vWF – Page 3 – Communicable Diseases Research

Von Willebrand factor collagen-binding capacity predicts in-hospital mortality in COVID-19 patients: insight from VWF/ADAMTS13 ratio imbalance

폰 빌레브란트 인자 콜라겐 결합 능력은 COVID-19 환자의 병원 내 사망률을 예측합니다: VWF/ADAMTS13 비율 불균형으로부터의 통찰력

Article

Published on 2021-08-012022-09-11
Journal: Angiogenesis [Category] SARS, 바이오마커,

The ADAMTS13-von Willebrand factor axis in COVID-19 patients

COVID-19 환자의 ADAMTS13-von Willebrand 요인 축

Article

Published on 2021-02-012022-09-11
Journal: Journal of thrombosis and haemostasis : JTH [Category] 바이오마커,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus ADAMTS13 ADAMTS13 Protein Admission Antigen Care characterized cofactor coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 progression cross-sectional cross-sectional study Deceased disease severity elevated ENhance Evidence evidence of hypercoagulable Hypercoagulable state Imbalance increased risk intensity lung Lungs mechanical ventilation mechanism median Microthrombosis microvasculature nasal nasal cannula Oxygenation Patient patients positive airway pressure propeptide ranged respiratory risk severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe coronavirus disease stratified thromboembolic Thromboembolic events thrombosis von Willebrand factor vWF with intensity
[DOI] 10.1111/jth.15191 PMC 바로가기 [Article Type] Article

Low ADAMTS13 Activity Correlates with Increased Mortality in COVID-19 Patients

Original Article

Published on 2021-01-092022-10-29
Journal: TH Open: Companion Journal to Thrombosis and Haemostasis [Category] COVID-19,

[키워드] Activation activity ADAMTS13 Admission Antigen association Biomarker Biomarkers cause Coagulation Coagulopathy conducted coronavirus disease COVID-19 COVID-19 patient D-dimer died discharged disease severity distribution Efficacy elevated elevated lactate dehydrogenase endothelial greater Hemolysis hospitalized COVID-19 patient hospitalized patients Increased less metalloproteinase Mortality motif nonsurvivors organ damage Patient Presence Randomly Retrospective study schistocytes selected significantly significantly increased significantly lower subset survived survivor Treatment von Willebrand factor vWF
[DOI] 10.1055/s-0041-1723784 PMC 바로가기 [Article Type] Original Article

Inflammatory and Prothrombotic Biomarkers Associated With the Severity of COVID-19 Infection

COVID-19 감염의 심각성과 관련된 염증성 및 혈전성 바이오마커

Article

Published on 2021-01-012022-08-31
Journal: Clinical and applied thrombosis/hemostasis : offic [Category] 바이오마커,

[키워드] Admission alteration Biomarker blood sample Blood samples chronic degenerative diseases Coagulation Comorbidities Complication Concentration Control control group COVID-19 COVID-19 patient COVID-19 patients D dimer D-dimer Deceased degenerative dimer disease elevated evaluate Evolution Glucose group groups healthy donor High flow nasal cannula hospital hospitalized patients immunothrombosis incidence Inflammatory interleukin interleukin 6 interleukin 8 interleukin-6 Laboratory mechanical ventilation nasal nasal cannula outcome oxygen oxygen demand oxygen mask P-selectin PAI-1 Patient plasma plasma concentrations poor prognosis procoagulant prothrombotic routine selectin severe severe COVID-19 severe COVID-19 patient severe COVID-19 patients Severe patient severe patients severity significant difference significantly significantly higher the disease von Willebrand factor vWF was performed WBC
[DOI] 10.1177/1076029621999099 PMC 바로가기 [Article Type] Article

