Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and JAK/STAT signaling pathwaysNF-kB 및 JAK/STAT 신호 전달 경로와 관련된 COVID-19 염증 과정에 관여하는 microRNA의 예측 및 분석Review Published on 2021-11-012022-09-11 Journal: International immunopharmacology [Category] SARS, 유전자 메커니즘, [키워드] activated Acute inflammation Analysis approved Cityscape connection contribute COVID-19 COVID-19 complications COVID-19 disease COVID-19 patient Critical Diseases Evidence exacerbate feature Host Inflammation Inflammatory inflammatory gene inflammatory genes inflammatory pathway inflammatory pathways inflammatory process Inflammatory response Inflammatory responses Interaction involved JAK-STAT signaling pathway JAK/STAT JAK/STAT signaling pathway manifestation microRNA miR-214 miR-223 miR-9 miRNA miRNAs mitigate morbidity and mortality NF-kB non-coding RNA Non-coding RNAs pandemic pathophysiological mechanism pathway Perturbation perturbations prediction Previous studies previous study Regulation STAT target target gene Target genes therapeutic target therapeutic targets virus [DOI] 10.1016/j.intimp.2021.108071 PMC 바로가기 [Article Type] Review
ORF3a Protein of Severe Acute Respiratory Syndrome Coronavirus 2 Inhibits Interferon-Activated Janus Kinase/Signal Transducer and Activator of Transcription Signaling via Elevating Suppressor of Cytokine Signaling 1Microbiology Published on 2021-09-282022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] accelerated accessory protein ORF3a activator acute respiratory syndrome Analysis appear blocked caused contribute coronavirus coronavirus 2 Coronavirus disease 2019 COVID-19 cytokine signaling dampen Degradation domain dose Elevating evade global public health host antiviral response host immune responses IFN IFN signaling inhibited interferon JAK/STAT signaling JAK2 janus Janus kinase Janus kinase 2 (JAK2) mechanism ORF3a outbreak pathogen Phosphorylation promoted Protein respiratory responsible SARS-CoV-2 SARS-CoV-2 viral Signaling siRNA SOCS1 STAT Stat1 suppressed suppressor Transcription transducer ubiquitin-proteasomal degradation upregulating upregulation [DOI] 10.3389/fmicb.2021.752597 PMC 바로가기 [Article Type] Microbiology
CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gammaCD147 항체는 SARS-CoV-2 및 그 변이체 델타, 알파, 베타 및 감마의 감염 및 사이토카인 폭풍을 특이적이고 효과적으로 억제합니다.Article Published on 2021-09-252022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Activation Alpha alveolar anti-CD147 antibody Beta caused CD147 cellular entry chemokines contribute COVID-19 COVID-19 pathogenesis COVID-19 treatment cytokine Cytokine storm Cytokines develop Effectiveness expression humanized IL-17 Immune escape immune response immune responses Infection Inflammation inhibit initiated JAK-STAT pathway lymphocyte Lymphocytes macrophages MAPK Meplazumab mice Neutralizing antibodies Neutrophils Pathogenesis pathway Perspective Pneumonia promoted provided receptor regulated SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 variants severe COVID-19 Signaling signaling pathway Spike protein STAT susceptible transgenic mice Transmissibility Treatment triggered Vaccine variant variants Viral viral entry [DOI] 10.1038/s41392-021-00760-8 PMC 바로가기 [Article Type] Article
STAT: a fast, scalable, MinHash-based k -mer tool to assess Sequence Read Archive next-generation sequence submissionsMethod Published on 2021-09-202022-11-01 Journal: Genome Biology [Category] COVID-19, SARS, [키워드] Analysis Biotechnology center criteria independent intrinsic K -mer lack limit Metadata metagenomics MinHash Scientific community sequence Sequence Read Archive STAT submission supplementary material Taxonomic utility [DOI] 10.1186/s13059-021-02490-0 PMC 바로가기 [Article Type] Method
Concise Update on Genomics of COVID-19: Approach to Its latest Mutations, Escalated Contagiousness, and Vaccine ResistanceReview Article Published on 2021-09-152022-10-31 Journal: Global Medical Genetics [Category] COVID-19, [키워드] acute respiratory distress Amino acid calreticulin canonical cause caused Cell changes in Chinese Clinical features complex connection coronavirus COVID-19 COVID-19 pandemic diagnostics Epidemiology genomic Genomics genomics of virus help histocompatibility complex Host hydrophobicity immune system Infectious disease inhibit intrinsic less membrane MHC-I Modification molecular multifunctional N-linked glycosylation Novel coronavirus novel coronavirus disease Nsp7 nucleus oligosaccharide outlined pandemic positive Protein proteomics Replication rate resistance response RNA genome SARS-CoV-2 sequence STAT structures syndrome transcription factor transfer translocated Treatment Vaccine development viral outbreak Viral protein virus [DOI] 10.1055/s-0041-1725143 PMC 바로가기 [Article Type] Review Article
SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT PathwaySARS-CoV-2는 JAK-STAT 경로에서 근위 요소를 방해합니다Article Published on 2021-09-092022-09-11 Journal: Journal of Virology [Category] Coronavirus, SARS, 유전자 메커니즘, 진단, [키워드] affected Analysis Antiviral benefit Brain Cell cell type cell types cellular cellular processe cellular processes components Culture culture systems cultures defined destabilize element evade heart help human body human cell human cell line human cell lines identify IFN IFN antagonism IFN signaling IFNAR1 immortalized immune immune evasion infect infected cell infected cells Infection inhibiting innate immune response Innate immunity interferon interferon receptor interferon signaling intestine Jak Jak-STAT JAK-STAT pathway JAK1 Janus kinase Janus kinase 1 kidney kinase kinases liver lung mechanism mediators molecular multiple organs organ pathway Pathways patients with COVID-19 performed Protein proteomics proximal receptor Replication representing resulting SARS-CoV-2 SARS-COV-2 infection STAT subunit suppression systematic analysis target the interferon these cell These cells tissue TYK2 Type I IFN type I interferon tyrosine Viral virus virus replication Virus-host interactions [DOI] 10.1128/JVI.00862-21 PMC 바로가기 [Article Type] Article
Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling PathwayReview Published on 2021-09-032024-09-02 Journal: Frontiers in Pharmacology [Category] 대상포진, [키워드] Jak phytochemicals polyphenols signaling pathway STAT [DOI] 10.3389/fphar.2021.716672 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Spike protein enhances ACE2 expression via facilitating Interferon effects in bronchial epitheliumSARS-CoV-2 스파이크 단백질은 기관지 상피에서 인터페론 효과를 촉진하여 ACE2 발현을 향상시킵니다.Article Published on 2021-09-012022-09-11 Journal: Immunology letters [Category] SARS, 치료기술, [키워드] ACE2 ACE2 expression activate Activation Analysis Antiviral association BEAS-2B BEAS-2B cell Beas-2B cells Bronchial epithelium co-immunoprecipitation co-IP downstream Effect Effects ENhance epithelial cell epithelial cell line expression help Host identify IFN Infection Interaction interferon ISG ISG15 ISGs JAK-STAT signaling JAK1 non-structural protein non-structural proteins overexpressed overexpression Phosphorylation promote Protein qRT-PCR receptor ACE2 RNA-Seq S protein SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 S spike STAT Stat1 STAT2 the SARS-CoV-2 Transcriptome transcriptome analysis Type upstream was performed were measured western blot [DOI] 10.1016/j.imlet.2021.06.008 PMC 바로가기 [Article Type] Article
JAK-STAT signaling in human disease: from genetic syndromes to clinical inhibitionArticle Published on 2021-08-182024-09-04 Journal: The Journal of Allergy and Clinical Immunology [Category] 대상포진, [키워드] immunodeficiency immunomodulation Jak Jakinib STAT [DOI] 10.1016/j.jaci.2021.08.004 PMC 바로가기 [Article Type] Article
Evaluation of the Performance of the Associates of Cape Cod STAT Assay for the Diagnosis of Invasive Fungal Disease in Critical-Care Patients with COVID-19COVID-19를 가진 중환자의 침습성 진균 질환 진단을 위한 Cape Cod STAT 분석의 Associates 성능 평가Article Published on 2021-08-182022-09-11 Journal: Journal of Clinical Microbiology [Category] SARS, 치료기술, [키워드] Associate benefit Cape Cape Cod case-control study comparable Control COVID-19 pandemic COVID-19 patient COVID-19-associated pulmonary aspergillosis Critical Critical care defined demonstrated Diagnosis fungal fungal disease greater International invasive invasive fungal disease Local moderate pandemic performance performed platform provide pulmonary aspergillosis Quantitative resulting Sample sensitivity Sensitivity and specificity serum sample serum samples Spearman specificity STAT threshold with COVID-19 β-d-glucan. [DOI] 10.1128/JCM.00869-21 PMC 바로가기 [Article Type] Article