Drug repurposing – Page 31 – Communicable Diseases Research

Network bioinformatics analysis provides insight into drug repurposing for COVID-19

Research article

Published on 2021-06-012022-10-05
Journal: Medicine in Drug Discovery [Category] 신약개발, 치료제,

Drug repurposing: new strategies for addressing COVID-19 outbreak

Review

Published on 2021-06-012023-07-12
Journal: Expert review of anti-infective therapy [Category] SARS,

[키워드] antivirals clinical trials Drug repurposing molecular docking plasma therapy SARS-COV-2 infection
[DOI] 10.1080/14787210.2021.1851195 [Article Type] Review

The pulmonary route as a way to drug repositioning in COVID-19 therapy

Review article

Published on 2021-06-012022-10-05
Journal: Journal of Drug Delivery Science and Technology [Category] 신약개발, 치료제,

SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective

SARS-CoV-2 RNA 의존성 RNA 중합효소(RdRp) 표적화: 인 실리코 관점

Article

Published on 2021-06-012022-09-11
Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, 치료제,

[키워드] Affect anti-viral drug Anti-viral drugs approved drug binding binding affinity build cefuroxime clinically Compound COVID-19 derivative docking drug drug candidates Drug repurposing Effectiveness Efficacy Favipiravir Galidesivir Health Health crisis help Hydroxychloroquine IDX-184 in silico include inhibit SARS-CoV-2 inhibitor molecular molecular docking molecular dynamics Molecular dynamics simulation must New nucleotide Perspective Proteins punch RdRP reduce Remdesivir ribavirin RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 RdRp SARS-CoV-2 RNA Setrobuvir sofosbuvir tenofovir the SARS-CoV-2 Treatment viral infection viral infections Viral protein
[DOI] 10.1080/07391102.2020.1761882 PMC 바로가기 [Article Type] Article

Virtual screening of peptides with high affinity for SARS-CoV-2 main protease

SARS-CoV-2 주요 프로테아제에 대한 높은 친화도를 갖는 펩타이드의 가상 스크리닝

Article

Published on 2021-06-012022-09-11
Journal: Computers in biology and medicine [Category] SARS, 신약개발, 치료제,

Rifampicin and Letermovir as potential repurposed drug candidate for COVID-19 treatment: insights from an in-silico study

COVID-19 치료를 위한 잠재적인 용도 변경 약물 후보로서의 Rifampicin 및 Letermovir: in-silico 연구의 통찰력

Article

Published on 2021-06-012022-09-11
Journal: Pharmacological Reports [Category] SARS, 신약개발, 치료제,

[키워드] acute respiratory distress acute respiratory distress syndrome Analysis approach ARDS binding affinity caused clinical trials Combination Compound COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients COVID-19 treatment Cytokine storm docking study drug drug candidate Drug repurposing examined FDA approved drug FDA approved Drugs free energy Free energy calculations high viral load host immune system hour identify IL-1β IL-6 in vitro in-silico inhibit involved Letermovir Lung function M pro Main protease Mpro medical emergency molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations multiple organ failure outcome protease provide respiratory distress Respiratory distress syndrome rifampicin SARS-CoV-2 SARS-CoV-2 main protease selected subsequent supported surface area syndrome the cytokine storm the SARS-CoV-2 these compounds TNF-α Treatment Viral load Virtual screening was performed
[DOI] 10.1007/s43440-021-00228-0 PMC 바로가기 [Article Type] Article

Bioactive Molecules of Tea as Potential Inhibitors for RNA-Dependent RNA Polymerase of SARS-CoV-2

Medicine

Published on 2021-05-312022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Promising drug repurposing approach targeted for cytokine storm implicated in SARS-CoV-2 complications

Review

Published on 2021-05-312023-06-15
Journal: Immunopharmacology and immunotoxicology [Category] MERS, SARS,

[키워드] complications COVID-19 Cytokine storm Drug repurposing Pathogenesis
[DOI] 10.1080/08923973.2021.1931302 PMC 바로가기 [Article Type] Review

A Review of Repurposed Cancer Drugs in Clinical Trials for Potential Treatment of COVID-19

Review

Published on 2021-05-302022-10-28
Journal: Pharmaceutics [Category] COVID-19,

Identification of SARS-CoV-2 Receptor Binding Inhibitors by In Vitro Screening of Drug Libraries

약물 라이브러리의 체외 스크리닝에 의한 SARS-CoV-2 수용체 결합 억제제의 식별

Article

Published on 2021-05-272022-09-10
Journal: Molecules [Category] SARS, 신약개발, 치료제,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Analysis angiotensin angiotensin-converting enzyme 2 (ACE2), high-throughput screening approach binding binding site Cell compounds coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapy described docking drug drug library Drug repurposing effective Efficacy ellagic acid enzyme global pandemic heparin sodium human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 IC50 identification identify in vitro inhibitor inhibitors Interaction library molecular docking analysis RBD RBD-ACE2 Receptor binding domain receptor binding domain (RBD) reduction respiratory responsible Safe SARS-CoV-2 SARS-CoV-2 RBD Screening severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 small molecule inhibitors (SMIs) sodium Spike protein the RBD the SARS-CoV-2 therapy these compound these compounds Vero E6 Vero E6 cell VERO E6 cells Viral viral infection virus virus spike protein
[DOI] 10.3390/molecules26113213 PMC 바로가기 [Article Type] Article