Potential benefits of ginseng against COVID-19 by targeting inflammasomesReview article Published on 2022-04-012022-10-05 Journal: Journal of Ginseng Research [Category] 변종, 치료제, [키워드] activate acute respiratory syndrome anti-inflammatory effect antiviral immunity benefit cause coronavirus coronavirus disease COVID-19 COVID-19 patients Cytokine storm death determinant evade ginseng Ginsenoside Host hyper-inflammation hyperinflammation immune system impair IMPROVE Inflammasome inflammasome activation inflammatory signaling inhibit multiple organs pathogenic virus Pathways Potential Regulatory Respiratory system Saponin SARS-CoV-2 Symptom therapeutic [DOI] 10.1016/j.jgr.2022.03.008 [Article Type] Review article
Defining the risk of SARS-CoV-2 variants on immune protection Reviews Published on 2022-03-312022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] acute respiratory syndrome Affect animal models antiviral immunity approach assessment caused coronavirus Critical diagnostics Effect Effectiveness effort facilitated genomic group identify immune protection Immunity implication Infection Infectious disease notable pandemic pathogen Protective public health public health threat reagents reduce resistance to infection risk SARS-CoV-2 SARS-CoV-2 variant the SARS-CoV-2 Transmission vaccination Vaccine Vaccine-induced immunity variant variants viral evolution virulence [DOI] 10.1038/s41586-022-04690-5 [Article Type] Reviews
Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients조합 분석은 경증 COVID-19 환자에서 나중에 항바이러스 면역을 예측하는 고도로 조정된 초기 단계 면역 반응을 보여줍니다Article Published on 2022-03-292022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] Analysis antibody antibody levels Antibody Response antibody-secreting cell antibody-secreting cells antiviral immunity Arm Asymptomatic CD4 CD8 T cells cellular Cohort combinatorial analysis controls COVID-19 CXCL10 cytokine cytokine response dendritic cell Diagnosis dominant early-stage response expression feature Frequency functional hospitalized patient hospitalized patients immune immune cells immune reaction immune response immune responses immunology immunopathology Inclusion innate immune cell Innate immune cells interferon IP10 marker Mild mild COVID-19 patient mild COVID-19 patients mild patient mild patients non-hospitalized observé Patient PCR predict predict antibody levels Predictive remained response reveal SARS-CoV-2 severe COVID-19 systematic analysis systems immunology T cell T cells trajectory transient cytokine response. while [DOI] 10.1016/j.xcrm.2022.100600 PMC 바로가기 [Article Type] Article
AMP5A modulates Toll-like receptors 7 and 8 single-stranded RNA immune responses in PMA-differentiated THP-1 and PBMCResearch Published on 2022-03-032022-10-29 Journal: Translational Medicine Communications [Category] COVID-19, [키워드] activate activated Activation acute respiratory syndrome addition agonist AhR AMP5A And Chemokines antagonist antiviral immunity Aryl hydrocarbon receptor Autoimmunity biologic chemokines clinical investigation condition coronavirus coronavirus disease Course COVID-19 CXCL10 cytokine Cytokines decrease detect differentially expressed dysregulated Effect ELISA enrichment analysis evaluate experiment fraction Human serum albumin hyperinflammation Hyperinflammatory IL-12 IL-1β IL-6 Imbalance Immune cell immune response immunomodulatory implicated Infection Inflammation inflammatory mediator Inflammatory response inhibit Intervention involved low molecular weight Lung disease mechanism modulate mononuclear cells myeloid cell myeloid cells NF-κB NF-κB activation Osteoarthritis pathway PBMC Peripheral blood PPARγ pro-inflammatory pro-inflammatory cytokine profiles progression Protective provided receptor REP Result resulting RNA Severe case Signaling single-stranded ssRNA suppresse Therapeutic approach THP-1 TLR TLR7 TLR7/8 Toll-like receptor toll-like receptor 7 Toll-like receptor 8 transcription factor transcription factors treat Treatment viral sequences were used with COVID-19 [DOI] 10.1186/s41231-022-00110-y PMC 바로가기 [Article Type] Research
Potential Inhibitors Targeting Papain-Like Protease of SARS-CoV-2: Two Birds With One StoneChemistry Published on 2022-02-232022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] acute respiratory syndrome Administered Antiviral antiviral immunity approach approved Bird Community COVID-19 crystal structure Efficacy and safety feature functional Health Host Infection inhibition inhibitor inhibitors innate immune response International Intervention mutate outbreak Papain-like protease pathogen PLPro Potential Prevent protease resulting SARS-CoV-2 Spread Stone Support suppresse targeting the patient Vaccine viral replication virus [DOI] 10.3389/fchem.2022.822785 PMC 바로가기 [Article Type] Chemistry
