alveolar macrophage – Page 4 – Communicable Diseases Research

Severe COVID-19: A multifaceted viral vasculopathy syndrome

중증 코로나19: 다면적 바이러스성 혈관병증 증후군

Article

Published on 2021-02-012022-09-11
Journal: Annals of diagnostic pathology [Category] SARS, 유전자 메커니즘, 치료기술, 치료제,

Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation

Article

Published on 2021-01-122022-10-04
Journal: Nature Communications [Category] 바이오마커,

Preventing the development of severe COVID-19 by modifying immunothrombosis

면역혈전증을 변형시켜 중증 코로나19 발병 예방

Review

Published on 2021-01-012022-09-12
Journal: Life sciences [Category] MERS, SARS, 진단,

[키워드] activated Activation acute respiratory distress alveolar alveolar cell alveolar epithelial cell alveolar macrophage ARDS chemokine Combination complexes COVID-19 Endothelial cell immunothrombosis include Infection Inflammation inflammatory mediator initial involved Macrophage Migration morbidity Mortality necroptosis NETs neutrophil Neutrophil extracellular trap NLRP3 pathophysiology Platelet Preventing producing Proinflammatory cytokine pyroptosis respiratory respiratory infection SARS-CoV-2 severe COVID-19 subsequent syndrome tissue damage translocation Treatment Vascular vascular endothelial cell vasculature
[DOI] 10.1016/j.lfs.2020.118617 PMC 바로가기 [Article Type] Review

FBA reveals guanylate kinase as a potential target for antiviral therapies against SARS-CoV-2

FBA, SARS-CoV-2에 대한 항바이러스 치료제의 잠재적 표적으로 구아닐레이트 키나제 밝혀

Systems

Published on 2020-12-292022-09-10
Journal: Bioinformatics [Category] Fulltext, SARS, 치료제,

[키워드] affecting alteration alveolar macrophage Alveolar macrophages analyses Analysis Antiviral antiviral therapies antiviral therapy approved change changed COVID-19 described Effect experiments FBA flux balance analysis growth Host host cell host cells implementation In-vitro increase Infection inhibitor investigation knock knock-out macrophages metabolic processe metabolism motivation Novel coronavirus nucleotide released Result reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections sequence Spread target targets the disease therapeutic effect therapeutic targets uninfected Viral viral nucleotide virus virus infection virus infections
[DOI] 10.1093/bioinformatics/btaa813 PMC 바로가기 [Article Type] Systems

Harnessing the immune system to overcome cytokine storm and reduce viral load in COVID-19: a review of the phases of illness and therapeutic agents

Review

Published on 2020-10-152022-10-28
Journal: Virology Journal [Category] COVID-19, MERS, SARS,

[키워드] activated acute respiratory distress acute respiratory distress syndrome alveolar macrophage angiotensin converting enzyme 2 antibody Antiviral article B cell bind blunt caused characterized China Chloroquine Combination coronavirus 2 Coronavirus disease 2019 COVID-19 COVID-19 illness CRS cytokine Cytokine release syndrome Cytokine storm drug target dysregulation enzyme epithelial cells Fever global pandemic hemodynamic instability hypoxia identify IFN IL-1β immune system immunological mechanism Immunotherapy imperative Innate immunity involved manifestation Necrosis Novel coronavirus nuclear Obstetric organ damage overcome Pathogenesis pathophysiology Patient pediatric Phase 2 Phase 3 receptor reduce respiratory respiratory symptoms responsible resulting SARS-CoV-2 SARS-CoV-2 epidemiology severe COVID-19 Signaling syndrome therapeutic agent therapeutic interventions tissue injury TLR Tocilizumab triggering Viral load viral replication virus Virus-host interaction Virus-host interactions World Health Organization worsening
[DOI] 10.1186/s12985-020-01415-w PMC 바로가기 [Article Type] Review

Airborne Particulate Matter and SARS-CoV-2 Partnership: Virus Hitchhiking, Stabilization and Immune Cell Targeting — A Hypothesis

