D614G – Page 31 – Communicable Diseases Research

Whole-genome sequencing of SARS-CoV-2 reveals the detection of G614 variant in Pakistan

SARS-CoV-2의 전체 게놈 시퀀싱은 파키스탄에서 G614 변이체의 검출을 보여줍니다

Research Article

Published on 2021-03-232022-08-13
Journal: PLoS ONE [Category] SARS, 유전자 메커니즘,

Pan-India novel coronavirus SARS-CoV-2 genomics and global diversity analysis in spike protein

Research Article

Published on 2021-03-192022-10-31
Journal: Heliyon [Category] COVID-19,

[키워드] ACE ACE2 Analysis antibodies antibody Belgium binding binding domain circulating clades Comparative genomics Consensus country COVID-19 D614G docking enzyme expected EY6A Fatality rate France Genome higher affinity higher fatality rate higher infectivity India infection rates Interaction isolate isolates Italy lowest Molecular dynamics simulation mortality rate Mutation N439K Neutralizing antibodies neutralizing monoclonal antibodies novel coronavirus SARS-CoV-2 pandemic Pathogenesis Prevalence prevalent RBM reactivity receptor Receptor binding domain receptor binding motif reported SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 virus Spike protein Support USA variant virulence Wuhan-1
[DOI] 10.1016/j.heliyon.2021.e06564 PMC 바로가기 [Article Type] Research Article

Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant

Clinical Trial

Published on 2021-03-162022-10-04
Journal: The New England Journal of Medicine [Category] Fulltext, SARS, 변종, 임상, 진단,

[키워드] 1:1 501Y.V2 95% CI 95% confidence interval acute respiratory syndrome African age Analysis analyzed assessment assigned AZD1222 B.1.351 B.1.351 variant caused ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine clinical conducted coronavirus Coronavirus 2019 D614G dose double-blind Efficacy end point enrolled foundation greater groups HIV HIV-negative Human immunodeficiency virus incidence laboratory-confirmed less median age Melinda Gate Mild-to-moderate multicenter Neutralization assay Pan participant Placebo placebo recipient placebo recipients Population primary end point primary end-point pseudovirus randomized, controlled trial receive recipient registry Result SARS-CoV-2 SARS-CoV-2 variant second dose Serious Adverse Event serum sample show protection against Sodium chloride South Africa symptomatic tested the vaccine two-dose regimen Vaccine variant viral particle virus
[DOI] 10.1056/NEJMoa2102214 PMC 바로가기 [Article Type] Clinical Trial

Molecular Analysis of SARS-CoV-2 Genetic Lineages in Jordan: Tracking the Introduction and Spread of COVID-19 UK Variant of Concern at a Country Level

Article

Published on 2021-03-052022-10-28
Journal: Pathogens [Category] COVID-19,

[키워드] acute respiratory syndrome amino acid substitution Analyzer B.1.1.7 B.1.1.7 lineage Bayesian Bayesian analysis Clustering collected concern coronavirus country COVID-19 COVID-19 case D614G Deleterious Effect Epidemiology Evolution Genetic genetic variability highest increase in Infection introduced investigated Jordan Level likelihood Lineage lineages manifested middle-income country molecular Mutation Non-synonymous mutation Phylogenetic Phylogenetic analysis proportion PROVEAN resulting SARS-CoV-2 SARS-CoV-2 mutant SARS-CoV-2 sequence spike gene spike glycoprotein Spread Substitution synonymous UK variant variant variant of concern
[DOI] 10.3390/pathogens10030302 PMC 바로가기 [Article Type] Article

Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance

면역글로불린 G, M 또는 A 스파이크 혈청 분석 성능에 대한 D614G 스파이크 변이체의 효과

Article

Published on 2021-03-032022-09-11
Journal: The Journal of Infectious Diseases [Category] SARS, 변종, 진단,

The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2

SARS-CoV-2의 스파이크 당단백질 구조에 대한 D614G 치환 효과

423

Published on 2021-03-022022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 binding circulating conformation coronavirus cryo Cryo-electron microscopy cryo-EM D614G D614G substitution electron microscopy facilitate High-resolution initial isolate isolates majority membrane fusion mutant open opening priming promote reason reason for receptor receptor ACE2 reported required respiratory SARS-CoV-2 SARS-CoV-2 receptor severe acute respiratory syndrome Coronavirus Significance spike spike glycoprotein spike glycoproteins Spike protein Spike proteins spikes structural rearrangement Structure subsequent suggested the SARS-CoV-2 the spike protein variant Viral viral membrane virus virus infectivity viruses
[DOI] 10.1073/pnas.2022586118 PMC 바로가기 [Article Type] 423

D614G and SARS-CoV-2 replication fitness

D614G 및 SARS-CoV-2 복제 적합성

Comment

Published on 2021-03-012022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종,

[키워드] D614G Infectious diseases SARS-CoV-2 replication Vaccines
[DOI] 10.1038/s41392-021-00498-3 PMC 바로가기 [Article Type] Comment

Emergence of European and North American mutant variants of SARS-CoV-2 in South-East Asia

동남아시아에서 SARS-CoV-2의 유럽 및 북미 돌연변이 변이의 출현

Article

Published on 2021-03-012022-09-11
Journal: Transboundary and emerging diseases [Category] SARS, 변종,

[키워드] Alter analysed Asia Asian characterized circulating conditions country COVID-19 COVID-19 pandemic D614G death distribution analysis dominant emergence Europe European Frequency Genome genome sequence GISAID group high temperature Humidity incidence rate India indicate Infection insight majority maximum-likelihood Multiple sequence alignment multiple sequence alignments mutant Mutation mutations non-structural protein Non-synonymous Non-synonymous mutation North North America P323L performed Phylogenetic analysis Phylogeny platform Prevalence prevalent Protein RdRP responsible SARS-CoV-2 SARS-CoV-2 coronavirus Spike protein Spread strain Strains subgroup subtropical Transmission routes unique variant variants of SARS-CoV-2 viral strain virus
[DOI] 10.1111/tbed.13748 PMC 바로가기 [Article Type] Article

Functional and Structural Characterization of SARS-Cov-2 Spike Protein: An In Silico Study

Original Article

Published on 2021-03-012022-10-31
Journal: Ethiopian Journal of Health Sciences [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome B-cell B-cell epitopes bioinformatics characterization CLC coronavirus coronavirus disease country D614G defined disulfide bond ENCODE feature functional glycosylation immunological in silico indicated Mutation NCBI GenBank outbreak pandemic Phosphorylation phosphorylation sites physicochemical physicochemical property Postmodification predict predicted Prevalence provided Registered Result retrieved SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein secondary sequence spike Spike protein structural proteins Structure the spike protein translate Vaccine Vaccines WHO
[DOI] 10.4314/ejhs.v31i2.2 PMC 바로가기 [Article Type] Original Article

SARS-CoV-2 spike D614G change enhances replication and transmission

Research

Published on 2021-02-262022-10-05
Journal: Nature [Category] SARS, 변종, 유전자 메커니즘,