Re-analysis of Single Cell Transcriptome Reveals That the NR3C1-CXCL8-Neutrophil Axis Determines the Severity of COVID-19Immunology Published on 2020-08-282022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] airway apoptotic axis BAL Bronchoalveolar lavage fluid Cell chemokine COVID-19 COVID-19 patient CXCL8 differential expression disease severity DNA damage drastic epithelial epithelial cells expressed gene expression feature glucocorticoid immunological Inflammation lung myeloid neutrophil Neutrophil extracellular traps neutrophil infiltration Neutrophils pandemic Patient Proinflammatory cytokine receptor recruited regulated SARS-CoV-2 SARS-COV-2 infection scRNA-seq scRNA-seq data severe COVID-19 symptom severe group Severe patient severe symptom suggested [DOI] 10.3389/fimmu.2020.02145 PMC 바로가기 [Article Type] Immunology
Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73 – Phenotype Identifies Polyfunctional Cytotoxic LymphocytesArticle Published on 2020-07-222022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] analyzed axis CD39 CD73 CD8 cells cellular Cohort correlated COVID-19 COVID-19 patient COVID-19 patients Cytokines cytotoxic cytotoxic lymphocytes decrease disease stage expression extracellular ATP functional Future granzyme B IFN-γ immune response Immunomodulatory therapies in healthy individuals Inflammation involved lymphocyte majority natural killer Necrosis NKT NKT cell pathophysiology Patient perforin Population populations Prognostic marker purinergic signaling regulate SARS-CoV-2 secreting secretion Serum ferritin significantly higher significantly lower subset T cell target TNF-α [DOI] 10.3390/cells9081750 PMC 바로가기 [Article Type] Article
COVID-19 – Endothelial Axis and Coronary Artery Bypass Graft Patency: a Target for Therapeutic Intervention?Special Article Published on 2020-01-012022-10-28 Journal: Brazilian Journal of Cardiovascular Surgery [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome angiotensin-converting enzyme 2 arteries Artery article axis binding bypass Coronary coronary artery bypass Coronary Artery Bypass Graft Surgery coronavirus coronavirus disease COVID-19 endothelial Endothelial dysfunction Graft grafting induce Infection Inflammation mammary patients progression receptor reported Saphenous Vein SARS virus SARS-CoV-2 target therapeutic potential thrombosis vascular dysfunction vascular inflammation vessel vessels [DOI] 10.21470/1678-9741-2020-0303 PMC 바로가기 [Article Type] Special Article
Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity비복제 Toxoplasma gondii Uracil Auxotrophs에 의한 Rhoptry 및 Dense Granule Effector 단백질의 분비는 항종양 면역의 발달을 제어합니다Research Article Published on 2016-07-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogated activate activated acute infection Auxotroph auxotrophic mutants axis CD4 CD8 Cell Nucleus Cell signaling cellular signaling pathway cellular signaling pathways conjunction Control deleted Deletion dendritic cells Dense development effective effective therapy effector effector molecule effector molecules effector protein effector proteins function Granule GTPase GTPases Host host cell host cell nucleus host cell response Host immune response host immune responses host innate immunity host response host responses identify IFN-γ immune responses Immune suppression Immunity independent Infection interferon Invasion latent infection mammalian cell mechanism membrane mice mutant not affect nucleus ovarian cancer parasite pathway Pathways Protein required responses rhoptry Safe secreted secretion shown Signaling solid tumor solid tumors survival T cell T cells target therapeutic These data Toxoplasma gondii transcriptional Trigger Tumor tumor microenvironment tumors type I uracil vaccination vaccine strain virulence [DOI] 10.1371/journal.pgen.1006189 PMC 바로가기 [Article Type] Research Article