A year in pharmacology: new drugs approved by the US Food and Drug Administration in 2021약리학의 1년: 2021년 미국 식품의약국 승인 신약Review Published on 2022-08-012022-09-11 Journal: Naunyn-Schmiedeberg's Archives of Pharmacology [Category] 신약개발, 유전자 메커니즘, [키워드] aducanumab adverse effect antibody approval approvals approved Cancer cancers class contrary COVID-19 pandemic disease drug drugs Effects Evidence evidence of FDA First-in-class First-in-indication followed by food genetic alterations had no identify indication Innovation molecular mechanism New New drugs Next Next-in-class. small molecule Small molecules target Treatment US Food and Drug Administration [DOI] 10.1007/s00210-022-02250-2 PMC 바로가기 [Article Type] Review
Neuropilin (NRPs) Related Pathological Conditions and Their Modulators뉴로필린(NRP) 관련 병리학적 상태 및 조절인자Review Published on 2022-07-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 addition Analysis antagonists Cancer clinical disease Community computer-aided drug design condition COVID-19 COVID-19 research Diversity foci form homologous human body in silico in silico drug design joint Last Ligand ligands modulator neuropathic neuropathic pain neuropilin neuropilins NRP1 Pain pathological pathological conditions pathological role peptidomimetics physiological receptor receptor modulator design small molecule small-molecule antagonists. splice the SARS-CoV-2 therapeutic tissue transmembrane glycoprotein variant variety vertebrates viral entry [DOI] 10.3390/ijms23158402 PMC 바로가기 [Article Type] Review
SARS-CoV-2 and the NucleusSARS-CoV-2와 핵Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] blocked caused cells cilia Clinical studies contribute COVID-19 pandemic Critical cytoplasm DNA DNA damage Epigenetic epigenetics Genome greatly reduce immune responses inhibitor innate immune responses Innate immunity lack life cycle mechanisms metabolism mRNA metabolism nuclear nuclear translocation nuclear transport. nucleus other coronavirus other coronaviruses pathway Pathways pharmacological Regulation replicated RNA virus rupture SARS-CoV-2 small molecule small molecule drug small molecule drugs Therapeutic treatment Transport virus infection virus replication [DOI] 10.7150/ijbs.72482 PMC 바로가기 [Article Type] Review
In-Silico Screening and Molecular Dynamics Simulation of Drug Bank Experimental Compounds against SARS-CoV-2SARS-CoV-2에 대한 드럭뱅크 실험 화합물의 인-실리코 스크리닝 및 분자 역학 시뮬레이션Article Published on 2022-07-082022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] ADME Area Bank can be used Community Compound conditions Coronaviridae family docking drug Drug Bank Dynamics Effectiveness experimental drug Experimental drugs followed by group In-vitro Infection infection rate inhibitor molecular molecular docking molecular dynamics Molecular dynamics simulation Mutation performed Precision reason reduce replication-transcription complex replication-transcription complex. Research RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 screened Screening Severe acute respiratory syndrome Simulation small molecule Small molecules stability surface surface area the Coronaviridae the patient the SARS-CoV-2 the vaccine the WHO thiophosphate thymidine Vaccine Virtual screening virus [DOI] 10.3390/molecules27144391 PMC 바로가기 [Article Type] Article
Multifaceted roles of plant derived small molecule inhibitors on replication cycle of SARS-CoV-2SARS-CoV-2의 복제 주기에 대한 식물 유래 소분자 억제제의 다면적 역할Review Published on 2022-07-012022-09-11 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affected Anti-inflammatory anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity Anti-viral antioxidant antiviral therapeutics approved assembly caused clinical trial compounds coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 drug candidate Economy Factor Google Scholar help highlight Host inhibiting knowledge mechanism New coronavirus plant plants platform polyprotein public health registry Replication SARS-CoV-2 SARS-COV-2 infection small molecule small molecule inhibitor Small molecule inhibitors Small molecules therapeutic approaches therapy Vaccine viral entry Viral replication cycle. [DOI] 10.1016/j.micpath.2022.105512 PMC 바로가기 [Article Type] Review
