Investigation of discordant SARS-CoV-2 RT-PCR results using minimally processed salivaArticle Published on 2022-02-182022-10-04 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome Bioanalytical chemistry Confirmed coronavirus coronavirus disease COVID-19 COVID-19 infection detect Dilution false negative result false negative results Genome healthy heat-inactivated heterogeneous highlight Improvements investigation negative sample positive processed Saliva SARS-CoV-2 RT-PCR significantly viral infection Viral RNA volunteers [DOI] 10.1038/s41598-022-06642-5 PMC 바로가기 [Article Type] Article
Gut bacterial dysbiosis and instability is associated with the onset of complications and mortality in COVID-19Research Article Published on 2022-02-172022-10-31 Journal: Gut Microbes [Category] COVID-19, [키워드] 16S rRNA gene Analysis analyzed approaches Asymptomatic Bacteria Bacterial clinical parameter Cohort Complication complications contribute Control controls coronavirus correlated COVID-19 COVID-19 patient COVID-19 patients demonstrated diagnostic Disease progression disease severity Factor Faecalibacterium fecal Germany Gut gut microbiome highlight Hospitalization hospitalized patient intra-individual microbial Microbiome microbiota Mortality Occurrence Oral microbiome oral microbiota parameters Pneumonia profiles recruited recruitment Saliva SARS-CoV-2 Sequencing was performed [DOI] 10.1080/19490976.2022.2031840 PMC 바로가기 [Article Type] Research Article
ACE and ACE2 Gene Variants Are Associated With Severe Outcomes of COVID-19 in MenACE 및 ACE2 유전자 변이는 남성의 심각한 COVID-19 결과와 관련이 있습니다Immunology Published on 2022-02-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] 95%CI ACE ACE2 ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus addition adjusted affecting age association clinical manifestation clinical manifestations Clinical manifestations of COVID-19 coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 Critical Critical illness death develop diabetes diagnosed died disease severity DNA evaluated explain Factor genetic background Genetic variant genetic variants Genomic DNA Genotype genotyped High-resolution Host hypertension IMPROVE individual insertion/deletion involved Logistic regression analysis male men Mild obesity Odds ratio outcome outcomes oxygen oxygen supplementation pandemic Peripheral blood polymorphism Polymorphisms probes respiratory respond responsible reverse transcription PCR risk factor rs2285666 RT-PCR Saliva SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity severity of COVID-19 Sex single-nucleotide single-nucleotide polymorphism SNP study population T allele TaqMan type 2 diabetes Variability variant [DOI] 10.3389/fimmu.2022.812940 PMC 바로가기 [Article Type] Immunology
Ultrasensitive assay for saliva-based SARS-CoV-2 antigen detectionArticle Published on 2022-02-162023-07-08 Journal: Clinical chemistry and laboratory medicine [Category] COVID19(2023년), [키워드] electrochemiluminescence (ECL) immunoassay Mass testing nasopharyngeal (NP) swab Saliva SARS-CoV-2 sensitivity [DOI] 10.1515/cclm-2021-1142
Accuracy of Real-Time Polymerase Chain Reaction in COVID-19 PatientsCOVID-19 환자의 실시간 중합효소 연쇄 반응의 정확도Research Article Published on 2022-02-162022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료법, 치료제, [키워드] RdRp-gene Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addressed Analysis assays caused CDC CDC N1, N2 center chain Characteristics Clinical practice clinical samples conducted Control coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cutoff value cycle threshold demonstrated Diagnosis diagnostic Diagnostic accuracy diagnostic specificity discrepancy disease control E gene enrolled followed by Health Organization highest house lowest majority Mild nasopharyngeal nasopharyngeal sample Nasopharyngeal samples NP gene nucleocapsid protein Numerous Oropharyngeal oropharyngeal samples pandemic prevention primer primer set primer sets Primers Prospective Study qPCR qPCR analysis RdRP reaction Real-time PCR real-time polymerase chain reaction Research respiratory Respiratory illness RT-PCR RT-qPCR RT-qPCRs Saliva SARS-CoV-2 SARS-CoV2 sensitivity Sensitivity and specificity Seroconversion severe acute respiratory syndrome Coronavirus severe respiratory illness significantly specificity specimen specimens sputum Sputum sample Viral Viral detection WHO World Health Organization [DOI] 10.1128/spectrum.00591-21 PMC 바로가기 [Article Type] Research Article
