Kinetics of SARS-CoV-2 antibody responses pre-COVID-19 and post-COVID-19 convalescent plasma transfusion in patients with severe respiratory failure: an observational case-control study중증 호흡부전 환자에서 코로나19 이전 및 코로나19 이후 회복기 혈장 수혈에 대한 SARS-CoV-2 항체 반응의 동역학: 관찰 사례-대조군 연구Observational Study Published on 2022-08-012022-09-12 Journal: Journal of Clinical Pathology [Category] MERS, SARS, 임상, 진단, [키워드] anti-RBD anti-RBD IgM antibodies antibody Antibody titre binding domain Blood blood draw Blood Transfusion case-control study CCP Clinical outcome clinical outcomes control patient controls convalescent plasma COVID-19 ECMO ELISA extracorporeal membrane oxygenation hospital ICU IgG IgG and IgM IMPROVE increase indicated individual intensive care Kinetics LOS median pandemic Patient patients patients with COVID-19 plasma Primary outcome RBD recipient SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody response SARS-CoV2 secondary outcome seronegative seropositive severe respiratory failure Support survival the SARS-CoV-2 titre Treatment vaccination ventilator ventilatory were measured while with COVID-19 [DOI] 10.1136/jclinpath-2020-207356 PMC 바로가기 [Article Type] Observational Study
In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding시험관 내 진화는 ACE2 및 종간 결합에 대한 높은 친화도로 새로운 SARS-CoV-2 돌연변이를 예측합니다Article Published on 2022-07-182022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 affinity being binding binding affinity binding domain boost complex Containment COVID-19 pandemic creating Cross-species transmission Cryo-electron microscopy determine determined by driven by electron microscopy Evolution high affinity human ACE2 immune evasion in vitro increase inhibit mechanism Mutation N501Y mutation predict Q498 Q498H RBD RBD variant RBD variants S477N SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 RBD SARS-CoV-2 receptor SARS-CoV-2 variant SARS-CoV-2 variants Transmissibility Vaccines variant variants [DOI] 10.1371/journal.ppat.1010733 PMC 바로가기 [Article Type] Article
NMR Reveals Specific Tracts within the Intrinsically Disordered Regions of the SARS-CoV-2 Nucleocapsid Protein Involved in RNA EncounteringNMR은 RNA 조우에 관여하는 SARS-CoV-2 뉴클레오캡시드 단백질의 본질적으로 무질서한 영역 내의 특정 경로를 나타냅니다Article Published on 2022-07-022022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] absence atomic binding domain concert COVID-19 Disordered domain engage event experiments genomic RNA identify IDP information Interaction intrinsically N-terminal NMR NMR spectroscopy NTD organized primary sequence priming Protein Region Regulatory RNA SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 RNA Specific the SARS-CoV-2 tract Transcription [DOI] 10.3390/biom12070929 PMC 바로가기 [Article Type] Article
Antibody Responses to SARS-CoV-2 After Infection or Vaccination in Children and Young Adults With Inflammatory Bowel Disease염증성 장 질환이 있는 소아 및 젊은 성인의 감염 또는 예방 접종 후 SARS-CoV-2에 대한 항체 반응Article Published on 2022-07-012022-09-11 Journal: Inflammatory bowel diseases [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 age angiotensin Antibody Response approved binding domain biologic biologic therapies Cell characterization children clinical symptom Cohort Crohn's disease disease dynamic range embryonic kidney enrolled enzyme expressing flow cytometry fluorescent HEK-293 Hospitalized IBD IgG antibodies IgG antibody IgG positivity IgG response immunization immunoassay Inflammatory bowel disease infliximab lentivirus less longitudinal cohort study measure Most patients natural infection neutralization antibodies Neutralization antibody Neutralization assay Neutralizing antibodies neutralizing antibody Patient PCR Pediatric patient performed post infection Protective Protein binding RBD IgG receiving Receptor binding domain Reinfection response risk robust S-RBD SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 spike protein receptor binding domain serum significantly lower Spike protein subject the spike protein therapy ulcerative colitis vaccination Vaccines variant vedolizumab was used wild type [DOI] 10.1093/ibd/izab207 PMC 바로가기 [Article Type] Article
SARS-COV-2 RBD (Receptor binding domain) mutations and variants (A sectional-analytical study)SARS-COV-2 RBD(수용체 결합 도메인) 돌연변이 및 변이체(섹션 분석 연구)Article Published on 2022-07-012022-09-11 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 receptor Alpha alpha and delta variants Alpha variant Amino acid amino acid substitutions amino acids amplified B.1.1.529 B.1.1.7 binding domain binding the receptor-binding body pain chill chills circulation Clinical outcome clinical outcomes Clinical sign Clinical signs cross-sectional D614G delta variant domain Effect enrolled essential amino acids Fever Frequency highest host cells identify Infection lung involvement mutant strain Mutation mutations N501Y omicron Omicron variant outcomes Pain pangolin Patient qRT-PCR RBD RBD region Receptor-binding domain SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV2 sequenced spike Spike protein strain T478K the patient the RBD the SARS-CoV-2 variant variants variants of concern variants of interest Variation viral infection virus VOCs VOIs [DOI] 10.1016/j.micpath.2022.105595 PMC 바로가기 [Article Type] Article
