monocyte – Page 32 – Communicable Diseases Research

Increased expression of hypoxia-induced factor 1α mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patients

Research Article

Published on 2020-12-212022-10-28
Journal: Annals of Medicine [Category] COVID-19,

A Potent SARS-CoV-2 Neutralizing Human Monoclonal Antibody That Reduces Viral Burden and Disease Severity in Syrian Hamsters

시리아 햄스터의 바이러스 부담과 질병 중증도를 감소시키는 강력한 SARS-CoV-2 중화 인간 단일클론 항체

Immunology

Published on 2020-12-182022-09-12
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단,

COVID-19 experience of the major pandemic response center in the capital: results of the pandemic’s first month in Turkey

수도에 있는 주요 팬데믹 대응 센터의 COVID-19 경험: 터키에서 팬데믹 첫 달의 결과

Article

Published on 2020-12-172022-08-31
Journal: Turkish Journal of Medical Sciences [Category] MERS, 바이오마커, 진단,

[키워드] acute respiratory illness Admission age Anosmia Bilateral chronic obstructive chronic obstructive pulmonary disease city Clinical characteristics Clinical course cohort study Comorbidity Coronary artery Coronary artery disease COVID-19 COVID-19 case COVID-19 cases COVID-19 patient COVID-19 patients Critical disease disease elevated elevated liver enzymes Enzymes epidemiological Epidemiology evaluate ferritin Fever GFR ground-glass opacity Hospitalized IL-6 illness onset increased risk infiltration liver liver enzymes loss of taste lymphocyte material median time monocyte Mortality mortality rate neutrophil obstructive pulmonary disease Older Older age on admission pandemic parameter patchy patients Platelet Platelet count positive patient predictor Prognosis pulmonary disease respiratory Result reveal SARI SARS-CoV-2 PCR severe disease significantly higher Symptoms Taste Turkey
[DOI] 10.3906/sag-2006-164 PMC 바로가기 [Article Type] Article

Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators

지질 방울은 SARS-CoV-2 복제 및 염증 매개체 생성을 촉진합니다

Research Article

Published on 2020-12-162022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 치료법,

[키워드] addition Analysis Antiviral biosynthetic CD36 Cell cell death cellular metabolism complex component contribute COVID-19 COVID-19 pandemic COVID-19 patient demonstrated described develop disease donors double-stranded droplet effort electron microscopy energy homeostasis ENhance enzyme expression function homeostasis Host host cell host cells host immunity human cell lines infected cells Infection Inflammation inflammatory mediator inhibited LDs Lipid lipid droplet lipid droplets lipid metabolism mechanism mediator mediators metabolism modulate modulation monocyte Monocytes organelle parasite Pathogenesis pathway Pathways Perspective pharmacological platform PPARγ pro-inflammatory response Protein recruit recruited reduce reduced Regulation Replication RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 replication SARS-CoV2 SARS-CoV2 infection significantly Support target therapeutic intervention Therapeutic strategies therapeutic strategy Transport triggered Vero Cell Vero cells Viral viral particle Viral particles viral replication virus virus replication viruses
[DOI] 10.1371/journal.ppat.1009127 PMC 바로가기 [Article Type] Research Article

Recombinant SARS-CoV-2 Spike Protein Mediates Glycolytic and Inflammatory Activation in Human Monocytes

Abstracts

Published on 2020-12-162022-10-30
Journal: Innovation in Aging [Category] COVID-19,

[키워드] ACE2 receptor activate Activation acute respiratory syndrome cause caused cell lysate Contamination coronavirus disease Coronavirus-2 COVID-19 cytokine production Cytokine storm Donor Efficacy ELISA endotoxin Evidence Extracellular facilitate Glycolysis healthy human monocyte human monocytes Immune cell increase in Inflammation Inflammatory Inflammatory response Interaction interleukin-6 investigated marrow-derived macrophage metabolic monocyte mouse processed Protein protein expression qPCR Rapamycin recombinant SARS-CoV-2 SARS-CoV-2 spike protein Seahorse spike stimulated subunit the spike protein treating COVID-19 upregulation
[DOI] 10.1093/geroni/igaa057.3493 PMC 바로가기 [Article Type] Abstracts

Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases

무증상, 경증 및 중증 사례의 SARS-CoV-2 감염에 대한 다양한 선천성 및 적응성 면역 반응

Clinical Trial

Published on 2020-12-162022-08-13
Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단,