Individualized Constellation of Killer Cell Immunoglobulin-Like Receptors and Cognate HLA Class I Ligands that Controls Natural Killer Cell Antiviral Immunity Predisposes COVID-19Genetics Published on 2022-02-222022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] absence activating acute respiratory syndrome anti-SARS-CoV-2 Antiviral antiviral immunity Asymptomatic Biomarker cause Cell characterized class Cognate Combination constellation Control controls coronavirus Coronavirus-2 COVID-19 COVID-19 cohort COVID-19 host genetics COVID-19 patient COVID-19 susceptibility Defense determine detrimental Frequency General population Genetic healthy HLA HLA association HLA class I HLA gene HLA-Bw4 Host Hypothesis individual individuals Infection Inflammatory cytokine KIR KIR receptors KIR-HLA KIR-HLA association KIR2DL2 + KIR2DS1 KIR2DS5 KIR3DL1 KIR3DL2 Ligand ligands majority maturation natural NK cell NK cell function NK cells offer outcome pathologic Patient patients hospitalized receptor reduce regulated responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility severe COVID-19 severe COVID-19 patient significantly lower subsequent tested the patient triggered variable with mild disease [DOI] 10.3389/fgene.2022.845474 PMC 바로가기 [Article Type] Genetics
RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infectionResearch article Published on 2022-02-132022-10-05 Journal: Molecular Therapy. Nucleic Acids [Category] 치료제, [키워드] Activation agonist Antiviral antiviral immunity antiviral response Antiviral treatment approach Brain coronavirus COVID-19 disease severity effective emerging viruses exhibited innate antiviral immunity innate immune Innate immunity K18-hACE2 K18-hACE2 mouse model Ligand lung Lung inflammation mice MT: Oligonucleotides: Therapies and Applications Neutralizing antibody response nucleic acid immunity oropharyngeal swab outcome pandemic Prophylactic PROTECT receptor reduce reduced RIG-I RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic Spread survival therapeutic therapy Treatment Type I IFN type I interferon Vaccine viral challenge Viral load virus viruses [DOI] 10.1016/j.omtn.2022.02.008 [Article Type] Research article
Targeting stem-loop 1 of the SARS-CoV-2 5′ UTR to suppress viral translation and Nsp1 evasion423 Published on 2022-02-112022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] 40S 5′ UTR Antisense oligonucleotide antiviral immunity block bypassing C-terminal domain circumvent Concentration conserved COVID-19 COVID-19 pandemic Critical drug resistance effective therapy evade expressing Health highly pathogenic Host host protein human ACE2 infected cell inhibit interfere maintain mechanism Messenger RNA mRNA mRNA stability nonstructural protein 1 nucleic acid pathogenicity presenting PROTECT protein trafficking Replication SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2–infected mice sequence Significance suppress susceptible targeting the SARS-CoV-2 therapeutic therapeutic target transgenic mice translation translational unique Vaccines variants variants of SARS-CoV-2 Viral protein viral replication virulence virus [DOI] 10.1073/pnas.2117198119 PMC 바로가기 [Article Type] 423
DExD/H-box helicase 9 intrinsically controls CD8 + T cell-mediated antiviral response through noncanonical mechanismsDExD/H-box 헬리카제 9는 비정규 메커니즘을 통해 본질적으로 CD8 + T 세포 매개 항바이러스 반응을 제어합니다Article Published on 2022-02-112022-09-11 Journal: Science Advances [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activated Activation antiviral immunity antiviral response Apoptosis binding CD8 Control Coordinate COVID-19 patients DHX9 domain effector effector cell ERK event expression Helicase independent independent of intrinsically LCK mechanism nuclear Phosphorylation proliferation proliferative promote PROTECT regulate Regulatory required survival T cell T cells TCR Transcription viral clearance virus infection ZAP70 [DOI] 10.1126/sciadv.abk2691 PMC 바로가기 [Article Type] Article
Differential immunogenicity of homologous versus heterologous boost in Ad26.COV2.S vaccine recipientsAd26.COV2.S 백신 수용자에서 동종 대 이종 부스트의 차등 면역원성Article Published on 2022-02-112022-09-11 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Ad26 Ad26.COV2.S Ad26.COV2.S vaccine Adenovirus Adenovirus Vector Antiviral antiviral immunity BNT162b2 boost breadth cellular immune responses cellular immunity ChAdOx1 ChAdOx1 nCoV-19 college coronavirus disease Coronavirus disease 2019 COV2.S COVID-19 dose ENhance feature Heterologous heterologous immunity heterologous vaccine homologous homologous or heterologous humoral immune responses immunological immunological parameter individual individuals knowledge lack Medical Research Council Ministry of Health mRNA of BNT162b2 offered protection pump quantity recipient second dose Singapore single dose small sample size SMD specific antibodies spike-specific antibodies Spike-specific antibody Support supported T cell T cells Trustee utilization vaccination Vaccine Vaccines [DOI] 10.1016/j.medj.2021.12.004 PMC 바로가기 [Article Type] Article