Knowledge Graphs for COVID-19: An Exploratory Review of the Current LandscapeReview Published on 2021-04-142022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] addition Analysis article clinical trial complex conducted corpus COVID-19 COVID-19 research current domain Drug repurposing effective exploratory FIVE for inclusion Google Google Scholar identify include information Isolation knowledge Knowledge graph landscape literature review natural language processing Patient care peer-reviewed Research review risk factor utility was used [DOI] 10.3390/jpm11040300 PMC 바로가기 [Article Type] Review
The Deadly Duo of COVID-19 and Cancer!Molecular Biosciences Published on 2021-04-122022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 added anti-cancer drugs Cancer cancer patient Cancer patients Cancer therapy Complication COVID-19 COVID-19 patient Diagnosis disease Drug repurposing effective effort enzyme Factor Health Immunity include increase in infection with COVID-19 Inflammation management molecular novel corona virus Patient Patient care severity Surgical Procedure the patient Treatment [DOI] 10.3389/fmolb.2021.643004 PMC 바로가기 [Article Type] Molecular Biosciences
Screening of FDA-Approved Drugs Using a MERS-CoV Clinical Isolate from South Korea Identifies Potential Therapeutic Options for COVID-19Article Published on 2021-04-092022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome calu-3 cells clinical clinical isolate Combination compounds Confirmed coronavirus coronavirus disease Corticosteroid COVID-19 demonstrated drug drug combinations Drug repurposing effective drugs eight FDA-approved drug FDA-approved drugs food greater high-content screening identify illnesses in vitro infections isolate Korean late stage lung organoids medical need MERS-CoV Middle East Middle East respiratory syndrome Coronavirus option pandemic Potential Remdesivir representing respiratory syndrome coronavirus SARS-CoV-2 screened Screening selected drug severe acute respiratory syndrome coronavirus disease South South Korea tested therapeutic therapeutic option treat United State VERO-E6 viral life cycle [DOI] 10.3390/v13040651 PMC 바로가기 [Article Type] Article
Identification of multipotent drugs for COVID-19 therapeutics with the evaluation of their SARS-CoV2 inhibitory activityResearch Article Published on 2021-04-072022-10-04 Journal: Computational and Structural Biotechnology Journal [Category] 신약개발, [키워드] Abstract Affect affected analyzed average bioinformatics cause Cell changed contagious coronavirus COVID-19 COVID-19 disease COVID-19 therapeutics disease manifestation docking drug Drug repurposing expression FDA approved drug help human host human protein IC50 identification identify in-silico inhibitory activity lung molecular dynamics network analysis nine pathogen Polypharmacology predicted molecule Protein Proteins SARS-CoV2 SARS-CoV2 infection targeting therapeutic option Treatment virus [DOI] 10.1016/j.csbj.2021.04.014 PMC 바로가기 [Article Type] Research Article
Host-Directed FDA-Approved Drugs with Antiviral Activity against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening MethodsArticle Published on 2021-04-062022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] activity Antiviral antiviral activity approach approved drugs carried compounds COVID-19 COVID-19 patients drug Drug repurposing effective entry inhibitors FDA approved drug FIVE Hierarchical host-based targets host-directed therapy Identified Imatinib pandemic proceed protocol SARS-CoV-2 SARS-CoV-2 evaluation Screening selected target Treatment viral entry Virtual screening [DOI] 10.3390/ph14040332 PMC 바로가기 [Article Type] Article
Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS‐CoV‐2 infection in vitroArticle Published on 2021-04-062023-07-01 Journal: British Journal of Pharmacology [Category] SARS, [키워드] combination therapy Drug repurposing Fluoxetine itraconazole Remdesivir SARS‐CoV‐2 [DOI] 10.1111/bph.15418 PMC 바로가기
Repositioning of histamine H 1 receptor antagonist: Doxepin inhibits viropexis of SARS-CoV-2 Spike pseudovirus by blocking ACE2히스타민 H 1 수용체 길항제의 재배치: Doxepin은 ACE2를 차단하여 SARS-CoV-2 Spike pseudovirus의 viropexis를 억제합니다Article Published on 2021-04-052022-09-11 Journal: European journal of pharmacology [Category] SARS, 신약개발, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antagonist anti-SARS-CoV-2 antiviral effects caused Cell clinical trials CMC coronavirus COVID-19 demonstrated Doxepin drug drug candidate drug repositioning Drug repurposing effective drug effective drugs enzyme feasible FIVE global health Health HEK293T cell help Histamine Histamine H(1) receptor antagonist Infection infection rate inhibit inhibit SARS-CoV-2 Interaction membrane outbreak overexpressing pandemic provide pseudovirus receptor receptor antagonist reducing reported repositioning SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus spike SPR Spread surface plasmon surface plasmon resonance Vaccine virus Virus Disease [DOI] 10.1016/j.ejphar.2021.173897 PMC 바로가기 [Article Type] Article
A Study of 3CLpros as Promising Targets against SARS-CoV and SARS-CoV-2Article Published on 2021-04-032022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] 3CLpro acute respiratory syndrome addition against SARS-CoV Antiviral Antiviral agents applied approach caused clinical trials Compound compounds coronavirus coronavirus disease COVID-19 COVID-19 patient docking study Drug repurposing FRET in silico indicate information inhibitor inhibitors inhibitory inhibitory activity inhibitory compounds inhibitory effect Interaction Medicine outbreak patients with COVID-19 Proteases Protein residue S1 and S2 SAR-CoV-2 SARS-CoV SARS-CoV-2 SARS-CoV-2 3CL protease selected target Treatment Vaccines variants [DOI] 10.3390/microorganisms9040756 PMC 바로가기 [Article Type] Article
A COVID-19 Drug Repurposing Strategy through Quantitative Homological Similarities Using a Topological Data Analysis-Based FrameworkArticle Published on 2021-04-022022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] 3CL accelerate analyses applied candidate carried COVID-19 death Dexamethasone drug Drug repurposing effective effort Final framework global pandemic identify in silico molecular docking persistent Betti function produced protease Protein repurposing RNA-dependent RNA polymerase SARS-COV-2 infection Scientific community Strategy Structure structures the SARS-CoV-2 topological data analysis transcriptomic treat Treatment Viral protein [DOI] 10.3390/pharmaceutics13040488 PMC 바로가기 [Article Type] Article
Repurposing drugs for the management of COVID-19Review Published on 2021-04-012023-07-13 Journal: Expert opinion on therapeutic patents [Category] SARS, [키워드] antiviral drugs coronavirus COVID-19 Drug repurposing Remdesivir SARS-CoV-2 [DOI] 10.1080/13543776.2021.1861248 [Article Type] Review