Rational Development of a Polysaccharide-Protein-Conjugated Nanoparticle Vaccine Against SARS-CoV-2 Variants and Streptococcus pneumoniaeSARS-CoV-2 변이체 및 폐렴 연쇄상 구균에 대한 다당류-단백질-접합 나노입자 백신의 합리적인 개발Article Published on 2022-05-012022-09-11 Journal: Advanced Materials (Deerfield Beach, Fla.) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 폐렴구균 감염증, [키워드] Against backbone capsular capsular polysaccharide caused Cellular immune response cellular immune responses chemical conjugation clinical evaluation COVID-19 COVID-19 pandemic cross-neutralize death development Diseases domain exhibit Final helper cell highlighting humoral immune responses immunization induce Infection Infectious diseases mice Mortality mouse-adapted strain murine models nanoparticle nanoparticle vaccines omicron other infectious diseases polysaccharide potency Prevent RATs RBD Receptor binding domain rhesus macaques S. pneumoniae S. pneumoniae serotype type 14 SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant serotype serum Spike protein Streptococcus pneumoniae Support T helper cell the SARS-CoV-2 thermal stability Type vaccination Vaccine vaccine platform variant VOCs [DOI] 10.1002/adma.202200443 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 B.1.351 Variant Can Transmit in Rats But Not in MiceOriginal Research Published on 2022-04-282023-07-02 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, [키워드] B.1.351 contact transmission mice RATs SARS-CoV-2 [DOI] 10.3389/fimmu.2022.869809 PMC 바로가기 [Article Type] Original Research
Nucleoside analog GS-441524: pharmacokinetics in different species, safety, and potential effectiveness against Covid-19뉴클레오시드 유사체 GS-441524: 다양한 종의 약동학, 안전성 및 Covid-19에 대한 잠재적 유효성Review Published on 2022-04-012022-09-11 Journal: Pharmacology Research & Perspectives [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration agent animals appear calculated cats clinical trials clinically collected data Concentration conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 treatment dose doses dosing interval effective Effectiveness evaluated GS-441524 humans in vitro study in vitro-in vivo extrapolation information inhibitory concentration median mice MOST normalization nucleoside nucleoside analog oral bioavailability parameter parent nucleoside pharmacokinetic pharmacokinetics plasma concentration randomized clinical trial ranged RATs Remdesivir reported required rodent rodents severe acute respiratory syndrome Coronavirus species treat Treatment Trial used to calculate virus [DOI] 10.1002/prp2.945 PMC 바로가기 [Article Type] Review
Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 M pro inhibitor in animal models동물 모델에서 경구용 SARS-CoV-2 M pro 억제제인 니르마트렐비르(PF-07321332)의 생식 및 발달 안전성Article Published on 2022-03-012022-09-11 Journal: Reproductive toxicology (Elmsford, N.Y.) [Category] 치료제, [키워드] administration age animal model Antiviral Clinical studies clinical study clinically coronavirus COVID-19 Critical death developmental during pregnancy Effect Embryo Embryo-Fetal development embryonic embryonic development enhancer evaluated Factor female female fertility Fertility Genetic Genetic toxicity high risk Hospitalization hospitalized patient ICH in viral infected with SARS-CoV-2 information inhibitor lack limit dose M pro male mammalian cells manifestation Nirmatrelvir NMV no effect no effects oral Oral COVID-19 therapy patient population Paxlovid PF-07321332 pharmacokinetic phase Pregnancy Prevent progression protease Protein rabbit RAT Rat. RATs Replication reported reproductive risk Ritonavir SARS-CoV-2 SARS-CoV-2 main protease selective severe disease shown specific protein the SARS-CoV-2 therapeutic option therapeutic target therapy Toxicity viral replication virus [DOI] 10.1016/j.reprotox.2022.01.006 PMC 바로가기 [Article Type] Article
Impaired detection of omicron by SARS-CoV-2 rapid antigen testsSARS-CoV-2 신속 항원 검사에 의한 오미크론 검출 장애Original Article Published on 2022-02-202022-09-10 Journal: Medical Microbiology and Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 치료기술, 치료법, [키워드] analytical sensitivity Awareness B.1.1.529 B.1.617.2 Cell Cell culture collected comparable country Ct values detection rate diagnostic test driven by dropped evaluated examined globe highest Impaired Infection infection rate infection rates isolate Laboratory lateral flow limit of detection National nine nucleocapsid protein omicron pandemic PCR-negative PCR-positive point-of-care tests positive positive test result Predictive Predictive value ranged rapid antigen test Rapid antigen tests RAT RATs reduced required respiratory RNA copies RNA copy SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 rapid antigen test sensitivity specificity specimen suggested supplementary material swab sample test results the SARS-CoV-2 variant virus load virus stock VoC [DOI] 10.1007/s00430-022-00730-z PMC 바로가기 [Article Type] Original Article
