Critical Aspects Concerning the Development of a Pooling Approach for SARS-CoV-2 Diagnosis Using Large-Scale PCR Testing대규모 PCR 검사를 사용한 SARS-CoV-2 진단을 위한 풀링 접근법 개발에 관한 중요한 측면Article Published on 2021-05-132022-09-01 Journal: Viruses [Category] SARS, 진단, 치료기술, 치료제, [키워드] approach aspect automated best condition COVID-19 Detection limit development diagnose Diagnosis diagnostic Efficiency Genes Hierarchical identify investigated molecular diagnostic multiple parameters nasopharyngeal swabs ORF1a pandemic PCR PCR reaction PCR testing pooling positive Prevalence quantification RdRP reliability RNA extraction RT-qPCR Sample pooling SARS-CoV-2 SARS-CoV-2 detection sensitivity specificity specimens Spread Testing the SARS-CoV-2 [DOI] 10.3390/v13050902 PMC 바로가기 [Article Type] Article
Development of a multiplex mass spectrometry method for simultaneous quantification of urinary proteins related to respiratory healthArticle Published on 2021-05-122022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] adverse effect airway epithelium binding Biomarker Biomarkers can be used cell protein characterized children children’s health complex confounder correlation development dysfunction Environmental impact facilitate handling Health health monitoring Human serum albumin immunoassay Lung disease multiplex Myoglobin NF-κB nine nuclear osteopontin peptide physiological Protein Proteins quantification ranged RBP4 renal renal dysfunction renal function reproducibility respiratory retinol selected Seven urinary dilution Urine Variation [DOI] 10.1038/s41598-021-89068-9 PMC 바로가기 [Article Type] Article
Study protocol for a phase II randomised, double-blind, placebo-controlled trial of perampanel as an antiepileptogenic treatment following acute stroke급성 뇌졸중 후 항간질 치료제로서 페람파넬에 대한 2상 무작위, 이중 맹검, 위약 대조 시험을 위한 연구 프로토콜Article Published on 2021-05-102022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] 1:1 adverse event adverse events analysed approved baseline Cognitive function collected Concentration correlation cortical double-blind dysregulation Efficacy and safety enrolled epilepsy Ethics ethics committee evaluate Evidence Fisher Fisher's exact test Glutamate high risk HREC Human include ischaemic stroke life lobar magnetic resonance imaging Magnetic resonance spectroscopy matching placebo mechanism of action medication mood MRI outcome outcomes participant Patient perampanel performed Placebo placebo-controlled trial plasma Primary prevention proportion protocol Quality quantification Questionnaires randomisation randomised receive reference registration number Research Ethics scale secondary Secondary outcomes Seizure Seizures stratified stroke stroke medicine study period Support titration transfer Treatment unique Withdrawal [DOI] 10.1136/bmjopen-2020-043488 PMC 바로가기 [Article Type] Article
Suggestions for global coagulation assays for the assessment of COVID-19 associated hypercoagulabilityCOVID-19 관련 과응고성 평가를 위한 글로벌 응고 분석에 대한 제안Article Published on 2021-05-012022-09-11 Journal: Thrombosis research [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition adjusted Alter Analysis Anticoagulant change Clotting time coagulant Coagulation Coagulopathy condition conditions coronavirus COVID-19 decrease Diagnosis diagnostic dose effective Effectiveness ellagic acid expected fibrinogen Fibrinogen levels fibrinolytic Final Follow-up healthy volunteers heparin heparins HPPH hypercoagulability ICU Patients Infection influence influences inhibitory effect LMWH material normalized outcome parameters pathophysiological mechanism patients phenotype plasma Population Prognosis prothrombotic protocol quantification reagent risk ROTEM SARS-CoV2 sensitivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suggestion thrombin Thrombin generation thrombosis tissue Tissue Factor triggered Variability variants was performed was used [DOI] 10.1016/j.thromres.2021.02.026 PMC 바로가기 [Article Type] Article
Will the extraction of COVID-19 from wastewater help flatten the curve?폐수에서 COVID-19를 추출하면 곡선을 평평하게 만드는 데 도움이 될까요?Article Published on 2021-05-012022-09-11 Journal: Chemosphere [Category] SARS, 치료기술, [키워드] absence And disadvantages approach Blancmange challenges complex coronavirus country COVID-19 determine Disadvantages distributions Efficiency excreta expel extraction Extraction method feces help hotspot humans hygiene identify lack Limited lockdown Log-normal distribution mathematical methodology movement Normal distribution Occurrence persistence quantification recommendation Research resulting Sanitation SARS-CoV-2 sewage suggested temperature Transmission Treatment Viral load waste wastewater Wastewater treatment widespread [DOI] 10.1016/j.chemosphere.2020.129429 PMC 바로가기 [Article Type] Article
