In silico screening of some compounds derived from the desert medicinal plant Rhazya stricta for the potential treatment of COVID-19 Research Published on 2022-07-012022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 치료기술, 치료법, 치료제, [키워드] Acidic Analysis antiviral activity aromatic group average binding affinities binding affinity binding free energy binding interaction Ceftazidime Cell Compound coronavirus COVID-19 demonstrated docking exceptional exhibited FIVE fraction functional greater groups Health high stability HPLC Hydrogen bond in silico in vitro study Interaction less lowest MD simulation Molecular dynamics simulation occurred oxygen pandemic penetration Potential treatment predict Protein RBD RBD residue Receptor binding domain required retained SARS-CoV-2 SARS-CoV-2 viral selected similarity suggested the RBD the SARS-CoV-2 these compound Toxicity Treatment [DOI] 10.1038/s41598-022-15288-2 [Article Type] Research
A prolonged innate systemic immune response in COVID-19 Research Published on 2022-06-152022-10-05 Journal: Scientific Reports [Category] 치료기술, 치료법, 치료제, [키워드] Activation Affect Cell COVID-19 driver expected expression flow cytometry gelatinase Granule healthy individuals immune cells implementation Inflammation Innate immunity investigated marker Migration NET neutrophil neutrophil function pathophysiology phenotype Potential treatment recruited Severe case systemic immune response targets therapy Treatment Vaccines variety [DOI] 10.1038/s41598-022-13986-5 [Article Type] Research
Photodynamic Inactivation of SARS-CoV-2 Infectivity and Antiviral Treatment Effects In VitroSARS-CoV-2 감염의 광역학적 비활성화 및 시험관 내 항바이러스 치료 효과Article Published on 2022-06-142022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antibody Antiviral Antiviral agents approach Cell cell cultures cell viability Concentration coronavirus Coronavirus-2 COVID-19 Critical Culture current death detectable Effect heat-inactivated in vivo inactivation Infection infectiousness Infectivity log measure Microscopy mitochondrial Mutation near-infrared light pandemic Pathogens PDI photodynamic inactivation photodynamic therapy photosensitizer Potential treatment qPCR reduce reduced reduction required SARS SARS-CoV-2 SARS-CoV-2 isolate severe acute respiratory syndrome Coronavirus severe disease significantly THPTS Toxicity Treatment uninfected Vaccines variety Vero Cell viability viral cytopathic effect viral infection viral infections Viral load Viral RNA virion virus virus load virus suspension viruses were assessed [DOI] 10.3390/v14061301 PMC 바로가기 [Article Type] Article
Molnupiravir combined with different repurposed drugs further inhibits SARS-CoV-2 infection in human nasal epithelium in vitro다양한 용도 변경 약물과 결합된 몰누피라비르는 시험관 내 인간 비강 상피에서 SARS-CoV-2 감염을 추가로 억제합니다Article Published on 2022-06-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Air-liquid interface antiviral activity Antiviral treatment antiviral treatments antivirals caused cellular Clinical efficacy clinical testing clinically Combination combinations complex Compound Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 drug drug combination drug combinations Drug repurposing effective effective antiviral treatment effort Emergency use evaluated highlighting identify Immunity in vitro in vitro model inhibit inhibiting molnupiravir nasal epithelium Potential treatment Repurposed drug SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected severe acute respiratory syndrome Coronavirus short duration tested the vaccine These data Treatment Vaccine variant worldwide pandemic [DOI] 10.1016/j.biopha.2022.113058 PMC 바로가기 [Article Type] Article
