Clinical Significance of Indeterminate QuantiFERON-TB Gold Plus Assay Results in Hospitalized COVID-19 Patients with Severe Hyperinflammatory SyndromeArticle Published on 2021-02-262022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] administration of corticosteroid affected Care clinical condition confidence interval Corticosteroid Corticosteroids COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity determine died epidemic wave evaluated Factor gold hospital Hospitalization hospitalized COVID-19 patient hospitalized patients immune dysregulation in-hospital mortality independent predictor indeterminate lack lactate dehydrogenase LDH Mortality Odds ratio outcome Patient performance predictor Prevalence QuantiFERON-TB Gold Plus reliability Result Retrospective analysis SARS-CoV-2 severe COVID-19 patients Significance Spain was performed [DOI] 10.3390/jcm10050918 PMC 바로가기 [Article Type] Article
Propolis, Bee Honey, and Their Components Protect against Coronavirus Disease 2019 (COVID-19): A Review of In Silico, In Vitro, and Clinical Studies프로폴리스, 꿀벌 꿀 및 그 구성 요소는 코로나바이러스 질병 2019(COVID-19)로부터 보호합니다: In Silico, In Vitro 및 임상 연구에 대한 검토Review Published on 2021-02-252022-09-10 Journal: Molecules [Category] MERS, 임상, 치료제, [키워드] ACE-II activities Anti-inflammatory antioxidant Antiviral antiviral drug Antiviral effect Antiviral treatment bee bee honey bee products caffeic acid clinical Combination component Compound coronavirus disease Coronavirus disease 2019 Coronaviruses COVID -19 COVID-19 cytokine Cytokine storm discharge Effect Effects examined exhibited Express fatality flavonoids green Honey hospital hospitalized COVID-19 patient hospitalized COVID-19 patients host cells immune immunomodulatory in silico in vitro inhibit inhibited less Liposome Luteolin main protease molecular docking/biochemical modeling molecular simulations Mortality naringin natural Nigella Sativa non-structural protein non-structural proteins Prophylactic Propolis randomized clinical trials receiving Remdesivir respiratory review rutin SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome spike glycoprotein standard care Symptom the cytokine storm these compound these compounds Treatment treatment for COVID-19 Treatment outcome Trigger Vero E6 VERO E6 cells Viral viral clearance viral replication viral spike viral-host interaction virulence [DOI] 10.3390/molecules26051232 PMC 바로가기 [Article Type] Review
Diagnosis, clinical characteristics, and outcomes of COVID-19 patients from a large healthcare system in northern New Jersey뉴저지 북부의 대규모 의료 시스템에서 COVID-19 환자의 진단, 임상 특성 및 결과Article Published on 2021-02-232022-09-01 Journal: Scientific Reports [Category] MERS, 임상, 진단, 치료기술, 치료법, [키워드] age analyzed case sery center Chain Reaction Characteristics clinical Clinical characteristics Clinical data clinical feature Clinical features collected Community consecutive patient consecutive patients correlated correlation COVID-19 COVID-19 pandemic COVID-19 patient cycle demographics diagnose Diseases females finding Hackensack University Medical Center Health care healthcare Healthcare system hospital Hospitalized hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients house indicated Infection information interquartile range intervals IQR laboratory-confirmed linear median age Medical research Meridian Microbiology New outcome outcomes Patient patient population polymerase chain polymerase chain reaction Research RT-PCR RT-PCR test significantly higher statistically significant survival The United States threshold United States university Viral Viral load virus virus test with infection [DOI] 10.1038/s41598-021-83959-7 PMC 바로가기 [Article Type] Article
Antibody affinity maturation and plasma IgA associate with clinical outcome in hospitalized COVID-19 patients입원한 COVID-19 환자의 임상 결과와 관련된 항체 친화도 성숙 및 혈장 IgAArticle Published on 2021-02-222022-09-12 Journal: Nature Communications [Category] MERS, 바이오마커, 진단, 치료기술, [키워드] Affinity maturation Analysis antibodies antibody antibody affinity Antibody binding antibody kinetics association binding antibodies clinical disease Clinical outcome Clinical severity Clinical symptoms COVID-19 COVID-19 disease COVID-19 patient Critical cytokine disease epitope Exacerbation fusion peptide hACE2 high plasma level high plasma levels hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients ICU patient ICU Patients IgA IgA level IL-6 IL-8 immune parameter immune response immune responses immunopathology lead maturation MCP-1 neutralization titers non-ICU outcome patients with COVID-19 peptide plasma plasma sample prefusion receptor binding motif SARS-CoV-2 SARS-CoV2 infection scrutiny severity Spike protein Survivors sustained the SARS-CoV-2 TNFα Viral host response viral infection [DOI] 10.1038/s41467-021-21463-2 PMC 바로가기 [Article Type] Article
Thyroid Function Abnormalities in COVID-19 PatientsEndocrinology Published on 2021-02-192022-10-31 Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, SARS, [키워드] abnormality addition Affect caused China Complete controls correlation COVID-19 COVID-19 patient COVID-19 patients CRP dysfunction early stage enrolled explained function healthy healthy subject Hormones hospitalized COVID-19 patient impairing lymphocyte Medicine non-COVID-19 patient nonthyroidal illness syndrome Novel coronavirus organ Pathogenesis Patient patients with pneumonia positive proportion Result School Severe case severe cases Thyroid thyroid function thyroid stimulating hormone triiodothyronine TSH university viral nucleic acid worldwide pandemic Zhejiang [DOI] 10.3389/fendo.2020.623792 PMC 바로가기 [Article Type] Endocrinology