Receptor binding domain of SARS-CoV-2 from Wuhan strain to Omicron B.1.1.529 attributes increased affinity to variable structures of human ACE2우한 균주에서 Omicron B.1.1.529까지의 SARS-CoV-2 수용체 결합 도메인은 인간 ACE2의 가변 구조에 대한 증가된 친화성을 특성으로 합니다.Article Published on 2022-07-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] ACE2 ACE2 receptor ACE2 receptors ACE2 variant ACE2 variants ACE2-RBD affinity analysed Analysis angiotensin Angiotensin-converting enzyme attribute B.1.1.529 binding binding domain binding efficiency binding energy Care caused changes in coding region complexes contributing to COVID-19 detect determine docking dynamic Dynamic simulation enzyme Genetic variant genetic variants global pandemic help highlight homology model Homology models Human human ACE2 human host Infectious disease Interaction isolates lead management molecular molecular dynamics nucleotide omicron pathogenic polymorphism Protein docking RBD RBD complex RBDs receptor Receptor binding domain Repository retrieved risk RMSD RMSF Safe SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 virus SARS‐CoV‐2 selected severity single nucleotide stability Structural variant structural variants Structure the RBD Total variant Variation was performed wildtype Wuhan Wuhan strain [DOI] 10.1016/j.jiph.2022.06.004 PMC 바로가기 [Article Type] Article
Characterization of the significant decline in humoral immune response six months post-SARS-CoV-2 mRNA vaccination: A systematic reviewSARS-CoV-2 mRNA 백신 접종 후 6개월 후 체액성 면역 반응의 현저한 감소 특성: 체계적인 검토Review Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration age anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-Spike IgG antibody Antibody Response Antibody titer Antibody titers appearance article binding domain BNT161b2 BNT162b2 booster Breakthrough infection breakthrough infections calculated characterization Comorbidities coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mRNA Vaccination determine Effect Efficacy Evidence exhibited Factor finding highlight humoral humoral immune response Humoral immunity Humoral response IgG Immunoglobulin Immunoglobulin G independent independent of Kinetics Longitudinal data Messenger RNA Moderna mRNA mRNA 1273 mRNA BNT162b2 mRNA vaccination mRNA-1273 Participants peak levels Pfizer-BioNTech postvaccination presence of comorbidities reached reported respiratory second dose serostatus Serum level serum levels severe acute respiratory syndrome Coronavirus Sex systematic review Vaccination strategy Vaccine Vaccines variant waning immunity was performed [DOI] 10.1002/jmv.27688 PMC 바로가기 [Article Type] Review
Statistics of antibody binding to the spike protein explain the dependence of COVID 19 infection risk on antibody concentration and affinity스파이크 단백질에 대한 항체 결합 통계는 항체 농도 및 친화도에 대한 COVID 19 감염 위험의 의존성을 설명합니다Article Published on 2022-06-072022-09-12 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] antibody Antibody binding antibody concentration binding binding domain Blood Breakthrough infection can be used Concentration COVID 19 COVID-19 Critical decrease distribution Efficacy explain IgG Immunity induce Infection infection risk Probability required risk risk of infection SARS-CoV-2 vaccine Spike protein Statistics the spike protein vaccination Vaccine Variation virus [DOI] 10.1038/s41598-022-13748-3 PMC 바로가기 [Article Type] Article
Assessment of BIV1-CovIran inactivated vaccine-elicited neutralizing antibody against the emerging SARS-CoV-2 variants of concern우려되는 신종 SARS-CoV-2 변이체에 대한 BIV1-CovIran 비활성화 백신 유도 중화 항체 평가Article Published on 2022-06-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Alpha antibody assessment B.1.1.7 B.1.351 B.1.617.2 Beta binding domain BIV1-CovIran vaccine candidate vaccine conventional virus neutralization test correlated correlation COVID-19 COVID-19 vaccine Delta delta variant Delta variants demonstrated effective exhibited inactivated individual investigated NAb NAbs neutralization neutralization test neutralize Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody Protein recipient recipients reduction in SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants sensitivity sera serum Spearman the SARS-CoV-2 titre Vaccine vaccinee vaccinees variant variants variants of concern virus neutralization test virus-neutralizing was measured Wuhan strain [DOI] 10.1016/j.cmi.2022.02.030 PMC 바로가기 [Article Type] Article
COVID-19 vaccine booster dose needed to achieve Omicron-specific neutralisation in nursing home residents요양원 거주자에서 Omicron-specific 중화를 달성하는 데 필요한 COVID-19 백신 부스터 용량Article Published on 2022-06-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] anti-RBD Anti-spike binding domain BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine booster booster dose booster vaccination CDC COVID-19 COVID-19 vaccine death detectable dose enrolled Evidence examined Geriatrics HCW HCWs healthcare worker Healthcare workers high-risk population Hope hospitalisation Humoral immunity initial lifted limit of detection Long-term care majority median age morbidity and mortality mRNA vaccine neutralisation neutralisation activity neutralisation titre Neutralisation titres Neutralising activity NIH nursing home omicron Omicron variant PROTECT RBD SARS-CoV-2 SARS-COV-2 infection significantly increased Support These data titre vaccination variant variants vulnerable population waning immunity Wuhan strain [DOI] 10.1016/j.ebiom.2022.104066 PMC 바로가기 [Article Type] Article