SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responsesMHC-I 제한 에피토프의 SARS-CoV-2 돌연변이는 CD8 + T 세포 반응을 회피합니다Research Articles Published on 2021-03-042022-09-10 Journal: Science Immunology [Category] Fulltext, SARS, 변종, 진단, [키워드] abrogated binding CD8 Cell COVID-19 patient COVID-19 patients COVID-19 severity CTL cytotoxic activity deep sequencing epitope Epitopes evade Ex vivo exhibited highlight IFN-γ Immunity implicated in vitro isolates MHC-I MHC-I epitope MHC-I epitopes mutant nonsynonymous mutation Nonsynonymous mutations peptide peptides Point mutation point mutations proliferation response RNA sequencing SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 virus Sequencing Surveillance T cell T cell epitope T cell epitopes T cells tetramer transcriptional response Viral virus [DOI] 10.1126/sciimmunol.abg6461 PMC 바로가기 [Article Type] Research Articles
COVID-19 Impairs Immune Response to Candida albicansCOVID-19는 Candida albicans에 대한 면역 반응을 손상시킵니다Immunology Published on 2021-02-262022-09-11 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, [키워드] abrogated Activation acute respiratory distress acute respiratory distress syndrome Antigen ARDS Aspergillus fumigatus Blood Candida Candida albican Candida albicans CD244 CD38 CD4 CD8 CD80 changes in characterization characterized clinical parameter Clinical parameters coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients cytokine cytokine release Cytokines cytokines IL-6 detrimental elevated fungal healthy controls HLA-DR ICU ICU admission IL-10 IL-1α IL-1β IL-6 IL-8 Immune phenotype immune response Infection lipopolysaccharide Listeria monocytogene Listeria monocytogenes LPS Lymphocytes marker monocyte Monocyte activation not differ Pathogenesis PD-1 plasma Prognosis recent respiratory distress response SARS-CoV-2 second hit Secondary infection secondary infections severe acute respiratory distress syndrome susceptibility syndrome T cells therapy TNF upregulation were assessed were used yeast [DOI] 10.3389/fimmu.2021.640644 PMC 바로가기 [Article Type] Immunology
Correlates of protection against SARS-CoV-2 in rhesus macaques붉은 털 원숭이에서 SARS-CoV-2에 대한 보호 상관 관계Article Published on 2021-02-012022-09-12 Journal: Nature [Category] MERS, SARS, 진단, [키워드] abrogated acute respiratory syndrome Antibody Response Antibody titre antibody titres CD8 Cellular immune response cellular immunity contribute convalescent coronavirus Depletion dose-dependent Efficacy humoral IgG Immunity implication infection with SARS-CoV-2 macaque macaques natural immunity PROTECT Protective purified recent reported required rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine T cell therapeutic agents transfer Treatment [DOI] 10.1038/s41586-020-03041-6 PMC 바로가기 [Article Type] Article
Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair ResponseSARS-CoV-2 및 담배 연기에 직접 노출되면 감염 심각도가 증가하고 줄기 세포 유도 기도 복구 반응이 변경됩니다Article Published on 2020-12-032022-09-11 Journal: Cell Stem Cell [Category] Fulltext, MERS, 유전자 메커니즘, [키워드] abrogated Affect Air-liquid interface airway airway basal stem cells ALI culture ALI cultures basal stem cell basal stem cells Cell cigarette cigarette smoke COVID-19 Culture cultures current Direct disease disease spread epithelial exposure to implication increase increase in increased risk infected airway cells Infection Injury injury and repair innate immune response interferon interferon response lack Mucociliary clearance number of infected potential mechanism proliferation reducing repair response RNA SARS-CoV-2 severe COVID-19 severity short term Single Cell single cell RNA sequencing smoke smoking STEM stem cells Viral viral infection was reduced with infection [DOI] 10.1016/j.stem.2020.11.010 PMC 바로가기 [Article Type] Article
Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila미세 조정 autophagy는 수명을 최대화하고 초파리의 미토콘드리아 유전자 발현 변화와 관련이 있습니다Research Article Published on 2020-11-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogated Amino acid applied approach Atg1 Atg5 autophagy block cellular cellular pathway changes in characteristic conditions conserved Critical damaged Degradation degrade Deletion detrimental disease down-regulated down-regulation downregulation Drosophila Effect energy expression extension feature Glucose Health healthy help highlight immune system IMPROVE in vivo increase in Increased insulin insulin receptor Intervention leads Longevity metabolism metabolomic Mild mitochondrial mitochondrial gene mitochondrial genes mitochondrial metabolism moderate Moderation organelle over-expressing overexpression pathway Pathways phenotype Phenotypes profile proteasomal Protein Rapamycin receptor reduced Research short-lived signature transcriptional profile Transcriptional upregulation triacylglycerol up-regulated up-regulation upregulated upregulation [DOI] 10.1371/journal.pgen.1009083 PMC 바로가기 [Article Type] Research Article
