Advancements in Testing Strategies for COVID-19COVID-19에 대한 테스트 전략의 발전Review Published on 2022-06-132022-09-11 Journal: Biosensors [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] addition advancement Analysis approach coronavirus COVID-19 Diagnosis diagnosis of COVID-19 diagnostic disease-causing expand four groups immunoassays infect methodology outbreak pathogen platform SARS-CoV-2 SARS-CoV-2 coronavirus selective Serological testing spread of COVID-19 Strategy susceptible Testing utilization variant variants Variation virulent [DOI] 10.3390/bios12060410 PMC 바로가기 [Article Type] Review
Protease inhibitor Camostat Mesyalte blocks wild type SARS-CoV-2 and D614G viral entry in human engineered miniature lungs프로테아제 억제제 Camostat Mesyalte는 인간이 조작한 소형 폐에서 야생형 SARS-CoV-2 및 D614G 바이러스 진입을 차단합니다Article Published on 2022-06-012022-09-11 Journal: Biomaterials [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] 3D model alveolar alveolar epithelial cell AT2 block camostat catastrophic cell line cell lines COVID-19 Culture D614G develop distal Effect epithelial epithelial cells evaluate Ex vivo highlight human lung in vitro model induce Infection inhibitor involved lentivirus lung lung epithelium maturation moderate organ organ culture organoids pandemic Pathogenesis pathogenesis of COVID-19 phenotype platform pluripotent stem cell Prevent progression Protease inhibitor provided pseudotyped real time reduced Research respiratory tract SARS-CoV-2 SARS-CoV-2 pandemic significantly the SARS-CoV-2 tissue treat type 2 alveolar epithelial cells viral entry viral infection viral infections virulent while wild type wildtype [DOI] 10.1016/j.biomaterials.2022.121509 PMC 바로가기 [Article Type] Article
Structure-based virtual screening, in silico docking, ADME properties prediction and molecular dynamics studies for the identification of potential inhibitors against SARS-CoV-2 M proSARS-CoV-2 M pro에 대한 잠재적 억제제 식별을 위한 구조 기반 가상 스크리닝, 인실리코 도킹, ADME 특성 예측 및 분자 역학 연구Article Published on 2022-06-012022-09-11 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] ADME affected Amino acid amino acid residue Asinex library ASN binding CADD carried caused complex Compound compounds computer Computer aided drug design conformational contagious COVID-19 COVID-19 patients docked docking drug drug candidate drug design druggability enzyme evaluated GLU Health Organization hydrogen Hydrogen bond hydrogen bond interactions identify in silico include Infection inhibitor interactions knocking down Ligand M pro maturation molecular molecular dynamics Molecular dynamics simulation Mortality Mpro protein Mutation optimization pandemic participated pharmacological PHE Protein protein-ligand protein-ligand interaction protein-ligand interactions Replication responsible RMSD RMSF SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 Mpro SARS-CoV-2 Mpro protein Schrodinger software stability strain therapeutic option these compound these compounds TRP Virtual screening virulent was used World Health Organization [DOI] 10.1007/s11030-021-10298-0 PMC 바로가기 [Article Type] Article
Multitarget in silico studies of Ocimum menthiifolium, family Lamiaceae against SARS-CoV-2 supported by molecular dynamics simulation분자 역학 시뮬레이션으로 지원되는 SARS-CoV-2에 대한 꿀풀과 Ocimum menthiifolium의 다중 표적 in silico 연구Article Published on 2022-06-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] 3CLpro acute respiratory syndrome anti-SARS-CoV-2 apigenin approved binding binding affinity binding energy binding interaction butanol can be used cause chose complex complexes Compound coronavirus COVID-2 docking results drug drugs targeting flavonoids high stability human coronavirus in silico indicated inquiry investigated M pro metabolic metabolomics molecular molecular docking molecular dynamics Molecular dynamics simulation Ocimum Ocimum menthiifolium other compound other compounds public health reported SAM SARS-CoV-1 SARS-CoV-2 Severe acute respiratory syndrome Spread stability structure-based design suggested supported targets these viruses Vaccine virulent virus [DOI] 10.1080/07391102.2020.1852964 PMC 바로가기 [Article Type] Article
Investigation of SARS-CoV-2 Epsilon Variant and Hospitalization Status by Genomic Surveillance in a Single Large Health System During the 2020-2021 Winter Surge in Southern California남부 캘리포니아의 2020-2021년 겨울 서지 동안 단일 대형 의료 시스템에서 게놈 감시에 의한 SARS-CoV-2 엡실론 변이체 및 입원 상태 조사Article Published on 2022-05-042022-09-11 Journal: American journal of clinical pathology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission B.1.427 B.1.429 California collected coronavirus COVID-19 Epsilon Epsilon variant frequencies Frequency genomic Genomic surveillance health system Hospitalization hospitalized patients ICU ICU admission ICU patient ICU Patients intensive care intensive care unit investigation outpatients patients respiratory sample Respiratory samples SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe disease status Surveillance System unique variant virulent was performed Winter [DOI] 10.1093/ajcp/aqab203 PMC 바로가기 [Article Type] Article
