A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes광범위한 Spike 결합 적용 범위와 최적의 치료 결과를 위해 변형된 SARS-CoV-2 중화 항체Article Published on 2021-05-112022-09-10 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] Analysis antibodies binding antibody Antibody therapy Antibody-dependent enhancement binding caused Complete complex Consequences convalescent patient Convalescent patients Coverage COVID-19 COVID-19 convalescent patients COVID-19 pandemic crystal structure Diseases enhancement exhibit global public health Health crisis High-resolution highlight Infection injection interact majority monoclonal antibodies mutant Neutralizing activity neutralizing antibody outcome pharmacokinetic populations potential risk Protein pseudoviruses receptor binding motif reduce related diseases rhesus safety profile SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 S protein SARS-CoV-2 spike protein SARS-CoV2 shown spike Spike protein Spike proteins spike receptor-binding domain the Spike therapeutic therapeutic efficacy These data Treatment Viral viral clearance Vulnerable populations wild type X-ray crystallography [DOI] 10.1038/s41467-021-22926-2 PMC 바로가기 [Article Type] Article
Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes신규 결합 에피토프를 갖는 SARS-CoV-2 중화 항체의 구조적 기초Research Article Published on 2021-05-072022-08-13 Journal: PLoS Biology [Category] Biochemistry, SARS, 진단, [키워드] ACE2 receptor acute respiratory syndrome coronavirus Ad5-hACE2 Ad5-hACE2 transduction mouse model angiotensin antibodies antibody antiviral efficiency applied binding binding epitope caused characterized coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 domain Economy epitope Epitopes global public health H2L2 platform H2L2 transgenic mice hACE2 help High-resolution X-ray crystallography structures human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human immunoglobulin human immunoglobulin variable regions humanized NAb identify immunize Immunoglobulin injection mAb mAb-related therapeutic intervention mAb-related therapeutic interventions monoclonal antibody mouse model NAbs Neutralizing activity Neutralizing antibodies neutralizing antibody novel non-blocking epitope pandemic platform PR1077 PR953 PR961 Prophylactic provide provided RBD RBM receptor-binding motif recombinant vaccines regions respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike protein Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein spike receptor-binding domain Structural analysis Structure subsequent tested the antibody the SARS-CoV-2 the spike protein therapeutic interventions therapy transgenic mice treatment groups variable regions X-ray crystallography [DOI] 10.1371/journal.pbio.3001209 PMC 바로가기 [Article Type] Research Article
Neutralizing activity to SARS-CoV-2 of convalescent and control plasma used in a randomized controlled trial무작위 대조 시험에서 사용된 회복기 및 대조 혈장의 SARS-CoV-2에 대한 중화 활성Randomized Controlled Trial Published on 2021-05-012022-09-11 Journal: Transfusion [Category] MERS, SARS, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] 293 T cells 293T ACE2 Administered antibody Antibody titers approach binding calculated Cell convalescent convalescent plasma COVID-19 COVID-19 infection criteria detect Donor donors excluded exhibited FDA FFP transfusion Human immunodeficiency virus IgG antibody immunochromatographic test immunology immunology (other than RBC serology) individual Infection inhibited IQR median medium neutralization titer neutralize Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers non-specific nucleocapsid protein optical optical density plasma pseudovirus random Randomized controlled trial Randomized controlled trials Randomly randomly selected samples RBC RCT SARS-CoV-2 SARS-CoV-2 pseudovirus SARS2 screened selected serology Spike protein subset T cells tested titer Viral was collected [DOI] 10.1111/trf.16283 PMC 바로가기 [Article Type] Randomized Controlled Trial
Neutralizing Antibody Responses After SARS-CoV-2 Infection in End-Stage Kidney Disease and Protection Against ReinfectionClinical Research Published on 2021-04-282022-10-04 Journal: Kidney International Reports [Category] 비임상, [키워드] absence Abstract acute respiratory syndrome Against anti-N IgG antibody Asymptomatic Asymptomatic disease baseline coronavirus COVID-19 detectable determine develop ELISA enzyme-linked immunosorbent ESKD evaluate evaluated functional Hemodialysis humoral immune response Humoral immunity IgG level immune response individual Infection infectious complication investigated Kidney disease median NAb Neutralization assay Neutralizing activity neutralizing antibody outcome Patient patients polymerase chain protection pseudotype renal Repeat response responses Result retained risk factor S1 subunit SARS-CoV-2 SARS-CoV-2 spike seroconvert seroconverted seroconverted patient serum sample susceptibility [DOI] 10.1016/j.ekir.2021.03.902 PMC 바로가기 [Article Type] Clinical Research
Impact of the N501Y substitution of SARS-CoV-2 Spike on neutralizing monoclonal antibodies targeting diverse epitopesShort Report Published on 2021-04-282022-10-28 Journal: Virology Journal [Category] COVID-19, SARS, [키워드] ACE2 affected antibodies B.1.1.7 B.1.1.7 lineage binding activity binding affinity binding kinetics detected antibody epitope Impact monoclonal antibody Monoclonal neutralizing antibody Mutant SARS-CoV-2 Mutation N501Y N501Y variant neutralization activity Neutralizing Neutralizing activity neutralizing antibody neutralizing monoclonal antibody pseudovirus raising RBD protein SARS-CoV-2 SARS-CoV-2 variant spike Spread supplementary material the RBD therapeutic VOC-202012/01 wild type [DOI] 10.1186/s12985-021-01554-8 PMC 바로가기 [Article Type] Short Report
