SARS-CoV-2 strain – Page 3 – Communicable Diseases Research

Nanotechnology-based strategies against SARS-CoV-2 variants

Reviews

Published on 2022-08-182022-10-05
Journal: Nature nanotechnology [Category] COVID19(2023년), SARS, 변종, 신약개발, 임상, 치료제,

Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2

SARS-CoV-2에 대한 구강 세정제 중 염화세틸피리디늄의 항바이러스 효과

Article

Published on 2022-08-182022-09-11
Journal: Scientific Reports [Category] SARS, 진단, 치료제,

Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis

SARS-CoV-2에 의한 폐 감염은 심각한 COVID-19에서 염증성 표현형과 함께 노화를 유도합니다: 바이러스 돌연변이 유발 가능성

Article

Published on 2022-08-182022-09-11
Journal: The European Respiratory Journal [Category] Fulltext, SARS, 진단, 치료기술,

[키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus alveolar analysed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 APOBEC Apolipoprotein B AT2 Cell cells cellular senescence chronic inflammation Comorbidity Control coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CXCL8 cytokine Cytokines demonstrated disease DNA damage electron microscopy enzyme Enzymes epithelial exhibited expressed expression extrapulmonary sites H2Ax IL-1β IL-6 IL-6 expression immunocytochemistry immunohistochemistry implication in vitro induce infecting Infection Inflammation inflammatory phenotype Inflammatory response investigated kidney liver lung tissue sample marker Microscopy molecular mechanism multisystemic disease Mutagenesis Non-COVID-19 persistence phenotype progeny proinflammatory promote pulmonary respiratory Respiratory system SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutagenesis SARS-CoV-2 mutations SARS-CoV-2 strain SARS-CoV-2 strains SASP senescence senescent cell Sequencing analysis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 Strains Vero-E6 cell Vero-E6 cells Viral mutagenesis
[DOI] 10.1183/13993003.02951-2021 PMC 바로가기 [Article Type] Article

Selection of Bis-Indolyl Pyridines and Triphenylamines as New Inhibitors of SARS-CoV-2 Cellular Entry by Modulating the Spike Protein/ACE2 Interfaces

스파이크 단백질/ACE2 인터페이스를 조절하여 SARS-CoV-2 세포 진입의 새로운 억제제로서 비스-인돌릴 피리딘 및 트리페닐아민 선택

Article

Published on 2022-08-162022-09-11
Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 변종,

[키워드] 50% effective concentration ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus approaches association biochemical caused Cell cell lines cellular cellular receptor circulating circulating variant complex Compound coronavirus coronavirus disease COVID COVID-19 docking drug functional human cell lines identify in silico indicate Infection infectious agent inhibit inhibitor inhibitory inhibitory effect Interaction interface Lentiviral vector lentiviral vectors modulating molecular molecules New pandemic parameter pseudotyped pyridine receptor ACE2 S protein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S protein SARS-CoV-2 strain screened selected Selection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike susceptible the SARS-CoV-2 the Spike therapeutic purposes these compound these compounds triphenylamine variant viral entry viral infection viral replication virus wild-type
[DOI] 10.1128/aac.00083-22 PMC 바로가기 [Article Type] Article

In Silico and In Vitro Studies of Alchemilla viridiflora Rothm-Polyphenols’ Potential for Inhibition of SARS-CoV-2 Internalization

Alchemilla viridiflora Rothm-Polyphenols의 SARS-CoV-2 내재화 억제 가능성에 대한 실리코 및 체외 연구

Article

Published on 2022-08-142022-09-11
Journal: Molecules [Category] SARS, 변종,

[키워드] ACE2 Alchemilla viridiflora Rothm. angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral agents binding binding energy binding interaction Compound computational studies Computational study Contact COVID-19 COVID-19 pandemic dose doses E484K effective Effectiveness exhibited flavonoid G476S glycoprotein Health higher affinity highest in silico in vitro inhibited inhibition internalization investigated K417N methanol molecular docking studies Molecular docking study Mutation N439K N501Y neuropilin Neuropilin-1 NRP1 outbreak plants polyphenols Potential Prevent quercetin receptor receptors resulting SARS-CoV-2 SARS-CoV-2 strain selected significantly spike glycoprotein tested V483A virus virus infection Virus spike wild strain
[DOI] 10.3390/molecules27165174 PMC 바로가기 [Article Type] Article

