Recombinant Antigens Based on Non-Glycosylated Regions from RBD SARS-CoV-2 as Potential Vaccine Candidates against COVID-19Article Published on 2021-08-202022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] animal model antibody Antigen candidate candidate vaccine controls coronavirus 2 COVID-19 COVID-19 patients determine Escherichia coli expressed glycosylated glycosylation glycosylation site highlight Host immune response Hypothesis IgG antibody immunized immunogenic potential limit mice Neutralizing activity neutralizing antibody not carry Patient polyclonal antibody Potential Prokaryotic expression Protein protein region purified raise RBD Receptor binding domain recombinant Region Research residue respiratory S-RBD SARS-CoV-2 selected sera serum Spike protein strong immune response the Spike Vaccine viral glycosylation [DOI] 10.3390/vaccines9080928 PMC 바로가기 [Article Type] Article
Anti-SARS-CoV-2 Antibody Levels Measured by the AdviseDx SARS-CoV-2 Assay Are Concordant with Previously Available Serologic Assays but Are Not Fully Predictive of Sterilizing ImmunityAdviseDx SARS-CoV-2 분석으로 측정된 항-SARS-CoV-2 항체 수준은 이전에 사용 가능한 혈청학적 분석과 일치하지만 살균 면역을 완전히 예측하지는 못합니다Article Published on 2021-08-182022-09-11 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 변종, 진단, 치료기술, 치료법, [키워드] 95% confidence interval Abbott Abbott Architect anti-SARS-CoV-2 anti-SARS-CoV-2 antibody Anti-spike antibody assay Antigen antigen binding Architect binding Breakthrough infection can not Characteristics clinical sensitivity concordant coronavirus correlates of protection COVID-19 demonstrated described Elecsy ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Euroimmun examined Factor fishing vessel FIVE Genscript Health care Health care worker healthy humoral Humoral response Immunoglobulin in vitro increasingly individual International international standard international units investigated Level median Neutralizing activity no significant difference outbreak Patient PCR peaked performed positive predicted Protective Protein Quantitative required Roche SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 vaccination seroconverting serologic Serological testing serology seropositive spike IgG Spike protein symptom onset vaccinated individuals vaccination Vaccine vaccine dose variants variants of concern vessel virus neutralization assay WHO widespread wild-type SARS-CoV-2 [DOI] 10.1128/JCM.00989-21 PMC 바로가기 [Article Type] Article
Pharmacokinetics and Safety of XAV-19, a Swine Glyco-humanized Polyclonal Anti-SARS-CoV-2 Antibody, for COVID-19-Related Moderate Pneumonia: a Randomized, Double-Blind, Placebo-Controlled, Phase IIa StudyCOVID-19 관련 중등도 폐렴에 대한 돼지 당-인간화 다클론성 항-SARS-CoV-2 항체인 XAV-19의 약동학 및 안전성: 무작위 배정, 이중 맹검, 위약 대조, IIa상 연구Clinical Trial Published on 2021-08-172022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] SARS, 비임상, 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration adverse event adverse events anti-SARS-CoV-2 antibody antibody baseline characteristics body weight breath C max Characteristics Concentration concentrations coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated drug during treatment enrolled evaluate group hypersensitivity IIa in vitro infusion inhibitory concentration intravenous dose maximum serum concentration median moderate Neutralizing activity optimal dose Patient Perfusion pharmacokinetics phase phase IIa Placebo Pneumonia polyclonal polyclonal antibody polyclonal glyco-humanized anti-SARS-CoV-2 antibody. Predictive Randomized reaction receive Registered reported Safety SARS-CoV-2 Serious Adverse Event Serious Adverse Events serum serum concentrations severe acute respiratory syndrome Coronavirus study drug Tolerability Treatment Trial XAV-19 [DOI] 10.1128/AAC.01237-21 PMC 바로가기 [Article Type] Clinical Trial
Delayed neutralizing antibody response in the acute phase correlates with severe progression of COVID-19급성기에서 지연된 중화 항체 반응은 COVID-19의 심각한 진행과 관련이 있습니다.Article Published on 2021-08-162022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immunity Admission analyzed antibodies chemiluminescence collected coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient Critical disease Delayed different time points disease disease severity Hospitalization moderate moderate disease NAb nAb response NAbs neutralization neutralization activity neutralization test Neutralizing activity neutralizing antibody Neutralizing antibody response on admission pathology Patient patients patients with moderate progression Pseudotyped virus reduction respiratory SARS-CoV-2 SARS-CoV-2 pseudotyped virus serum serum sample severe acute respiratory syndrome Coronavirus significantly higher symptom onset symptomatic viral infection were measured [DOI] 10.1038/s41598-021-96143-8 PMC 바로가기 [Article Type] Article
