Multiplex SARS-CoV-2 Genotyping Reverse Transcriptase PCR for Population-Level Variant Screening and Epidemiologic Surveillance인구 수준 변이 스크리닝 및 역학 감시를 위한 다중 SARS-CoV-2 유전자형 역전사효소 PCRArticle Published on 2021-07-192022-09-11 Journal: Journal of Clinical Microbiology [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 among others approach Area B.1.1.7 B.1.351 B.1.427 B.1.429 B.1.526 clinically concerning Concordance coronavirus COVID-19 detect E484K E484K mutation E484K mutations equipment facilitate failure rate Genomic surveillance Genotype genotyping Infection L452R Laboratory large cohort multiplex Mutation mutations N501Y N501Y mutation NAAT nonsynonymous nucleic acid nucleic acid amplification nucleic acid amplification test P.2 variants pandemic PCR phenotypic Prevalence public health qPCR resource reverse transcriptase reverse transcriptase PCR RT-qPCR San Francisco San Francisco Bay SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2-positive specimen screened Screening Sequencing severe acute respiratory syndrome Coronavirus specificity specimen Spike protein subset Support Surveillance unique variant viral spike protein whole-genome sequencing [DOI] 10.1128/JCM.00859-21 PMC 바로가기 [Article Type] Article
Pathogenic perspective of missense mutations of ORF3a protein of SARS-CoV-2SARS-CoV-2의 ORF3a 단백질의 미스센스 돌연변이의 병원성 관점Article Published on 2021-07-152022-09-11 Journal: Virus research [Category] SARS, 변종, 치료기술, [키워드] Amino acid among others Cluster coded Complete coronavirus COVID-19 COVID-19 pathogenesis Critical disease Effect function functions Genetic variations Genome include ion channel K-means clustering knowledge life-threatening Missense mutation Missense mutations morphogenesis Mutation mutations NCBI database Neutral Non-synonymous mutation ORF3 ORF3a ORF3a protein pathogenic pathogenicity Perspective Protein SARS-CoV-2 SARS-CoV-2 genome Shannon entropy stability the SARS-CoV-2 genome timeline virulence virus [DOI] 10.1016/j.virusres.2021.198441 PMC 바로가기 [Article Type] Article
Web-based, rapid and contactless management of ambulatory patients for SARS-CoV-2-testingSARS-COV-2 테스트를위한 외래 환자의 웹 기반, 신속하고 비접촉식 관리Research Published on 2021-06-072022-09-01 Journal: BMC Infectious Diseases [Category] MERS, 진단, [키워드] ambulatory patient ambulatory patients among others automated common cold communication concerning Contact cough COVID-19 COVID-19 pandemic Digital medicine duration of symptom effective facility FIVE headache implementation indicated indication indications information management mass mass casualty incident medical history occurred Outpatient outpatient appointment outpatients pandemic Patient per day physician potential risk provide provides QR code rapid response reduced representing Result retrieved SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 test SARS-CoV-2 testing SARS-CoV-2 testing strategy scheduling Seven sore throat supplementary material Support Symptom Symptoms test results the SARS-CoV-2 transmission of SARS-CoV-2 Travel Triage university university hospital was used Web Web-based patient management [DOI] 10.1186/s12879-021-06249-7 PMC 바로가기 [Article Type] Research
Estimates of gene ensemble noise highlight critical pathways and predict disease severity in H1N1, COVID-19 and mortality in sepsis patients유전자 앙상블 노이즈 추정치는 중요한 경로를 강조하고 H1N1, COVID-19의 질병 중증도 및 패혈증 환자의 사망률 예측Article Published on 2021-05-242022-09-01 Journal: Scientific Reports [Category] SARS, 바이오마커, 신종인플루엔자, 유전자 메커니즘, 진단, [키워드] alteration among others Analysis approach bioinformatics biological pathway Biomarker calculated changes Clinical outcome clinical outcomes Complex I COVID-19 Critical Differential gene expression differential gene expression analysis disease disease severity disease-associated dissect estimate expression of gene finding Gene Expression Gene expression analysis gene network gene networks genes encoding H1N1 hallmark heterogeneous highlight immune include individual inter-individual Interpretation measure mitochondrial molecular molecular mechanism molecular mechanisms Mortality oxidative stress pathology pathway Pathways Patient patients peroxisomes predict Predictive markers Prism Prognostic markers protein complex protein complexes reflected respiratory chain Respiratory system models response Sepsis sepsis patient sepsis patients subunit subunits Variability variance [DOI] 10.1038/s41598-021-90192-9 PMC 바로가기 [Article Type] Article
