics Molecular dynamics simulation MPro network pharmacology organ pathway Pathway analysis Pathways pharmacological mechanism PI3K PI3K-Akt signaling Prevention and control protease PTGS2 respiratory S protein Spike protein stability Statistics target targets TCM the spike protein these compound these compounds TNF-α Traditional Chinese medicine Treatment treatment of COVID-19 [DOI] 10.18632/aging.202622 PMC 바로가기 [Article Type] Research Paper
MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 programMBD2는 대식세포 M2 프로그램을 억제하여 폐 섬유증에 대한 실행 가능한 표적으로 작용합니다.Article Published on 2021-01-012022-09-11 Journal: Science Advances [Category] 유전자 메커니즘, [키워드] administration binding domain Bleomycin BLM characterized clinical settings coronavirus disease Coronavirus disease 2019 deficiency demonstrated Depletion domain expression fibrosis growth idiopathic inhibiting Interstitial lung disease intratracheal administration Liposome lung Lung disease lung injuries Lung injury Lungs M2 macrophage Macrophage macrophages Mbd2 mechanism mice Patient PI3K promote promoter pulmonary fibrosis reduced repressed Signaling significantly siRNA Support Systemic sclerosis TGF-β1 [DOI] 10.1126/sciadv.abb6075 PMC 바로가기 [Article Type] Article
Examining the effector mechanisms of Xuebijing injection on COVID-19 based on network pharmacologyResearch Published on 2020-10-162022-10-28 Journal: BioData Mining [Category] COVID-19, [키워드] activated Activation Active ingredient ALB albumin Analysis Anti-inflammatory AutoDock B cell binding activity biological process BPS cascade CASP3 cellular response Chinese component Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease Cytoscape Cytoscape software database demonstrated disease docking score Effect effective Effector mechanism Effects EGFR endothelial enrichment analysis epidermal ESR1 estrogen receptor Examining explain Extracellular GAPDH GeneCard Genes growth factor IL-2 Inflammation ingredient injection International JUN KEGG Kyoto less MAPK MAPK1 MAPK14 MAPK8 mechanism Mild molecular docking Necrosis network pharmacology NF-κB nuclear Ontology participated Pathways pharmacological mechanism PI3K potential mechanism potential therapeutic target PPI predict produced Protein protein-protein interaction provided PTGS2 RAS receptor regulated Regulation renin-angiotensin system Result searched Sepsis severe pneumonia signaling pathway STAT3 SwissTargetPrediction database synergistic T-cell receptor target targets therapeutic effect TLR TNF Toll-like receptor Topology Transcription Treatment TRP VEGF was used Xuebijing [DOI] 10.1186/s13040-020-00227-6 PMC 바로가기 [Article Type] Research
PI3Kδ Inhibition as a Potential Therapeutic Target in COVID-19Immunology Published on 2020-08-212022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE2 airway allergic diseases angiotensin-converting enzyme 2 Antiviral approaches Cardiovascular function Central nervous system COVID-19 demonstrated drug ebastine Epidemic faster global public health Idelalisib IL-1β IL-6 IL-8 increase in Infection Inflammation inflammatory reaction inhibition inhibitors lung mitigate Mortality Patient PI3K Potential potential therapeutic target pro-inflammatory cytokines pro-inflammatory factor receptor reduce Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 pandemic Spread suppress T cells target therapeutic therapy TNF-α Treatment upper respiratory tract virus [DOI] 10.3389/fimmu.2020.02094 PMC 바로가기 [Article Type] Immunology