The Kinetics of COVID-19 Vaccine Response in a Community-Vaccinated Population지역사회 백신 접종 인구에서 COVID-19 백신 반응의 역학Article Published on 2022-02-152022-09-12 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analyzed collected COVID-19 IgG individual individuals Kinetics Moderna mRNA-based vaccine noninvasive patients Pfizer Population prevaccination Quantitative quantitative assay response Saliva salivary Sample SARS-CoV-2 S1 second vaccination subset vaccination vaccine response widespread [DOI] 10.4049/jimmunol.2100919 PMC 바로가기 [Article Type] Article
How do we engage people in testing for COVID-19? A rapid qualitative evaluation of a testing programme in schools, GP surgeries and a universityCovid-19 테스트에 사람들을 어떻게 참여 시키나요?학교, GP 수술 및 대학의 시험 프로그램의 신속한 질적 평가Research Article Published on 2022-02-142022-09-01 Journal: BMC Public Health [Category] COVID19(2023년), Fulltext, MERS, SARS, 진단, [키워드] city collected communication Community Community engagement Community leader conducted convenience Council COVID-19 COVID-19 testing declined Effectiveness Emergency engage Engagement Environmental impact feasibility focus GP surgery group Health healthcare implementation individual involved isothermal amplification Loop-mediated isothermal amplification Modification modifications modify NHS overcome participant Participation programme development pupil Pupils Rapid Rapid qualitative evaluation reduce responsible Result RT-LAMP SAGE Saliva saliva samples SARS-CoV-2 virus Schools suggested supplementary material Surveillance Testing the SARS-CoV-2 virus Transcription Trust university [DOI] 10.1186/s12889-022-12657-4 PMC 바로가기 [Article Type] Research Article
Implementation of a Rapid RT-LAMP Saliva-Based SARS-CoV-2 Testing Program in the WorkplaceCase Report Published on 2022-02-122022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] added Asymptomatic COVID-19 diagnostics employee flexible Group testing heat-inactivated household contact individual isothermal amplification microorganisms non-infectious Non-invasive occupational health and safety ORF1ab performed positive pre-symptomatic Program provided qRT-PCR Rapid rapid molecular testing reduced reverse transcription risk RNase P RT-LAMP Saliva SARS-CoV-2 SARS-COV-2 infection second wave self-administration test tested Testing the SARS-CoV-2 Transmission turnaround times Workplace [DOI] 10.3390/diagnostics12020474 PMC 바로가기 [Article Type] Case Report
Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individualsSARS-CoV-2에 대한 타액 IgG는 혈청 전환을 나타내며 mRNA 백신 접종 면역 저하된 개인의 혈청 중화와 상관 관계가 있습니다Article Published on 2022-02-112022-09-12 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] acute respiratory syndrome ALF Allogeneic Analysis Anti-SARS-CoV-2 S antibody Antigen AUC Cancer CAR-T caused center CLL CLL patient comparable coronavirus correlated Council COVID-19 disease dose Elecsy entire cohort foundation group healthy control HIV Human immunodeficiency virus IgG IgG response IgG titer immunocompromised individual immunodeficiency Immunoglobulin immunosuppressants indicate individual Infection Innovation Knut leukemia Medical Research Council mRNA BNT162b2 mRNA BNT162b2 vaccine multiplex neutralizing capacity parameter participated Patient PID Positive predictive value PPV predictive power Primary Immunodeficiency primary site Prospective clinical trial reactivity receiver operating characteristic receptor Region response responses revaccination Saliva salivary SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike antigen Seroconversion serum Serum Neutralization solid organ transplantation SOT spike IgG Stem cell transplantation Stockholm County susceptible Swedish T cell therapy transplantation vaccination vaccine response Vaccine-induced immunity were measured [DOI] 10.1016/j.medj.2022.01.001 PMC 바로가기 [Article Type] Article
Efficient SARS-CoV-2 Quantitative Reverse Transcriptase PCR Saliva Diagnostic Strategy utilizing Open-Source Pipetting Robots오픈 소스 피펫팅 로봇을 활용한 효율적인 SARS-CoV-2 정량적 역전사효소 PCR 타액 진단 전략Article Published on 2022-02-112022-09-11 Journal: Journal of visualized experiments : JoVE [Category] COVID19(2023년), SARS, 치료기술, [키워드] automated Automation average Chain Reaction Clemson University clinical testing Community comparable complex Concentration COVID-19 pandemic diagnostic diagnostic testing efficient epidemiological handling Health Health crisis introduced invasive less Mortality multiplex RT-qPCR nasopharyngeal swabs nucleic acid nucleic acid testing Participants PCR physically polymerase chain polymerase chain reaction Population population surveillance Quantitative reagent Reporting Research reverse transcriptase robot RT-qPCR Saliva SARS-CoV-2 Sensitivity and specificity shown Strategy Supply chain Surveillance thermocycler thermocyclers transcriptase Transmission Viral RNA [DOI] 10.3791/63395 PMC 바로가기 [Article Type] Article