An enveloped virus-like particle vaccine expressing a stabilized prefusion form of the SARS-CoV-2 spike protein elicits highly potent immunitySARS-CoV-2 스파이크 단백질의 안정화된 예비융합 형태를 발현하는 외피 바이러스 유사 입자 백신은 매우 강력한 면역을 유도합니다Article Published on 2021-08-162022-09-12 Journal: Vaccine [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome adjuvant aluminum Antibody binding clinical evaluation Coronavirus disease 2019 Coronavirus-2 COVID-19 effort elicit evaluated expressing form Formulation identify IgG1 IgG2 Immunity immunization immunogenicity injection isotype mice neutralization titer Neutralizing activity Neutralizing antibodies phosphate prefusion SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 spike protein selected single dose Spike protein Support Syrian golden hamster the SARS-CoV-2 Vaccine vaccine candidate Virus-like particle virus-like particle vaccine Virus-like-particles. [DOI] 10.1016/j.vaccine.2021.07.034 PMC 바로가기 [Article Type] Article
Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants다양하고 전염성이 높은 SARS-CoV-2 변이체에 대한 초강력 항체Article Published on 2021-08-132022-09-11 Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, 진단, [키워드] antibodies antibody B.1.1.7 B.1.351 B.1.429 B.1.526 B.1.617 binding Combination combinations convalescent decrease determinant Donor escape mutants functional highlight in vitro inhibitory concentration milliliter neutralization titer Neutralizing activity P.1 reactive Receptor binding SARS-CoV-2 variant therapeutic therapeutic antibodies variants VOCs [DOI] 10.1126/science.abh1766 PMC 바로가기 [Article Type] Article
Plant-Produced Glycosylated and In Vivo Deglycosylated Receptor Binding Domain Proteins of SARS-CoV-2 Induce Potent Neutralizing Responses in MiceArticle Published on 2021-08-122022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 antibody antigens Antiviral binding caused country COVID-19 COVID-19 pandemic elicited enzyme global public health glycosylated greater high risk immunized in vivo knowledge mice monoclonal antibody Neutralizing activity Nicotiana benthamiana plant potent prevention of COVID-19 produced Protein purification purified RBD RBD antigen RBD protein RBD proteins RBD-specific antibody reactivity receptor Receptor binding domain receptor binding domain (RBD) vaccine response Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 vaccines Spike protein spread to Support the SARS-CoV-2 therapeutic drug transient expression system vaccine candidate vaccine candidates virus-neutralizing [DOI] 10.3390/v13081595 PMC 바로가기 [Article Type] Article
Recombinant chimpanzee adenovirus AdC7 expressing dimeric tandem-repeat spike protein RBD protects mice against COVID-19Research Article Published on 2021-08-122022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] Adenovirus Adenovirus-vectored vaccine administration antibody Antibody Response approved Bronchoalveolar lavage fluid cellular immune responses circulating variants COVID-19 COVID-19 pandemic COVID-19 vaccine delta variant dimeric domain effective elicit expressing humoral immune response Immunity immunogenic intramuscular intranasal route lung Lung injury mice mucosal Neutralizing activity preserved PROTECT Protein RBD recombinant recombinant chimpanzee adenovirus RNA Safe SARS-CoV-2 sera spike protein RBD Support undetectable vaccination Vaccine [DOI] 10.1080/22221751.2021.1959270 PMC 바로가기 [Article Type] Research Article
Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variantsCOVID-19 회복기 개인에서 중화 항체의 일시적 성숙은 순환하는 SARS-CoV-2 변이체의 효능과 폭을 향상시킵니다Article Published on 2021-08-102022-09-11 Journal: Immunity [Category] MERS, SARS, 변종, 진단, [키워드] 501Y.V2 Affect Affinity maturation analyzed antibody Antibody Response Antibody titer Antibody titers B.1.351 breadth circulating SARS-CoV-2 variant circulating variants convalescent convalescent individual convalescent plasma COVID-19 cross-neutralizing cross-neutralizing antibodies cross-neutralizing antibody declining examined exhibited IgG antibodies IgG antibody IMPROVE Longitudinal evaluation maturation neutralization assays neutralization potency Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody P.1 persistence plasma RBD IgG reactivity Receptor binding domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants of concern specific IgG antibodies Temporal the antibody response variants variants of concern virus viruses VOCs [DOI] 10.1016/j.immuni.2021.06.015 PMC 바로가기 [Article Type] Article
A Single-Cycle Influenza A Virus-Based SARS-CoV-2 Vaccine Elicits Potent Immune Responses in a Mouse ModelArticle Published on 2021-08-032022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 5′ UTR Antigen antigenic C-terminus Cell Cell-mediated immunity chimeric cytoplasmic demonstrated domain elicited exhibited expressed expressing Frame gene encoding hosts humoral immune response immunized increasingly infected cell Influenza Influenza virus inoculated MDCK cell Model mouse mucosal Neutralizing activity ORF passages peptide-based platform potent prime-boost regimen producing Protein Pseudotyped virus RBD response robust SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccine sera Seven single-cycle influenza virus-based vaccine spike RBD spike-pseudotyped virus the RBD the SARS-CoV-2 the vaccine Vaccine Vaccine development variants virus [DOI] 10.3390/vaccines9080850 PMC 바로가기 [Article Type] Article