SARS-CoV-2-Specific T Cell Responses Are Stronger in Children With Multisystem Inflammatory Syndrome Compared to Children With Uncomplicated SARS-CoV-2 InfectionSARS-CoV-2-특이적 T 세포 반응은 단순 SARS-CoV-2 감염 아동에 비해 다기관 염증 증후군 아동에서 더 강력합니다Comparative Study Published on 2022-01-182022-09-11 Journal: Frontiers in Immunology [Category] 진단, 치료법, [키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Adults antibody Antigen Blood children collected convalescent Coronavirus-2 COVID-19 CST cytokine cytokine production evaluated finding flow cytometry Immunity Infection LIPS luciferase Luciferase immunoprecipitation system magnitude manifestation MIS-C morbidity and mortality nucleocapsid Patient patients pediatric peptides Presence rates of infection respiratory response risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific peptides seropositive Seropositivity serum/plasma Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly higher specificity Stimulation surface markers T cell was measured [DOI] 10.3389/fimmu.2021.793197 PMC 바로가기 [Article Type] Comparative Study
Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells인간 폐 조직 세포에서 SARS-CoV-2 진입, 염증 및 새로운 치료제 평가Research Article Published on 2022-01-132022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, 신약개발, 치료제, [키워드] ACE2 ACE2 expression alveolar Alveolar Type II anti-inflammatory compound anti-inflammatory compounds anti-SARS-CoV-2 therapeutics Antiviral antiviral activity antiviral drug approaches Behavior can be used candidate CD147 Cell Cell culture cell cultures cell lines cell suspension cells cellular complexity Compound drug candidate Drug evaluation early stage early stages expression Factors growth heterogeneous host-pathogen interaction host-pathogen interactions human lung tissue identify immortalized cell lines immune in viral in vitro Infection Inflammation inhibitor interferon interferons involved Laboratory local inflammatory response lung cell modulate modulated offer overcome pathogen Pathogens physiological platform populations primary cell primary cells primary human cell primary human cells Protein provide required respiratory Respiratory pathogens reveal SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 variants Stimulation surgical resection susceptible cell target Therapeutics TMPRSS2 Viral viral entry viral infection [DOI] 10.1371/journal.ppat.1010171 PMC 바로가기 [Article Type] Research Article
Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patientsToll-유사 수용체 7의 희귀 변이는 COVID-19 환자에서 기능 손상 및 사이토카인 매개 신호의 하향 조절을 초래합니다Brief Communication Published on 2021-12-242022-09-10 Journal: Genes and Immunity [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, [키워드] ACOD1 affected antiviral responses Cell Chronic diseases component COVID-19 patient CXCL10 Cytokines decrease downregulation failure functional Genes genetics hypomorphic IFIT2 IFN IFNα IFNγ imiquimod immune responses immunology impairment innate antiviral responses innate immune response innate immune responses interferons loss-of-function male men mononuclear cell mononuclear cells mRNA level mRNA levels Pathogens pathway Patient performed Peripheral blood Peripheral blood mononuclear cells pro-inflammatory cytokine pro-inflammatory cytokines recognize responses responsible RNA sequencing RSAD2 SARS-CoV-2 severe COVID-19 Signaling single-stranded RNA virus Stimulation TLR TLR7 TLRs Toll-like receptor toll-like receptor 7 Toll-like receptors Transcriptome triggering type I upregulation variant variants Variation variety viruses was performed [DOI] 10.1038/s41435-021-00157-1 PMC 바로가기 [Article Type] Brief Communication
Use of Transcutaneous Auricular Vagus Nerve Stimulation as an Adjuvant Therapy for the Depressive Symptoms of COVID-19: A Literature ReviewPsychiatry Published on 2021-12-152022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] acute respiratory syndrome adjuvant Anti-inflammatory Auricular Brain brain circuits cardiometabolic condition China coronavirus disease COVID-19 Depression depressive symptom Depressive symptoms dysfunction Epidemic immune function immune system IMPROVE increasingly interact literature modulate morbidity Multiorgan myocardial injury nerve nerve stimulation pathway Patient Proinflammatory cytokine renal review Stimulation therapy Transcutaneous transcutaneous auricular vagus nerve stimulation Treatment Vagus [DOI] 10.3389/fpsyt.2021.765106 PMC 바로가기 [Article Type] Psychiatry
Single-Cell and Bulk RNASeq Profiling of COVID-19 Patients Reveal Immune and Inflammatory Mechanisms of Infection-Induced Organ DamageCOVID-19 환자의 단일 세포 및 벌크 RNaseQ 프로파일 링은 감염에 의한 장기 손상의 면역 및 염증 메커니즘을 나타냅니다.Article Published on 2021-12-022022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] accounted Analysis analyzed cardiac hypertrophy correlated COVID-19 COVID-19 infection COVID-19 organ damage COVID-19 patients gene expression Critical Cytokines damage deleterious effect determine downregulated downstream Effect effective Effectiveness eIF2 eukaryotic eukaryotic initiation factor 2 fibrosis Host host protein host proteins hypercytokinemia hypertrophy IL-17A IL-2 IL-6 IL-8 immune and inflammatory mechanisms of COVID-19 imperative induce Inflammation Inflammatory inflammatory genes inhibitors inhibitory initiation factor innate immune response Interaction interleukin investigation lead lung Lungs mechanism Mild moderate multiple organ failure NF-κB organ Organ failure organ injury organs overactive pathway Pathways patients peptide peptides potential therapeutic target potential therapeutic targets pro-inflammatory cytokine pro-inflammatory cytokines Profiling reduced RNAseq SARS-CoV-2 SARS-CoV-2 virus severe and critical patients severely infected patients Severity of infection single and bulk RNASeq cell profiling and analysis single-cell Stimulation suppress suppression therapeutic targets tissues translation Treatment upregulation Viral viral infection Viral protein Viral proteins viral-host protein was increased [DOI] 10.3390/v13122418 PMC 바로가기 [Article Type] Article
