Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cellArticle Published on 2021-06-232023-06-15 Journal: Cell Reports [Category] MERS, SARS, [키워드] ACE2-independent Clathrin-mediated endocytosis COVID-19 heparan sulfate proteomics RIG-I-like receptors SARS-CoV-2 spike variants type I interferon Virus-host interactions [DOI] 10.1016/j.celrep.2021.109364 PMC 바로가기 [Article Type] Article
Temporal proteomic changes induced by nicotine in human cells: A quantitative proteomics approach인간 세포에서 니코틴에 의해 유발된 시간적 단백질체 변화: 정량적 단백질체학 접근법Article Published on 2021-06-152022-09-11 Journal: Journal of proteomics [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] A549 A549 cell line A549 cell lines affected alteration approach association biological processe Cancer cell line change changes in complement complement system complex compounds concerning COVID19 dataset decrease diabetes disease Diseases Effect event FAIMS heart disease host protein immune pathways implication in vitro in vivo Infection mitochondrial Nicotine Phosphorylation Protein protein-protein interactions proteome proteomes proteomic proteomics public health quantified Quantitative Real time search reported RTS SARS-CoV2 SH-SY5Y smoke smoking smoking cessation stroke susceptibility susceptibility to infection Temporal TMTpro. Tobacco Treatment type 2 diabetes Viral protein Viral proteins [DOI] 10.1016/j.jprot.2021.104244 PMC 바로가기 [Article Type] Article
Integrating Proteomics for Facilitating Drug Identification and Repurposing During an Emerging Virus PandemicArticle Published on 2021-06-112023-07-12 Journal: ACS Infectious Diseases [Category] SARS, [키워드] COVID-19 Drug repurposing emerging viruses kinase inhibitors kinome Pandemics proteomics SARS-CoV-2 [DOI] 10.1021/acsinfecdis.0c00579
Unbiased Analysis of Temporal Changes in Immune Serum Markers in Acute COVID-19 Infection With Emphasis on Organ Failure, Anti-Viral Treatment, and Demographic Characteristics장기 실패, 항 바이러스 치료 및 인구 통계 학적 특성에 중점을 둔 급성 코비드 -19 감염에서 면역 혈청 마커의 시간적 변화에 대한 편견없는 분석Immunology Published on 2021-06-112022-08-31 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, [키워드] 48 hour 48 hours Admission age analyzed Biomarker Biomarkers CCL23 CD28 change chemokine chemokines collected condition convalescent plasma correlated Course COVID-19 COVID-19 admission Deceased decorin demographic demographics demonstrated elevated failure GzmB heterogeneity Hydroxychloroquine ICU identification IL-15 IL-18 immune immunological increased expression individual kidney Kidney failure lack LAG3 LAMP3 ligands Longitudinal studies MCP MCP-1 MCP-3 monocyte Mortality Older age pathology pleiotrophin positively correlated programmed death Protein proteomics remdesavir Remdesivir respiratory serum serum levels Serum Marker Seven severity of COVID-19 steroid Steroids target Temporal the disease therapeutic TNFRSF21 Variation VEGF with COVID-19 [DOI] 10.3389/fimmu.2021.650465 PMC 바로가기 [Article Type] Immunology
Rintatolimod Induces Antiviral Activities in Human Pancreatic Cancer Cells: Opening for an Anti-COVID-19 Opportunity in Cancer Patients?Article Published on 2021-06-092022-10-31 Journal: Cancers [Category] COVID-19, [키워드] activated activating activity adaptive immune system additional treatment option Anti-viral Antiviral effect block cancer patient cascade cells chemokine cytokine Cytokines death demonstrated epidemiological epithelial epithelial cancerous cells epithelial cells expression fibrosis Gene expression profiling Human independent induce infected with SARS-CoV-2 Infection innate immune system interferon signaling opening opportunity outcome overexpression pancreatic cancer cell pathway patients with COVID-19 Prevent producing proteomics Rintatolimod RNase RNase L SARS-CoV-2 SARS-COV-2 infection severity signaling pathway simple Specific Spread stimulated the disease the interferon TLR3 Toll-like receptor 3 treat Treatment treatment for COVID-19 treatment regimen uninfected USA virus replication was measured [DOI] 10.3390/cancers13122896 PMC 바로가기 [Article Type] Article