Robust Neutralizing Antibodies to SARS-CoV-2 Develop and Persist in Subjects with Diabetes and COVID-19 PneumoniaSARS-CoV-2에 대한 강력한 중화 항체, 당뇨병 및 COVID-19 폐렴 환자에서 개발 및 지속Article Published on 2021-04-232022-09-12 Journal: The Journal of Clinical Endocrinology and Metaboli [Category] MERS, 진단, [키워드] absence acute respiratory syndrome analyzed characterized Cohort coronavirus correlated COVID-19 COVID-19 pathogenesis Demonstrating diabete diabetes early phase Glucose hazard ratio Hospital admission Hospitalization humoral Humoral response hyperglycemia include increased risk lentiviral Mortality Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody response not affect not affected Patient patients with diabete Pneumonia Randomly Reinfection SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 neutralization selected Spike protein survival rate the SARS-CoV-2 vaccination Vaccine development Variability [DOI] 10.1210/clinem/dgab055 PMC 바로가기 [Article Type] Article
Safe and effective two-in-one replicon-and-VLP minispike vaccine for COVID-19: Protection of mice after a single immunizationCOVID-19에 대한 안전하고 효과적인 2-in-1 레플리콘 및 VLP 미니스파이크 백신: 단일 면역 후 마우스 보호Research Article Published on 2021-04-212022-09-12 Journal: PLoS Pathogens [Category] MERS, SARS, 진단, [키워드] animals Antigen antigen expression approach Author boost build candidate caused Cell cell surface chimeric classic Complication concern COVID-19 disease COVID-19 patients COVID-19 vaccine Critical disease domain effective Efficiency emergence of virus encoding enhancement envelope expressing expression functional glycoprotein humans immune response immunization immunogen include induce K18-hACE2 mice mice Neutralizing activity Neutralizing antibodies non-infectious Non-neutralizing antibodies outcome Particles pathogenic problem protection protective immune response Protein Rabies virus RBD RBD antigen Receptor binding domain Replication replication-competent virus replication-competent viruses RNA S antigen Safe SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 pandemic SARS-CoV-2 spike secreted sequence Side effect single dose Spread stimulated transgenic transmembrane tropism of SARS-CoV-2 vaccination Vaccine vaccine platform vectors vesicular stomatitis vesicular stomatitis virus viral DNA virus virus propagation Virus-like particle virus-neutralizing antibody VLP VLPs VSV VSVΔG [DOI] 10.1371/journal.ppat.1009064 PMC 바로가기 [Article Type] Research Article
Case Report: Stepwise Anti-Inflammatory and Anti-SARS-CoV-2 Effects Following Convalescent Plasma Therapy With Full Clinical Recovery증례 보고: 완전한 임상 회복과 함께 회복기 혈장 치료 후 단계적 항염 및 항 SARS-CoV-2 효과Case Reports Published on 2021-04-212022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] administration anti-CD20 anti-inflammatory activity anti-SARS-CoV-2 anti-SARS-CoV-2 antibody B cell B-cell B-cell depletion blood cell counts Chemotherapy chronic lymphoid leukemia chronic SARS-CoV-2 infection clinical clinical recovery Complete convalescent plasma Convalescent plasma therapy COVID-19 pandemic COVID-19 patient COVID-19 patients cumulative depleting Effect evaluate humoral IgA IgG IgM Immunocompromised patients Immunosuppressed implication increase in Inflammation initial lymphopenia mechanism monoclonal antibody Neutralizing activity Neutralizing antibodies neutralizing antibody outcome patients plasma Plasma transfusion Pneumonia quantification radiological raised receiving resulting SARS-CoV-2 clearance SARS-COV-2 infection SARS-CoV-2 RNA severe immunosuppression the patient Therapeutic approach therapeutic option Treatment treatment effect understanding upper respiratory tract viral clearance virus isolation were assessed [DOI] 10.3389/fimmu.2021.613502 PMC 바로가기 [Article Type] Case Reports
Comparison of virus neutralization activity and results of 10 different anti-SARS-CoV-2 serological tests in COVID-19 recovered plasma donorsFull Length Article Published on 2021-04-202022-10-29 Journal: Practical Laboratory Medicine [Category] COVID-19, [키워드] anti-SARS-CoV-2 antibody Antibody neutralization Antibody Response Antigen AUC, area under the curve Correlate of protection correlation COVID COVID-19 COVID-19, Coronavirus disease 2019 cut off cut-off value diagnostic value Donor ECDC, European Centre for Disease Prevention and Control ELISA ELISA kit ELISA test epidemiological epidemiological survey examined expected gold standard greater identify individual Infection information moderate NAbs, neutralizing antibodies NC, Nucleocapsid neutralization neutralization activity neutralize Neutralizing activity nucleocapsid OD, optical density onset of symptom performed plasma predict Protein ranged RBD RBD antigen response to vaccination responses against ROC, Receiver Operating Characteristic S1, Spike protein 1 S2, Spike protein 2 SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 Sensitivity and specificity serological serological test serum sample Spearman correlation coefficient specificity Test tested therapeutic vaccinated individuals virus Virus neutralization virus neutralization test VNT, virus neutralization test were measured [DOI] 10.1016/j.plabm.2021.e00222 PMC 바로가기 [Article Type] Full Length Article
Weak correlation between antibody titers and neutralizing activity in sera from SARS-CoV-2 infected subjectsArticle Published on 2021-04-012023-06-19 Journal: Journal of medical virology [Category] MERS, SARS, [키워드] COVID-19 diagnostic assays Neutralizing activity SARS-CoV-2 serology [DOI] 10.1002/jmv.26605 PMC 바로가기