Conserved MicroRNAs in Human Nasopharynx Tissue Samples from Swabs Are Differentially Expressed in Response to SARS-CoV-2Article Published on 2022-02-142022-10-31 Journal: Genes [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] conserved contribute differentially expressed differentially expressed miRNA disease expression level groups Human humans miR-21 miRNA miRNA profile miRNA profiles miRNAs modifications nasopharynx non-infected patients positive real-time RT-PCR response RNA RNA sample RNA sequencing Sample SARS-CoV-2 SARS-CoV-2 pathogenesis selected small RNA sequencing Symptom the SARS-CoV-2 tissue tissue sample tissues various tissues were expressed [DOI] 10.3390/genes13020348 PMC 바로가기 [Article Type] Article
Towards digital health equity – a qualitative study of the challenges experienced by vulnerable groups in using digital health services in the COVID-19 eraResearch Published on 2022-02-122022-10-28 Journal: BMC health services research [Category] Coronavirus, COVID19(2023년), Fulltext, MERS, SARS, [키워드] Adults Analysis approach benefit boost Care challenge conducted contact with COVID-19 COVID-19 pandemic determinant Digital Digital determinants of health Digital health equity Digital health services element equity examined exclusion fear framework group Health Health Service Health services identify implementation IMPROVE lack less likelihood Local mental health misunderstanding offered Older participant Participants platform Prevent prevented Qualitative replacing Result risk supplementary material Support Vulnerable groups was used were expressed while [DOI] 10.1186/s12913-022-07584-4 PMC 바로가기 [Article Type] Research
Increased levels of soluble fms-like tyrosine kinase-1 are associated with adverse outcome in pregnant women with COVID-19Article Published on 2022-02-012022-11-16 Journal: Ultrasound in obstetrics & gynecology : the offici [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI acute respiratory syndrome addition adjusted adjusted odds ratio Admission adverse outcome affected age Analysis association Care carried Concentration coronavirus COVID-19 criteria death detection rate endothelial Endothelial dysfunction Endothelium events False-positive FIVE growth factor Gynecology hospital Hospitalization ICU ICU admission Increased intensive care Logistic regression analysis Lungs marker Maternal death Mexico City outcome patients Placenta placental placental growth factor Pneumonia polymerase chain positive predict Predictive predictor Pregnancy pregnant women Primary outcome Probability prospective cohort study Quantitative SARS-CoV-2 SARS-COV-2 infection secondary Sepsis serum severe coronavirus disease severe COVID-19 Severe COVID-19 pneumonia severe pneumonia severity of COVID-19 Society the median tyrosine Ultrasound were expressed with COVID-19 women [DOI] 10.1002/uog.24798 PMC 바로가기
Efficacy of antiviral therapies for COVID-19: a systematic review of randomized controlled trialsCOVID-19에 대한 항 바이러스 요법의 효능 : 무작위 대조 시험의 체계적인 검토Research Published on 2022-01-312022-09-10 Journal: BMC Infectious Diseases [Category] SARS, 임상, 치료제, [키워드] Administered Antiviral antiviral therapy Antiviral treatment approved article Clinical improvement clinical outcomes controlled trials coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 mortality COVID-19 patients COVID-19 treatment daclatasvir demonstrated Descriptive statistics disease course effective Efficacy Evidence examined exhibited guideline heterogeneity identify improve clinical outcome include inferential statistics network not performed patients performed public health randomized clinical trial randomized clinical trials Randomized controlled trial Randomized controlled trials RCT reducing reducing mortality Remdesivir Result retrieved SARS-CoV-2 Scottish sofosbuvir sofosbuvir/daclatasvir Statistical power study heterogeneity suggested supplementary material systematic literature search systematic review the disease therapeutic Time to recovery Treatment trials was performed were excluded were expressed [DOI] 10.1186/s12879-022-07068-0 PMC 바로가기 [Article Type] Research
Moral panic about “covidiots” in Canadian newspaper coverage of COVID-19Research Article Published on 2022-01-182022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] amplified Compliance condition Consensus Coverage COVID-19 COVID-19 pandemic evaluate examined expressed facilitate group Health imperative Infection infection control Infection prevention lack Moral moral panic normalization Panic preventive measures promote Public public health reaction reduce Surveillance threat variety were expressed widespread [DOI] 10.1371/journal.pone.0261942 PMC 바로가기 [Article Type] Research Article
Role of herbal medicines in the management of patients with COVID-19: A systematic review and meta-analysis of randomized controlled trialsReview article Published on 2022-01-012022-10-05 Journal: Journal of Traditional and Complementary Medicine [Category] 임상, [키워드] 95% CI adverse event applied cause China Clinical effect Cochrane Library Continuous data COVID-19 COVID-19 patient CRP CTRI database demographics Direct eligible ESR evaluate Google Scholar Herbal herbal medicine Hospital stay IL-6 improvement India Inflammatory marker Intervention Iran laboratory parameter Level Lymphocyte count management medication Meta-analysis Patient portal Randomized controlled trial RCT RCTs Result role Science significantly higher standard care group statistically Symptom systematic review Treatment WBC were expressed [DOI] 10.1016/j.jtcme.2022.01.002 [Article Type] Review article
