Severe relapse of SARS-CoV-2 infection in a kidney transplant recipient with negative nasopharyngeal SARS-CoV-2 RT-PCR after rituximab리툭시맙 후 비인두 SARS-CoV-2 RT-PCR 음성인 신장 이식 수혜자의 중증 SARS-CoV-2 감염 재발Case Reports Published on 2022-08-012022-09-12 Journal: American journal of transplantation : official jou [Category] MERS, SARS, 진단, [키워드] BAL Cell culture clinical research/practice COVID-19 Diagnosis Fever G142D in viral Infection infection and infectious agents-viral Infectious disease initial kidney kidney transplant kidney transplantation/nephrology lung lung disease: infectious Moderate COVID-19 Mutation N-terminal domain nasopharyngeal Patient prolonged viral shedding respiratory symptom RT-PCR SARS-COV-2 infection SARS-CoV-2 PCR SARS-CoV-2 RT-PCR severe COVID-19 specimen suggested symptomatic therapy translational translational research/science viral clearance Whole genome sequencing [DOI] 10.1111/ajt.17000 PMC 바로가기 [Article Type] Case Reports
Molecular Characterization of Kunitz-Type Protease Inhibitors from Blister Beetles (Coleoptera, Meloidae)딱정벌레(딱정벌레목, 멜로과)의 쿠니츠형 프로테아제 억제제의 분자 특성화Article Published on 2022-07-152022-09-12 Journal: Biomolecules [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] active site acute lung injury Analysis Anticoagulant Beetle biochemical bioinformatics Blister blister beetle characterization characterized drug drugs example feature full-length increasingly inhibitor involved Kunitz-type protease inhibitors lesions mRNA natural nervous system organ Organisms pathology pathophysiology protease Protease inhibitor Protein protein modelling Proteins reported resource SARS-COV-2 infection sequence serine protease Side effect targets transcriptomic transcriptomic analysis transcriptomic analysis. translational validation widespread [DOI] 10.3390/biom12070988 PMC 바로가기 [Article Type] Article
Exploring the Immunomodulatory Aspect of Mesenchymal Stem Cells for Treatment of Severe Coronavirus Disease 19중증 코로나바이러스 질환 치료를 위한 중간엽 줄기세포의 면역조절 측면 탐색 19Review Published on 2022-07-122022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 치료법, [키워드] ACE-2 acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 administration affected Alpha alveolar epithelial cell alveolar epithelial cells angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-apoptotic Anti-inflammatory anti-oxidative aspect Asymptomatic average Betacoronavirus breathlessness cause cellular characterized chemokines chest pain Clinical outcome Clinical symptoms colony-stimulating factor coronavirus 2 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients curative cytokine Cytokine storm Cytokine storms damaged dependent on Deterioration disease severity dry cough Effectiveness Effects elicited endothelial engage enzyme epithelial cells excessive inflammation family Coronaviridae fatigue Fever fibroblast fibroblast growth factor functional GCSF genus genus Betacoronavirus granulocyte granulocyte colony-stimulating factor growth factor Growth factors Health healthy histological IL-6 IL-7 IL-8 IL-9 immune cells immune response immune responses immunomodulation immunomodulatory immunomodulatory capabilities immunomodulatory capability Incubation period individual infected individual infected individuals infiltrating immune cells Inflammatory Inflammatory cytokines inflammatory protein inhalation Injury Intention interferon interleukin intravenous intravenous infusion Invasion IP10 lung Lungs Macrophage majority MCP1 Mesenchymal stem cells MIP1A mitigate monocyte monocyte chemotactic protein-1 MSC MSCs multitude myriad Necrosis organ PDGFB persistence Platelet platelet-derived growth factor positioned positive Protein receptor reduce respiratory Respiratory droplets RNA SARS-CoV-2 SARS-COV-2 infection secretion Secretome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sore throat STEM stem cell stem cells subunit supportive therapy symptomatic therapeutic therapy tissue TNF-α translational transmitted Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha undergo Vascular virus widespread [DOI] 10.3390/cells11142175 PMC 바로가기 [Article Type] Review
Endothelial Cells as a Key Cell Type for Innate Immunity: A Focused Review on RIG-I Signaling Pathway선천성 면역을 위한 핵심 세포 유형으로서의 내피 세포: RIG-I 신호 전달 경로에 대한 집중 검토Review Published on 2022-07-052022-09-11 Journal: Frontiers in Immunology [Category] 치료법, [키워드] Activation anti-viral response Atherosclerosis Bacteria Bacterial bacterial and viral infections bloodstream cardiovascular disease cardiovascular diseases caused Cell cell type close contact contact with COVID-19 danger signals DDX58 demonstrated disorder disorders dsDNA dsRNA endothelial Endothelial cell endothelial cells Endothelial dysfunction Evidence expression function heterogeneous highlight host antiviral response immune immune functions immune surveillance Immunity Infectious disease Inflammation inhibited Innate Innate immunity interferons invading pathogen Ligand Like LPS macrophages microbial infection Panax notoginseng pathogen Pathogens PPARγ provided PRR recent receptor retinoic acid review RIG-I saponins shown signal signaling pathway Surveillance translational Type Vascular endothelium viral infection viral infections virus virus infection [DOI] 10.3389/fimmu.2022.951614 PMC 바로가기 [Article Type] Review
Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2SARS-CoV-2에 대한 활성을 갖는 광범위한 1차 항바이러스제로서의 거대분자 바이러스 진입 억제제Article Published on 2022-07-012022-09-11 Journal: Advanced Science [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activity analyzed antiviral activity broad-spectrum antivirals Cell culture cell entry clinical isolates entry inhibitors gold Gold nanoparticle in vitro in vivo inhibitor inhibitors inhibitory activity investigated isolate macromolecular macromolecules mice pathogen Pathogens polyanions quantified respiratory syncytial virus respiratory syncytial virus (RSV). respiratory viral respiratory viruses Result RSV SARS-CoV-2 shown STYRENE sulfonate tested translational variants variants of concern viral cell virus viruses [DOI] 10.1002/advs.202201378 PMC 바로가기 [Article Type] Article
Characterization and Utilization of Disulfide-Bonded SARS-CoV-2 Receptor Binding Domain of Spike Protein Synthesized by Wheat Germ Cell-Free Production System밀 배아 무세포 생산 시스템에 의해 합성된 스파이크 단백질의 이황화 결합 SARS-CoV-2 수용체 결합 도메인의 특성화 및 활용Article Published on 2022-07-012022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 receptor Analysis bind cell-free protein synthesis characterization contribute COVID-19 COVID-19 therapeutics Disulfide disulfide bond Drug screening Endoplasmic reticulum evaluate Express functional Germ immunogenicity Interaction Mutation PDI Production Protein protein disulfide isomerase protein synthesis Rapid RBD RBD protein RBD-ACE2 SARS-CoV-2 SARS-CoV-2 SP spike Spike protein System translational utilization Vaccine viral infection Viral variants wheat [DOI] 10.3390/v14071461 PMC 바로가기 [Article Type] Article
The Translational Landscape of SARS-CoV-2-infected Cells Reveals Suppression of Innate Immune GenesSARS-CoV-2에 감염된 세포의 번역 환경은 선천 면역 유전자의 억제를 나타냅니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] abundantly expressed acute respiratory syndrome acute respiratory syndrome coronavirus Air-liquid interface airway Cell cell cultures cell line cells cellular cellular mRNAs chemokine ciliated ciliated cell coding coronavirus cytokine downregulation event help highlight host mRNA host response host responses immune immune response immune responses infected cells Inflammatory Innate innate immune innate immune response Interaction interferon-stimulated genes involved landscape mechanism mediators modulate mRNA mRNA translation mRNAs notable primary cells programmed frameshifting regulated respiratory ribo-seq ribosomal frameshifting ribosome ribosome profiling ribosomes RNAs SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2-infected cell SARS-CoV-2-infected cells sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suppression therapeutic therapeutic intervention These data transcriptional Transcriptional upregulation translated translation translation initiation translational translational repression unique upregulation Viral viral mRNA viral mRNAs virus virus replication Virus-host interaction [DOI] 10.1128/mbio.00815-22 PMC 바로가기 [Article Type] Article
Redefining critical illness Reviews Published on 2022-06-172022-10-05 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, [키워드] accelerate acute respiratory syndrome approach Basic science change clinical trial clinically coronavirus Critical Critical care defined determinant effective heterogeneous Mounting outcomes Patient recent finding Research Respiratory failure respond SARS-CoV-2 Support therapy translational Treatment turn [DOI] 10.1038/s41591-022-01843-x [Article Type] Reviews
Heparanase Is a Putative Mediator of Endothelial Glycocalyx Damage in COVID-19 – A Proof-of-Concept Study헤파라나제는 COVID-19에서 내피 글리코칼릭스 손상의 추정 매개체입니다 - 개념 증명 연구Article Published on 2022-06-102022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] atomic Bacterial sepsis changes in Coronavirus disease 2019 correlated COVID-19 COVID-19 patient cultured cell damage dimension disease endothelial endothelial glycocalyx (EG) enzyme excess experiments glycocalyx Heparanase heparanase (HPSE) heparin HPSE immunofluorescence inhibition Injury marker mediator Microscopy plasma plasma sample prevented Protective protective effect serum shown translational Vascular endothelium vessel videomicroscopy. [DOI] 10.3389/fimmu.2022.916512 PMC 바로가기 [Article Type] Article
NAD(H)-loaded nanoparticles for efficient sepsis therapy via modulating immune and vascular homeostasis Research Published on 2022-06-062022-10-05 Journal: Nature nanotechnology [Category] 바이오마커, [키워드] addition Apoptosis approach Bacteremia Cell cells cellular death demonstrated help homoeostasis immune immunomodulator Infection Inflammation key factor life-threatening maintain modulating multidrug-resistant multiorgan injury NAD+ NADH organ dysfunction outcome Pathogenesis prevented Pseudomonas aeruginosa pyroptosis reduced responsible Sepsis suppressed the United State therapeutic efficacy therapy translational Transport treat Vascular function vascular homeostasis [DOI] 10.1038/s41565-022-01137-w [Article Type] Research