Safety of Biologic-DMARDs in Rheumatic Musculoskeletal Disorders: A Population-Based Study over the First Two Waves of COVID-19 OutbreakObservational Study Published on 2022-07-012022-10-05 Journal: Viruses [Category] COVID19(2023년), SARS, 임상, [키워드] anti-TNF antiviral drugs Autoimmune biologic carrier Cohort coronavirus disease Corticosteroid Course COVID-19 COVID-19 positive subject disease disorder drug eligible Fever gastro-intestinal General population identify immunosuppressed patients immunosuppressive drug include Infection Italy low dose Mortality Musculoskeletal outbreak pandemic Patient patients treated Prevalence prevalence of COVID-19 protective effect reported rheumatic Safety significant difference small molecule steroid Swab Symptom Symptoms therapy treated Treatment vaccination viral persistence Wave were recorded [DOI] 10.3390/v14071462 PMC 바로가기 [Article Type] Observational Study
Small molecule stabilization of non-native protein-protein interactions of SARS-CoV-2 N protein as a mechanism of action against COVID-19COVID-19에 대한 작용 기전으로서 SARS-CoV-2 N 단백질의 비천연 단백질-단백질 상호작용의 소분자 안정화Article Published on 2022-07-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료법, [키워드] absence addition Affect analyzed applicability catechin caused Compound coronavirus COVID-19 docking drug design Drug discovery effective exploration identify inhibit mechanism mechanism of action MERS MERS-CoV molecular molecular dynamics NTD nucleocapsid protein outbreak protein-protein interaction protocol reported Research residue responsible SARS-CoV-2 SARS-CoV-2 N protein small molecule the disease Treatment viral replication Virtual screening [DOI] 10.1080/07391102.2020.1860828 PMC 바로가기 [Article Type] Article
Development of COVID-19 therapies: Nonclinical testing considerationsCOVID-19 치료법 개발: 비임상 테스트 고려 사항Article Published on 2022-07-012022-09-12 Journal: Regulatory toxicology and pharmacology : RTP [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, 치료제, [키워드] agency antibody authorization Candidates COVID-19 development Emergency EUA mAb monoclonal monoclonal antibody neutralization Nonclinical occurred pathway Patient performed pharmacokinetic platform Recognition reduced Regulatory Result SARS-CoV-2 small molecule Small molecules the spike protein therapy Toxicity Treatment USA utility vaccination Vaccine Vaccines [DOI] 10.1016/j.yrtph.2022.105189 PMC 바로가기 [Article Type] Article
Synergistic Antiviral Activity of Pamapimod and Pioglitazone against SARS-CoV-2 and Its Variants of ConcernSARS-CoV-2 및 우려 변종에 대한 파마피모드 및 피오글리타존의 상승적 항바이러스 활성Article Published on 2022-06-202022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acting activity agonist Alpha Anti-inflammatory antiviral activity antiviral potency approved Arthritis assumption Beta cell type cellular cellular pathway cellular targets clinical study clinically evaluated Combination components concern coronavirus COVID-19 COVID-19 patients Delta described diabetes drug effective evaluated Gamma in vitro inhibit SARS-CoV-2 inhibitor kinase mitogen mitogen-activated protein kinase molnupiravir omicron p38-inhibitor pamapimod pathway Paxlovid pioglitazone polymerase potential therapy PPRy-agonist Protease inhibitor protein kinase public health threat reduce Replication replication of SARS-CoV-2 rheumatoid arthritis SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 replication selective Severity of disease small molecule Small molecules Support synergistic These data transmitted treat Treatment type 2 diabetes Vaccine-induced immunity variant variants variants of concern viral replication virulent virus variants VOCs Wuhan [DOI] 10.3390/ijms23126830 PMC 바로가기 [Article Type] Article
Evaluating Upadacitinib in the Treatment of Moderate-to-Severe Active Ulcerative Colitis: Design, Development, and Potential Position in TherapyReview Published on 2022-06-172024-09-04 Journal: Drug design, development and therapy [Category] 대상포진, [키워드] Inflammatory bowel disease JAK1 inhibitor small molecule ulcerative colitis Upadacitinib [DOI] 10.2147/DDDT.S340459 PMC 바로가기 [Article Type] Review