Efficacy of liriope platyphylla extract for improving respiratory functions Study protocol for a randomized, double-blinded, placebo-controlled pilot trial호흡기 기능 향상을위한 Liriope Platyphylla 추출물의 효능 무작위, 이중 맹검, 위약 대조 파일럿 시험을위한 연구 프로토콜의 효능3700 Published on 2022-02-112022-08-31 Journal: Medicine [Category] COVID19(2023년), MERS, SARS, 임상, 치료제, [키워드] liriope platyphylla accompany allergic inflammation anti-inflammatory effect Anti-inflammatory effects anti-inflammatory properties antioxidant assumption Asthma breathlessness bronchitis changes in chronic obstructive chronic obstructive pulmonary disease chronic obstructive pulmonary disease (COPD) clinical symptom Clinical symptoms clinical trial conducted COPD COPD Assessment Test score cough COVID-19 determine disease dose double-blind double-blinded Dyspnea Effect Efficacy and safety ENhance enzyme activity exclusion criteria first randomized controlled trial Follow-up Frequency frequency of occurrence functional health help immune cells immune factor immune factors Immunity IMPROVE include Inclusion Intervention mechanism nitric oxide obstructive pulmonary disease Occurrence outcome participant Placebo placebo-controlled Previous studies previous study Primary outcome proceed protocol pulmonary disease Pulmonary function questionnaire Randomized Randomized controlled trial Randomly RATs receive reported respiratory Respiratory disease Respiratory function respiratory inflammation secondary Secondary outcomes single-center sputum Symptom Trial [DOI] 10.1097/MD.0000000000028452 PMC 바로가기 [Article Type] 3700
Usefulness of rapid antigen testing for SARS-CoV-2 screening of healthcare workers: a pilot study의료 종사자의 SARS-CoV-2 선별을 위한 신속한 항원 검사의 유용성: 파일럿 연구Article Published on 2022-02-012022-09-11 Journal: Clinical and experimental medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition Antigen Asymptomatic Chain Reaction clinic coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 detect diagnosing evaluate feasible HCW HCWs healthcare healthcare worker Healthcare workers hospital identification identify Infection molecular molecular test Molecular tests Nasopharyngeal swab nasopharyngeal swabs Nurse Nurses pilot study point-of-care polymerase chain polymerase chain reaction positive presymptomatic Rapid rapid antigen test Rapid antigen tests RATs Registered registration number respiratory reverse transcription reverse transcription polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 infections Screening serological serum sample serum samples Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Swab tested Transmission university unlikely Volume was collected [DOI] 10.1007/s10238-021-00722-y PMC 바로가기 [Article Type] Article
Local-scale diversity of Yersinia pestis: A case study from Ambohitromby, Ankazobe District, MadagascarArticle Published on 2022-02-012023-06-22 Journal: Zoonoses and Public Health [Category] 조류인플루엔자, [키워드] madagascar phylogeography plague public health RATs Yersinia pestis [DOI] 10.1111/zph.12892
Performance of Rapid Antigen Tests for COVID-19 Diagnosis: A Systematic Review and Meta-AnalysisSystematic Review Published on 2022-01-042022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] analyses Analysis assessment asymptomatic patient calculated caused COVID-19 cycle threshold diagnostic disease early phase evaluate evaluated gold standard highest Infection Laboratory limitation literature nasal swab Nasopharyngeal swab performance polymerase chain QUADAS-2 Quality Quantitative Rapid rapid antigen test RAT RATs Registered reverse transcription review risk of bia RT-qPCR Saliva Sample SARS-CoV-2 sensitivity Sensitivity and specificity specificity symptomatic patient systematic review Test throat swab Viral RNA was performed was used [DOI] 10.3390/diagnostics12010110 PMC 바로가기 [Article Type] Systematic Review
RBC-hitchhiking chitosan nanoparticles loading methylprednisolone for lung-targeting delivery폐-표적 전달을 위해 메틸 프레드니솔론을 로딩하는 RBC-Hitchhiking 키토산 나노 입자Article Published on 2022-01-012022-08-31 Journal: Journal of controlled release : official journal o [Category] SARS, 치료제, [키워드] accumulation acute lung injury acute respiratory distress acute respiratory distress syndrome AUC cause chitosan Chitosan nanoparticle chronic administration circulation Circulation time cytokine Cytokine storm syndrome Cytokines distribution drug effective erythrocyte erythrocytes facilitated Fluorescein glucocorticoid Glucocorticoids High dose high mortality hitchhiking hyper-inflammation IL-6 in vivo indicated Inflammatory cytokine Inflammatory cytokines Inflammatory response inhibit inhibited injection Interaction leads lipopolysaccharide liver lung Lung injury Lungs Methylprednisolone Methylprednisolone sodium succinate patients with COVID-19 pharmacokinetic plasma concentration RATs RBC-hitchhiking. red blood cell red blood cells reduce respiratory distress Respiratory distress syndrome Side effects significantly significantly higher sodium sodium succinate syndrome tissue TNF-α Treatment treatment groups [DOI] 10.1016/j.jconrel.2021.12.018 PMC 바로가기 [Article Type] Article