An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2Article Published on 2020-12-222023-07-13 Journal: Cell Reports [Category] SARS, [키워드] ACE2 transgenic coronavirus D614G Entry inhibitor Fc fusion lentiviral pseudotype microbody SARS-CoV-2 soluble ACE2 Spike protein [DOI] 10.1016/j.celrep.2020.108528 PMC 바로가기
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivoSARS-CoV-2 D614G 변이체는 생체 외에서 효율적인 복제 및 생체 내 전달을 나타냅니다.Report Published on 2020-12-182022-09-10 Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter angiotensin animal models Antisera appear both virus both viruses change Changing Characteristics China coronavirus D614G D614G substitution D614G variant dominant Effect Efficacy ENhance enzyme epithelial cell epithelial cells Ex vivo exhibit experiment faster glycine greater greater transmissibility hamster hamsters Human human Angiotensin-converting enzyme human cell human cells in vitro in vivo indicate infecting Infection maintain morphology Mutation neutralization Neutralizing new virus pandemic spread Pathogenesis pathogenicity Population prevalent primary human airway Primary human airway epithelial cells primary human cell primary human cells pulmonary disease replaced REPLACED BY replicate Replication respiratory respiratory tissue respiratory tissues SARS-CoV-2 SARS-CoV-2 D614G SARS-CoV-2 variant Science severe acute respiratory syndrome Coronavirus significantly Spike protein strain Strains susceptible the times These data transgenic mice Transmissibility Transmission vaccine candidate vaccine candidates variant variant of SARS-CoV-2 Viral viral pathogenesis viral spike protein viral titer virulence virus viruses wild-type virus [DOI] 10.1126/science.abe8499 PMC 바로가기 [Article Type] Report
Two SARS-CoV-2 Genome Sequences of Isolates from Rural U.S. Patients Harboring the D614G Mutation, Obtained Using Nanopore SequencingGenome Sequences Published on 2020-12-172022-10-29 Journal: Microbiology Resource Announcements [Category] COVID-19, [키워드] acute respiratory syndrome ARTIC Network protocol coronavirus D614G isolate Oxford Nanopore Technology Patient SARS-CoV-2 sequence Sequencing The United States viral genome was obtained [DOI] 10.1128/MRA.01109-20 PMC 바로가기 [Article Type] Genome Sequences
Genomic analysis of SARS-CoV-2 reveals local viral evolution in GhanaOriginal Research Published on 2020-12-162022-10-31 Journal: Experimental Biology and Medicine [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome America amplicon-based enrichment analyses Analysis appear B4 clade carried Case fatality rate circulating clade coronavirus coronavirus disease country COVID-19 D614G dropped East Asian Epidemic European Evolution Fatality rate FIVE Genome genome assembly Genomics global genome Hungary Illumina Miseq India indicate infected individual Infection isolate Local mapped Norway Novel coronavirus Phylogenetic analysis quality control processes reported reveal SARS-CoV-2 SARS-CoV-2 cDNA SARS-CoV-2 genome sequence Sequencing significantly similarity strain the United State Transmission United Kingdom viral evolution virus viruses whole genome Wuhan strain [DOI] 10.1177/1535370220975351 PMC 바로가기 [Article Type] Original Research
COVID-19-neutralizing antibodies predict disease severity and survivalArticle Published on 2020-12-152023-06-14 Journal: Cell [Category] MERS, SARS, [키워드] COVID-19 D614G disease severity ELISA Neutralizing antibodies pro-inflammatory cytokines RBD SARS-CoV-2 spike WIV1-CoV [DOI] 10.1016/j.cell.2020.12.015 PMC 바로가기 [Article Type] Article
