Tolerability and usability of 0.5% PVP-I gargles and nasal drops in 6692 patients: Observational studyObservational Study Published on 2021-03-012022-10-05 Journal: American journal of otolaryngology [Category] 임상, [키워드] adverse effect Antiviral benefit Care COVID COVID 19 ENT examination evaluated feasibility global health Health care worker hospital Level MERS nasal nasal drop nasal drops observational study Otorhinolaryngologic consultations Patient povidone Povidone Iodine Public public health PVP-I gargles and nasal drops reaction reported SARS CoV SARS CoV 2 SARS CoV 2, MERS, prophylaxis SARS Cov. secondary staining the patient Tolerability Transmission [DOI] 10.1016/j.amjoto.2020.102880 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2/COVID-19 pandemic: first wave, impact, response and lessons learnt in a fully integrated Regional Blood and Tissue Bank. A narrative reportSARS-CoV-2/COVID-19 전염병: 완전히 통합된 지역 혈액 및 조직 은행에서 첫 번째 물결, 영향, 대응 및 교훈. 내러티브 보고서Article Published on 2021-03-012022-09-11 Journal: Blood transfusion = Trasfusione del sangue [Category] SARS, 치료기술, [키워드] activity adverse effect Ambiguity Bank being Blood BST Care cells changes in clinical trial clinical trials Combination complexity convalescent plasma COVID-19 COVID-19 pandemic Critical described development diagnoses Donor donors effective element First wave flexibility Health health system International management material measure Mesenchymal stromal cells occurred pandemic Participation Patient patients promote Recognition recommendation Regional Research research and development response risk service Stress stromal cells Support tissue Tissue Bank volatility [DOI] 10.2450/2021.0259-20 PMC 바로가기 [Article Type] Article
Hydroxychloroquine for treatment of nonsevere COVID-19 patients: Systematic review and meta-analysis of controlled clinical trials중증이 아닌 COVID-19 환자의 치료를 위한 Hydroxychloroquine: 대조 임상 시험의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-03-012022-09-11 Journal: Journal of medical virology [Category] 임상, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus-2 adverse effect adverse effects age arising authors being bias risk Case fatality rate clearance clinical benefit clinical benefits clinical evidence clinical trial clinical trials confidence interval Controlled clinical trial coronavirus coronavirus disease Coronavirus-2 COVID-19 COVID-19 confirmed patient COVID-19 patients COVID-19 progression data extraction determine Efficacy ENhance Evidence failure Fatality rate Hydroxychloroquine hydroxychloroquine therapy inclusion criteria independent Intervention Meta-analysis Mortality pandemic Patient Pharyngeal swab polymerase chain polymerase chain reaction Prevent Primary outcome Primary outcomes progression protective effect radiological radiological progression reduce reported risk Risk assessment risk difference secondary outcome Secondary outcomes Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly Treatment usual care viral clearance [DOI] 10.1002/jmv.26442 PMC 바로가기 [Article Type] Meta-Analysis
SARS-CoV-2-Specific Memory T Lymphocytes From COVID-19 Convalescent Donors: Identification, Biobanking, and Large-Scale Production for Adoptive Cell TherapyCell and Developmental Biology Published on 2021-02-252022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] absence adoptive cell therapy (ACT) adverse effect Biobank Blood CD3 CD4 CD45RA CD8 central memory Complete convalescent coronavirus COVID-19 develop disease Donor donors effective Effective vaccines effector memory feasible GMP hospitalized patient identification immune protection Infection lymphopenia memory T cell memory T cells (Tmem) outbreak pandemic pathogen patients patients hospitalized Production reduce respond SARS-CoV-2 SARS-CoV-2-specific T cell Secondary infection severity of COVID-19 significantly subpopulations subset Symptoms therapeutic option these cell treat Treatment with COVID-19 [DOI] 10.3389/fcell.2021.620730 PMC 바로가기 [Article Type] Cell and Developmental Biology
Treatment of severe COVID-19 with convalescent plasma in Bronx, NYC뉴욕 브롱크스에서 회복기 혈장으로 중증 COVID-19 치료Comparative Study Published on 2021-02-222022-09-12 Journal: JCI Insight [Category] MERS, 진단, [키워드] acute respiratory disease Admission adverse effect age aging analyses antibody anticoagulation body mass body mass index CCP Clinical outcome Comorbidities Control Controlled trial controlled trials controls convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 Corticosteroid COVID-19 criteria D-dimer Deterioration Efficacy Ethnicity hospitalized patient hospitalized patients IgA titer IgA titers IgG IgM immunoglobulins Infectious disease less lower risk lymphocyte lymphocyte counts matching median Mortality no difference oxygen Oxygen requirement Oxygenation patients with COVID-19 plasma promise Propensity score recipient recipients SARS-CoV-2 severe COVID-19 Sex Spike protein stratified Treatment [DOI] 10.1172/jci.insight.142270 PMC 바로가기 [Article Type] Comparative Study
Evaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19Research Paper Published on 2021-02-182022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, MERS, [키워드] ACE2 ACE2 expression adverse effect Analysis Cancer cancer patient cancers COVID-19 case COVID-19 disease COVID-19 patient COVID-19 patients event expressed expression expression profile GRP78 HSPA5 indicate individual lung cancer malignant tumor management medical treatment mRNA level much higher Patient prognostics provide receptor reported SARS-CoV-2 severity significant difference significantly significantly increased survival susceptibility susceptible These data tissue tissues transcriptomics tumors virus with COVID-19 [DOI] 10.7150/ijbs.54055 PMC 바로가기 [Article Type] Research Paper
Precision Medicine and Public Health: New Challenges for Effective and Sustainable HealthReview Published on 2021-02-162022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] adverse effect applicability approach can be used challenge communicable Course Diseases early disease prevention effective Effectiveness Epigenetic epigenetic modulations genetic and microbiome markers genetic polymorphisms Health Health status Health technology assessment Human genetics implementation implication Implications Italian Italy knowledge Medicine medium Microbiome miRNA modulation National New omics technology Public public health public health genomics rapid increase Regulation [DOI] 10.3390/jpm11020135 PMC 바로가기 [Article Type] Review
Comprehensive Landscape of Heparin Therapy for COVID-19COVID-19에 대한 헤파린 요법의 종합적인 전망Review Published on 2021-02-152022-09-11 Journal: Carbohydrate polymers [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition administration adverse effect adverse effects Anti-inflammation Anti-inflammatory Anticoagulant anticoagulant agent anticoagulation antiviral activities antivirus binding biochemical caused cells clinical clinical observation clinical observations Comprehensive concerning coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Effect Effectiveness Evidence heparin in vitro study Infection landscape observation pandemic coronavirus pharmacological mechanism Protein public health emergency pulmonary thrombosis respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spike protein systemic symptom systemic symptoms the Spike therapy thrombosis Viral viral infection [DOI] 10.1016/j.carbpol.2020.117232 PMC 바로가기 [Article Type] Review
Natural Products and Nutrients against Different Viral Diseases: Prospects in Prevention and Treatment of SARS-CoV-2다양한 바이러스성 질병에 대한 천연물 및 영양소: SARS-CoV-2의 예방 및 치료 전망Review Published on 2021-02-142022-09-10 Journal: Medicina [Category] 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adverse effect Antiviral approach approaches bat bats caused Coronavirus-2 effective global pandemic humans medicinal plants mineral Minerals natural nutrient occurred pandemic plant plants prevention Previous studies previous study product Protective respiratory SARS-CoV SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 shown therapeutic transferred Viral diseases virus Vitamin vitamins zoonotic zoonotic virus [DOI] 10.3390/medicina57020169 PMC 바로가기 [Article Type] Review
Between a hygiene rock and a hygienic hard place Avoiding SARS-CoV-2 while needing environmental exposures for immunityReview Published on 2021-02-122022-11-01 Journal: Evolution, Medicine, and Public Health [Category] COVID-19, [키워드] acute respiratory syndrome adverse effect Adverse reaction allergic alleviate Autoimmune disease Avoiding benefit characterized clinicians and researcher Community Complete component coronavirus coronavirus disease country COVID-19 COVID-19 pandemic described disorders Effect Effects environmental exposure evolutionary mismatch Health hygiene immune function immune response Immunity infectious agents Infectious disease intestinal many case measure Neuropsychiatric Pandemics plants predicted Prevent problem provided reduced researcher SARS-CoV-2 social distancing supported Treatment worm [DOI] 10.1093/emph/eoab006 PMC 바로가기 [Article Type] Review