IFN-γ + cell response and IFN-γ release concordance after in vitro SARS-CoV-2 stimulation시험관 내 SARS-CoV-2 자극 후 IFN-γ + 세포 반응 및 IFN-γ 방출 일치Article Published on 2021-12-012022-09-11 Journal: European Journal of Clinical Investigation [Category] SARS, 치료법, [키워드] Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody case-control study CD4 T-cell CD8 CD8 T-cell Cell cellular Cellular immune response cellular response Concordance convalescent COVID-19 cross-sectional determine ELISA exposed healthcare workers. flow cytometry greater HCW HCWs healthcare healthcare worker Healthcare workers IFN-γ immune in vitro increased risk individual Infection less magnitude proportion protective immunity quantification SARS-CoV-2 SARS-CoV-2-infected patients Stimulation susceptibility Symptoms T cell T cells T-cell Response uninfected Viral protein Viral proteins [DOI] 10.1111/eci.13636 PMC 바로가기 [Article Type] Article
Specific detection of memory T-cells in COVID-19 patients using standardized whole-blood Interferon gammarelease assay표준화된 전혈 인터페론 감마 방출 분석을 사용하여 COVID-19 환자에서 기억 T 세포의 특정 검출Article Published on 2021-12-012022-09-11 Journal: European Journal of Immunology [Category] SARS, 치료기술, [키워드] complementary COVID-19 patient immune immune memory interferon interferon gamma interferon gamma release assay Interferon-gamma memory MONITOR peptide peptide pools protective immunity SARS-CoV-2 SARS-CoV-2 immunity Serological assay serological assays Specific Stimulation T-cell T-cell Response T-cells T-cells response [DOI] 10.1002/eji.202149296 PMC 바로가기 [Article Type] Article
Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based IsolationReview Published on 2021-11-262022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] adhesion Affect affecting Anti-inflammatory anticancer Biomolecule biosensors CAM can be used Cell Cell adhesion cellular classical Compound concerning Effect Effects Evidence experiment faster fungi Gene Expression greater Health highlighting integrin Isolation knowledge mechanism metabolite metabolites Migration movement natural natural compound plant plants preparation quantification SARS-CoV-2 SARS-CoV-2 treatment signaling pathway Stimulation surface receptor target viability virus [DOI] 10.3390/biomedicines9121781 PMC 바로가기 [Article Type] Review
COVID-19 Infection Among Women in Iran Exposed vs Unexposed to Children Who Received Attenuated Poliovirus Used in Oral Polio Vaccine경구 소아마비 백신에 사용된 약독화된 소아마비 바이러스에 감염된 어린이와 노출되지 않은 이란 여성의 COVID-19 감염Research Published on 2021-11-242022-09-12 Journal: JAMA Network Open [Category] MERS, 진단, 폴리오, [키워드] 95% CI age Analysis Care Chain Reaction children cohort study conducted COVID-19 COVID-19 infection COVID-19 vaccine develop diagnosed diagnosed with COVID-19 evaluate exclusion criteria exposure exposure to finding Follow-up group had no Health Health care Health Organization Importance incidence of COVID-19 Inclusion inclusion and exclusion criteria individual Infection Infectious disease Infectious diseases innate immune system IQR Iran less Live attenuated vaccine Live attenuated vaccines longitudinal cohort study measure median mother objective OPV oral organization participant Petroleum Point polio Polio vaccine Poliovirus Probability protective effect Received receiving Relevance Result SARS-CoV-2 setting significantly Stimulation study period study population survival curve Survival curves symptomatic symptomatic COVID-19 symptomatic infection Vaccine with COVID-19 women [DOI] 10.1001/jamanetworkopen.2021.35044 PMC 바로가기 [Article Type] Research
SARS-CoV-2 recombinant proteins stimulate distinct cellular and humoral immune response profiles in samples from COVID-19 convalescent patientsSARS-CoV-2 재조합 단백질은 COVID-19 회복기 환자의 샘플에서 뚜렷한 세포 및 체액 면역 반응 프로필을 자극합니다Original Article Published on 2021-11-232022-09-10 Journal: Clinics [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen antigens blood sample Blood samples CD3+ cellular Cellular immune response cellular immune responses cellular immunity chemiluminescence Contact contact with convalescent convalescent individual convalescent individuals coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent patient Determination domain Donor ELISA ELISAs examined groups humoral humoral immune response Humoral response IFN-γ IgG antibodies IgG antibody Immune profile immune response immune responses Immunity individual individuals investigated Lymphocytes membrane nucleocapsid overlapping Patient peptide peptide pool peptide pools peptides pool profile Proteins RBD Receptor-binding domain Recombinant protein recombinant proteins regions respiratory S1/S2 SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 spike sequence serum serum IgG antibodies serum IgG antibody severe acute respiratory syndrome Coronavirus shown stimulate Stimulation T cell T cells T lymphocyte T lymphocytes volunteers [DOI] 10.6061/clinics/2021/e3548 PMC 바로가기 [Article Type] Original Article