WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinomaArticle Published on 2022-03-092022-10-04 Journal: Cell Death Discovery [Category] 바이오마커, [키워드] Bile duct cancer Biological functions CCK-8 Cell Cholangiocarcinoma chromatin immunoprecipitation Clinical prognosis correlated detect Effect expressed expression expression pattern facilitate Hepatocellular carcinoma ICC IHC immunofluorescence immunohistochemistry intrahepatic investigated Mechanisms of disease Metastasis molecular mechanism MYC NDFIP1 Oncogenes overexpression Patient performed poor prognosis potential mechanisms potential therapeutic target predict progression proliferation promote promoter region Protein protein level reduce reported rescued reveal target tissue tissues Transwell tumor progression Ubiquitylation upregulated upregulation were used WWP1 [DOI] 10.1038/s41420-022-00882-0 PMC 바로가기 [Article Type] Article
A computational and bioinformatic analysis of ACE2: an elucidation of its dual role in COVID-19 pathology and finding its associated partners as potential therapeutic targetsACE2의 컴퓨터 및 생물정보학 분석: COVID-19 병리학에서 ACE2의 이중 역할에 대한 설명 및 잠재적인 치료 표적으로서 관련 파트너 찾기Article Published on 2022-03-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acting acute respiratory distress acute respiratory distress syndrome Acute respiratory distress syndrome Predicted ACE2 structure Analysis analyzed angiotensin Angiotensin-converting enzyme Angiotensin-converting enzyme -2 angiotensin-converting enzyme 2 ARDS bioinformatic analysis CDS Cell coding COVID-19 pandemic COVID-19 pathology determine Differentially expressed genes disease distress DNA sequence downregulation effort enzyme FOS FOXO4 FOXP2 healthy human lung tissue involved list low expression mechanism MiR-212-5p miRNA miRNA target miRNA targets miRNA-1246. pandemic pathological changes potential therapeutic target provide receptor respiratory distress Respiratory distress syndrome Spike protein Spread syndrome transcription factor transcription factors upregulation Vaccine viral entry viral spike protein [DOI] 10.1080/07391102.2020.1833760 PMC 바로가기 [Article Type] Article
The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication2019년 코로나바이러스 질환의 폐외 합병증의 기저 메커니즘 및 치료적 의미Review Published on 2022-02-232022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 임상, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect caused clinical implication clinical implications Complication complications complications of COVID-19 coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Disease progression Effect feature global public health host inflammatory response immunological indirect mechanism Infectious diseases management mechanism multifactorial Pathogenesis pathophysiologic patients with COVID-19 Perspective potential therapeutic target potential therapeutic targets provide Recognition respiratory respiratory distress Respiratory system Respiratory tract diseases SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe cases severe pneumonia syndrome therapeutic Therapeutic strategies [DOI] 10.1038/s41392-022-00907-1 PMC 바로가기 [Article Type] Review
Trained Immunity: An Overview and the Impact on COVID-19Immunology Published on 2022-02-172022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] activate alleviate approach B-glucan Bacillus BCG cell type cells clinical study clinical trials component Corona COVID-19 COVID-19 crisis COVID-19 pandemic develop disease pathogenesis effective greater Health immune immune protection immune response immune system Immunity Impact in vitro in vivo Infection Infectious disease innate immune cell innate immune system Innate immunity involved LPS mechanism monocyte Monocytes natural killer natural killer (NK) non-specific Pathogens pathway potential therapeutic target Protective respiratory SARS-CoV-2 SARS-COV-2 infection signaling pathway therapeutic target trained immunity understanding [DOI] 10.3389/fimmu.2022.837524 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 Infection Triggers Phosphorylation: Potential Target for Anti-COVID-19 TherapeuticsSARS-CoV-2 감염은 인산화를 유발합니다: Anti-COVID-19 치료제의 잠재적 표적Review Published on 2022-02-172022-09-11 Journal: Frontiers in Immunology [Category] 치료기술, 치료제, [키워드] Affect AKT autophagy change COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients Drug discovery EIF2AK2 elevated enzyme function GFR Host infected cells kinase kinases MAPK mutations Phosphorylation phosphorylation site PIKfyve PKC Potential potential therapeutic target potential therapeutic targets Protein regulate responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral SARS-CoV-2-infected cells Signaling signaling pathway signaling pathways specific inhibitor specific inhibitors survival target TGF-β Therapeutics Trigger triggers Viral proteins virus [DOI] 10.3389/fimmu.2022.829474 PMC 바로가기 [Article Type] Review
