Numbers and phenotype of non-classical CD14dimCD16+ monocytes are predictors of adverse clinical outcome in patients with coronary artery disease and severe SARS-CoV-2 infection비고전적 CD14dimCD16+ 단핵구의 수와 표현형은 관상동맥 질환 및 중증 SARS-CoV-2 감염 환자에서 불리한 임상 결과의 예측인자입니다Article Published on 2021-01-012022-08-31 Journal: Cardiovascular Research [Category] 바이오마커, 진단, [키워드] acute SARS-CoV-2 infection adhesion Admission assessment Blood blood sampling CAD CD14 CD80 classical monocytes clinical assessment Clinical outcome Cohort Complication consecutive patient Coronary artery Coronary artery disease CX3CR1 Decreased decreased expression defined echocardiography Electrocardiography Endpoint Follow-up healthy control healthy controls help HLA-DR identify immune response Immuno-response index Infection infections Kaplan-Meier Kaplan-Meier curve Kaplan-Meier curves life-threatening log-rank Lung injury marker mechanical ventilation median Migration monocyte Monocytes non-classical monocyte Non-classical monocytes number Occurrence participant Patient Peripheral blood phenotype Phenotypes predictor prognostic progressive respiratory failure prospectively studied reached respiratory Respiratory failure risk risk assessments SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients severe SARS-CoV-2 significantly more stratified subsequent T-cell activation the median [DOI] 10.1093/cvr/cvaa328 PMC 바로가기 [Article Type] Article
Targeting the NO-cGMP-PDE5 pathway in COVID-19 infection. The DEDALO projectCOVID-19 감염에서 NO-cGMP-PDE5 경로를 표적으로 합니다. 데달로 프로젝트Article Published on 2021-01-012022-09-11 Journal: Andrology [Category] SARS, 임상, 치료제, [키워드] acting activated T cells administration alveolar ANG-II anti-inflammatory response biological drug biological drugs cause Cell cGMP clinical trial clotting Complication complications of COVID-19 contraindication contraindications COVID-19 COVID-19 disease COVID-19 infection cyclic GMP cytokine cytokine release Cytokine storm Cytokines diabete diabetes Diabetes Mellitus Diabetic diffusion disease downregulation drug dysregulation endothelial Endothelial cell endothelial cell damage Evidence expressed favor fibrosis IL-6 immune system implication IMPROVE infiltration inhibiting interstitial interstitial pneumonia limit Liver function low-grade inflammation Lungs material men mesenchymal cells Metabolic diseases modulating monocyte Necrosis nitric oxide Numerous offer ongoing trial ongoing trials outbreak oxygen pandemic pathophysiology pathway Patient patients with COVID-19 PDE5 inhibitor PDE5 inhibitors performed positive presenting pro-inflammatory cytokines pulmonary artery pulmonary fibrosis raise reducing renal impairment resource respiratory respiratory infection responsible severe COVID-19 disease Sildenafil smooth muscle smooth muscle cell smooth muscle cells stability storm switching systematic review systemic disease T cells targeting temperature thrombotic Thrombotic complications transition type 2 diabete Type 2 diabetes mellitus Vascular vessel widespread [DOI] 10.1111/andr.12837 PMC 바로가기 [Article Type] Article
Elevated plasma sTIM-3 levels in patients with severe COVID-19중증 COVID-19 환자의 혈장 sTIM-3 수치 상승Clinical Trial Published on 2021-01-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 임상, [키워드] activated Activated neutrophils activated T cell activated T cells Activation analyzed association CD25 Clinical outcome coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 infection disease severity disorder downregulation dysregulation examined Exhaustion fraction high plasma level high plasma levels Hospital admission ICU ICU treatment immune activation immune dysregulation Immunoglobulin Infection intensive care intensive care unit leukocyte macrophage activation marker monocyte mucin myeloperoxidase N-terminal N-terminal pro-B-type natriuretic peptide neutrophil neutrophil activation Neutrophils outcome oxygen parameter Pathogenesis pathogenesis of COVID-19 Patient peptide plasma Plasma levels positively correlated pro-B-type natriuretic peptide Respiratory failure severe COVID-19 subset T cell T cells T-cell T-cell activation TIM-3 Treatment [DOI] 10.1016/j.jaci.2020.09.007 PMC 바로가기 [Article Type] Clinical Trial