Peripheral blood microRNAs and the COVID-19 patient: methodological considerations, technical challenges and practice points말초혈액 microRNA와 COVID-19 환자: 방법론적 고려사항, 기술적 과제 및 실천 포인트Review Published on 2021-05-012022-09-11 Journal: RNA Biology [Category] SARS, 바이오마커, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addressed among others Analysis angiotensin Angiotensin-converting enzyme ARDS Biomarker biopsies Blood circulating circulating miRNA profile circulating miRNA profiles Clinical practice coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 emergency COVID-19 patients detection Early detection experimental design heparin infection with SARS-CoV-2 Interpretation liquid biopsy LMWH low molecular weight low molecular weight heparin management methodological Methods microRNA MicroRNAs miRNA miRNA signature miRNAs ncRNA noncoding RNA pandemic peripheral public health qPCR reproducibility respiratory respiratory distress resulting rigour robust RT-qPCR SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus transcriptomic translation variable [DOI] 10.1080/15476286.2021.1885188 PMC 바로가기 [Article Type] Review
Human coronaviruses in idiopathic Parkinson’s disease: Implications of SARS-CoV-2’s modulation of the host’s transcriptome특발성 파킨슨병의 인간 코로나바이러스: SARS-CoV-2의 숙주 전사체 조절의 의미Article Published on 2021-04-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] among others analyses Analysis comparison Control coronavirus determine disease Diseases Effect enriched pathways enrichment analyses enrichment analysis false discovery rate FDR Gene Expression Gene ontology Gene Set Enrichment Analyses GSEA head Head-to-head comparisons Host Human human coronavirus human coronaviruses Huntington's disease immune response indicated modulation mononuclear cell motor nucleus mRNA NAFLD neurodegeneration neurodegenerative Neuroinvasive nigra not limited Ontology overlap overlapping parasitism parkinson s disease Parkinson's Disease Pathogenesis pathway Patient PBMC performed Peripheral blood Perturbation retrieved SARS-CoV-2 SARS-COV-2 infection scrutiny statistically significant substantia substantia nigra Surveillance tissue tissues Transcriptome transcriptomic Whole blood [DOI] 10.1016/j.meegid.2021.104733 PMC 바로가기 [Article Type] Article
Restructuring maternal services during the covid-19 pandemic: Early results of a scoping review for non-infected women코로나19 팬데믹 기간 동안 모성 서비스 구조 조정: 감염되지 않은 여성에 대한 범위 검토의 초기 결과Article Published on 2021-03-012022-09-11 Journal: Midwifery [Category] SARS, 치료기술, [키워드] among others antenatal care approach Care carried caused changes in clinical Clinical distancing Community complications continuity Continuity of care COVID-19 hazards Health Health Service Health services health system health systems in-person visit include integration Local Midwifery mother non-infected Novel coronavirus outbreak pandemic Postpartum Postpartum care potential risk preference Pregnancy pregnancy complications preventive measure Referral resource restructuring symptomatic Telemedicine Variation women [DOI] 10.1016/j.midw.2020.102916 PMC 바로가기 [Article Type] Article
Comorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infection난소암과 관련된 동반 질환 및 염증 및 SARS-CoV-2 감염에 대한 영향Review Published on 2021-02-252022-09-12 Journal: Journal of Ovarian Research [Category] MERS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age aldosterone among others androgen angiotensin Cancer patients caused cellular Characteristics chemokine chemokines chronic inflammation colony-stimulating factor comorbid condition comorbid conditions Comorbidities Comorbidity condition contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 symptoms Cytokines death develop disease dysregulated early stage G-CSF gonadotropin granulocyte granulocyte colony-stimulating factor greater Hormones Hospitalization hospitalizations IL-10 IL-2 IL-6 Immunocompromised Increased Infection Inflammation Inflammatory cytokine Inflammatory cytokines interferon involved IP-10 M-CSF Macrophage macrophage colony-stimulating factor MCP-1 mechanism microenvironment molecular monocyte monocyte chemoattractant protein-1 Necrosis organs outcome ovarian cancer Pathogenesis Patient pro-inflammatory Protein public health RAAS Renin renin-angiotensin-aldosterone system risk risk factor SARS-CoV-2 SARS-COV-2 infection sera Severe case severe cases significantly subject TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor α upregulation vulnerable population women [DOI] 10.1186/s13048-021-00787-z PMC 바로가기 [Article Type] Review
Use of geographic information systems web mapping application to support active case search to guide public health and social measures in the context of COVID-19 in Zimbabwe: a preliminary report to guide replication of methods in similar resource settings짐바브웨의 COVID-19 맥락에서 공중 보건 및 사회적 조치를 안내하기 위한 적극적인 사례 검색을 지원하기 위한 지리 정보 시스템 웹 매핑 애플리케이션의 사용: 유사한 리소스 설정에서 방법의 복제를 안내하기 위한 예비 보고서Research Published on 2021-02-122022-09-10 Journal: The Pan African Medical Journal [Category] MERS, 치료기술, [키워드] active case search acute respiratory illness acute respiratory illnesses acute respiratory syndrome among others Analysis ArcGIS ArcMap ARI Care carried China Complete conducted confirmed case Contact tracing coronavirus country COVID-19 COVID-19 cases COVID-19 pandemic COVID-19 transmission COVID19 Decision-making detect develop Early detection effective Epidemic geo-spatial analysis geographic information systems GIS globe Health Health care hotspot identify IMPROVE information Information Systems Isolation lockdowns management measure New coronavirus pandemic Pandemics platform Pneumonia positive preliminary report public health reduce Replication representing resource respiratory Result SARI Severe acute respiratory syndrome shown social distancing Spread statistical Support virus Visualization web mapping Wuhan Zimbabwe [DOI] 10.11604/pamj.2021.38.159.27143 PMC 바로가기 [Article Type] Research
Severe SARS-CoV-2 disease in the context of a NF-κB2 loss-of-function pathogenic variantNF-κB2 기능 상실 병원성 변이체의 맥락에서 심각한 SARS-CoV-2 질병Case Reports Published on 2021-02-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS, 변종, 진단, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus Affect affecting among others appear B-cell biologic biologic therapies cardiovascular system Central nervous system Clinical management combined immunodeficiency common variable immunodeficiency Complication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease dysregulation evaluated functional Gain gain-of-function gastrointestinal tract global pandemic heterozygous variant heterozygous variants Hospitalization Host Host immune response hyperinflammatory responses immune immune dysfunction immune dysregulation immunodeficiency Infection intrinsic kidney loss of function loss-of-function Lungs male management mechanical ventilation memory B cells NF-κB NF-κB pathway NF-κB2 NFKB2 Novel coronavirus nuclear organ systems outcome pathogenic variant Patient patients with SARS-CoV-2 phenotype reported required respiratory respiratory distress Respiratory distress syndrome risk factor SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity of COVID-19 skin susceptible Symptom symptomatic SARS-CoV-2 infection syndrome therapy treat variant virus [DOI] 10.1016/j.jaci.2020.09.020 PMC 바로가기 [Article Type] Case Reports