Production of full-length SARS-CoV-2 nucleocapsid protein from Escherichia coli optimized by native hydrophobic interaction chromatography hyphenated to multi-angle light scattering detection다각도 광산란 검출에 하이픈으로 연결된 천연 소수성 상호작용 크로마토그래피에 의해 최적화된 대장균으로부터 전장 SARS-CoV-2 뉴클레오캡시드 단백질 생산Article Published on 2021-12-012022-09-11 Journal: Talanta [Category] SARS, 치료기술, 치료법, 치료제, [키워드] abundantly expressed acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analytical method Cell cell lysis chaperone Chromatography complementary coronavirus cpCasp2‐based platform fusion protein process (CASPON technology). Critical diagnostic dimerized downstream Downstream processing (DSP) DSP E. coli enhanced enzyme-linked immunosorbent enzyme-linked immunosorbent assay Escherichia coli explained fermentation fraction full-length SARS-CoV-2 fusion protein host cell hydrophobic Hydrophobic interaction chromatography-multi-angle light scattering (HIC-MALS) Infection information Interaction life cycle mass spectrometry minor molecular MONITOR novel Novel coronavirus Novel coronavirus (termed SARS-CoV-2) Nuclease nucleic acids nucleocapsid protein nucleoprotein peptide platform produced Production Protein protein expression purification purified purity resolving power SARS-CoV-2 scattering SEC selectivity sequence severe acute respiratory syndrome Coronavirus target protein Treatment variable viral life cycle was used were expressed yield [DOI] 10.1016/j.talanta.2021.122691 PMC 바로가기 [Article Type] Article
Clinical and Laboratory Factors in Predicting Mortality Among COVID-19 RT-PCR Positive Patients: A Retrospective Observational Study From a Tertiary Care CenterInternal Medicine Published on 2021-11-212022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Acute kidney injury acute respiratory distress acute respiratory distress syndrome [ards] addition age age and sex AKI albumin analyzed Aspartate aminotransferase AST C-reactive protein (CRP Cardiac arrest carried categorical variable cause center clinical clinical and laboratory characteristics co-morbidities co-morbidity complications condition control group coronavirus disease coronavirus disease (COVID-19) Corticosteroids COVID-19 COVID-19 infection CRP D-dimer death diabetes Factor Frequency Gender higher odds hypertensive IL-6 independent risk factor information Intervention laboratory parameter lactate dehydrogenase LDH Lymphocytes lymphopenia mechanically ventilated medical records Monocytes Mortality Mortality predictors multivariable logistic regression nasal neurological Neutrophils non-survivor outcome Oxygen therapy patients with COVID-19 positive COVID-19 Prevent procalcitonin raised Randomly Result retrospective risk factor risk stratification RT-PCR selected serum creatinine severity shown significantly statistically survivor syndrome Tertiary Tocilizumab univariable was collected were expressed were used [DOI] 10.7759/cureus.19791 PMC 바로가기 [Article Type] Internal Medicine
Analysis of Serological Biomarkers of SARS-CoV-2 Infection in Convalescent Samples From Severe, Moderate and Mild COVID-19 Cases중증, 중등도 및 경증 COVID-19 사례의 회복기 샘플에서 SARS-CoV-2 감염의 혈청학적 바이오마커 분석Comparative Study Published on 2021-11-192022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 변종, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome addition antibodies antibody Antibody binding antibody levels Antibody Response Antibody responses Antibody Units Antigen Asymptomatic asymptomatic infection average BAU binding antibodies binding antibody binding antibody units Biomarker Biomarkers candidate Clinical severity convalescent sera correlated correlates of protection COVID-19 COVID-19 disease COVID-19 immune response COVID-19 pandemic COVID-19 patients Electroporation ELISA epidemiological studies Epidemiological study flow cytometry HCW healthcare worker Humoral immunity identify IgA IgM increasingly International international standard international units Lateral flow test microneutralisation test Mild mild or asymptomatic infections multiplex neutralisation neutralisation assay Neutralising Antibodies neutralising antibody neutralising antibody response Neutralising antibody responses nucleocapsid positive correlation Prevalence protection pseudotyped RBD Re-infection respiratory Sample SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike SARS-CoV-2-specific IgG Serological biomarkers SEROLOGICAL STUDY seronegative seropositive Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus-2 severe COVID-19 patient severe COVID-19 patients severity significantly higher spike statistically to define unit vaccination Vaccine vaccine trial variants of concern Virus neutralisation virus neutralisation assay virus neutralising antibody VoC were expressed WHO WHO guideline WHO International Standard World Health Organisation [DOI] 10.3389/fimmu.2021.748291 PMC 바로가기 [Article Type] Comparative Study
Expression of SARS‐CoV‐2 entry factors, electrolyte, and mineral transporters in different mouse intestinal epithelial cell typesOriginal Article Published on 2021-11-092022-10-28 Journal: Physiological Reports [Category] COVID-19, MERS, SARS, [키워드] abundantly expressed ACE2 Amino acid apical membrane AT1 basolateral calcium Cell cell type cells CFTR COVID‐19 diarrhea DRA Enterocyte enzyme epithelial cell type Evidence expressed expressing expression expression pattern Factor Factors goblet greater heterogeneous Hypothesis identity indicated infect Infection intestinal intestinal cell intestine iron mammalian mucosa multifunctional multifunctional protein pandemic Paneth cells protease provide receptor ACE2 required responsible SARS‐CoV‐2 SARS‐CoV‐2 infection SIT1 small intestine tested TMPRSS TMPRSS2 TMPRSS4 transmembrane Transport villus virus were expressed [DOI] 10.14814/phy2.15061 PMC 바로가기 [Article Type] Original Article