Hypocalcemia is a distinctive biochemical feature of hospitalized COVID-19 patients저칼슘혈증은 입원한 COVID-19 환자의 독특한 생화학적 특징입니다.Article Published on 2021-01-012022-09-11 Journal: Endocrine [Category] Coronavirus, SARS, 바이오마커, [키워드] biochemical hospitalized COVID-19 patient Hypocalcemia [DOI] 10.1007/s12020-020-02541-9 PMC 바로가기 [Article Type] Article
Effect of hydroxychloroquine with or without azithromycin on the mortality of coronavirus disease 2019 (COVID-19) patients: a systematic review and meta-analysis2019년 코로나바이러스 감염증(COVID-19) 환자 사망률에 대한 아지트로마이신 유무에 따른 하이드록시클로로퀸의 영향: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-01-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] 신약개발, 치료제, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Antiviral effect articles Azithromycin Bayesian meta-analysis Chloroquine Cochrane Library Combination conducted control group controlled trials coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mortality Critical disease Effect effect sizes eligibility evaluated Google Scholar hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients Hydroxychloroquine hydroxychloroquine group in vitro inclusion criteria increased mortality initial search medRxiv Meta-analysis moderate Mortality mortality rate Multiple non-randomized trial observational studies participant Patient patients treated promoted random-effects model Randomized controlled trials reduced Relative risk respiratory risk risk of bia Risk of bias SARS-CoV-2 searched severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly significantly increased Standard of care systematic review treat Web of Science [DOI] 10.1016/j.cmi.2020.08.022 PMC 바로가기 [Article Type] Meta-Analysis
Association of liver steatosis and fibrosis with clinical outcomes in patients with SARS-CoV-2 infection (COVID-19)SARS-CoV-2 감염(COVID-19) 환자의 임상 결과와 간 지방증 및 섬유증의 연관성Article Published on 2021-01-012022-09-11 Journal: Annals of hepatology [Category] SARS, 바이오마커, [키워드] abnormality Admission association clinical Clinical outcome clinical outcomes Comorbidity conducted COVID-19 COVID-19 patient COVID-19 patients determine FIB-4 fibrosis hospitalized COVID-19 patient hospitalized COVID-19 patients ICU ICU admission independent Infection intensive care unit liver Liver fibrosis Liver function test liver function tests liver steatosis male material Mortality NAFLD obese outcome outcomes patients patients with COVID-19 patients with SARS-CoV-2 Prevalence reported Retrospective study risk SARS-CoV-2 steatosis [DOI] 10.1016/j.aohep.2020.09.015 PMC 바로가기 [Article Type] Article
Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosisResearch Article Published on 2020-12-282022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] AUC Blood blood test both groups clinical clinical suspicion clinically Computed tomography consecutive patient COVID-19 COVID-19 symptom COVID-19 symptoms criteria D-dimer D-dimer level develop diagnosed Diagnosis feature group Hospitalized hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient in both groups incidence Laboratory median median value non-PE patient non-PE patients Occurrence parameter Patient PE patient Potential reported Result Retrospective study ROC Curve Sensitivity and specificity statistically significant Symptom Thrombotic events utility with COVID-19 [DOI] 10.1371/journal.pone.0243533 PMC 바로가기 [Article Type] Research Article
D-Dimers Level as a Possible Marker of Extravascular Fibrinolysis in COVID-19 PatientsArticle Published on 2020-12-242022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% CI abnormality absence Activation analysed baseline Chest computed tomography contribute coronavirus COVID-19 COVID-19 patient Critical CRP level evidenced fibrin degradation product fibrinolysis haemostasis hospitalized COVID-19 patient ICU In-hospital death include increase in independent Inflammatory intensive care less Level Lung injury marker mechanism Occurrence outcome Patient primary endpoint Prognostic value quantification Respiratory distress syndrome secondary outcome significantly Stage stage 2 threshold thrombosis Thrombotic events transfer virus infection [DOI] 10.3390/jcm10010039 PMC 바로가기 [Article Type] Article
Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertensionArticle Published on 2020-12-222022-10-04 Journal: Cell Discovery [Category] 바이오마커, 변종, 신약개발, 임상, 치료제, [키워드] acute respiratory syndrome administration angiotensin-converting enzyme inhibitor anti-SARS-CoV-2 antihypertensive drugs antiviral drug blocker blockers calcium channel caused CCBs Cell Biology Chloroquine clinical investigation clinics Comorbidity coronavirus coronavirus disease country COVID-19 COVID-19 patient COVID-19 patients effective Efficacy elevated event Fatality rate global public health hospitalized COVID-19 patient hypertension IMPROVE in vitro inhibited Mechanisms of disease Mortality outcome receptor reduced Replication retrospective SARS-CoV-2 Severe infection significantly spread to the disease therapy treat [DOI] 10.1038/s41421-020-00235-0 PMC 바로가기 [Article Type] Article