Antibodies induced by an ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.1

Alpha에서 Omicron BA.1까지 변이체를 교차 중화하는 조상 SARS-CoV-2 균주에 의해 유도된 항체

Article

Published on 2022-08-122022-09-11
Journal: Science Immunology [Category] Fulltext, SARS, 변종, 진단,

[키워드] ACE2 binding antibodies antibody B cell binding binding site breadth caused Cell Clusters complexes cross-neutralize Defense defined Delta determinant determinants determine disease driven by Efficacy escape Fab FIVE greater highest Host host defense identifying Immune escape immune protection Infection initial memory B memory B cell Mitigation Mutation neutralization neutralization potency neutralize neutralized Neutralizing activity Neutralizing antibodies neutralizing antibody omicron Prevalence RBD real-world data Receptor binding domain recognize recognizing Region SARS-CoV-2 SARS-CoV-2 spike glycoprotein SARS-CoV-2 strain sensitivity Specificities specificity spike glycoprotein Spike receptor binding domain Structure structures tested the RBD the SARS-CoV-2 Vaccine vaccine efficacy variant variants variants of concern Viral viral escape viral invasion Wuhan strain
[DOI] 10.1126/sciimmunol.abo3425 PMC 바로가기 [Article Type] Article

Safety and immunogenicity following a homologous booster dose of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373): a secondary analysis of a randomised, placebo-controlled, phase 2 trial

Clinical Trial

Published on 2022-08-102022-10-06
Journal: The Lancet. Infectious Diseases [Category] SARS, 변종, 진단,

[키워드] 1:1 Administered administration adverse event adverse events age amplifying analysed Analysis antibody concentration Antigen assigned available data BMI booster booster dose Breastfeeding Coalition Contraception COVID-19 pandemic diagnosis of COVID-19 dose Efficacy enrolled evaluated event Evidence exclusion geometric mean titre GMT group healthy homologous IgG immune response inactive increase in initial intramuscular Local Matrix-M median Medical conditions Novavax NVX-CoV2373 outcome participant per-protocol per-protocol population phase 2 trial phase 3 study Placebo placebo-controlled pregnant primary endpoint proportion Protein randomisation randomised Randomly reaction reactogenicity receive Recombinant spike protein recruited regimens Registered Safety SARS-CoV SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant screened serum IgG single booster dose stratified Support the SARS-CoV-2 the vaccine titres Treatment Trial USA vaccination Vaccine variant were excluded women
[DOI] 10.1016/S1473-3099(22)00420-0 PMC 바로가기 [Article Type] Clinical Trial

Inhibition of a broad range of SARS-CoV-2 variants by antiviral phytochemicals in hACE2 mice

hACE2 마우스에서 항바이러스 식물화학물질에 의한 광범위한 SARS-CoV-2 변이체의 억제

Article

Published on 2022-08-012022-09-11
Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 치료제,

SARS-CoV-2 variants inactivation of plasma units using a riboflavin and ultraviolet light-based photochemical treatment

Article

Published on 2022-08-012022-11-15
Journal: Transfusion and apheresis science : official journ [Category] COVID19(2023년), SARS, 변종, 치료기술,

A Comparison of Bioinformatics Pipelines for Enrichment Illumina Next Generation Sequencing Systems in Detecting SARS-CoV-2 Virus Strains

SARS-CoV-2 바이러스 균주 검출 시 Illumina 차세대 시퀀싱 시스템 강화를 위한 생물정보학 파이프라인 비교

Comparative Study

Published on 2022-07-262022-09-11
Journal: Genes [Category] COVID19(2023년), SARS, 치료기술, 치료제,

[키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Algorithm Amino acid bioinformatics bioinformatics pipeline capture method characterization coronavirus 2 coronavirus disease Coronavirus disease 2019 Coverage COVID-19 Critical Deletion downstream enrichment enrichment. full-length SARS-CoV-2 genome Generation Hope Human genome Illumina Indonesia insertion limitation Major mapped mapping metagenomic mutations next generation sequencing NGS normal nucleotide nucleotide substitution nucleotide substitutions pandemic Panel Previous studies previous study reads respiratory respiratory virus respiratory viruses SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 strain SARS-CoV-2 strains sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus situation SNPs strain Strains System table the SARS-CoV-2 genome utilization Variation virus worldwide pandemic worsening
[DOI] 10.3390/genes13081330 PMC 바로가기 [Article Type] Comparative Study