The role of chest CT in management of asymptomatic SARS-CoV-2 infections: A longitudinal multi-center study in Chongqing, China무증상 SARS-CoV-2 감염 관리에서 흉부 CT의 역할: 중국 충칭의 다기관 종단 연구Multicenter Study Published on 2021-01-012022-09-12 Journal: International Journal of Medical Sciences [Category] 진단, [키워드] Abnormalities analyzed Asymptomatic asymptomatic infection asymptomatic infections Chest CT chest CT scan China Chongqing clinical Clinical data clinical feature condition consolidation COVID-19 CT scan CT scans enrolled Evidence Evolution exhibited feature Follow-up GGO group groups individual involved longitudinal lung management Manifestations men Mild monocyte monocyte count Multiple outcome PCR tests positive positive result progression Radiographic RT-PCR testing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 RT-PCR test severe pneumonia Significant significant difference significant differences Society the median women [DOI] 10.7150/ijms.50705 PMC 바로가기 [Article Type] Multicenter Study
Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19사이토카인 폭풍의 특성은 COVID-19의 과염증성 내피 기능 장애를 반영합니다Article Published on 2021-01-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADP-ribose Adult patients age Analysis analyzed assays association attenuate Baricitinib Biomarker Biomarkers blood sample Blood samples cardiovascular cardiovascular disease characterization characterized circulating circulation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CXCL10 CXCL5 CXCL9 cytokine Cytokine storm Cytokine storms disease severity dominant dysregulation endothelial damage Endothelial dysfunction healthy control healthy controls help host inflammatory response host response Hyperinflammatory identify IFN-γ IL-10 IL-1ra IL-6 immune response immune responses increasingly Infection Inflammation Intervention marker MCP-3 mechanism Mild moderate monocyte observé Ordinal Scale Pathogenesis Patient patients hospitalized patients with COVID-19 physician platform polymerase Protein proteomic pursuit reduce reflect Regulation reliability reproducibility respiratory Result scale severe acute respiratory syndrome Coronavirus Spectrum statistically significant stratified the cytokine storm therapeutic options Vascular with COVID-19 [DOI] 10.1016/j.jaci.2020.08.031 PMC 바로가기 [Article Type] Article
Mismatch between circulating cytokines and spontaneous cytokine production by leukocytes in hyperinflammatory COVID-19과염증 COVID-19에서 백혈구에 의한 순환 사이토카인과 자발적 사이토카인 생산 간의 불일치Clinical Trial Published on 2021-01-012022-09-12 Journal: Journal of leukocyte biology [Category] MERS, 임상, 진단, [키워드] activated Activation analyzed blockade cellular circulating cytokine circulating leukocyte contribute Control controls COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine production Cytokine storm cytokine storm, monocytes. Cytokines disease example flow cytometry healthy control healthy controls hyperinflammation Hyperinflammatory IL-1β IL-6 IL-8 immunoassay investigated leukocyte LPS lymphocyte mismatch monocyte Monocytes Patient patients with COVID-19 PBMC produced recruited Sepsis sepsis patient sepsis patients severe COVID-19 Support surface marker TNF Treatment university was used were measured worldwide pandemic [DOI] 10.1002/JLB.5COVBCR0720-310RR PMC 바로가기 [Article Type] Clinical Trial
