ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients중환자실 COVID-19 환자의 사망률 예측인자로서의 내피 바이오마커의 ICU 입원 수준Observational Study Published on 2021-01-192022-09-11 Journal: Cells [Category] MERS, 바이오마커, 임상, [키워드] Adhesion Molecule Admission Ang-1 angiopoietin association Biomarker Biomarkers characteristic Cohort COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients determine died E-selectin elevated endothelial endothelial damage endothelial marker Endothelial markers endotheliopathy greater growth factor hospitalized patients ICU ICU admission Ill intensive care intensive care unit intercellular intercellular adhesion molecule involved Kaplan–Meier analysis Level marker Mortality non-survivor observational study predict Probability Prognostic value receiver operating characteristic ROC ROC Curve sE-selectin selectin sICAM-1 significantly sP-selectin suggested survival survivor Survivors Vascular vascular endothelial growth factor VEGF von Willebrand factor was used were assessed were measured [DOI] 10.3390/cells10010186 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 infection is associated with a pro-thrombotic platelet phenotypeSARS-CoV-2 감염은 전혈전성 혈소판 표현형과 관련이 있습니다Article Published on 2021-01-052022-09-11 Journal: Cell Death & Disease [Category] 치료기술, [키워드] abnormal coagulation Activation addition Adhesion Molecule adhesion molecules antibodies antiplatelet Antithrombotic cardiovascular complications CD63 characterized Coagulation complex condition contribute Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19 sample COVID-19 samples Cytometry donors expressed expression healthy control healthy controls hospitalized COVID-19 patient hospitalized COVID-19 patients hypercoagulable Hypercoagulable state in vitro incidence intensity intensive care intensive care support interactions investigated involved LAMP marker mass Mechanisms of disease median novel Novel coronavirus novel coronavirus disease P-selectin parameter patients peptide phenotype phenotypical Platelet platelet activation Platelets pro-thrombotic reduced Research SARS-COV-2 infection selectin signal intensity significantly Stimulation Support thrombin thrombin receptor transmembrane protein TRAP Treatment viral infection [DOI] 10.1038/s41419-020-03333-9 PMC 바로가기 [Article Type] Article
Serum proteins may facilitate the identification of Kawasaki disease and promote in vitro neutrophil infiltrationArticle Published on 2020-09-242022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] activated Adhesion Molecule Affect age antibody applied attenuate Biomarkers cause children clinically conducted DEFA1 demonstrated develop Developing Diagnosis diagnostic Diseases ELISA endothelial endothelial cells enrolled evaluate facilitate glycoprotein immune immunology in vitro in vitro study infiltration Inflammatory Kawasaki disease lesion leukocyte Medical research Molecular medicine neutrophil neutrophil infiltration neutrophil surface neutrophil-like cell ORM1 Pathogenesis pathogenic patients potential mechanism potential therapeutic target PRDX2 promote promoted Protein Proteins proteomics reducing responsible rheumatology risk robust S100A12 S100A8 S100A9 Satisfaction serum Serum protein significantly subject Treatment [DOI] 10.1038/s41598-020-72695-z PMC 바로가기 [Article Type] Article
COVID-19, Renin-Angiotensin System and Endothelial DysfunctionReview Published on 2020-07-092022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory distress Adhesion Molecule ARDS caused CD209L Cell cell types complications COVID-19 Critical Cytokine storm Endothelial cell endothelial cell injury Endothelial dysfunction endothelial injury enzyme exacerbate expressed generate global public health hallmark homeostasis host cells hypertension immune response induce Infection Injury interact involved L-SIGN molecular basis molecular mechanism Mortality novel coronavirus disease obesity offer outbreak pathophysiology pathway physiological primary mechanism RAS Regulation related viruses renin-angiotensin system respiratory epithelium SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 virus Signaling spike glycoprotein stimulate syndrome System therapeutic strategy thought understanding Vascular damage Vascular endothelium [DOI] 10.3390/cells9071652 PMC 바로가기 [Article Type] Review
Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19Immunology Published on 2020-06-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE2 Activation acute lung injury acute phase response acute respiratory distress Adhesion Molecule alveolar macrophage ARDS Bisphosphonates Blood Bone marrow Cell Combination COVID-19 CSS cytokine Cytokine storm syndrome decrease develop dissemination Endothelium expression Factors fibrinogen IL-1β IL-6 immature Impact increase infiltration of neutrophil Inflammation Inflammatory inflammatory monocytes Intervention Kallikrein-kinin system knowledge lung lung epithelial cell Lung infection Lung injury Monocytes MOST patients Platelets pro-thrombotic proinflammatory cytokines reducing renin-angiotensin system response SARS-CoV-2 SARS-CoV2 SARS-CoV2 infection severe COVID-19 stimulate syndrome systemic systemic inflammation TNF VEGF [DOI] 10.3389/fimmu.2020.01626 PMC 바로가기 [Article Type] Immunology
Nrf2 Activator PB125 ® as a Potential Therapeutic Agent against COVID-19Article Published on 2020-06-122022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] “cytokine storm” HDAC5 ACE2 activate Activation activator Adhesion Molecule affecting age agent ALI Antiviral assays Cell cellular chronic inflammation coronavirus COVID-19 CXCL10 cytokine Cytokine storm Cytokines Decline decrease Diseases downregulate downregulation E-selectin endothelial cells Evidence examined expression gene expression level GeneChip Genes genes encoding HepG2 cells host cells ICAM-1 IL-6 Immunity include Inflammation intensity involved LIF mechanism Microarray mRNA expression NFE2L2 Nrf2 oxidative Potential regulate Replication RNA-Seq SARS-CoV-2 SARS-CoV-2 entry significantly surface receptor susceptibility susceptible the spike protein TMPRSS2 TNF-α transcription factor type 2 diabetes VCAM-1 viral infections [DOI] 10.3390/antiox9060518 PMC 바로가기 [Article Type] Article
Exercise intervention alters HDL subclass distribution and function in obese women운동 중재는 비만 여성의 HDL 하위 분류 분포와 기능을 변경합니다.Research Published on 2018-10-102022-09-06 Journal: Lipids in Health and Disease [Category] Communicable Disease, [키워드] activating activity Adhesion Molecule aerobic African Alter Analysis Anti-inflammatory anti-inflammatory function Antioxidative assigned Blood body mass body mass index cardiovascular risk cell adhesion molecule cellular cholesterol Cholesterol efflux clinical condition controls decrease distribution endothelial exercise Exercise intervention expression HDL HDL structure HDL subclass high-density High-density lipoprotein Intervention Level modify obese obese patients obesity Platelet platelet activating factor Randomly reduce reduction in resistance exercise Result serum South subclass supplementary material Trial vascular cell adhesion venous venous blood were measured western blotting women [DOI] 10.1186/s12944-018-0879-1 PMC 바로가기 [Article Type] Research
Vascular adhesion protein-1 is actively involved in the development of inflammatory lesions in rat models of multiple sclerosisResearch Published on 2018-05-012023-08-30 Journal: Journal of Neuroinflammation [Category] E형 간염, [키워드] Adhesion Molecule Blood brain-barrier Experimental allergic encephalomyelitis Inflammation multiple sclerosis [DOI] 10.1186/s12974-018-1152-2 PMC 바로가기 [Article Type] Research