Angiotensin Converting Enzyme-2 (ACE-2) role in disease and future in researchArticle Published on 2021-07-242022-10-31 Journal: Journal of lung, pulmonary & respiratory research [Category] COVID-19, [키워드] ACE-2 acute respiratory syndrome angiotensin Angiotensin converting enzyme-2 angiotensin converting enzyme-2 (ACE-2) binding caused coronavirus COVID-19 disease Epidemic facilitate host cell Like Lung injury membrane fusion novel SARS-CoV-2 virus proteolytic cleavage receptor renin angiotensin system Research SARS-CoV SARS-CoV-2 shown Spike protein the SARS-CoV-2 TMPRSS2 protease virus PMC 바로가기 [Article Type] Article
Regulated Intramembrane Proteolysis of ACE2: A Potential Mechanism Contributing to COVID-19 Pathogenesis?Immunology Published on 2021-06-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE2 Amino acid angiotensin converting enzyme binding cellular cellular activation cleaved COVID-19 Critical domain ectodomain shedding endodomain cleavage expression Extracellular knowledge mapped MOST outcome phase 2 trial Potential preventative measure prophylactic treatment proteolysis proteolytic cleavage receptor regulated regulated intramembrane proteolysis SARS-CoV SARS-CoV infections SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease signaling molecule target the spike protein Treatment [DOI] 10.3389/fimmu.2021.612807 PMC 바로가기 [Article Type] Immunology
Hypoxia induces expression of angiotensin‐converting enzyme II in alveolar epithelial cells: Implications for the pathogenesis of acute lung injury in COVID‐19Original Article Published on 2021-05-152022-10-28 Journal: Physiological Reports [Category] COVID-19, [키워드] 24 hour ACE2 ACE2 expression ACE2 mRNA acute lung injury acute respiratory distress AEC airway epithelial cell alveolar alveolar epithelial cell alveolar epithelial cells ARDS binding Cell Characteristics Course COVID‐19 Critical Culture dependent on develop distal enzyme II epithelial experiment expression facilitate Features FiO2 host cell surface host serine protease hypoxia hypoxic hypoxic environment in vitro in vivo increase in increased expression induce Isolation lung lung epithelial cell mechanism mice mRNA murine murine model normoxia Pathogenesis Patient progression Protein protein expression proteolytic cleavage purified reduced SARS‐CoV‐2 significantly increased Spike protein Stress subset syndrome TMPRSS2 type I viral spike protein [DOI] 10.14814/phy2.14854 PMC 바로가기 [Article Type] Original Article
Computational Identification of a Putative Allosteric Binding Pocket in TMPRSS2Molecular Biosciences Published on 2021-04-302022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] activated Activation acute respiratory syndrome allosteric pocket binding binding site camostat catalytic site computer conformational change coronavirus docking enzyme identification inactive induce inhibit inhibitor MD simulation Molecular dynamics simulation Molecular modeling N-terminal pocket Prevent promote proteolytic cleavage reported SARS-CoV-2 selective shown TMPRSS2 TMPRSS2 inhibitors TMPRSS2 protein transmembrane serine protease viral infection viruses [DOI] 10.3389/fmolb.2021.666626 PMC 바로가기 [Article Type] Molecular Biosciences
Pharmacological Modulators of Autophagy as a Potential Strategy for the Treatment of COVID-19Review Published on 2021-04-152022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] angiotensin-converting enzyme inhibitor antiviral properties autophagy autophagy machinery Camostat mesylate can be used Chloroquine clinically Compound coronavirus CoV COVID-19 CoVs drug Effect effort endolysosomal system Glucocorticoids growth highlight host cell host cells Hydroxychloroquine identify in vitro in vivo infected with SARS-CoV-2 Infection inhibit lysosomotropic agents modulate modulator Mortality Patient Pharmacology Potential Prevent promote Protease inhibitor Protein proteolytic cleavage Rapamycin reducing Research risk SARS-COV-2 infection signaling pathways Stage Strategy treat umifenovir viral entry viral infection [DOI] 10.3390/ijms22084067 PMC 바로가기 [Article Type] Review