SARS-CoV-2 infection induces mixed M1/M2 phenotype in circulating monocytes and alterations in both dendritic cell and monocyte subsetsSARS-CoV-2 감염은 순환 단핵구에서 혼합 M1/M2 표현형을 유도하고 수지상 세포 및 단핵구 하위 집합 모두에서 변경을 유도합니다Clinical Trial Published on 2020-12-312022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 바이오마커, 임상, 진단, [키워드] activated Activation adoptive immunity alteration Analysis B lymphocytes Cell center circulating monocyte clinical Clinical Center clinical manifestation clinical manifestations COVID-19 patient cytometric dendritic cell dendritic cells event expressed Flow Flow cytometric analysis functional highlight Immunity immunological indicated induce Innate immunity less low expression lymphocyte Lymphocytes M1 and M2 monocytes M2 marker M2 monocyte M2 monocytes marker Mild mild case mild cases Mild symptom mild symptoms monocyte Monocytes myeloid NK cell NK cells Patient Peripheral blood peripheral blood cell peripheral blood cells phenotype phenotypic preserved proportion recruited SARS-COV-2 infection severe cases severe disease severe symptom severity subset Symptom T and B lymphocytes the disease was performed [DOI] 10.1371/journal.pone.0241097 PMC 바로가기 [Article Type] Clinical Trial
Phosphatidylserine inside out: a possible underlying mechanism in the inflammation and coagulation abnormalities of COVID-19포스파티딜세린 인사이드 아웃: COVID-19의 염증 및 응고 이상에서 가능한 기본 메커니즘Review Published on 2020-12-272022-09-10 Journal: Cell Communication and Signaling : CCS [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Abnormalities abnormality ACE2 Activation Acute inflammation ADAM17 ADAMTS13 addition aggregation association biochemical C reactive protein cascade cause cell membrane clinical complication clinical complications Coagulation coagulation cascade coronavirus coronavirus disease COVID-19 COVID-19 pathophysiology Cytokines damage death DIC-COVID-19 EGFR Endothelial cell endothelial cells Endothelium explained expression extrinsic pathway factor VII Health humans IFN-γ IL-1β IL-6 IL-6R IL-8 immune induce infected cell Inflammation Inflammatory response inhibitory action involved management mechanism membrane monocyte pathophysiological pathophysiology Phosphatidylserine plasma Platelet Platelets pro-inflammatory cytokines pro-inflammatory molecule pro-inflammatory molecules SARS-CoV-2 Spread Support the cell the SARS-CoV-2 thrombi tissue Tissue Factor TNF-α Vascular Viral viral infection [DOI] 10.1186/s12964-020-00687-7 PMC 바로가기 [Article Type] Review
A distinct innate immune signature marks progression from mild to severe COVID-19뚜렷한 타고난 면역 신호는 경증에서 중증 COVID-19로의 진행을 나타냅니다.Article Published on 2020-12-262022-09-11 Journal: Cell Reports Medicine [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] appearance CCL3 CCL4 CD16 CD169 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytometry emergency granulopoiesis healthy individuals identify IFN-γ immune responses immune signature Inflammation inflammatory phenotype Inflammatory response Inflammatory responses innate immune innate immune response innate response mass cytometry mechanism Mild mild COVID-19 patient mild COVID-19 patients mild or severe Covid-19 MIP1α monocyte Monocytes observé Patient progression proteomics sampling SARS-CoV-2 severe COVID-19 severe disease severe patients sialoadhesin sialoadhesin. signature Stage stages sustained symptom onset targeted intervention targeted interventions trajectory [DOI] 10.1016/j.xcrm.2020.100166 PMC 바로가기 [Article Type] Article
Imaging Mass Cytometric Analysis of Postmortem Tissues Reveals Dysregulated Immune Cell and Cytokine Responses in Multiple Organs of COVID-19 PatientsMicrobiology Published on 2020-12-232022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] accompanied alteration Antigen B cell CD11b CD11c controls coronavirus COVID-19 COVID-19 patient COVID-19 patients cytokine Cytometry dendritic cell evaluated expression IL-10 imaging imaging mass cytometry (IMC) Immune cell immune dysregulation immunosuppressive immunosuppressive cytokine infiltration Inflammatory response intestine involved kidney kidneys leukocyte liver liver tissues lung Lungs Macrophage mass monocyte Multiple natural killer Necrosis not express organ organ specific response Pathogenesis patients with COVID-19 Postmortem postmortem tissues pro-inflammatory prognostic response spleen suggested T cell therapeutic target TNF-α [DOI] 10.3389/fmicb.2020.600989 PMC 바로가기 [Article Type] Microbiology