Frontline Screening for SARS-CoV-2 Infection at Emergency Department Admission by Third Generation Rapid Antigen Test: Can We Spare RT-qPCR?3세대 신속 항원 검사를 통한 응급실 입원 시 SARS-CoV-2 감염에 대한 최전선 검사: RT-qPCR을 절약할 수 있습니까?Article Published on 2021-05-012022-09-01 Journal: Viruses [Category] SARS, 진단, 치료기술, [키워드] 95% CI active viral replication acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission antigenic test Can Clinical use complement coronavirus country COVID-19 cycle threshold demonstrated Department Diagnosis diagnostic digital PCR droplet Emergency emergency department expected false-negative Generation genomic hospital increase infections Infectivity introduced IQR lack median Nasopharyngeal swab nasopharyngeal swabs Patient PCR persists qPCR quantification Rapid Rapid antigen tests Rapid diagnostic test respiratory risk RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA Screening sensitivity severe acute respiratory syndrome Coronavirus specificity subgenomic RNA subject suggested the WHO Viral Viral load [DOI] 10.3390/v13050818 PMC 바로가기 [Article Type] Article
Susceptibility of neuroblastoma and glioblastoma cell lines to SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 신경모세포종 및 교모세포종 세포주의 감수성Article Published on 2021-05-012022-09-11 Journal: Brain research [Category] SARS, 치료기술, [키워드] Analysis Apoptosis Cell cell line cell lines cell type cells Coronavirus-2 CTSB CTSL Cytopathic effect death demonstrated described downregulation epithelial cell epithelial cells Express Gene Expression Genes Glioblastoma Glutamate idea In situ hybridization infected cell infected cells Infection maintain MOI MOIs Neuroblastoma neuronal neurotropism Perspective quantification replicate retinoic acid RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain severe acute respiratory coronavirus Severe acute respiratory coronavirus-2 SH-SY5Y susceptibility tropism upregulation Vero E6 VERO E6 cells virus were expressed were infected [DOI] 10.1016/j.brainres.2021.147344 PMC 바로가기 [Article Type] Article
Rapid single-molecule detection of COVID-19 and MERS antigens via nanobody-functionalized organic electrochemical transistors Research Published on 2021-05-012022-10-05 Journal: Nature biomedical engineering [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Antigen complex coronavirus disease Coronavirus-2 COVID-19 detect fluids fluorescent fusion protein high-density human saliva maintain MERS MERS-CoV Middle East nanobody Nasopharyngeal swab pandemic point-of-care Polymer Protein quantification Rapid respiratory syndrome coronavirus robust Saliva SARS-CoV-2 sensitivity serum specific antigen specificity Spike proteins viral loads widespread [DOI] 10.1038/s41551-021-00734-9 [Article Type] Research
Correlation between lung ultrasound and chest CT patterns with estimation of pulmonary burden in COVID-19 patientsCOVID-19 환자의 폐부하 추정과 폐초음파와 흉부 CT 패턴 간의 상관관계Article Published on 2021-05-012022-09-11 Journal: European Journal of Radiology [Category] SARS, 치료기술, [키워드] analysed Analysis assessment AUC calculated characteristic Chest CT correlation correlations COVID-19 COVID-19 patient CT finding CT findings CT scan CT scans Department determine diagnostic techniques and procedures disease Emergency emergency department lesion lung moderate not differ number Patient patients PCR-confirmed COVID-19 performed positive quantification receiver operating characteristic receiver operating characteristic curve revision score sensitivity severity Severity Score specificity the disease tomography Ultrasonography Volume were assessed X-ray X-ray computed zone [DOI] 10.1016/j.ejrad.2021.109650 PMC 바로가기 [Article Type] Article
Isoprostanes in wastewater as biomarkers of oxidative stress during COVID-19 pandemicCOVID-19 전염병 동안 산화 스트레스의 바이오마커로서의 폐수 내 이소프로스탄Article Published on 2021-05-012022-09-11 Journal: Chemosphere [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] Ammoniacal nitrogen based population analytical method Anxiety approach average Biomarker clinically Community COVID COVID pandemic COVID-19 COVID-19 pandemic Depression elevated Epidemiology estimation Injury Isoprostane Isoprostanes metabolism nitrogen oxidative oxidative stress PGE2 Potential biomarker potential biomarkers quantification quantified Quantitative significantly significantly increased suggested two-tailed ultra-performance liquid chromatography wastewater wastewater based epidemiology [DOI] 10.1016/j.chemosphere.2020.129489 PMC 바로가기 [Article Type] Article