Integrating longitudinal clinical laboratory tests with targeted proteomic and transcriptomic analyses reveal the landscape of host responses in COVID-19Article Published on 2021-06-082022-10-04 Journal: Cell Discovery [Category] 바이오마커, 변종, 진단, 치료제, [키워드] addition alveolar epithelial cells Alveolar macrophages Analysis blood cell bronchoalveolar cause Cell signalling characterized conditions coronavirus disease Course COVID-19 cytokine diagnostics Disease progression elevated events Factor gene regulatory network host response host responses immunology indicate Integrative analysis Laboratory test Laboratory tests lung lymphocytopenia microenvironment monocyte organ pathophysiology Patient Peripheral blood proteomes proteomic proteomics provide Shanghai systemic immune response therapy Transcriptome transcriptomic [DOI] 10.1038/s41421-021-00274-1 PMC 바로가기 [Article Type] Article
Bioinformatics Accelerates the Major Tetrad: A Real Boost for the Pharmaceutical IndustryReview Published on 2021-06-082022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] addressed Analysis approach association bioinformatics COVID-19 database Diagnosis dimension disorders Drug discovery drug side effects genetics Genome sequencing genomic sequencing healthcare information Interpretation Major management manuscript Microbiology microRNA miRNA pandemic pharmaceutical pharmacovigilance promoted proteomics public health Research researcher Stratification Systems biology translational Treatment [DOI] 10.3390/ijms22126184 PMC 바로가기 [Article Type] Review
Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistanceArticle Published on 2021-06-072022-10-04 Journal: Nature Communications [Category] 변종, [키워드] antibiotic Antibiotic resistance Antibiotics antimicrobial antimicrobial agent antimicrobial resistance Antimicrobials approach Bacterial binding biological pathways catalytic combating develop Efficacy identify inhibit Metals molecular molecular mechanism molecular target MRSA offer Protein proteomics public health question silver Staphylococcus aureus susceptibility X-ray crystallography [DOI] 10.1038/s41467-021-23659-y PMC 바로가기 [Article Type] Article
Proteomics-Based Insights Into the SARS-CoV-2–Mediated COVID-19 Pandemic: A Review of the First Year of ResearchSARS-CoV-2 매개 COVID-19 팬데믹에 대한 Proteomics 기반 통찰력: 연구 첫해에 대한 검토Review Published on 2021-06-042022-09-10 Journal: Molecular & Cellular Proteomics : MCP [Category] MERS, 바이오마커, 비임상, 유전자 메커니즘, [키워드] ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody article Betacoronavirus biological system Biomarker Biomarkers caused China CK2, casein kinase II Community coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19, Coronavirus disease 2019 DDA, data-dependent acquisition death develop Diagnosis effort evidenced Factor feature focus Genome genome sequence glycome glycosylation Health help Host host cell host response human disease immune system Infection information initial insight Interaction MS NSP, nonstructural protein pandemic peer-reviewed Perspective PIKFyve, a FYVE finger–containing phosphoinositide kinase post-translational modification post-translational modifications PPI, protein–protein interaction PRM, parallel reaction monitoring probe Protein–protein interaction protein–protein interactions proteome proteomic proteomic study proteomics provide PTM, post-translational modification qPCR, quantitative PCR Qualitative Quantitative respiratory responses review robust SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 selected severe acute respiratory syndrome Coronavirus the disease Therapies tissue TMPRSS2, Transmembrane serine protease 2 TMT, tandem mass tag Transmissibility Viral viral infection virulence virus worldwide pandemic Year [DOI] 10.1016/j.mcpro.2021.100103 PMC 바로가기 [Article Type] Review
Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response자기소화 결핍 마우스 대식세포의 다중 단백질체 분석은 산화 스트레스 반응을 통한 향상된 항균 면역을 드러낸다.Article Published on 2021-06-042024-07-30 Journal: eLife [Category] 세균성이질, [키워드] autophagy macrophages mass spectrometry mouse Other oxidative damage proteomics Shigella flexneri [DOI] 10.7554/eLife.62320 PMC 바로가기