Potential “Therapeutic” Effects of Tocotrienol-Rich Fraction (TRF) and Carotene “Against” Bleomycin-Induced Pulmonary Fibrosis in Rats via TGF-β/Smad, PI3K/Akt/mTOR and NF-κB Signaling PathwaysArticle Published on 2022-03-052022-10-31 Journal: Nutrients [Category] COVID-19, MERS, SARS, [키워드] administration alteration Anti-inflammatory antioxidant Apoptosis approach Bacterial biochemical BLM candidate carotene caused collagen Combination demonstrated develop disease downregulated downregulation drug Effect expressions Factors fibrosis fraction functions genetics histopathological histopathological finding hydroxyproline increased expression Inflammatory cytokine influences inhibit injection interstitial investigated Lung fibrosis Lung injury lung tissues management modulation molecular NF-κB NF-κB signaling Pathways post-COVID-19 patient Potential preventive effects Probability proinflammatory cytokines provided pulmonary pulmonary fibrosis rapid progress RAT reduction in reported shown significantly tocotrienol-rich fraction treated Treatment TRF upregulation variety viral infections [DOI] 10.3390/nu14051094 PMC 바로가기 [Article Type] Article
Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 M pro inhibitor in animal models동물 모델에서 경구용 SARS-CoV-2 M pro 억제제인 니르마트렐비르(PF-07321332)의 생식 및 발달 안전성Article Published on 2022-03-012022-09-11 Journal: Reproductive toxicology (Elmsford, N.Y.) [Category] 치료제, [키워드] administration age animal model Antiviral Clinical studies clinical study clinically coronavirus COVID-19 Critical death developmental during pregnancy Effect Embryo Embryo-Fetal development embryonic embryonic development enhancer evaluated Factor female female fertility Fertility Genetic Genetic toxicity high risk Hospitalization hospitalized patient ICH in viral infected with SARS-CoV-2 information inhibitor lack limit dose M pro male mammalian cells manifestation Nirmatrelvir NMV no effect no effects oral Oral COVID-19 therapy patient population Paxlovid PF-07321332 pharmacokinetic phase Pregnancy Prevent progression protease Protein rabbit RAT Rat. RATs Replication reported reproductive risk Ritonavir SARS-CoV-2 SARS-CoV-2 main protease selective severe disease shown specific protein the SARS-CoV-2 therapeutic option therapeutic target therapy Toxicity viral replication virus [DOI] 10.1016/j.reprotox.2022.01.006 PMC 바로가기 [Article Type] Article
Impaired detection of omicron by SARS-CoV-2 rapid antigen testsSARS-CoV-2 신속 항원 검사에 의한 오미크론 검출 장애Original Article Published on 2022-02-202022-09-10 Journal: Medical Microbiology and Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 치료기술, 치료법, [키워드] analytical sensitivity Awareness B.1.1.529 B.1.617.2 Cell Cell culture collected comparable country Ct values detection rate diagnostic test driven by dropped evaluated examined globe highest Impaired Infection infection rate infection rates isolate Laboratory lateral flow limit of detection National nine nucleocapsid protein omicron pandemic PCR-negative PCR-positive point-of-care tests positive positive test result Predictive Predictive value ranged rapid antigen test Rapid antigen tests RAT RATs reduced required respiratory RNA copies RNA copy SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 rapid antigen test sensitivity specificity specimen suggested supplementary material swab sample test results the SARS-CoV-2 variant virus load virus stock VoC [DOI] 10.1007/s00430-022-00730-z PMC 바로가기 [Article Type] Original Article
Detection of Trypanosoma lewisi DNA from Rattus norvegicus and Rattus rattus in Hanoi, VietnamArticle Published on 2022-02-012023-06-22 Journal: Vector Borne and Zoonotic Diseases [Category] 조류인플루엔자, [키워드] RAT Trypanosoma lewisi Vietnam zoonosis [DOI] 10.1089/vbz.2021.0043
Integration Analysis of Pharmacokinetics and Metabolomics to Predict Metabolic Phenotype and Drug Exposure of RemdesivirPharmacology Published on 2022-01-052022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] adenosine Administered Analysis AUC Biomarker blood sample C max change collected Comprehensive Concentration conducted correlated correlation Correlation analysis COVID-19 drug drug exposure evaluated Evidence exposure integration intravenously investigated metabolic metabolite metabolites metabolomics multivariate Nuc offer pharmacokinetics pharmacological PK parameter Potential biomarker precision therapy predict predicted RAT Remdesivir responders SARS-CoV-2 significantly spermine statistical analysis Toxicity Treatment Variation [DOI] 10.3389/fphar.2021.779135 PMC 바로가기 [Article Type] Pharmacology