A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate BindingSARS-CoV-2의 스파이크 수용체 결합 도메인과 친밀한 결합의 구조적 기초를 표적으로 하는 강력한 중화 나노바디Article Published on 2022-05-182022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Basis binding binding affinity binding site biochemical analyses characterization competing complex coronavirus delta variant Diseases domain drug candidates engage epitope In-vitro increase nanobodies nanobody neutralization neutralization activity Neutralizing overlapping potent Potential treatment raised receptor related diseases respiratory reveal S-RBD SARS-CoV-2 SARS-CoV-2 S severe acute respiratory syndrome Coronavirus spike receptor-binding domain Spread structural basis target targeting the Spike These data Viral viral spike virus [DOI] 10.3389/fimmu.2022.820336 PMC 바로가기 [Article Type] Article
Rapidly progressive dementias — aetiologies, diagnosis and management Reviews Published on 2022-05-042022-10-05 Journal: Nature reviews. Neurology [Category] 바이오마커, 변종, 진단, 치료제, [키워드] addition aetiology antibody Biomarker cause clinically clinician cognitive condition contribute Dementia diagnosed Diagnosis diagnostic differential diagnoses disease Diseases disorder Encephalopathy epidemiological Factor help heterogeneous High-dose Immune-mediated include management morbidity and mortality neurodegenerative Potential treatment prion protocol reducing review RPD syndrome therapy treatable Treatment utility [DOI] 10.1038/s41582-022-00659-0 [Article Type] Reviews
Azacytidine targeting SARS-CoV-2 viral RNA as a potential treatment for COVID-19Short communication Published on 2022-05-012022-10-05 Journal: Science Bulletin [Category] 치료법, [키워드] Azacytidine COVID-19 Potential treatment SARS-CoV-2 viral RNA [DOI] 10.1016/j.scib.2022.02.002 [Article Type] Short communication
Web-based exercise interventions for patients with depressive and anxiety disorders: a systematic review of randomized controlled trials우울 및 불안 장애 환자를 위한 웹 기반 운동 중재: 무작위 대조 시험의 체계적인 검토Article Published on 2022-05-012022-09-11 Journal: Revista brasileira de psiquiatria (São Paulo, Bra [Category] 비임상, 임상, [키워드] age Anxiety anxiety disorders anxiety symptom anxiety symptoms approach article assessment available data benefit breath changes in Cochrane Library Control controlled trials controls coronavirus disease Coronavirus disease 2019 COVID-19 cumulative database Depression depressive depressive symptom Depressive symptoms development Effect eligible Evidence Exercise intervention inclusion criteria involved item outcome pandemic participant Patient PICOS Potential treatment Primary outcomes PROSPERO provided Randomized Randomized controlled trial Randomized controlled trials recommendation Registration registration number Reporting review risk of bia SciELO searched strength strength training systematic review systematic reviews Web of Science women yoga [DOI] 10.1590/1516-4446-2021-2026 PMC 바로가기 [Article Type] Article
Characterization, in-silico, and in-vitro study of a new steroid derivative from Ophiocoma dentata as a potential treatment for COVID-19 Research Published on 2022-04-072022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 임상, 치료법, 치료제, [키워드] Anti-inflammatory anti-inflammatory activity anti-inflammatory properties antiviral drug characterization component computer Concentration conducted COVID-19 curative demonstrated Efficacy evaluate exhibited fibroblast cells IC50 in-silico In-vitro inhibitor invertebrate investigation molecular docking plaque Potential treatment Red reduction SARS-CoV2 Standard Toxicity Virtual screening [DOI] 10.1038/s41598-022-09809-2 [Article Type] Research
Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19Article Published on 2022-04-072022-10-04 Journal: Nature Communications [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, 치료제, [키워드] 3CL antiviral potency binding binding pocket cellular characterized complex Compound coronavirus Coronaviruses COVID-19 COVID-19 pandemic Critical development drug drug target eliminating human cells in vivo inhibit SARS-CoV-2 inhibiting Lead optimization maturation Pandemics pharmacokinetic Potential treatment protease Protease inhibitor Proteases Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected small molecule small molecule inhibitor Small molecules specificity stability Structure the SARS-CoV-2 therapy these compounds Treatment [DOI] 10.1038/s41467-022-29413-2 PMC 바로가기 [Article Type] Article