CD8 T cell epitope generation toward the continually mutating SARS-CoV-2 spike protein in genetically diverse human population: Implications for disease control and prevention유전적으로 다양한 인간 집단에서 지속적으로 돌연변이를 일으키는 SARS-CoV-2 스파이크 단백질을 향한 CD8 T 세포 에피토프 생성: 질병 통제 및 예방에 대한 시사점Research Article Published on 2020-12-102022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] absence Affect Algorithm allele Analysis anti-S anti-SARS-CoV-2 immune response anti-SARS-CoV-2 immune responses B cell B cells CD8 T cell CD8 T cells collected CoV Critical cross-reactive D614G disease Effect epitope Epitopes genetic background Health care Health care system health care systems HLA HLA allele HLA alleles HLA-A HLA-B immune responses Immunity indicated individual isolate life Mutation mutations pandemic Point mutation predicted Protein reported S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 spike protein sequence Spike protein suggested T cell T cells the SARS-CoV-2 understanding Vaccine design Viral viral evolution [DOI] 10.1371/journal.pone.0239566 PMC 바로가기 [Article Type] Research Article
Contributory role of SARS-CoV-2 genomic variations and life expectancy in COVID-19 transmission and low fatality rate in AfricaResearch Published on 2020-12-092022-11-01 Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19, [키워드] accumulation Africa African age Analysis analyzed average Characteristics claimed contributed coronavirus country COVID-19 COVID-19 transmission D614G database death drug resistance economic devastation Epidemiology Factor Factors fatality Fatality rate Genomic variability genomic variation GISAID Health health care systems highest Host incidence infected patient initiative Invasion lockdown Low fatality Mutation mutational hotspot mutations novel coronavirus disease nucleocapsid Older outbreak pandemic predicted Prevalence prevalence of COVID-19 public health recurrent mutation Region Regulatory Result RNA-dependent RNA polymerase SARS-CoV-2 selective sequence Sequencing spike glycoprotein Strains the disease the SARS-CoV-2 Transmissibility viral sequence virulent virus [DOI] 10.1186/s43042-020-00116-x PMC 바로가기 [Article Type] Research
Spike protein D614G and RdRp P323L: the SARS-CoV-2 mutations associated with severity of COVID-19Original Article Published on 2020-12-072022-11-01 Journal: Genomics & Informatics [Category] COVID-19, [키워드] acute respiratory syndrome affected aligned caused coronavirus coronavirus disease COVID-19 COVID-19 patient D614G database detective disease severity downloaded Frequency Genome genome sequence genomic sequence GISAID groups help initiative mutant Mutation mutations non-coding region P323L P323L mutation Patient pneumonia virus profile Protein RdRP reference sequence required resulting RNA-dependent RNA polymerase SARS-CoV-2 sequence severity severity of COVID-19 Severity of disease silent spike Spike protein spike protein D614G statistically significant the SARS-CoV-2 typing variant Wuhan [DOI] 10.5808/GI.2020.18.4.e44 PMC 바로가기 [Article Type] Original Article
D614G Spike Mutation Increases SARS CoV-2 Susceptibility to NeutralizationClinical Trial Published on 2020-12-012023-06-15 Journal: Cell Host & Microbe [Category] MERS, SARS, [키워드] COVID-19 D614G electron micrograph LNP mRNA neutralization nucleoside-modified SARS-CoV-2 spike Vaccine [DOI] 10.1016/j.chom.2020.11.012 PMC 바로가기 [Article Type] Clinical Trial
Analysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associations530 Published on 2020-12-012022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] 5′ UTR acute respiratory syndrome allelic allelic association Analysis association associations biological significance Characteristics characterized China Clustering coding region collected Complete coronavirus country COVID 19 COVID-19 D614G developmental distribution dominant Frequency Genome genomic Haplotype highest independent of Interaction Interpretation majority management Mutation Nsp12 Nsp3 nucleotide pandemic Protein provided reported reveal S protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence Sequencing Significance single nucleotide variation SNV SNVs spike spread to strain strain type Strains submitted subsequent analysis Subtypes Surveillance the disease the SARS-CoV-2 genome understanding UTR Variation [DOI] 10.1073/pnas.2007840117 PMC 바로가기 [Article Type] 530