CD71 + Erythroid Cells in Human Neonates Exhibit Immunosuppressive Properties and Compromise Immune Response Against Systemic Infection in Neonatal MiceImmunology Published on 2020-11-242022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] abrogated activated Against age apocynin appear Asymptomatic Bacteria Blood Bone marrow Brain CD14 CD45 CD71+ erythroid cells compromise control group COVID-19 COVID-19 infection cytokine production Diseases erythroid explain expressing Frequency highlight Human Immune cell immune system Immunosuppression immunosuppressive in vitro Infant Infants Infection Listeria monocytogene liver mechanism mice Mild monocyte Neonatal neonatal infections Neonate Newborn Newborns Older Peripheral blood physiological potential mechanism precursor property proportion reactive oxygen specy reduction in regulated response ROS ROS production significantly higher spleen suppressed survival rate susceptibility susceptible systemic T cells these cell [DOI] 10.3389/fimmu.2020.597433 PMC 바로가기 [Article Type] Immunology
Performance of nucleocapsid and spike-based SARS-CoV-2 serologic assaysResearch Article Published on 2020-11-022022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] abrogated acute respiratory syndrome anti-SARS-CoV-2 antibodies Antibody test Antigen antigens cause component coronavirus COVID-19 ELISA ELISAs evaluated exhibiting False positive False-positive highest identification IgA IgG IgG and IgM IgM/IgG in some lateral flow non-specific novel nucleocapsid nucleocapsid IgM PCR-confirmed COVID-19 performance plasma antibody positive presence of antibody reaction reactivity reproducibility S1 IgG SARS-CoV-2 sensitivity Sensitivity and specificity serologic assay specificity spike IgG System target trimer Variability was used [DOI] 10.1371/journal.pone.0237828 PMC 바로가기 [Article Type] Research Article
Hemophagocytic lymphohistiocytosis in a patient with COVID-19 treated with tocilizumab: a case reportCase Report Published on 2020-10-152022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, MERS, SARS, [키워드] abrogated Admission biochemical blockade C-reactive protein Case report clinical picture coronavirus disease COVID-19 criteria decrease described develop eight elevated ferritin Fever FIVE hemophagocytic lymphohistiocytosis HLH hyperinflammation Hyperinflammatory IL-6 Immune thrombocytopenia Immune-mediated IMPROVE induce inflammatory parameter intensive care interleukin-6 interleukin-6 receptor lactate dehydrogenase majority Manifestations measurement monoclonal antibody Patient patient with COVID-19 performed Pulmonary function purpura quantification Randomized controlled trials Respirator Respiratory failure Respiratory illness severe COVID-19 Specific syndrome therapeutic thrombotic Tocilizumab treated Treatment [DOI] 10.1186/s13256-020-02503-9 PMC 바로가기 [Article Type] Case Report
Structures and dynamics of the novel S1/S2 protease cleavage site loop of the SARS-CoV-2 spike glycoproteinArticle Published on 2020-10-052022-10-30 Journal: Journal of Structural Biology: X [Category] COVID-19, [키워드] ab initio modelling abrogated Abstract cleavage site conformations coronavirus furin cleavage site glycan host cells human pathogen insertion Interaction Molecular dynamics simulation prefusion protease proteolytic cleavage regulate representing S1/S2 SARS-CoV-2 spike glycoprotein spike glycoprotein gene Structure the SARS-CoV-2 therapeutic target viral entry virulent [DOI] 10.1016/j.yjsbx.2020.100038 PMC 바로가기 [Article Type] Article
An alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primatesResearch Article Published on 2020-07-202022-10-29 Journal: Science Translational Medicine [Category] COVID-19, MERS, SARS, [키워드] abrogated Anti-SARS-CoV-2 S Antibody Response booster caused collected comparable component coronavirus COVID-19 COVID-19 pandemic Deleterious dose effective elicited ENhance Health Service highlighting human serum IgG antibody immune response immunization individual induce Infection Intramuscular injection isotype Lipid lung macaques mice nanoparticle neutralized neutralizing antibody Prophylactic Protein regimen response RNA RNA vaccine robust robust antibody responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody spleen stability Support T cell response T helper cell the SARS-CoV-2 Type Vaccine vaccine candidate [DOI] 10.1126/scitranslmed.abc9396 PMC 바로가기 [Article Type] Research Article