In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 InfectionResearch Article Published on 2021-04-092022-10-27 Journal: BioMed Research International [Category] [키워드] ACE2 ACE2 protein ADP-ribosylation analyzed Angiotensin-converting enzyme bioinformatics ConSurf cumulative score Deleterious functional Human human host cell in silico analysis information less missense variant Modification nucleotide pathogenic Protein proteolytic cleavage PROVEAN provide receptor SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus SIFT stability susceptibility variant were used [DOI] 10.1155/2021/6685840 PMC 바로가기 [Article Type] Research Article
In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 InfectionResearch Article Published on 2021-04-092022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 protein ADP-ribosylation analyzed Angiotensin-converting enzyme bioinformatics ConSurf cumulative score Deleterious functional Human human host cell in silico analysis information less missense variant Modification nucleotide pathogenic Protein proteolytic cleavage PROVEAN provide receptor SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus SIFT stability susceptibility variant were used [DOI] 10.1155/2021/6685840 PMC 바로가기 [Article Type] Research Article
In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection인간 ACE2 유전자의 고위험 미스센스 변이체 및 SARS-CoV-2 감염에 대한 감수성의 실리코 분석Research Article Published on 2021-04-092022-09-10 Journal: BioMed Research International [Category] 변종, [키워드] ACE2 ACE2 protein ADP-ribosylation analyzed angiotensin Angiotensin II Angiotensin-converting enzyme bioinformatics ConSurf conversion coronavirus cumulative score Deleterious functional host cells Human human host cell human host cells in silico analysis information less missense variant Modification nucleotide pathogenic Protein protein structure proteolytic cleavage PROVEAN provide receptor SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus SIFT stability STRING susceptibility variant were used [DOI] 10.1155/2021/6685840 PMC 바로가기 [Article Type] Research Article
Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19COVID-19에 대한 SARS-CoV-2의 구조적 및 비구조적 단백질과 치료 표적의 역할Review Published on 2021-04-062022-09-11 Journal: Cells [Category] MERS, SARS, 신약개발, 진단, 치료법, [키워드] 2019-nCoV accessory protein accessory proteins ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Amino acid angiotensin angiotensin converting enzyme 2 Angiotensin-converting enzyme angiotensin-converting enzyme 2 bats cats causative agent cellular entry cleavage components consequence convalescent plasm Coronaviridae coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 death downstream drugs encapsulate event family focus functional Genome genomic genomic RNA greater gRNA host cell host cell receptor hosts humans Infection lead mammalian MERS MERS-CoV molecular molecular function molecular target myriad non-structural protein Novel coronavirus polymerase polyproteins positive-sense pp1a pp1ab protease proteolytic cleavage RBD Receptor binding domain referred to replicase respiratory resulting RNA genome role S protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection sequence identity Serine serine 2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus sgRNAs similarity single-stranded Spike protein spike protein of SARS-CoV-2 Spread ssRNA structural protein structural proteins subgenomic mRNA subgenomic mRNAs synthesis target therapeutic therapy TMPRSS2 translated translation transmembrane transmembrane protease serine 2 undergo Vaccine Variability Viral Viral RNA virus [DOI] 10.3390/cells10040821 PMC 바로가기 [Article Type] Review
The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell typesSpike D614G 돌연변이는 여러 인간 세포 유형의 SARS-CoV-2 감염을 증가시킵니다Research Article Published on 2021-02-112022-09-10 Journal: eLife [Category] MERS, 변종, 유전자 메커니즘, [키워드] A549 ACE2 ACE2 receptor binding Caco-2 Calu Calu-3 cell Cell coronavirus COVID-19 D614G D614G mutation D614G variant effective epithelial cells expressing fold functional G614 variant genetics Huh7.5 Human human cell human cell lines human cells human lung human lung epithelial cells increase Lentiviral particle lentiviral particles Linkage disequilibrium mechanism Mutation ORF1b overexpressing Point mutation Population genetics Prevalence Protein proteolytic cleavage pseudotyped ranged SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus site-directed mutagenesis spike Spike protein surpassed the SARS-CoV-2 virus the Spike transducing variant variants virus wild-type [DOI] 10.7554/eLife.65365 PMC 바로가기 [Article Type] Research Article