Performance of Rapid Antigen Tests for COVID-19 Diagnosis: A Systematic Review and Meta-AnalysisSystematic Review Published on 2022-01-042022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] analyses Analysis assessment asymptomatic patient calculated caused COVID-19 cycle threshold diagnostic disease early phase evaluate evaluated gold standard highest Infection Laboratory limitation literature nasal swab Nasopharyngeal swab performance polymerase chain QUADAS-2 Quality Quantitative Rapid rapid antigen test RAT RATs Registered reverse transcription review risk of bia RT-qPCR Saliva Sample SARS-CoV-2 sensitivity Sensitivity and specificity specificity symptomatic patient systematic review Test throat swab Viral RNA was performed was used [DOI] 10.3390/diagnostics12010110 PMC 바로가기 [Article Type] Systematic Review
Comparison of Rapid and Automated Antigen Detection Tests for the Diagnosis of SARS-CoV-2 InfectionArticle Published on 2022-01-042022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Antigen antigen detection antigen testing automated automated assay comparable Concentration COVID-19 detection diagnosis of SARS-CoV-2 diagnostic France Infection intensity investigated less manual assay nasopharyngeal sample Nasopharyngeal swab nucleocapsid Paris performance Quantitative Rapid RAT RT-PCR RT-PCR assay RT-PCR Ct SARS-CoV-2 SARS-CoV-2 viral sensitivity Test tested university variants variants of SARS-CoV-2 was determined [DOI] 10.3390/diagnostics12010104 PMC 바로가기 [Article Type] Article
Multicenter Technical Validation of 30 Rapid Antigen Tests for the Detection of SARS-CoV-2 (VALIDATE)Article Published on 2021-12-152022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] applied buffer caused COVID-19 COVID19 detection diagnostic diagnostics lack media Nasopharyngeal swab pandemic patients PCR-negative PCR-positive protocol ranged Rapid rapid antigen test RAT RATs reached SARS-CoV-2 sensitivity specificity Standard Q Test tested validation viral loads virus virus testing [DOI] 10.3390/microorganisms9122589 PMC 바로가기 [Article Type] Article
Performance evaluation of automated chemiluminescence immunoassay based antigen detection – Moving towards more reliable ways to predict SARS-CoV-2 infection자동화된 화학발광 면역분석 기반 항원 검출의 성능 평가 - SARS-CoV-2 감염을 예측하는 보다 신뢰할 수 있는 방법으로 이동Article Published on 2021-12-012022-09-11 Journal: Journal of virological methods [Category] SARS, 치료기술, [키워드] antigen detection automated Care Chain Reaction chemiluminescence immunoassay Chemiluminescence immunoassay (CLIA) CLIA COVID-19 Ct values diagnosis of COVID-19 evaluated high viral load immunoassay Infection Infectivity Laboratory lack Patient patients performance polymerase chain polymerase chain reaction predict provided Rapid RAT RATs reference standard reverse transcription RT-PCR SARS-CoV-2 SARS-COV-2 infection sensitivity shown specificity Test the disease Viral load was tested [DOI] 10.1016/j.jviromet.2021.114299 PMC 바로가기 [Article Type] Article
Diagnostic performance of rapid antigen tests (RATs) for SARS-CoV-2 and their efficacy in monitoring the infectiousness of COVID-19 patientsSARS-COV-2에 대한 신속한 항원 검사 (RAT)의 진단 성능 및 COVID-19 환자의 전염성을 모니터링하는 효능Article Published on 2021-11-242022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] arise clinical sample contagious COVID-19 patient detect diagnosis of SARS-CoV-2 diagnostic Diagnostic markers effective Efficacy examined exhibited Fluorescence identify individual individuals infected individual infected individuals infected with SARS-CoV-2 Infection leads limit of detection patients PCR PCR test percentage positive rate Positive test positive test result quarantine Quarantine period question rapid antigen test RAT RATs receiving reduce RNA rRT-PCR SARS-CoV-2 SARS-COV-2 infection sensitivities sensitivity Surveillance test result threshold Variability viral infection [DOI] 10.1038/s41598-021-02197-z PMC 바로가기 [Article Type] Article