Immune profile and responses of a novel dengue DNA vaccine encoding an EDIII-NS1 consensus design based on Indo-African sequences인도-아프리카 서열을 기반으로 하는 EDIII-NS1 컨센서스 디자인을 암호화하는 새로운 뎅기열 DNA 백신의 면역 프로필 및 반응Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] MERS, 변종, 진단, [키워드] antibody Antibody-dependent enhancement Antigen antigens clinical isolates coding sequence Consensus consensus sequence conserved COVID-19 pandemic Dengue dengue surveillance. dengue virus DENV-2 DNA DNA vaccine domain domain III EDIII domain emerging viruses envelope protein epitope Epitopes expand Genotype highlight IgG1 immune immune response immunogenic Immunoglobulin India Indo-African interferon isolate mice neutralizing antibody non-structural protein NS1 protein passive transfer protein expression response sequence Sequencing sera serotype serotype-specific staining Stand Structural analysis Surveillance T cell T cell responses transfer translation vaccination Vaccine vaccine candidate Vaccine design Viral Viral variants virulent viruses whole genome Whole genome sequencing [DOI] 10.1016/j.ymthe.2022.01.013 PMC 바로가기 [Article Type] Article
Genetic Sequence of Coronavirus Strains Isolated from Iraqi Patients and their Relationship with some Liver Enzymes and InterleukinsArticle Published on 2022-04-302022-11-15 Journal: Archives of Razi Institute [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome Admission Alpha ALT assigned AST asymptomatic patients Baghdad blood sample cause caused characterized coronavirus coronavirus disease correlation COVID-19 Deceased disease severity enzyme faster five group Genetic Genetic sequence genus Betacoronavirus groups hospitalized patient Il -10 Il- 18 IL-10 IL-18 Illumina indicated intensive care units interleukin Iraq isolate Isolated isolation hospital lactate dehydrogenase LDH less liver enzyme Ministry of Health moderate nasopharyngeal outcome polymerase chain positive sample positive-sense single-stranded RNA Public Quantitative relationship RT-PCR SARS-CoV-2 sequence severe symptom significantly Spread statistically significant strain TNF- α venous virulence virulent virus was determined WHO World Health Organization Wuhan Wuhan strain [DOI] 10.22092/ARI.2022.357089.1967 PMC 바로가기
Human SARS-CoV-2 has evolved to increase U content and reduce genome size인간 SARS-CoV-2는 U 함량을 증가시키고 게놈 크기를 줄이기 위해 진화했습니다Article Published on 2022-04-152022-09-11 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid caused collected conducted content contributed coronavirus current Delta Evolution Evolution of SARS-CoV-2 Genome Health help Human in-depth analysis less lineages mutability Mutation no significant difference nucleotide omicron Omicron variants reduce reducing Replication SARS-CoV-2 significant difference Transmission understanding variant Variation variations virulent virus virus sample virus samples [DOI] 10.1016/j.ijbiomac.2022.02.034 PMC 바로가기 [Article Type] Article
Projecting the Pandemic Trajectory through Modeling the Transmission Dynamics of COVID-19COVID-19의 전파 역학 모델링을 통한 팬데믹 궤적 예측Article Published on 2022-04-092022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 변종, [키워드] circulating classic Community compartmental model compartmental modeling Course COVID-19 COVID-19 pandemic Critical deaths disease Disease progression disease severity Diseases dominant doses Dynamics effective Effectiveness Efficiency epidemiological Epidemiology extension groups immunization result infected individuals Infection Local majority mathematical Mild modeling Modification modifications observation observations omicron Omicron variant pandemic Pandemics population groups powerful tool public health reduce reduction in single variant SIRS Spread Support supported Transmissibility Transmission Transmission dynamics understanding vaccination Vaccine variant virulent [DOI] 10.3390/ijerph19084541 PMC 바로가기 [Article Type] Article
Antiviral Efficacy of Selected Natural Phytochemicals against SARS-CoV-2 Spike Glycoprotein Using Structure-Based Drug Designing구조 기반 약물 설계를 사용한 SARS-CoV-2 스파이크 당단백질에 대한 선택된 천연 파이토케미컬의 항바이러스 효능Article Published on 2022-04-082022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] Absorption ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis binding binding affinity Bioavailability candidate Compound conducted Coronaviral coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID-19 crystal structure database disease distribution docked docked complex docked complexes drug drug candidate drug targets Effectiveness Environment excretion flavonoid Health host cells Immunological response library metabolism milk molecular molecular docking molecular dynamic simulation molecular interaction MPD3 natural pandemic PDB penetrate pharmacological target Phylloflavan phytochemical phytochemicals Protein PubChem Receptor binding domain S-RBD SARS-CoV-2 selected severe acute respiratory syndrome Coronavirus Sickness silico studies silico study spike spike glycoprotein Spike protein subgroups thistle Virtual screening virulent was obtained Zinc [DOI] 10.3390/molecules27082401 PMC 바로가기 [Article Type] Article