Immunology

Published on 2020-09-242022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] alveolar macrophage COVID-19 dendritic cell hitchhiking Immunity matter Particulate Particulate matter pulmonary delivery SARS-CoV-2 targeting trained immunity
[DOI] 10.3389/fimmu.2020.579352 PMC 바로가기 [Article Type] Immunology

Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies

Immunology

Published on 2020-07-032022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] administration alveolar macrophage animal model binding blockade blunting cells circulating Clinical improvement clinical trial compassionate use COVID-19 Cytokine release syndrome death described driven by FDA approval GM-CSF healthy controls help Hospitalization hyperinflammation IL-6 Increased Inflammatory cytokine Inflammatory response inflammatory signaling interferon-γ intranasal intravenous dose involved lung damage Macrophage macrophages mavrilimumab mechanical ventilation Mild symptom monoclonal antibodies monoclonal antibody MOST outcomes Oxygenation patients with COVID-19 placebo-controlled trial produced proliferation Prospective provided Randomized rationale receptor Respiratory failure respiratory infections SARS-CoV-2 Severe case severe pneumonia Signaling Strategy syndrome T-cells targeting tested treated Trial while
[DOI] 10.3389/fimmu.2020.01625 PMC 바로가기 [Article Type] Immunology

Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19

Immunology

Published on 2020-06-262022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] ACE2 Activation acute lung injury acute phase response acute respiratory distress Adhesion Molecule alveolar macrophage ARDS Bisphosphonates Blood Bone marrow Cell Combination COVID-19 CSS cytokine Cytokine storm syndrome decrease develop dissemination Endothelium expression Factors fibrinogen IL-1β IL-6 immature Impact increase infiltration of neutrophil Inflammation Inflammatory inflammatory monocytes Intervention Kallikrein-kinin system knowledge lung lung epithelial cell Lung infection Lung injury Monocytes MOST patients Platelets pro-thrombotic proinflammatory cytokines reducing renin-angiotensin system response SARS-CoV-2 SARS-CoV2 SARS-CoV2 infection severe COVID-19 stimulate syndrome systemic systemic inflammation TNF VEGF
[DOI] 10.3389/fimmu.2020.01626 PMC 바로가기 [Article Type] Immunology

Non-sterilizing, Infection-Permissive Vaccination With Inactivated Influenza Virus Vaccine Reshapes Subsequent Virus Infection-Induced Protective Heterosubtypic Immunity From Cellular to Humoral Cross-Reactive Immune Responses

Original Research

Published on 2020-06-092023-06-08
Journal: Frontiers in Immunology [Category] Fulltext, 신종인플루엔자,

[키워드] alveolar macrophage germinal center B cell Heterosubtypic immunity Influenza pre-existing immunity tissue-resident memory T cell TIV
[DOI] 10.3389/fimmu.2020.01166 PMC 바로가기 [Article Type] Original Research

Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-06-052022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 A-a gradient acute lung injury acute respiratory distress addition allergic reaction alveolar macrophage alveolar pressure antiviral immunity Antwerp ARDS Belgium blinded Breastfeeding Bruges carbonate clinical clinician Confirmed COVID-19 infection control group Controlled trial COVID-19 COVID-19 pandemic defined Delta dissemination Effect element enrolled enrolment EudraCT ferritin level Ghent GM-CSF granulocyte-macrophage colony-stimulating factor High dose hospital Hypothesis hypoxic failure hypoxic respiratory failure Immune homeostasis inflammatory monocyte Inhaled Intervention intravenous invasive mechanical IWRS system leukine® lung malignancy mechanical ventilation mechanical ventilator Methylprednisolone number objective Open-label outcome oxygen Oxygenation paO2/fiO2 parameters Partial participant Participants Patient PF ratio pregnant primary endpoint progression of disease promote Protein protocol randomised randomised controlled trial randomization Randomized reached receive recruitment Registered Repair mechanisms replaced Respiratory failure Roeselare Sample size sargramostim SpO2 standard care Standard of care status Study protocol supplemental oxygen Support syndrome therapy treat Treatment Trial university ventilatory support Version website were excluded White blood cell
[DOI] 10.1186/s13063-020-04451-7 PMC 바로가기 [Article Type] Letter