An observational cohort study of bacterial co-infection and implications for empirical antibiotic therapy in patients presenting with COVID-19 to hospitals in North West LondonObservational Study Published on 2021-02-112022-10-05 Journal: Journal of Antimicrobial Chemotherapy [Category] 임상, [키워드] 48 hour Admission age all-cause mortality Antibiotic therapy Antibiotic treatment Bacterial bacterial co-infection clinically Co-infection co-morbidities collected COVID-19 infection COVID-19 patient CRP Gender hospital Hospital admission hospitalized COVID-19 patient ICU ICU admission illnesses implication in-hospital mortality Infection Inflammatory marker inflammatory markers London majority neutrophil count no significant difference North Observational cohort study Patient patient age presenting Prevalence Result retrospective selected significantly higher specimen Treatment West white cell with COVID-19 [DOI] 10.1093/jac/dkaa475 PMC 바로가기 [Article Type] Observational Study
Impact of SARS-CoV-2 Infection on Cognitive Function: A Systematic ReviewPsychiatry Published on 2021-02-102022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] affected Brain brain health characteristic characterized Cognitive function Cognitive impairment cognitive impairments COVID-19 COVID-19 case criteria cytokine Cytokine storm Cytokines delirium demonstrated Depression determine disrupt elevated estimate etiology Evidence for inclusion Health hospitalized COVID-19 patient hospitalized patient IL-6 immune response Impact impairment increases in individual Inflammation Inflammatory marker knowledge memory Neuroinflammation neurotropism Other Outpatient pooling Prevalence produced reported review SARS-CoV-2 systematic review systemic inflammation the disease TNFα Topic [DOI] 10.3389/fpsyt.2020.621773 PMC 바로가기 [Article Type] Psychiatry
Impact of Treatment and Anticoagulation on Thrombosis in COVID-19 PatientsConference abstract Published on 2021-02-062022-10-05 Journal: Blood [Category] 치료법, [키워드] 95% CI Accuracy Adjusting African American age Analysis analyzed anticoagulation BMI CDC Coagulopathy complications COVID-19 COVID-19 patient decrease demographics described discharge download DVT Endothelial dysfunction event figure Frame Gender global pandemic Hispanic patient Hospitalized hospitalized COVID-19 patient hospitalized patient hospitalized patients Impact incidence incidence of COVID-19 include inflammatory state less lowest morbidity and mortality Mortality mortality rate no difference Non-COVID-19 Non-pulmonary occurred outcome Patient patient population patients patients with COVID-19 patients with PE positive pro-inflammatory state Prophylactic prophylactic anticoagulation Prophylaxis prothrombotic state reduce reported respiratory compromise Result resulting Retrospective analysis severe COVID-19 severe disease severe inflammation significantly significantly higher specific treatment steroid Steroids stroke therapeutic therapeutic anticoagulation Thromboembolism thrombosis thrombotic event Treatment Trial VTE was performed with COVID-19 [DOI] 10.1182/blood-2020-137707 [Article Type] Conference abstract
Association between Clinical Characteristics and Laboratory Findings with Outcome of Hospitalized COVID-19 Patients: A Report from Northeast IranResearch Article Published on 2021-02-052022-10-29 Journal: Interdisciplinary Perspectives on Infectious Diseases [Category] COVID-19, [키워드] Admission admitted to ICU age association C-reactive protein (CRP Characteristics chest pain China clinical clinician Coronavirus disease 2019 correlation COVID-19 CRP CRP level Decreased duration of hospitalization Dyspnea early diagnosis erythrocyte sedimentation rate ESR evaluated Evaluating help hospital Hospitalization hospitalized COVID-19 patient ICU Imam intensive care Iran Laboratory laboratory feature laboratory finding management medical record mortality rate nonsurvivor nonsurvivors outcome Pain Patient patients who survived patients with COVID-19 Predictive predictor Prognosis report Reza risk Sex significantly significantly higher Spread statistically survivor variable was determined WBC White blood cell [DOI] 10.1155/2021/5552138 PMC 바로가기 [Article Type] Research Article
Systematic review and subgroup analysis of the incidence of acute kidney injury (AKI) in patients with COVID-19Research Article Published on 2021-02-052022-10-28 Journal: BMC Nephrology [Category] COVID-19, MERS, [키워드] Acute kidney injury age AKI conducted Coronavirus disease-19 COVID-19 COVID-19 patient COVID-19 patients CRRT disease severity evaluate Evidence hospitalized COVID-19 patient hospitalized COVID-19 patients in-hospital mortality incidence indicated induce investigated Kidney injury occur package in R Patient patients with COVID-19 proportion provide Remdesivir renal replacement therapy Result SARS-COV-2 infection subgroup subgroup analysis supplementary material systematic review treated Treatment was performed Web of Science [DOI] 10.1186/s12882-021-02244-x PMC 바로가기 [Article Type] Research Article