Derivation and validation of a prognostic model for predicting in-hospital mortality in patients admitted with COVID-19 in Wuhan, China: the PLANS (platelet lymphocyte age neutrophil sex) modelResearch Article Published on 2020-12-172022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] age approach assist averaged bootstrap clinician Cohort collected competing COVID-19 COVID-19 patient cumulative demonstrated derivation discharged evaluated External external validation fatality female females Final FIVE healthcare hospital hospitalized COVID-19 patient in-hospital mortality incidence independent internal lack lymphocyte Lymphocyte count median age neutrophil neutrophil count overfitting Patient patient population physician PLANS Platelet predict predicted Predictive predictor predictor variable profiles prognostic model reduce resource Result retrospective cohort risk Sex statistical analyses suggested Support were used with COVID-19 Wuhan Wuhan, China [DOI] 10.1186/s12879-020-05688-y PMC 바로가기 [Article Type] Research Article
Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome질병 중증도 및 결과와 관련된 SARS-CoV-2 감염에 대한 항체 반응의 특징 및 기간 정의Research Articles Published on 2020-12-072022-09-10 Journal: Science Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] ACE2 acute illness Affect analyzed angiotensin angiotensin-converting enzyme 2 antibody antibody levels Antibody Response Antibody responses Asymptomatic Asymptomatic individuals Clinical outcome clinical outcomes Cohort correlated COVID-19 COVID-19 patients decrease decreases disease severity ELISA feature FIVE hospitalized COVID-19 patient Host IgG IgG antibodies IgG antibody IgG titer illness Illness severity in viral increase Interaction mild illness Most patients Neutralization assay neutralize nucleocapsid antigen observation outcome outcomes Outpatient outpatients Patient patients patients died plasma antibody plasma sample Post-infection predict Pseudovirus neutralization assays RBD RBD domain RBD-ACE2 receptor Receptor binding domain responses SARS-CoV-2 antibodies SARS-COV-2 infection SARS-CoV-2-specific antibodies serological serological response severely ill patients severity specific antibodies specificity Viral viral spike virus [DOI] 10.1126/sciimmunol.abe0240 PMC 바로가기 [Article Type] Research Articles
Prevalence and predictors of death and severe disease in patients hospitalized due to COVID-19: A comprehensive systematic review and meta-analysis of 77 studies and 38,000 patientsCOVID-19로 인해 입원한 환자의 사망 및 중증 질환의 유병률 및 예측인자: 77건의 연구 및 38,000명의 환자에 대한 포괄적인 체계적 검토 및 메타 분석Research Article Published on 2020-12-072022-08-13 Journal: PLoS ONE [Category] COVID-19, Medicine and Health Sciences, MERS, SARS, [키워드] 95% CI adjusted adverse outcome adverse outcomes analyzed association China Chronic kidney disease chronic liver disease CKD CLD Comorbidities confidence interval COPD COVID-19 COVID-19 patient death determine diabete diabetes died disease Disease progression Europe fatality Health health screening heart disease heterogeneity Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients hypertension Inclusion inclusion criteria individual Infection Kidney disease male males Meta-analysis morbidity morbidity and mortality objective observational studies observational study Patient patients hospitalized predictor Prevalence Public reduce Relative risk Result risk risk factor Risk factors searched severe disease smoking susceptibility susceptibility to infection systematic review Web of Science [DOI] 10.1371/journal.pone.0243191 PMC 바로가기 [Article Type] Research Article
Early Humoral Response Correlates with Disease Severity and Outcomes in COVID-19 Patients조기 체액 반응은 COVID-19 환자의 질병 중증도 및 결과와 관련이 있습니다Article Published on 2020-12-042022-09-01 Journal: Viruses [Category] MERS, 진단, 치료법, [키워드] Admission anti-N antibodies anti-N antibody Anti-S1 antibody Antibody Response Antibody responses Antigen caused Clinical management Clinical presentations coronavirus disease Coronavirus disease 2019 correlated strongly COVID-19 COVID-19 patient COVID-19 patients COVID19 death detectable disease disease severity hospitalized COVID-19 patient hospitalized COVID-19 patients ICU IgG IgG and IgM IgM IgM antibodies intensive care unit intensive care units investigated Kinetics Mild moderate morbidity and mortality mortality rates NAb NAbs Neutralizing Neutralizing antibodies neutralizing antibody outcome outcomes Patient Protein response SARS-CoV-2 severe symptoms significantly significantly higher Spread survival symptoms onset [DOI] 10.3390/v12121390 PMC 바로가기 [Article Type] Article