Cathepsin B is a potential therapeutic target for coronavirus disease 2019 patients with lung adenocarcinoma카텝신 B는 폐 선암종을 가진 코로나바이러스 질병 2019 환자를 위한 잠재적인 치료 표적입니다Article Published on 2022-02-012022-09-11 Journal: Chemico-biological interactions [Category] 바이오마커, [키워드] angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Atla available data Basigin bioinformatics cancers cathepsin cathepsin B cause Cell coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CTSB database determine diagnosed with COVID-19 dipeptidyl peptidase Dipeptidyl peptidase 4 drug therapy explain expressed expression Gene Expression Omnibus GEO global public health Hyperinflammatory Hyperinflammatory response identify Immune cell infiltration implicated lung adenocarcinoma lung cancer lung cancer patient lung cancer patients mortality rate outcome Patient patients patients with COVID-19 positively correlated potential therapeutic target presenting Proinflammatory cytokine SARS-CoV-2 SARS-COV-2 infection severe COVID-19 susceptibility the SARS-CoV-2 therapeutic target therapy for COVID-19 tissue upregulation [DOI] 10.1016/j.cbi.2022.109796 PMC 바로가기 [Article Type] Article
Time-Dependent Molecular Motifs of Pulmonary Fibrogenesis in COVID-19COVID-19에서 폐 섬유 생성의 시간 의존적 분자 모티프Multicenter Study Published on 2022-01-292022-09-10 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, 진단, [키워드] analyzed assigned BST2 Control COVID-19 death duration of hospitalization Evolution expression Fibrogenesis fibrosis healthy controls; Hospitalization IL1R1 increased expression independent independent of Inflammation molecular mechanism mRNA pathway Pathway analysis Pathways Patient PDGFRB performed potential therapeutic target potential therapeutic targets Prevalence pro-inflammatory progressive respiratory failure protein expression pulmonary pulmonary fibrosis Respiratory failure SARS-CoV-2 severe COVID-19 shift significantly study group survivor was increased [DOI] 10.3390/ijms23031583 PMC 바로가기 [Article Type] Multicenter Study
Clinico-histopathologic and single-nuclei RNA-sequencing insights into cardiac injury and microthrombi in critical COVID-19중요한 COVID-19에서 심장 손상 및 미세 혈전에 대한 임상 조직 병리학 및 단일 핵 RNA 시퀀싱 통찰력Clinical Trial Published on 2022-01-252022-09-10 Journal: JCI Insight [Category] 임상, 진단, 치료기술, 치료제, [키워드] Acute cardiac injury Analysis antiplatelet association bioinformatics Biomarkers biomarkers of inflammation C-reactive protein cardiac injury Cardiology cardiovascular disease cause clinical factors Cohort conducted controls Corticosteroid corticosteroid treatment COVID-19 Critical enrichment erythrocyte sedimentation erythrocyte sedimentation rate etiology Extracellular matrix Features fibrinolysis fibroblast heart hearts identify In-hospital increased mortality Injury microthrombi Molecular pathology myocarditis Necrosis New York City pathophysiology Patient potential therapeutic target prevalent Prospective Study RNA-sequencing sedimentation rate Sequencing analysis Signaling tested therapeutic anticoagulation Therapies therapy transcriptomic were used [DOI] 10.1172/jci.insight.154633 PMC 바로가기 [Article Type] Clinical Trial
A Novel Prognostic Signature for Survival Prediction and Immune Implication Based on SARS-CoV-2–Related Genes in Kidney Renal Clear Cell CarcinomaBioengineering and Biotechnology Published on 2022-01-242022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] ACADM Accuracy Analysis applicability carcinoma caused Cell CENPF cohorts correlation COVID-19 CTLA-4 dataset enrichment analysis exhibit expand expressed gene expression follicular General population Genes global public health GSEA higher risk immune Immune cell indicated investigated kidney renal clear cell carcinoma LAG-3 Macrophage malignancy nomogram novel pathway Patient patients PDCD1 PLOD2 potential therapeutic target prediction Predictive predictor prognostic prognostic signature proportion provided Regulatory T cell renal reported SARS-CoV-2 SARS-COV-2 infection serious complication severe disease signature significantly survival TIGIT tissues Tregs TRMT1 urinary system [DOI] 10.3389/fbioe.2021.744659 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non-Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical TrialCOVID-19로 입원한 중환자 중 장기 지원 없이 생존에 대한 P2Y12 억제제의 효과: 무작위 임상 시험Randomized Controlled Trial Published on 2022-01-182022-09-25 Journal: JAMA [Category] 임상, 진단, 치료법, [키워드] 1:1 adaptive addition adjusted odds ratio age anticoagulant therapy assigned benefit bleeding Brazil clinical Clinical outcome conducted COVID-19 criterion defined dose Effect evaluate evaluated Final Follow-up Free hospital hospital discharge Hospitalization Hospitalized Ill In-hospital death inhibitor IQR Italy less Major major bleeding median non-critically ill patient occurred Odds ratio Open-label organ organ support outcome outcomes P2Y12 Patient patients with COVID-19 posterior probability potential therapeutic target Primary outcome Randomized randomized clinical trial risk Society Spain therapeutic those who survived ticagrelor Trial usual care usual care group was used women [DOI] 10.1001/jama.2021.23605 PMC 바로가기 [Article Type] Randomized Controlled Trial