Correlation of ACE2 with RAS components after Losartan treatment in light of COVID-19Article Published on 2021-12-222022-10-04 Journal: Scientific Reports [Category] SARS, 임상, 치료법, [키워드] ACE2 ACE2 expression addition angiotensin receptor blocker ARB clinical trial clinically component conducted coronavirus disease correlated COVID-19 COVID-19 patients ENhance enzyme examined expression Health care interactions LOS MAS1 mechanism Medical research patient data patients positive predict protective role RAS regulated Regulation restored suggested Treatment Treatment response [DOI] 10.1038/s41598-021-03921-5 PMC 바로가기 [Article Type] Article
Immediate and Longer-Term Changes in the Mental Health and Well-being of Older Adults in England During the COVID-19 PandemicResearch Published on 2021-12-222022-10-30 Journal: JAMA Psychiatry [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 95% CI accompanied age Ageing analyzed Anxiety anxiety symptom assessment Autonomy change changed changes changes in clinically cohort study Control COVID-19 COVID-19 pandemic Depression depressive symptom deteriorate Deterioration England English Evidence exposure finding Generalized greater group Health Immediate Importance increases in individual inequality initial introduced later phase less lockdown loneliness longitudinal longitudinal cohort study Los Angeles lowest measure Mental mental health mental health service National objective Older pandemic participant Participants pleasure Point poor quality Prevalence progressed provided psychological Impact Psychological intervention psychosocial stressor Quality of life regression models Relevance repeated Result Self-realization setting Sex significantly Sociodemographic characteristics Support tested the mean University of California Well-being white women [DOI] 10.1001/jamapsychiatry.2021.3749 PMC 바로가기 [Article Type] Research
Impact of COVID-19 on Infertility Treatments: Not Even a Global Pandemic Was Strong Enough to Hamper Successful PregnanciesArticle Published on 2021-12-212022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] Affect clinically clinics coronavirus correlation COVID-19 Enough Final global pandemic Hamper Impact infertility infertility treatments negatively affected outcome pandemic performed Pregnancy pregnant pregnant women proportion Psychological reduction in retrospective Rome Spain Strong study population translated Treatment Two-arm women [DOI] 10.3390/life12010006 PMC 바로가기 [Article Type] Article
Microfluidic Chip with Two-Stage Isothermal Amplification Method for Highly Sensitive Parallel Detection of SARS-CoV-2 and Measles VirusArticle Published on 2021-12-192022-10-30 Journal: Micromachines [Category] COVID-19, [키워드] acute respiratory syndrome amplification clinical specificity clinically coronavirus cross-contamination detection Detection limit Diagnostic method identify isothermal amplification lowest Measle measles virus Microfluidic chip molecular multiplex Nasopharyngeal swab nucleic acid offer parallel molecular diagnostic POCT point-of-care polymerase real time RPA SARS-CoV-2 sensitive sensitivity Sensitivity and specificity target tested two-stage isothermal amplification virus [DOI] 10.3390/mi12121582 PMC 바로가기 [Article Type] Article
Temporal Patterns of COVID-19-Associated Pulmonary Pathology: An Autopsy StudyPathology Published on 2021-12-192022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory distress age alveolar alveolar cell Autopsy Bulgaria cause Cell change changes in clinical complication clinically Cohort coronavirus COVID-19 criteria develop disease disease onset distress Endotheliitis Endothelitis expired female fibrosis Gross Hematoxylin and eosin Histopathology hyaline membrane independent Infection interstitial light microscopy long-lasting lung changes Lungs male manifested Marina material mechanism morbidity and mortality notable Novel coronavirus novel coronavirus disease pathology Patient pattern polymerase chain Probability pulmonary pulmonary morphology Pulmonary pathology respiratory tract Result SARS-CoV-2 selected severe complication severe COVID-19 severe disease severity significantly increased squamous cell metaplasia symptom onset syndrome Temporal the disease the mean Type II pneumocyte university variant Varna Vascular withdrawn [DOI] 10.7759/cureus.20522 PMC 바로가기 [Article Type] Pathology