Insights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13

Immunology

Published on 2020-12-022022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

SARS-CoV-2에 감염된 붉은털 원숭이의 혈관 질환 및 혈전증

Case Reports

Published on 2020-11-252022-09-11
Journal: Cell [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] Analysis Bronchoalveolar lavage C-reactive protein clinical Clinical features Coagulation collagen complement COVID-19 COVID-19 pandemic Critical endothelial feature Human IFNα IL-1 IL-6 IL-8 include infected with SARS-CoV-2 Inflammation Inflammatory Interaction lead lung Lungs macaque macaques Macrophage molecular morbidity and mortality MX1 NF-κB pathway performed Peripheral blood Platelet platelet activation potential therapeutic target potential therapeutic targets proinflammatory proteomic rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 pathogenesis serum thrombosis TNFα transcriptomic Transcriptomic analyses upregulation Vascular vascular disease vascular thrombosis vWF
[DOI] 10.1016/j.cell.2020.10.005 PMC 바로가기 [Article Type] Case Reports

Circulating Biomarkers of COVID-19-Triggered Endotheliopathy: From Conjecture to Certainty

Conference abstract

Published on 2020-11-042022-10-05
Journal: Blood [Category] 바이오마커,

[키워드] Activation acute phase reactants Admission affecting analyzed appear Biomarker Blood board Boehringer Ingelheim certainty chest imaging circulating clinical collected complement Complication Conjecture contribute Control controls coronavirus Course COVID-19 COVID-19 patient COVID-19 patients Critical Culture Degradation detection diagnostic disease download dsDNA elevated ELISA test endothelial Endothelial cell endothelial damage endothelial function endothelial injury evaluated figure form funding healthy donor Hoffmann-La Roche Hospitalization identify immunofluorescence Inflammatory information Injury janssen Jazz Lancet Level marker Mortality multiple organs Nasopharyngeal swab NET NETs Neutrophil extracellular trap no significant difference non-critically ill patient non-infectious not differ notable Novartis pathophysiology Patient plasma Pneumonia positive potentially life-threatening prognostic protein C pulmonary complication radiological reduced responsible Result Science Septic shock Sharp Siemens Healthineers significantly significantly higher significantly increased significantly lower speaker Stress syndrome systemic inflammatory response Takeda the disease therapeutic intervention Therapeutics thrombotic vWF were assessed were measured were used
[DOI] 10.1182/blood-2020-142311 [Article Type] Conference abstract

Coagulation biomarkers are independent predictors of increased oxygen requirements in COVID-19

응고 바이오마커는 COVID-19에서 증가된 산소 요구량에 대한 독립적인 예측자입니다.

Article

Published on 2020-11-012022-09-11
Journal: Journal of thrombosis and haemostasis : JTH [Category] 바이오마커,

[키워드] 95% CI 95% confidence interval activated Admission adult COVID-19 patient adverse outcome adverse outcomes age Analysis Antigen association baseline Biomarker Biomarkers BMI body mass body mass index C-reactive protein Coagulation Comorbidity confounder contribute COVID-19 COVID-19 patients CRP D-dimer D-dimers death diabetes factor VIII fibrinogen Follow-up FVIII hazard ratio hypercoagulability hypertension independent predictor leucocytes metabolic syndrome outcomes oxygen Oxygen requirement Oxygen requirements partial thromboplastin time Pathogenesis plasma Platelet platelet-poor plasma Platelets Pneumonia Predictive Prothrombin time regression analysis risk SARS-CoV-2 pneumonia SARS-CoV2 Sex significantly subdistribution syndrome THROMBOPLASTIN thrombosis univariable von Willebrand factor vWF
[DOI] 10.1111/jth.15067 PMC 바로가기 [Article Type] Article

Modulation of endothelial organelle size as an antithrombotic strategy

Original Article

Published on 2020-10-162022-10-30
Journal: Journal of thrombosis and haemostasis : JTH [Category] COVID-19,

Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes

Review

Published on 2020-07-212022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome approach Biomarker bleeding circulating Coagulation Coagulopathy Comorbidities Complication coronavirus coronavirus disease COVID-19 D-dimer D-dimer level dysfunction endothelial endothelial cells erythrocyte erythrocytes event Factor Fibrin(ogen) fibrinogen healthy implication Infection Inflammatory involved lung management marker methodology MOST occur P-selectin pathology pathway Patient patients Personalized medicine Platelet point-of-care poor prognosis progression receptor risk factor subject the cytokine storm the disease thrombosis thrombotic treated Treatment upregulated Vascular vWF
[DOI] 10.3390/ijms21145168 PMC 바로가기 [Article Type] Review