[키워드] adaptive Adaptive immune response antibodies Antibody Response Asymptomatic asymptomatic individual Asymptomatic individuals B cells Clinical course clinical expression Clinical presentations Course COVID-19 COVID-19 cases COVID-19 disease eight excessive inflammation Follow-up Frequency healthy humans IgA IgG IgM immune responses Immunity Immunological studies Immunological study individual immune response infected cases Infection Innate innate and adaptive immunity innate and adaptiveimmune response kinetics of antibody memory Mild Mild COVID-19 disease Mild disease moderate to severe monocyte Monocytes NK cell NK cells Novel coronavirus organ damage Patient patients with moderate performed produced Protective protective immune response response SARS-CoV-2 SARS-CoV-2 illness SARS-COV-2 infection SARS-CoV-2-negative contact serological analysis severe COVID-19 severe COVID-19 disease severe disease short-lived Spectrum tissue tissues with mild disease
[DOI] 10.3389/fimmu.2020.610300 PMC 바로가기 [Article Type] Clinical Trial

Temporal changes in laboratory markers of survivors and non-survivors of adult inpatients with COVID-19

COVID-19 성인 입원 환자의 생존자와 비생존자의 실험실 마커의 시간적 변화

Comparative Study

Published on 2020-12-112022-08-31
Journal: BMC Infectious Diseases [Category] MERS, SARS, 바이오마커,

[키워드] acidity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 albumin albumin-globulin ratio alkaline phosphatase Analysis aspartate Aspartate aminotransferase base excess Bicarbonate Blood blood cell blood cell count C-reactive protein calcium carbon dioxide caused Cell changes changes in cholesterol cholinesterase Clinical characteristics clinician coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 creatine creatine kinase cystatin C D-dimer death Degradation Degradation product determine diagnosed with COVID-19 distribution eosinophil Eosinophil count estimated glomerular filtration rate Extracellular Extracellular fluid FIBRIN filtration rate fluorescent fraction glomerular filtration rate Glucose Haemoglobin high risk High-density lipoprotein High-density lipoprotein cholesterol Hospitalized hypersensitive C-reactive protein immature Inpatient International international normalized ratio Laboratory Laboratory test Laboratory tests Lactate lactate dehydrogenase lipoprotein cholesterol lymphocyte Lymphocyte count Magnesium marker mean platelet volume Mild monocyte Myoglobin neutrophil neutrophil count nitrogen non-survivor Non-survivors normalized occurred ogen outbreak Patient patient condition phosphatase phosphorus plasma plasma urea Platelet Platelet count platelet distribution width prealbumin procalcitonin progression Protein prothrombin Prothrombin time red blood cell red blood cell count Result SARS-CoV − 2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease significant difference significant differences significantly significantly increased sodium supplementary material survivor Temporal Temporal changes test results total calcium Total cholesterol total protein Treatment Triglyceride urea urea nitrogen uric acid variable variables Volume White blood cell white blood cell count width with COVID-19 Wuhan
[DOI] 10.1186/s12879-020-05678-0 PMC 바로가기 [Article Type] Comparative Study

Transcriptional Profiling of Immune and Inflammatory Responses in the Context of SARS-CoV-2 Fungal Superinfection in a Human Airway Epithelial Model

Article

Published on 2020-12-112022-10-29
Journal: Microorganisms [Category] COVID-19,

Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm

Observational Study

Published on 2020-12-092022-10-04
Journal: Science Advances [Category] MERS, 임상,

Early Phases of COVID-19 Are Characterized by a Reduction in Lymphocyte Populations and the Presence of Atypical Monocytes

Immunology

Published on 2020-12-092022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] 28-day mortality acute respiratory syndrome Admission association Atypical CD14 CD3+ CD4+ cell CD8+ Cell cells characterized composed coronavirus coronavirus disease COVID-19 Diagnosis died early phase evaluated expression HLA-DR Immune profile immune profiling immunological change include Infection Inflammation Inflammatory biomarker IQR lymphocyte lymphocytopenia mean value median value monocyte Monocytes mononuclear cell mononuclear cells natural killer pathogen patients patients with COVID-19 Peripheral blood Peripheral blood mononuclear cells phase Population Presence preserved reduced reduction responsible Result SARS-CoV-2 side scatter subpopulation
[DOI] 10.3389/fimmu.2020.560330 PMC 바로가기 [Article Type] Immunology