Managing life during the pandemic: communication strategies, mental health, and the ultimate toll of the COVID-19Article Published on 2021-12-172022-10-29 Journal: Turkish Journal of Medical Sciences [Category] COVID-19, SARS, [키워드] addition Anxiety clinically condition Coronavirus disease-19 COVID-19 COVID-19 pandemic database Depression disorder effective emotional Google Scholar growth health communication individual intervention study literature loneliness managing material mental health mental health problem mental health problems mental illness negative emotion obsessive compulsive pandemic Posttraumatic growth Posttraumatic Stress precautions problem problems protective factor Protective factors Psychological intervention reducing Result risk Stress syndrome trauma Web of Science [DOI] 10.3906/sag-2106-175 PMC 바로가기 [Article Type] Article
Psychological impact of COVID-19 pandemic on healthcare workers in a highly burdened area of north-east ItalyOriginal Article Published on 2021-12-172022-11-01 Journal: Epidemiology and Psychiatric Sciences [Category] COVID-19, MERS, SARS, [키워드] 95% CI age Analysis Anxiety asked Characteristics China clinically collected Complete consequence Coronavirus 2019 COVID-19 COVID-19 pandemic Depression distress Factor Gender greater Health health workers healthcare healthcare worker hospital Hospital staff ICUs identify IES-R Impact increased risk Intervention Italy Logistic regression magnitude mental health moderate multivariable logistic regression Non-COVID-19 Nurses outcomes pandemic participant Participants participated Patient patients PHQ-9 physician post-traumatic Post-traumatic stress provide Psychological distress psychological Impact psychological problem Psychological problems psychologically reported Result SAS scale socio-demographic information Symptom university Veneto Verona was performed were assessed with COVID-19 women [DOI] 10.1017/S2045796020001158 PMC 바로가기 [Article Type] Original Article
Role of advanced respiratory support in acute respiratory failure in clinically frail patients with COVID-19Short Communication Published on 2021-12-172022-10-31 Journal: Future Microbiology [Category] COVID-19, [키워드] acute respiratory support Admission advanced respiratory support age Cardiopulmonary CFS clinical frailty score (CFS) clinically COVID-19 COVID-19 patient COVID-19 patients died discharge frailty Invasive mechanical ventilation ISARIC 4C mortality score Mortality no significant difference noninvasive mechanical ventilation (CPAP & HFNO) overall survival PaO PaO2/FiO2 ratio Patient patients with COVID-19 PF ratio Respiratory failure role single-center study those who survived [DOI] 10.2217/fmb-2021-0226 PMC 바로가기 [Article Type] Short Communication
Optical trapping assisted label-free and amplification-free detection of SARS-CoV-2 RNAs with an optofluidic nanopore sensor광유체 나노포어 센서를 사용한 SARS-CoV-2 RNA의 광학 트래핑 보조 라벨 및 증폭 없는 검출Article Published on 2021-12-152022-09-11 Journal: Biosensors & bioelectronics [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] amplification Analysis approach assisted delivery Biomarker biosensors clinically Combination Concentration COVID-19 diagnosis COVID-19 pandemic Critical demonstrated Device diagnostics disease electrical functional molecular Nanopore nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples Personalized medicine practicality RNA RNAs SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNAs sensitivity Single-molecule detection Solid-state nanopores. Swab target target specificity [DOI] 10.1016/j.bios.2021.113588 PMC 바로가기 [Article Type] Article
CalmBelt: Rapid SARS-CoV-2 Genome Characterization for Outbreak TrackingMedicine Published on 2021-12-142022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] caused characterization clade clinical samples clinically Cluster Clusters COVID-19 COVID-19 pandemic Critical demonstrated determine diagnostic draft epidemiological Establishing generate Genome GISAID Health healthcare healthcare worker hospital identify Impact Increasing infection control information Laboratory lack lineages nanopore sequencing outbreak outbreak tracking patient safety potential transmission Rapid required SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant sequence Sequence analysis Sequencing sequencing technology Spread Transmission transmission pattern web application whole genome Whole genome sequencing [DOI] 10.3389/fmed.2021.790662 PMC 바로가기 [Article Type] Medicine